[WHAT IS VASCULAR TONUS?STUDIES ON THE RELATIONS OF VASCULAR MUSCLE CONTRACTION AND VOLUME CHANGES].
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Different variants of vegetative nervous system dysfunction were identified during the examination of 86 children with vasomotor rhinitis. Based on the findings of the examination a pathogenetically-based method of acupuncture was proposed for the management of this patients' group. Acupuncture with regard to vegetative dysfunction attenuated the latter's manifestations and corrected associated psychoemotional disorders. As a result the clinical manifestations of vasomotor rhinitis were eliminated.
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Seven structurally-related compounds consisting of three antidepressant drugs (imipramine, desmethylimipramine and amitriptyline), three tranquillizing agents (promazine, chlorpromazine and chlorprothixene) and a hybrid, desmethylpromazine, have been examined in a series of tests involving autonomic functions and antagonism of reserpine. Activities of the compounds in antagonizing reserpine-induced ptosis in rabbits and prolongation of alcohol hypnosis in mice give good correlation with their clinical actions, whilst their activities in augmenting excitation of rats by amphetamine and yohimbine toxicity in mice, and in reversing reserpine-induced bradycardia in rats offer further evidence for drug-induced sensitization to adrenergic or tryptaminic mechanisms, which is not however specific for antidepressant agents. No evidence has been obtained to indicate that a central parasympatholytic action is an important component of the antidepressant activity of imipramine and related drugs.
In anesthetized cats, the cold block or coagulation of intermediate zones of the bulbar ventro-lateral surface (BVLS) resulted in profound decrease of the blood pressure (BP) level. The descending tonic activation of spinal vasomotor mechanism in formed by spontaneous discharges of antidromically identified output sympatho-activating neurons with mean firing rate about 14.4/sec. After coagulation of the intermediate zone, pressure reflexes of the BP and late somato-sympathetic response in white rami disappear whereas the spino--bulbo--spinal somato--somatic reflex remains unchanged. The reflex discharges of single sympatho--activating neurons were within the time limits of the late somato--sympathetic response and followed by the silent period. The preferable inhibition of the long-latency white rami discharges elicited by BVLS stimulation arise 200-250 msec after R-wave of the ECG. The inhibition of long-latency discharges was observed during the increase of the BP level induced with vasoconstrictor drugs. The intermediate zone structures of BVLS seem to play the key role in supporting of the BP level and organization of pressure reflexes. These structures are suggested to be the actual elements of the bulbar vasomotor center.
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