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At least 1,513 records · Page 84Linked to original sources
PubMed1977

Prevalence of high blood pressure treated and untreated in an urban adult New Zealand population: Napier 1973.

The prevalence of hypertensive levels of blood pressure was investigated in a random sample of 2535 adults in Napier in 1973. More than 70 percent of all persons examined had been measured for blood pressure within the previous five years. A retrospective analysis of results using the WHO classification indicated that 16.4 percent of the adult population had a mean systolic pressure of not less than 160mmHg or mean diastolic pressure of not less than 95mmHg. One third of the hypertensive group was receiving treatment and one half of those on therapy were effectively controlled. The total prevalence of treated and untreated hypertensives was estimated to be 20 percent of the survey population. According to the WHO criteria for blood pressure classification 33 percent of those over 60 years were hypertensive.

Adult↗
PubMed1988

Chondroitin sulphate proteoglycan production by NK cells and T cells: effects of xylosides on proliferation and cytotoxic function.

Cultured human NK cells and T cells grown in the presence of IL-2 and phytohaemagglutinin incorporated 35S sulphate into two distinct macromolecular species. The larger molecule was identified as a chondroitin-4-sulphate proteoglycan and was present in both cell-associated and secreted material. The smaller component was identified as free glycosaminoglycan and was present only in the cell-associated material. The sulphated macromolecules synthesized by NK cells were smaller than those produced by T cells. Growth in the presence of beta-D-xyloside led to a decrease in proteoglycan production, together with an increase in the synthesis of free glycosaminoglycan. The latter molecule was found in the secreted as well as the cell-associated fraction. In all instances, growth of T cells was inhibited by xyloside in a dose-dependent fashion. However, growth of NK cells from 3/7 donors was stimulated at low concentrations of xyloside (0.25 and 0.5 mM). Growth of NK cells in xyloside had no effect on their lytic activity, and the 'NK-like' cytolytic capacity of cultured T cells was similarly unaffected. Both NK cells and T cells grown in xyloside at a concentration resulting in a 50% inhibition of intact proteoglycan synthesis did not show increased susceptibility to autolysis in the presence of NK-cell targets. These findings suggest that optimal production of the intact proteoglycan molecule may not be essential for NK-cell lytic function or protection of effector cells in vitro.

Cells, Cultured↗
PubMed1987

Blister beetle dermatosis in New Zealand.

Seventy-four New Zealand Army personnel with a distinctive bullous dermatosis caused by an endemic beetle are described. These are the first reported cases of this condition in New Zealand. The beetle, Thelyphassa lineata (Fabricius) belonging to the family Oedemeridae was shown to be a vesicant species, as skin contact induced blisters in volunteers. This is a previously unrecognised property of this species.

Animals↗
PubMed1988

Gas in the urinary tract: its aetiology and management.

Gas within the urinary tract may be an incidental finding or it may be detected in the course of investigating a patient with urinary or abdominal symptoms. In the immediate postoperative period it is unlikely to be of any significance, but at any other time it is a sign of serious underlying pathology. In this article its aetiology and management are discussed.

Gases↗
PubMed1987

Pyoderma gangrenosum: a Waikato experience.

Ten cases of pyoderma gangrenosum were seen over a period of nine years at the Waikato Hospital dermatology clinic. Several associated conditions were found. Four cases were associated with inflammatory bowel disease, three cases with arthritis, one case was found in association with myelofibrosis. Four patients were diabetic, an incidence higher than in previous studies. Most patients were treated with oral steroids but additional therapies were used to achieve disease control and for their steroid-sparing effect.

Adult↗
PubMed1986

Studies of the effect of 1,25-dihydroxycholecalciferol on the proliferation and differentiation of the human promyelocytic leukaemia cell line HL-60.

Treatment of the human promyelocytic leukaemia cell line HL-60 with 1,25(OH)2D3, the active metabolite of vitamin D3, led to a dose- and time-dependent inhibition of growth and 3H-TdR incorporation at the population level. A similar effect was noted at the single cell level in clonogenic assays and autoradiographic experiments. Flow cytometry indicated that there was an arrest of cells in the G0/G1 phase of the cell cycle. Parallel to the loss of proliferative capacity 1,25(OH)2D3 induced differentiation of HL-60 into monocyte/macrophages as measured by the enzyme NSE and the macrophage membrane antigen recognised by the monoclonal antibody EB11 as well as by morphological changes. These findings reinforce the concept of concordant induction of differentiation and loss of proliferative capacity and demonstrate that the latter occurs not only at the population level but also at the single cell level in this system. In limiting dilution assays in liquid culture there was evidence for positive interactions between HL-60 cells as untreated cells gave less colonies at low dilutions than would have been expected by Poisson statistical analysis. In the presence of 10(-8) M 1,25(OH)2D3 more complex growth parameters were noted indicating the involvement of both positive and negative cellular interactions.

Calcitriol↗
PubMed1979

A comparative study of the effects of prostaglandins and H2-receptor antagonists on gastric acid secretion, mucosal blood flow and ulcer formation.

The prostaglandins E2 and 16,16-dimethyl-PGE2 methyl ester were compared with the H2-receptor antagonists burimamide and metiamide for their effects on gastric acid secretion (GAS) and gastric mucosal blood flow (MBF) in rats and dogs, and on ulcer formation in rats. Orally, both 16,16-dimethyl-PGE2 methyl ester (20 microgram/kg) and metiamide (6 mg/kg) were markedly effective inhibitors of GAS stimulated by histamine acid phosphate or pentagastrin in Heidenhain pouch dogs, producing a reduction both in volume of gastric juice and in the concentration of titratable acid. In anaesthetised rats, however, the H2-receptor antagonists, when perfused into the gastric lumen, did not consistently inhibit the increased GAS caused by various secretagogues. In contrast, the prostaglandins, under the same conditions, caused marked inhibition of GAS provoked by all secretagogues. Intravenously, both burimamide and metiamide were effective in inhibiting GAS in rats but were less potent than the prostaglandins. The order of potency was: 16,16-dimethyl-PGE2 methyl ester greater than PGE2 greater than metiamide greater than burimamide. By the oral route, the H2-receptor antagonists were found to be very weak inhibitors of indometacin-induced gastric ulcer in rats, as compared to the prostaglandins. MBF studies in rats and in Heidenhain dogs showed that i.v. or p.o. administration inhibited both GAS and MBF in most cases. The ratio r = [MBF (ml/min)/GAS (mumol H+/min)] was generally increased by both types of compounds, suggesting a preferential effect on GAS.

16,16-Dimethylprostaglandin E2↗
PubMed1985

Streptococcus bovis bacteraemia requires rigorous exclusion of colonic neoplasia and endocarditis.

Twelve patients presented to the hospitals of the Auckland Hospital Board with bacteraemia caused by Streptococcus bovis in the years 1979-84. Ten had endocarditis, affecting homograft valves in two cases and the tricuspid valve in one case. Of nine patients who underwent investigation of the large bowel, only one did not have a colorectal tumour. Three had colonic adenocarcinoma and three had colorectal villous adenoma. Two, including a patient with acute hepatic failure from alcoholic cirrhosis, had colonic adenomata. Colonoscopy provided a tissue diagnosis of colorectal neoplasia despite negative radiological studies in three patients. Bacteraemia due to S. bovis should prompt rigorous investigation to exclude both endocarditis and tumours of the large bowel.

Adenocarcinoma↗
PubMed1974

The story of James.

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Adolescent Psychiatry↗