Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “STERILITY”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,495 records · Page 83Linked to original sources

Eugenic sterilization and a qualified Nazi analogy: the United States and Germany, 1930-1945.

In the United States and Germany before World War II, physicians participated in state-authorized eugenic sterilization programs in an attempt to prevent persons deemed to possess undesirable heritable characteristics from propagating. A comparison of U.S. and German histories reveals similarities that argue against easy dismissal of a Nazi analogy. On the basis of a review of editorials in New England Journal of Medicine and Journal of the American Medical Association from 1930 to 1945 it is difficult to accept the suggestion that the alliance between the medical profession and the eugenics movement in the United States was short-lived. Comparison of the histories of the eugenic sterilization campaigns in the United States and Nazi Germany reveals important similarities of motivation, intent, and strategy and differences that explain why support for eugenic sterilization in the United States gradually weakened. The eugenics movement in Germany was influenced by economic crisis, radical nationalism, Hitler's totalitarianism, and the medical profession's willing participation and attraction to Nazism for financial and ideological reasons. In the United States, a combination of public unease, Roman Catholic opposition, federal democracy, judicial review, and critical scrutiny by the medical profession reversed the momentum of the eugenics movement and led to the conclusion that eugenic sterilization should be voluntary.

Editorial Policies↗

[A survey of ethylene oxide sterilization in a hospital].

The health and environmental problems of ethylene oxide gas sterilization in a hospital are reported. Eight nurses who had been engaged in the gas sterilization, sometimes operated the auto-sterilizer in an inadequate manner; they exposed more than several hundred ppm of ethylene oxide once or twice a week. The main acute effects on these nurses after massive exposure were headaches, general fatigue and irritation of the eyes and throat. But no signs of polyneuropathy were seen. This survey suggests that there is a great risk of ethylene oxide poisoning while sterilizing instruments in a hospital.

Ethylene Oxide↗

A new integrator for monitoring time and temperature of steam sterilizers.

Steam sterilization is the simplest and most useful method of sterilization of thermostable materials. Sterilization depends upon three factors: time, temperature, and the presence of live steam. For the first time an instrument can be employed to monitor these three factors with immediate readout. This paper contrasts the advantages of this integrator with sterilizer controls, and biological and chemical indicators; and describes methods utilized in testing the integrator.

Cross Infection↗

Steam sterilization costs: a guide for the central service manager.

The Nassau County Medical Center CS department, East Meadow, New York, was faced with a staff layoff and an increased workload. With some hard thinking and strong staff support, new processes/systems were designed to save time and money. These included outsourcing the sterilization of "easy" trays, instituting a case cart program and developing custom packs. In order to determine where savings could be had, it was first important to examine current costs. By breaking the costs of sterilization processing down into an average cost per load, a formula was developed that helped determine many additional cost comparisons for the department. For example, the cost analysis formula could be used by CS departments to determine the cost-effectiveness of off-site sterilization, to compare using disposable vs. reusable items and to determine costs for EtO sterilization and aeration.

Central Supply, Hospital↗

The 1993 Medical Device Technology sterilization survey.

The 1993 Medical Device Technology survey on sterilization is the second in a series of annual surveys that examines the use of sterilization techniques within the European medical device industry. By conducting this study each year, a database will be established and maintained on the various ways in which the sterilization of medical devices is achieved. In the longer term this will indicate changes in the market for sterilization equipment and services and will identify future trends in this very important segment of the medical device industry. Such information will be passed on to the readers of Medical Device Technology in forthcoming issues of the magazine.

Equipment Contamination↗

The economics of sterilization.

In this approach to selecting the most appropriate sterilization method, comparisons are made of the initial and ongoing costs for sterilization by ethylene oxide, gamma radiation, and electron radiation. Considerations that have an impact on cost include the monetary value of the time that elapses between sending a product for processing and its release for sale, anticipated growth in the level of product to be sterilized, labour, electricity and utilities, and the price of the sterilant.

Capital Expenditures↗

Medical Device Technology sterilization survey.

This fourth Medical Device Technology sterilization survey reports on trends in the use of sterilization methods in the European medical device and diagnostic manufacturing industry. It compares the levels of in-house and subcontracted sterilization and provides comment on the future of sterilization by electron-beam.

Contract Services↗

Sterilization equipment and services: a medical device technology survey.

Most medical device manufacturers use sterilization procedures at some point in their production processes. Many factors affect the choice of sterilization method and whether manufacturers sterilize products in-house or subcontract their sterilization requirements. Underlying trends are apparent, and this article summarizes these trends from the results of a survey recently conducted among European medical device, diagnostic, and pharmaceutical manufacturers.

Disposable Equipment↗

Steam sterilization: a suitable alternative?

Extracorporeal blood-circuit devices can be sterilized by ethylene oxide (EtO), irradiation, or steam. The majority of these devices are sterilized by the first two processes, and the use of steam sterilization seems to be limited. This article compares the different processes, discusses their advantages and disadvantages, and makes a case for sterilizing these products by steam.

Ethylene Oxide↗

Sterile by any other name.

Will manufacturers of CE-marked medical devices produced under aseptic conditions be able to label their products with the harmonized symbol for sterile? Perhaps not. This is because there are differences of opinion concerning the sterility assurance level that a European harmonized symbol for sterile should represent. This article will discuss the current proposed criteria for labelling a medical device with the European harmonized symbol for sterile, a more stringent approach, and some factors that should be taken into consideration before reaching any final decisions.

Consumer Product Safety↗

[Standardization. Sterilization standards and their impact on hospital services].

The European commission produced series of Directives which were aimed at harmonizing the European market whilst maintaining high standards to protect the citizens. Within each directive drafted Essential Requirements which had to be satisfied in order to market throughout Europe. The Medical Device Directive (93/42/EEC) covers the vast majority of medical devices including active non-implantable and non-active implantable medical devices. Demonstration of compliance to harmonized European Standards (EN) was proof of compliance with Essential Requirements of the Directives. The European Standards Body (CEN) created a series of European Standards which would enable to demonstrate compliance with Essential Requirements. The CEN organisation has a pyramidal structure. Standards are produced in the CEN Technical Committees (TC's) composed of representatives from each country's own standards organization. The Technical Committee in turned created a series of Working Groups (WG), who's job it was to actually generate the text of the standards. Two of standards committees are working to generate standards which relate to sterilizers and sterilization: TC102--the standards emanating from this committee are product related, TC 204--the standards relate to sterilization practice. In Poland, the standarisation activity is provide by Polish Committee of Standardisation. From 5th June 1997 operate Problem Commission number 272 for sterilization affairs. The job of the commission consist on translation of European'offs Standards and transform them to Polish Standards. After accede Poland to European Union, Polish hospitals will have to adjust to European Standards.

Centralized Hospital Services↗

Male sterilization in El Salvador: A preliminary report.

The expectation that male sterilization would not be an acceptable method of fertility control to the Latin American male has not been upheld in the initial phases of male sterilization programs in Colombia, Costa Rica, Guatemala, and El Salvador. On the contrary, in all of these programs and also at the Asociación Demográfica Salvadoreña, a free-standing, non-profit family planning clinic in San Salvador, the initial success has been impressive, with 180 men accepting sterilization during the first two years (February, 1972 to February, 1974). All sterilizations were performed by excising a 10-15 mm segment of each vas and ligating each vas end. Procedures were performed on an outpatient basis using a local anesthetic. Follow-up examinations were conducted at one week and three months after the procedure. Although complications were reported by 24.0% of the subjects at the one-week follow-up, the complications were minor: most were scrotal infections not requiring antibiotic therapy. Rates of complications were low for subjects returning for a three-month examination and semen test. Only one subject had a positive semen test.

Adult↗

Reuse of healing abutments: an in vitro model of plasma cleaning and common sterilization techniques.

The reuse of transgingival healing abutments has been advocated by several implant manufacturers, but cleaning and sterilization procedures to yield clean and optimal surfaces have yet to be developed. The objective of this in vitro project was to investigate various cleaning and sterilization regimens for the removal of biological debris to support reattachment of subgingival connective tissue. Simulated clinical healing abutment surfaces were exposed to culture medium with serum for 1 hour to simulate biological exposure. Simulated healing abutment surfaces not contaminated by serum were used to represent the "as-is" healing abutment surface without prior in vivo use. The discs were cleaned with detergent before sterilization by ultraviolet light (UV) or steam autoclaving (AC) both with and without 1- and 5-minute plasma cleaning (PC). A series of surface analytical techniques (XPS, AES, and surface contact angles) and in vitro analysis of cell attachment and spreading using gingival fibroblasts were performed. After exposure to the simulated biological conditions, clinical cleaning followed by UV resulted in contaminated surfaces and relatively high levels of cell attachment. PC before UV treatment enhanced surface energetics but did not affect cell attachment and spreading. AC increased surface wetting angles; which were decreased somewhat by previous PC. Cell attachment was significantly reduced by AC. Although some increase in cell attachment after longer plasma cleaning was noted in the AC group, no difference in cell spreading was seen in any AC group. Cell spreading seemed to be less for all AC groups compared with all UV, as-is, and control groups. Although certain cleaning (PC) and sterilization (UV) procedures can be effective for cleaning transgingival healing abutments, those using AC are questionable due to their propensity for organic and inorganic contamination and unfavorable surface alteration.

Blood↗

Office microlaparoscopy for female sterilization under local anesthesia. A cost and clinical analysis.

OBJECTIVE: To evaluate the clinical and cost effectiveness of permanent female sterilization using microlaparoscopy and bipolar cauterization. The authors also tested how well the procedure was tolerated when performed under local anesthesia and conscious sedation. STUDY DESIGN: Patients undergoing microlaparoscopic permanent sterilization were prospectively followed. The rate of procedure completion, patients' pain scores and complication rates were reviewed. RESULTS: The procedure was completed in 93% of patients (28 of 30). The pain scores decreased substantially within one day after the procedure. The total cost savings for the 29 cases were $16,211. Two patients experienced severe intraoperative discomfort and were rescheduled for endoscopic sterilization under general anesthesia. There were no complications. CONCLUSION: Permanent female sterilization using microlaparoscopy is cost effective and safe in selected patients, patient exclusion criteria need to be instituted to ensure the safety and success of the procedure.

Ambulatory Surgical Procedures↗

[Hygiene and methods of decontamination, disinfection and sterilization in dental offices in Yaounde].

Hygiene and asepsis of the dental office depend on medical ethics and legal obligation. The survey done with the participation of 33 practitioners over the 42 practicing in Yaounde allows apprehending the reality of the daily hygiene. The ways of cleaning, decontamination, disinfection or of sterilization of the premises, the dental equipment and instruments, hand-washing, disposable materials and the vaccination protection of the practitioners were analyzed. The cleaning of the floor and door mats is daily (100%); disinfection is done daily in 83% of the departments in all of the centers. The cleaning and disinfection of the dental chair is daily and is done using soap (23%) and/or bleaching-water (56%). Cleaning or disinfection of the suction machine is done with soap (24%) or with bleaching-water (47%). The hand-pieces and the turbines are cleaned and/or disinfected after each usage in (94%) with alcohol (17%) or with bleaching-water (32%) and sterilized with a heat sterilizer (45%), an autoclave(40%) or cold disinfected(15%). The frequency of the treatment of the instruments is well-respected (83%). Nevertheless the products used are very varied and are not always used in the prescribed order. Hand-washing is systematic after each patient; 50% of the practitioners use soap bars or powered soap and 50% use an antiseptic or a disinfectant solutions. With the regard to the vaccination, only 3 practitioners were properly vaccinated against hepatitis B, tetanus, diphtheria, poliomyelitis and tuberculosis. With regard to the protection of the practitioners, 72% do not wear caps, 56% do not wear eyeglasses, 40% do not wear masks, 95% do not use rubber dams, 56% do not disinfect the radiographic films and 37% do not disinfect the impressions; the habitual attire consists of a smock worn over street clothes (78%) and street shoes (90%). The debris is burnt in 35% of the centers. Better knowledge of the different stages (cleaning, decontamination, disinfection or sterilization and the products used, absolute respect of the disposable materials, optimal vaccination protection and the elaboration of the correct procedures written and posted up in the different departments are fundamental points for quality treatment. As a matter of fact, negligence and ignorance of the rules of hygiene and asepsis should not be part and parcel of the therapeutic hazard in the dental department.

Cameroon↗

[Use of ethylene oxide for the sterilization of thermoplastic articles].

The author applied ethylene oxide for sterilization of articles incompatible with thermal sterilization. This method has been widely accepted in many counteries. The tests have been made in the Warsaw Medical School Clinic of Pediatric Surgery, the Polish made "Rotanox" being the source of ethylene oxide. The following items served as sterilizing chambers in this order: Polyethylene foil bags, glass flask and pressurized chambers. The gas pressure of 1 at and temperature of 40-50 degrees C were maintained in the chamber. Sterilized material was closed in the polyethylene foil bags. The effectiveness of this method was proved by bacterial tests.

Bacteria↗

[Effect of certain methods of sterilization on the quality of dental instruments].

Comparative investigations of the sterilizing action produced on the stomatological instruments by 4 chemical bactericidal agents and hot air tend to give preference to sterilization with a 2% solution of glutamic acid in a combination with a 70% isopropyl alcohol at a 45 minutes long exposure. Such a sterilization does not cause any corrosion of the instruments and reduces to a lesser degree the resistance of the cutting edges than in the case of sterilization with hot air.

1-Propanol↗

Examination of sterilization parameters with a view to improving the quality of infusion solutions.

A determining time factor in the course of sterilization in autoclaves is the time required for killing microorganisms. Damaging of microorganisms takes its course as an exponential function of time. Taking into account this fact, the parameters of sterilization are determined by the technical standards of the equipment used for autoclaving. The authors present the sterilization problems of infusion solutions, with special regard to the sterilization conditions of heat labile preparations. The results of experiments carried out with autoclaves of different technical standards are discussed.

Infusions, Parenteral↗