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At least 1,495 records · Page 83Linked to original sources
PubMed1979

Effect of feeding 1,3-butanediol-1,3-dioctanoate as an energy source for chicks for catch-up growth during recovery from Newcastle disease virus.

1,3-Butanediol-1,3-dioctanoate (BDDO), a synthetic source of energy, has been shown to be equal to corn oil when fed to chicks recovering from moderate and severe Newcastle disease virus infections. Body weight increments of chicks fed diets containing 10% BDDO were equal to or greater than those of chicks fed 10% corn oil, both with restricted feeding regimens. Kilocalories of metabolizable energy required to produce 100 g of body weight increment over a basal group was used as a means of quantitating energy demand. BDDO was comparable to corn oil as an energy source with no adverse effects. Liver/body weight ratios were greater in the BDDO-fed chicks. Circadian rhythmicity of liver size and liver glycogen content was demonstrated. Chicks fed BDDO had total liver glycogen content threefold that of the corn oil controls, which was attributed to stimulation of insulin secretion. Catch-up growth in the chick following the growth depression of disease appears to be as well facilitated by a synthetic source as by a natural one.

Animals↗
PubMed1982

Immune response to the simultaneous vaccination of day-old chickens with live and inactivated oil-based Newcastle disease vaccines.

THe immune response, as measured by the haemagglutination-inhibition test, to the simultaneous administration of live Hitchner B1 and 2 commercially available, inactivated, oil-based, emulsified, Newcastle disease vaccines at day-old is described. The response was monitored from day-old to 18 weeks, when the birds were challenged with a standardized virulent virus. It was found that the haemagglutination-inhibition titre fell below log2 5 when the chicks were 10 weeks of age. Challenge at 18 weeks yielded a mortality rate of 25% in the groups receiving both live Hitchner B1 and an oil-based vaccine in comparison with 94% in the group receiving Hitchner B1 alone. Simultaneous application of live and oil-based vaccines at day-old is conclusively insufficient to maintain adequate protection until 18 weeks and it is recommended that a booster vaccine be administered at 10 weeks.

Animals↗
PubMed1986

The synergistic neutralization of Newcastle disease virus by two monoclonal antibodies to its haemagglutinin-neuraminidase protein.

Monoclonal antibodies (MAbs) to 2 epitopes on the haemagglutinin-neuraminidase (HN) protein of the Ulster strain of Newcastle disease virus neutralized synergistically: MAbs to HN-1 and HN-2 neutralized 1.2 and 1.7 log10 infectious units (i.u.) of virus when single as compared to 4.1 when combined. Although MAb to HN-1 but not to HN-2 inhibited haemagglutination they both neutralized more virus on desialyzed cells compared to normal cells and were considered to have interfered with viral attachments in a cooperative manner when combined. A third MAb to fusion (F) protein reduced infectivity by five log10 i.u. HN-1, HN-2 and F were not the only immunodominant epitopes because mutants, which simultaneously lacked all 3 epitopes, were indistinguishable from wild type when neutralized by polyclonal mouse, rabbit or chicken antiserum to whole virus.

Adsorption↗
PubMed1951

Mechanism of production of pulmonary lesions in mice by Newcastle disease virus (NDV).

Infectious NDV particles produce extensive pulmonary consolidation in the mouse in the absence of demonstrable virus multiplication. The lesions are indistinguishable from those of influenza A virus infection. This effect of NDV was blocked by intranasal injection of RDE or immune serum before virus inoculation, but not by immune serum injected 5 minutes or more after NDV. Influenza A virus infection did not diminish fixation of NDV in excised lungs but did interfere with the injurious action of this agent in the living mouse. The analogy between these reactions and those which take place in a progressive virus infection is pointed out, and the mechanism of production of lesions in virus pneumonias discussed.

Animals↗
PubMedDate not supplied

Local pathological reactions and immune response of chickens to ISA-70 and other adjuvants containing Newcastle disease virus antigen.

Chickens were examined for gross and microscopic changes at the injection site for 16 weeks after an intramuscular injection of the following oil adjuvant emulsions containing inactivated Newcastle disease virus (NDV) antigen: ISA-70, Freund's incomplete adjuvant (FIA), Freund's complete adjuvant (FCA), and aluminum phosphate gel (APG). The reactions induced by ISA-70 emulsion were characterized by proliferation of macrophages, epithelioid cells, and fibroblasts around the small cysts in the muscle. Infiltration of lymphocytes and plasma cells also was present. These changes peaked 2 weeks postinjection and were milder than lesions due to the Freund's adjuvants. FCA induced the most severe granulomatous lesions with abscess formation. The reactions to APG were characterized by proliferation and accumulation of macrophages. The serological results revealed that the enhancing effect of ISA-70 on NDV antigen was the same as that of FIA.

Adjuvants, Immunologic↗
PubMed1989

Proteins of Newcastle disease virus envelope: interaction between the outer hemagglutinin-neuraminidase glycoprotein and the inner non-glycosylated matrix protein.

Using linear sucrose-density ultracentrifugation analysis of Triton-solubilized Newcastle Disease Virus envelopes, we have evidenced, for the first time, the existence of interactions between the outer hemagglutinin-neuraminidase transmembrane glycoprotein and the inner non-glycosylated peripheral matrix protein. Such interactions seem to be electrostatic. These conclusions are based on the behavior of both proteins at different ionic strengths. When in low ionic strength buffer, hemagglutinin-neuraminidase and matrix proteins band together in the sucrose gradient, whereas at high ionic strength both proteins band at different rates in the gradient. The behavior of the inner matrix protein in our conditions was the expected one for a peripheral protein. The results of these 'in vitro' studies are also discussed in terms of the possible 'in vivo' role of such interactions.

Animals↗
PubMed1986

Anomalous behaviour of Newcastle disease virus haemagglutinin-neuraminidase protein in Western blotting analysis of monoclonal antibody binding sites.

Previous studies with a particular monoclonal antibody (MAb 445) raised against the Ulster strain of Newcastle disease virus (NDV) have shown that this MAb immunoprecipitates only the 74,000 mol. wt. (74K) haemagglutinin-neuraminidase protein (HN) of both Ulster and Beaudette C strains of NDV. Using the technique of Western blotting, it is shown that under certain denaturing conditions virion proteins comigrating in SDS-polyacrylamide gels with the faster migrating 67K fusion protein and 53K nucleocapsid/nucleocapsid-associated protein, as well as the 74K HN, all reacted strongly with MAb 445 and with MAb 14 which is also directed against the HN protein. Analysis of this anomalous behaviour using SDS-polyacrylamide diagonal gel electrophoresis has led to the unexpected conclusion that the 74K HN can electrophorese as three immunoreactive species of apparent mol. wt. 74K, 67K and 53K. If the Western blotting technique is to be applied to proteins which have not been sufficiently denatured (in an attempt to preserve epitope integrity) it is important to establish that no additional proteins remain associated with the protein bands that react with the MAb.

Antibodies, Monoclonal↗