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PubMed1996

Mini ecosystem in space--preliminary experiment on board STS-77.

An enclosed ecosystem which is stable on Earth will behave differently when brought into space. Micro-gravity and radiation will affect the dynamics of material circulation or the activities of small creatures of the ecosystem. One series of space experiments aiming to address such issues was planned in the United States (It is termed as ABS--Autonomous Biological System) and Japanese group has been involved with cooperating with the analysis of the flight samples. Before the ecosystem will be on board Russian Space Station "Mir" later 1996 for 3 months, a preliminary flight was carried out in May 1996 on Space Shuttle (STS-77) for 10 days flight. It was the first of such experiments to fly one whole ecosystem in space.

Animals↗
PubMed1999

NASDA aquatic animal experiment facilities for Space Shuttle.

National Space Development Agency of Japan (NASDA) has been developed aquatic animal experiment facilities for space experiments using NASA Space Shuttle. Vestibular Function Experiment Unit (VFEU) has been firstly designed and developed for Spacelab-J mission (STS-47), and 8 days space experiment with carp has been performed. Following, the VFEU, Aquatic Animal Experiment Unit (AAEU) has been developed to accommodate small aquatic animals second International Microgravity Laboratory mission (IML-2, STS-65). Four kinds of space experiments with goldfish, medaka, newt, and newt eggs have been performed for 15 days mission duration. Then, VFEU has been improved to accommodate marine fish under low temperature condition for Neurolab (STS-90) and STS-95 missions. 17 days (STS-90) and 9 days (STS-95) experiments with oyster toadfish have been performed by using the VFEU. This report summarizes the outline of these aquatic animal experiment facilities.

Animals↗
PubMed2003

Engineering of closed ecological system in space and inter-organismal interactions.

Space agriculture is a concept of synthesis and operation of closed ecological system for controlling living environment and supplying materials in order to sustain life and to meet metabolic needs of space crew. It revitalizes metabolites and other excretion of crew for their recycled usage. It is an advanced concept for life support for long and large scaled manned space missions, where open loop system for materials cycle is not feasible to apply. Several issues, such as cost-benefit analysis with considering benefits of amenity and psychological factors of crew, are discussed in this essay, together with reliability and productivity of biological systems. Studies on plant physiology for inter-organismal interaction contribute to design work for space agriculture, and associate with our engagements to our future, sustainable development of our civilization both on the earth and extending to outer space.

Agriculture↗
PubMed1976

Relationship between spatial density and sensory overload, personal space, and systolic and diastolic blood pressure.

Selected effects of high spatial density were investigated with 26 boys, serving as their own controls and undergoing alternate confinements in high and relatively low spatial density. Measured effects were changes in minimal aversion threshold values of white sound, projective measures of desire to alter room size, and systolic and diastolic blood pressure. High spatial density increased systolic and diastolic blood pressure and projective measures of desire to alter room size but did not affect minimal aversion threshold values. Semi-projective measures of personal space requirements were obtained prior to experimental trials. Analysis showed a significant interaction of minimal aversion threshold values with requirements for personal space; the minimal aversion threshold values of subjects requiring large personal space tended to decrease following confinement under high spatial density. The interaction of personal space with projected measures of desire to alter room size was not significant. High spatial density may, then, exert adverse effects on blood pressure and may induce sensory overload conditions in individuals requiring large personal space.

Adolescent↗
PubMed1989

A light and electron microscopy study of normal human stratum corneum with particular reference to the intercellular space.

Intercellular and skin-surface substances, and exfoliating corneocytes, were clearly visualized by both light and electron microscopy. The intercellular space constituted an essential part of the normal human stratum corneum, in the basal and middle zones of which this space was filled with substances producing a compact appearance. The intercellular constituents were a nonhomogeneous substance, intact, single and "compound" lamellar granules and an intensely stained, membrane-like material that in some parts, but not in others, had a lamellar pattern. The artifacts produced by ultrathin sectioning for electron microscopy were too small to provide sufficient explanation for the porous appearance of the superficial zone. More important factors seemed to be enlargement of the intercellular space with decrease in the number of desmosomes and alterations of the intercellular substances, with decrease in the amount of nonhomogeneous substance and transformation of the single and "compound" lamellar granules into single and "compound" vesicular bodies. The hypothesis is advanced that the single and "compound" vesicular bodies together with the decreased amount of nonhomogeneous substance may contribute to maintain the patency of the intercellular space in the superficial zone (stratum disjunctum), thereby facilitating absorption of surface-applied agents into the stratum corneum by some shunt mechanism, while the content of the intercellular space in the basal and middle zones (stratum compactum) forms the principal barrier to free diffusion.

Adult↗
PubMed1993

Bioencapsulation: a biotechnological tool for biological life support for manned missions by the European Space Agency.

ESA (European Space Agency) decision in 1987 to acquire the capability needed to support man living and working in space, was the trigger for initiating the development of space life support technologies in Europe. The discipline of life support covers basically all the techniques that ensure the biological autonomy of man when isolated from his original biosphere. Biological life support technologies are presently under development at ESA either for their intrinsic ability to better achieve specific tasks than the currently available physico-chemical processes, or because only they can achieve these tasks. Moreover, a global integration of these biotechnologies leads us to the important notion of closed ecological life support system (CELSS). Indeed, a CELSS is the ultimate form of life support system we currently foresee for long-term space missions (over 2 years). Among those biotechnologies, immobilisation processes such as bioencapsulation are considered as potentially potent tools. They are detailed and presented in their life support context as they are currently standing along with their possible future time course in the ESA life support space program.

Ammonia↗
PubMed1992

Clearance of brain edema and macromolecules through the cortical extracellular space.

The transit routes of fluid and particulate matter through brain tissue remain unclear. The object of this study was to examine the movement of macromolecules through brain tissue to further clarify the clearance pathways of edema proteins as they migrate toward the cortex. For this purpose, albumin solution (20 microliters rat albumin diluted to 65 mg/ml with mock cerebrospinal fluid (CSF)) was intracerebrally infused into the caudate putamen, and the migration through brain tissue as well as through the ultrastructure of the cortical surfaces was explored using an immunocytochemical technique. The authors observed immunoreactive product on the glial limitans and pial lining as well as in the extracellular space of the cortical neuropil at 24 hours postinfusion, confirming that the protein had reached the cortical surface. To confirm the efflux of macromolecules into the subarachnoid CSF, 71,200 D fluorescein isothiocyanate-dextran (FITC-dextran 71,200) was infused; cortical surfaces of brains removed en bloc as well as coronal sections were macroscopically observed under ultraviolet illumination at 15 minutes and 24 hours postinfusion. It was observed that infused FITC-dextran 71,200 mainly localized in the cortical white matter and caudate putamen of the infusion site at 15 minutes postinfusion and by 24 hours was distributed in the entire cortex of the infused hemisphere. However, the dynamics of lower-molecular-weight substances was completely different. The spatial distribution of FITC-dextran 4400 diverged upward toward the cortical surface and spread more extensively than FITC-dextran 71,200. These observations were consistent with a diffusion process as the spread of the tracer was dependent upon molecular size. These studies provide compelling evidence that a process other than bulk flow was involved in the spread of macromolecules through the extracellular space of the normal cortical neuropil to sink into the subarachnoid space. It was concluded that the CSF pathway via the extracellular space of the cortical neuropil is a primary route for clearance of extracellular edema proteins to the subarachnoid space and that diffusion is involved in this process.

Albumins↗
PubMed2005

Line spacing in Mondrian paintings and computer-generated modifications.

Students compared computer-generated pictures of which 1 had line spacing and orientation proportional to that in a Mondrian picture (Mondrian-like), and 9 had divergent line spacing (divergently spaced). Preference was above average for the Mondrian-like picture compared with that for the divergently spaced pictures. However, participants did not prefer the Mondrian-like picture to divergently spaced pictures that were preselected as aesthetically pleasing by other participants. The results of the present experiments suggest that a computer algorithm can be developed to modify a picture in a way that is comparable with the way in which humans modify a picture to obtain a preferred picture. If aesthetic appeal is used in the storage and retrieval of visual information, then the algorithm could provide a better understanding of human perceptual processes. The results are related to consistency of aesthetic judgments across participants, levels of processing, and apparent contrast effects.

Adolescent↗
PubMed2004

Distortions of distance and shape are not produced by a single continuous transformation of reach space.

We investigated whether distortions of perceived distance and shape could be captured by a single continuous one-to-one transformation of the underlying space. In Experiment 1, the participants reached to touch points around the perimeter of spherical targets viewed at five different distances, to yield simultaneous measures of perceived distance and shape. Different participants reached while using dynamic monocular, static binocular, or dynamic binocular vision. Thin plate spline (TPS) analysis was applied so as to transform a Cartesian grid in such a way as to carry the original target points to the mean reach locations. In all cases, discontinuities appeared in the transformed grid from folding of the space. In Experiment 2, the participants reached to points that lay at the same locus in reach space, but on different portions of the visible target spheres (e.g., front vs. side). The participants reached to different locations when the points were different with respect to shape (e.g., front vs. side) but reached to the same locations when the points were the same with respect to shape (left vs. right side). TPS analysis revealed discontinuities from holes torn in the underlying space. The results show that perceived distance and perceived shape entail different distortions and cannot be captured by a single continuous transformation of reach space.

Adult↗
PubMed1999

Compression of visual space in natural scenes and in their photographic counterparts.

Classical theories of space perception posit continuous distortions of subjective space. These stand in contrast to the quantitatively and qualitatively different distortions experienced in space that is represented pictorially. We challenge several aspects of these theories. Comparing real-world objects with depictions of the same objects, we investigated to what extent distortions are introduced by the photographic medium. Corners of irregularly shaped buildings had to be judged in terms of the vertical dihedral angles subtended by two adjacent walls. Across all conditions, a robust effect of viewing distance was found: Building corners appear to flatten out with distance. Moreover, depictions of corners produce remarkably similar results and should not receive a different theoretical treatment than do real-world scenes. The flattening of vertical angles cannot be explained by a linear distortion of the entire visual space. We suggest that, for natural scenes, compression of space is local and dependent on contextual information.

Adult↗
PubMed2005

[The relationship between idea search space and creativity].

This study investigated the relationship between participants' evaluation of creativiy and characteristics of creative products towards a clear and objective definition of the concept of creativity. Three experiments examined whether the size of "idea search space" in the creative process predicts the score of products in creativity assessments. In Experiment 1, in order to construct an multidimensional scaling (MDS) space which was supposed to correspond to creators' "idea space," 20 participants exhaustively evaluated the strength of semantic connection between every pair of 50 (physical) parts of possible creatures. In Experiment 2, 40 participants drew novel extraterrestrial creatures using five out of 50 parts used in Experiment 1. In Experiment 3, 20 participants assessed the creativity of each of the 40 drawings from Experiment 2. The results showed that a drawing with a larger idea search space estimated by the MDS score have a tendency to receive a higher creativity score. These results support the framework of idea search space and a possibility of explaining the creativity in terms of this model is suggested.

Adult↗
PubMed2000

Perception of facial features and face-to-face communications in space.

This paper examines how human face-to-face communications may be compromised by exposure to the microgravity environment of space. Although efficient face-to-face communications are acknowledged to be essential for astronauts to work safely and effectively, the space environment causes facial edema, and allows speakers and listeners to confront one another in multiple orientations that can potentially interfere with many important non-linguistic communication cues. In addition, high background noises in space shuttles and stations can mask auditory messages. Currently, the effects of spaceflight on the ability to identify facial features, to read lips, to integrate visual and auditory sensory information, and to interpret spoken messages in noisy environments while the speakers are at various orientations with respect to the listeners, are virtually unknown. Ground-based experiments conducted in our laboratory with computer-displayed facial images presented at various orientations have suggested how non-linguistic cues may be degraded by changes in the retinal orientations of facial images. The results of our ground-based studies illustrating impaired recognition of facial features in non-erect images are described, their implications for effective face-to-face communications among astronauts in space are discussed, and two experiments that can quantify the effects of microgravity on face-to-face communications in space are outlined.

Adult↗
PubMed2000

Non-hindbrain-related syringomyelia. Obstruction of the subarachnoid space and the central canal in rats. An experimental study.

BACKGROUND: The aim is to determine the mechanism of non-hindbrain-related syringomyelia in experimental models. The effects of obstruction of central canal and subarachnoid space on occurrence of cavities were discussed. METHODS: 31 Sprague-Dawley rats were used with eight (Group D) as a control. In 10 rats (Group A) 1.5 microl kaolin was microinjected into the dorsal columns and central gray matter of the spinal cord at the level of Th6-10. In 10 rats (Group B) 0.1 cc kaolin was injected into the subarachnoid space at the same level. In 3 rats (Group C), 1.5 microl kaolin was administered into both dorsal midline of the spinal cord and the subarachnoid space. RESULTS: In Group A, histological examination revealed cystic cavity and dilatation of the central canal in five rats; denuded ependymal line and multicystic formations in ependymal and periependymal areas in seven rats. In Group B, denuded ependymal line in three rats and microcystic formations in ependymal and periependymal areas in four rats were revealed. In Group C, there were microcystic formations in two rats and syrinx cavity in one rat. CONCLUSIONS: Developments leading to occurrence of cavities are focused on the central canal in all groups. These models indicate that the CSF-flow is from the subarachnoid space to the central canal leading to changes of cavities. In cases of obstruction of the subarachnoid space or the central canal, the occurrence of syrinx cavity initially is due to increased CSF (cerebrospinal fluid) pressure in the central canal. Flow changes in spinal cord is indicated by this study.

Animals↗
PubMed2001

Hyperintense signal abnormality in subarachnoid spaces and basal cisterns on MR images of children anesthetized with propofol: new fluid-attenuated inversion recovery finding.

BACKGROUND AND PURPOSE: MR imaging is the method of choice for pediatric neuroimaging. Sedation is often needed to suppress patient motion and ensure diagnostic image quality, and propofol is rapidly becoming the preferred anesthetic. The purpose of this study was to document a new finding on fast fluid-attenuated inversion recovery (fast-FLAIR) MR images of children anesthetized with propofol that can be mistaken for subarachnoid space pathologic abnormality. METHODS: A retrospective analysis was conducted of 55 MR images of the brain for children who ranged in age from 1 week to 12 years. Forty-two patients received chloral hydrate, and 13 received propofol anesthetic. Multiplanar MR images were studied to detect the presence or absence of hyperintense signal (artifact) in the subarachnoid spaces and basal cisterns. The T1 values and null times of chloral hydrate, propofol, and CSF were determined in vitro at room temperature by using an inversion recovery pulse sequence at 1.5 T. RESULTS: The fast-FLAIR images of all 13 patients who received propofol had hyperintense signal abnormality. For 10 (77%) of 13 patients, this artifact was in the basal cisterns and subarachnoid spaces overlying the brain convexity. For three (23%) of 13 patients, this artifact was in the convexity region only. Two patients underwent follow-up MR imaging with a nonpropofol anesthetic agent, and the artifact resolved. None of the images of the children who received chloral hydrate had this artifact. The T1 value of chloral hydrate was 0.2 s, of propofol was 1.86 s, and of CSF was 2.32 s at room temperature. CONCLUSION: The fast-FLAIR images of children anesthetized with propofol have artifactual hyperintense signal in the basal cisterns and subarachnoid spaces, and this artifact mimics disease of the subarachnoid space. The T1 value of propofol approaches that of CSF. Depending on the chosen null time, there may be incomplete nulling of signal coming from propofol. To account for this observation, other possible causes include increased CSF pulsation in children creating motion artifact, changes in arterial oxygen concentration intrinsic to propofol or related to the supplemental oxygen normally administered, or changes in CSF protein levels related to propofol binding to proteins for uptake into CSF.

Anesthesia↗
PubMedDate not supplied

[Cytogenetic studies of blood lymphocytes of cosmonauts after long-ter, space flights].

An analysis was performed of unstable chromosomal aberrations in peripheral blood of 36 cosmonauts after long-term space missions on "Mir" orbital station. 25 cosmonauts were examined before their flights to score spontaneous yields of cytogenetical damage. In all cases the doses absorbed by crews during space flights did not exceed permissible levels of irradiation, adopted for cosmonauts. The frequencies of chromosomal-type aberrations after space missions were found to increase significantly compared to the pre-flight levels. The yields of dicentrics and centric rings on the average were as high as 0.12 +/- 0.02 and 0.47 +/- 0.06% before and after the 1st flight, 0.18 +/- 0.05 and 0.71 +/- 0.11% before and after the 2nd flight respectively. During the inter-flight periods, usually lasted 1.5-2 years, the yields of chromosome damage lowered, but did not reach their spontaneous values. After each next flight the yields of chromosome aberrations increased again. The cytogenetical damage detected in cosmonauts' peripheral blood lymphocytes after chronic action of low doses of space radiation points out a possible increase in risks of stochastic effects in distant future for crews after long-term space missions.

Adult↗
PubMed2001

Permanent depression of plasma cGMP during long-term space flight.

The purpose of this study was to investigate plasma concentrations of cyclic guanosine monophosphate (cGMP) and atrial natriuretic peptide (ANP) during and after real and simulated space flight. Venous blood was obtained 3 min after the beginning and 2 min after the lower body negative pressure maneuver in two cosmonauts preflight (supine), inflight, and postflight (supine) and in five other subjects before, at the end, and 4 days after a 5-day head-down tilt (-6 degrees) bed rest. In cosmonaut 1 (10 days in space), plasma cGMP fell from preflight 4.3 to 1.4 nM on flight day 6, and was 3.0 nM on the fourth day after landing. In cosmonaut 2 (438 days in space), it fell from preflight 4.9 to 0.5 nM on on flight day 3, and stayed <0.1 nM with 5, 9, and 14 months in space, as well as on the fourth day after landing. Three months after the flight his plasma cGMP was back to normal (6.3 nM). Cosmonaut 2 also displayed relatively low inflight ANP values but returned to preflight level immediately after landing. In a ground-based simulation on five other persons, supine plasma cGMP was reduced by an average of 30% within 5 days of 6 degrees head-down tilt bed rest. The data consistently demonstrate lowered plasma cGMP with real and simulated weightlessness, and a complete disappearance of cGMP from plasma during, and shortly after long-duration space flight.

Adult↗
PubMed1984

Experiments on plants grown in space. Status and prospects.

Space flight provides a unique capability to gravitational research by providing an environment in which gravity can be manipulated below the Earth norm of 1 to a state comparable to weightlessness. Although space experiments with seeds and plants have been conducted for almost 25 years, we are only now entering an era that promises the capability of routinely conducting controlled plant experiments in space. Results from experiments with higher plants and seeds flown thus far in both manned and unmanned spacecraft from both the USA and USSR are briefly summarized. An overview of the current status of space biology experimentation as it relates to plants is presented and present and future opportunities to conduct plant experiments under space flight conditions are discussed.

Gravitation↗
PubMed1997

Microbiology of the Space Shuttle water system.

The Space Shuttle has a once-through water system that is initially filled on the ground, partially drained before launch and then refilled with fuel-cell generated water on orbit. The microbiological standard for the Space Shuttle potable water system during this study period allowed only 1 microbe of any kind per l00mL and no detectable coliforms. Contamination episodes in more than 15 years of Shuttle operation have been rare; however, for the past 24 missions, bacterial contamination has been detected in 33% of the samples collected 3d before launch. These samples have had on average 55CFU/100mL of bacteria, with the median less than 1CFU/100mL. Burkholderia cepacia has been the primary contaminant of the Shuttle water supply system both before and after flight. Water samples assessed during the STS-70 mission aboard the Space Shuttle Discovery were found to be contaminated (<20CFU/100mL) with B. cepacia and B. pickettii. In 1991, waste and water lines were removed from the Space Shuttle Columbia and the waste lines were found to harbor biofilms containing Bacillus spp. Nevertheless, the water systems of the four Space Shuttle vehicles provide extremely pure water.

Bacillus↗