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The action of ANP, BNP and related peptides on motivated behavior in rats.

This review summarizes the action of atrial natriuretic (ANP) and some related compounds such as BNP, CNP and fragments on the central nervous system, based mainly on the results obtained in the author's laboratory. The aim of the investigations was to assess the physiological significance of the natriuretic peptide family in the brain by administering the peptides into the lateral brain ventricle. Effects were studied on motivated behavior, including active and passive avoidance learning, food-reinforced conditioning, open-field activity, electroshock-induced amnesia, development of morphine tolerance and dependence, and picrotoxin-kindled seizure syndrome. Antisera against ANP were used in order to follow the specificity of the resulting action. The role of neurotransmitters in the mediation of peptide action was elucidated by treating the animals with receptor blockers before peptide administration.

Amino Acid Sequence↗

Cognitive enhancement therapy: a therapeutic treatment strategy for first-episode schizophrenia patients.

Cognitive enhancement therapy (CET) for first-episode schizophrenia combines supportive therapy with social skills and cognitive remediation training. It includes exercises aimed at ameliorating cognitive and negative symptoms in a purposefully motivational format. In this treatment model, the clinician takes an active role as coach, teacher, and therapist in order to engage patients in skills-enhancing work matched to levels of illness and abilities. The therapeutic alliance allows for a safe environment to utilize principles of errorless learning and positive reinforcement. Although this strategy is best implemented in groups, it can be adapted to the individual mode of treatment. Skills-building exercises are described in sufficient detail to be useful to clinicians working with patients in the first years of schizophrenia.

Adolescent↗

Rate differential reinforcement in monkey manipulation.

A set of four manipulanda were presented to four Cebus monkeys, individually, and later in pairs. Step 1 provided an estimate of each S's probability of operating each item, while Step 2 determined whether pairing the items would disturb the ordinal relations among individual response probabilities. Both procedures provided information necessary for testing the assumption that a reinforcer is simply a contingent response whose independent probability of occurrence is greater than that of the associated instrumental response. Step 3 tested this assumption by again presenting pairs of items, but with one locked and its operation made contingent upon operation of the free item of the pair. The four Ss differed markedly in the extent to which the items produced different independent response probabilities, and correspondingly, in the extent to which the contingent pairs subsequently produced reinforcement. Confirmation of the present assumptions came primarily from one S, which differed substantially on the individual items, and showed five cases of reinforcement, all in the predicted direction. Further, reinforcement was shown by an increase in both contingency and extinction sessions. Finally, the response of intermediate probability reinforced the response of least, but not the one of greatest, probability, indicating that a reinforcer cannot be identified absolutely, but only relative to the base response.

Animals↗

Continuous, fixed-ratio, and fixed-interval reinforcement in honey bees.

Bees learned to enter a Plexiglas tube and to suck small portions of sugar solution; every entry or every fifth entry was reinforced. During an extinction phase, the bees on the fixed-ratio schedule emitted twice as many responses as did those given continuous reinforcement. Bees on a fixed-interval schedule of reinforcement emitted lower response rates than did those given fixed-ratio reinforcement. By extending the conditioning procedure for several days, it was possible to maintain responding with fixed-ratio schedules requiring 30 responses per reinforcement and with fixed-interval values up to 90 sec. Under fixed-interval schedules, response rates did not increase toward the end of the reinforcement intervals.

Journal Article↗

Learning opportunities through camping for mental health nursing.

1. To equip nurses with the skills necessary for working with disturbed people, nurse educators need to be mindful of not watering down the essential skills necessary for nurses to deal with difficult behaviour in all branches of nursing. 2. These components of a mental health clinical experience should equip the graduate to deal with the pressures of dealing with disturbed people in any environment, as the skills learned generalize to any branch of nursing. 3. Universities can combine with traditional hospital services and community mental health services to provide services to clients with mental illness. An additional benefit is in providing students with an intensive clinical learning experience that reinforces the theory taught in the classroom.

Camping↗

Promoting occupational therapy by using a simulated hemiplegic arm to demonstrate dressing technique.

When creating a promotional booth to increase awareness about occupational therapy remember that (a) people learn by participating and (b) positive reinforcement encourages a greater sense of learning. In addition, follow these rules: (a) keep the task simple, (b) eliminate jargon and use nonmedical terms, (c) encourage interaction and reward thoughtful reflections, and (d) make sure that participants leave with some promotional materials in hand. As described here participants acquired a hemiplegic arm and tried to dress. They were immediately rewarded with an occupational therapy sticker. Acting as patients, they experienced visual deficits with a special pair of glasses. The occupational therapist encouraged people to ask questions about dressing and visual deficits and about the display of splints and adaptive equipment. People helped themselves to occupational therapy promotional buttons and literature. They left with a basic understanding of hemiplegia. They also understood how an occupational therapist works with a patient to help the patient regain functional independence.

Health Fairs↗

[The development of a network game to prevent osteoporosis among adolescent females].

In carrying out their research plan, the researchers used the Instruction System Design to develop a network game to prevent osteoporosis among adolescent females. First of all, demand analysis and learner analysis were adopted to explore data gathered from interviews and a questionnaire. In accordance with what was learned from that analysis, a variety of programs were set up. After that, the learner's characteristics were integrated into a system together with a software screen, interface, interaction and sound effects as a model osteoporosis prevention game. The authors solicited evaluations from professionals and users to improve the game. With this network game, not only do we provide a diversified learning environment to reinforce adolescent females' interest in and willingness to carry out health promotion behavior, but we also entertain and inform our users.

Adolescent↗

[The modelling of the process of image-sequence fixation and reproduction in a projective-associative network made up of excitatory neuron-like elements].

On mathematic model of several interconnected networks of excitatory neurone-like elements realized in the form of program on computer "Nord-100", a study of conditions of fixation and reproduction of symbols (words) succession was conducted. Connections between the receptive (C1 and C2) and associative (A1 and A2) networks were by the principle "one to one", connections between the networks A1 and A2 with reinforcing general activating network (GAN) were by the principle "all with all". Possibility was shown of restoration of images succession fixed in the network on the basis of the principle of chain conditioned reflexes provided a successive change of reinforcing GAN elements by means of the decrease of the threshold of their activation. It was found that contacts transferring the influences of the reinforcing network at learning by the Hebb principle, must either initially exert a subthreshold action or be "unlearning" for the elimination of the process of overexcitation.

Animals↗

Psychotherapy and research: an anaclitic depression. The Twenty-third Annual Frieda Fromm-Reichmann Memorial Lecture.

The twin fields of psychotherapy and psychotherapy research have emerged, developed, and flourished in essentially untrammeled independence of each other. They have grown along parallel lines, and, like well-mannered parallel lines, they have only rarely touched. It may appear self-evident that each field could be advanced by active cooperation and reciprocal use of the findings and insights of the other. And so it might, were it not for the empirically demonstrated truth that the separate interests of each have been equally or better served by the tacit agreement not to intrude seriously on each other's territory or claims. We researchers have, for the most part, overlooked much of psychotherapy as actually practiced because it is difficult to study; instead we have elected to investigate those forms which albeit less widely practiced are more accessible to research. In turn, we psychotherapists appear to have ignored much of the available research findings. As a consequence, the efforts of the practitioner-theorist have provided but little stimulus to the researcher, and the researcher had had but little impact on the mainstream of psychotherapies. The therapist and researcher appear, too, to have other reasons for maintaining a seeming aloofness. While both are avowed seekers after the truth--or truths--each has selected different belief systems to serve as prosthetic devices for the mind in achieving their common goals of certitude. The therapist holds to the view that psychotherapy is and must remain primarily an art form, while the resercher believes that psychotherapy is but a quasi-art form and must become a science, or at least a quasi-science. The resultant differences in the values of the protagonists are frequenty characterized or caricatured by highlighting differences in the emphases placed by scientists and artists on such counterposed concepts as: reality vs. symbols, determinism vs. freedom, events vs. meanings, logic vs. intuition, and quantification vs. comprehension. The psychotherapits finds compelling the authority of revealed theory--theory which is confirmed regularly by personal experience with one's patients. Such experiential learning is also reinforced by like-minded colleagues and supervisors. The psychotherapists' enduring devotion to a preferred theory appears to confirm the observation of William Hazlitt, who said, "A favorite theory is a possession for life." The researcher, on the other hand, finds compelling the authority of rigorously controlled, logically designed, replicable studies which are intended to place even a favorite hypothesis in dire jeopardy. To the scientist, not the least of the charms of a theory is the possibility that it may be refutable. The scientist seems to find comfort in maintaining an attitude of doubt and skepticism--an attitude frequently mistaken for evidence of scientific rectitude...

Cost-Benefit Analysis↗

Design and implementation of a simulation exercise for teaching confidentiality of patient information.

Allied health students, making the transition from a purely academic to a professional school setting, are suddenly faced with judgment decisions about disclosure of medical information. Obscure guidelines and new interpersonal relationships with other members of the health care team complicate this transition and pose a threat to confidentiality of patient information. This article describes the design and implementation of a simulation exercise to reinforce lecture guidelines specifying disclosure of medical information without risk to the patient or student. The simulation is comprised of 10 critical incidents calling for responses ranging from logical to judgmental. Although written primarily for medical technologists, with emphasis on limitations governing release of patient laboratory data, the simulation approach is presented here as a model for other allied health professions. The use of a latent image format provides learners with positive or negative reinforcement as they learn the consequences of their decisions. The simulation activity described is easily adapted to small group discussion or computer-assisted instruction. While the simulation appears to be an accurate representation of reality, peer and real-life pressures could not be totally simulated.

Allied Health Personnel↗

[Failure and complications of transesophageal echocardiography. Apropos of 1500 consecutive cases].

Transesophageal echocardiography (TEE) requires the introduction of a flexible probe into the oesophagus and therefore cannot be strictly considered to be non-invasive. This manipulation exposes the patient to complications which are benign in the large majority of cases. The authors report their experience in a prospective study analysing the failures and complications of TEE in the first 1,500 cases performed in their laboratory between May 1988 and May 1992, in mainly adult and ambulatory patients. The probe could not be introduced in 24 patients (1.6%), including 5 cases during the initial learning period. No serious complications were observed during of after TEE. Minor incidents were noted in 28 cases (1.9%) intolerance of the probe (12 cases), nausea and/or vomiting (4 cases), dyspnea (4 cases) due to tracheal intubation in 2 patients, laryngeal in 1 patient and to cardiac failure in 1 case. Pharyngeal haemorrhage (2 cases), atrial fibrillation (3 cases), vertigo (1 case), mandibular dislocation (1 case) and salivary hypersecretion affecting the quality of the imaging (1 case), were also observed. The investigation had to be interrupted prematurely in 12 cases (0.8%) usually because of intolerance of the probe. These results show that TEE is not dangerous in trained hands. Failure to introduce the probe is usually encountered during the learning period, which reinforces the need for apprenticeship in a teaching center. The safety of this technique, plus its considerable diagnostic value in many clinical indications, justify its present role in everyday cardiological practice.

Atrial Fibrillation↗

Mother and adolescent knowledge of sexual development: the effects of gender, age, and sexual experience.

As part of a larger study on the impact of personal and family characteristics on adolescents' HIV risk and risk-reduction behavior, 90 adolescents and 73 mothers were asked to define in their own words seven terms related to sexual development: ejaculation, hormones, menstruation, ovulation, puberty, semen, and wet dreams. Mother and adolescent knowledge of sexual development terms and the effects of age and sexual experience on that knowledge were examined. Results suggest that the mothers were not able to adequately define the sexual development terms and thus may be ill-prepared to teach their children about sex or reinforce information they learn in school. Since adolescent knowledge did not significantly increase with age and sexual experience, the researchers suggest that continuing sex education about normal sexual development is needed.

Adolescent↗

The establishment of stimulus control by instructions and by differential reinforcement.

A repeated acquisition design was used to study the effects of instructions and differential reinforcement on the performance of complex chains by undergraduates. The chains required responding on a series of keys that corresponded to characters that appeared on a monitor. Each day, subjects performed a new chain in a learning session and later relearned the same chain in a test session. Experiment 1 replicated previous research by showing that instructional stimuli paired with the correct responses in the learning sessions, combined with differential reinforcement in both learning and test sessions, resulted in stimulus control by the characters in each link. Experiment 2 separated the effects of instructional stimuli and differential reinforcement, and showed that stimulus control by the characters could be established solely by differential reinforcement during the test sessions. Experiment 3 showed that when a rule specified the relation between learning and test sessions, some subjects performed accurately in the test sessions without exposure to any differential consequences. This rule apparently altered the stimulus control properties of the characters much as did differential reinforcement during testing. However, compared to differential reinforcement, the rule established stimulus control more quickly.

Journal Article↗