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PubMed1982

[The barrier-function of the gastrointestinal (author's transl)].

The present review tries to coordinate anatomical barriers and the biochemical and immunological events controlling and even preventing the entry of substances from the external environment into the extra- and intra-cellular space of the body. A selection of diseases with disturbance of the "barrier function" is included.

Biological Transport↗
PubMed1981

[Morphofunctional characteristics of the intestinal insufficiency syndrome].

Phase morphofunctional alterations determining the stages of development of the intestinal deficiency syndrome were detected in a composite investigation of the motor, evacuatory, secretory, digestive and absorbing functions of the small intestine in experimental animals in the immediate period after operations on the gastrointestinal tract organs and elimination of acute mechanical ileus, as well as morphological (histological and electron microscopic) examinations of small intestine mucous membrane biopsies taken at various stages of the disease.

Animals↗
PubMedDate not supplied

[Homeostatic influence of the lipid composition of the chyme and the effect of the correlation of basic lipid classes on the intensity of their absorption in the small intestine].

Experiments on normal unanesthetized polyfistulous dogs kept on a mixed diet were made to study the basal lipid ratios of the duodenal and small intestinal chyme. It was shown that the duodenal and small intestinal chyme underwent homeostasis as regards the basal lipid class at the expense of the adding endogenous lipids to digestive juices. The ratios mentioned did not change substantially as a result of lipid absorption during exposure of the chyme in an isolated part of the intestine. The data obtained suggest that the rate of lipid absorption depends on the lipid profile of the chyme.

Animals↗
PubMed1981

[Radiological changes of adult sprue (author's transl)].

Radiological findings of 10 adult patients with sprue were compared with histology. Patients suffering from subtotal villous atrophy were showing distinct radiological changes. The most important finding of sprue is the dilatation of the small intestine. Further typical changes are segmentations and fragmentations as well as mucous hypertrophy and the sign of moulage. In a 57-year-old female patient who was suffering from sprue for 35 years, a carcinoma of the small bowl was found and was resected during laparatomy. Sprue is a premalignant disease; therefore radiological investigations are of special importance. Therapy by a diet without gluten can reduce the radiological changes to normal, very bad changes rarely can be reduced totally. Radiological changes are not significant, but the diagnosis can be made in most cases by investigation with barium.

Celiac Disease↗
PubMed1981

Carcinogenicity of trichloromethine hydrochloride (TS-160 Spofa) and morphological damage after its intraamniotic injection.

The cytostatic TS-160 (trichloromethine hydrochloride, tris-/2-chloroethyl/amine hydrochloride) was injected subcutaneously into SPF Wistar rats of both sexes. After all doses used, spindle-cell or even polymorphocellular sarcomas developes at the injection sites in both sexes: after the dose of 0.1 mg/kg daily for 6 months, in 70%; after 0.25 mg/kg, in 79%; and after 1.0 mg/kg weekly for 6 months, in 45% of the rats. Besides, in 21% of the rats receiving the dosage of 0.25 mg/kg mucus-secreting intestinal adenocarcinomas were found. A relationship was apparent between the incidence figures of subcutaneous tumors on the one hand and the daily injection of the low dose versus the intermittent injection of the dose higher by a decimal order on the other hand. In a concurrent test, TS-160 was given to rats in intraamniotic injection on day 18 of pregnancy in doses of 1, 2.5, and 5 micrograms per embryo. On the first postnatal days, in the affected young rats there were observed morphogenetic disturbances: splanchnocrania and juvenile hair alopecia. These changes became repaired in the further course of postnatal development.

Adenocarcinoma↗
PubMed1980

Impaired local immune response in vitamin A-deficient rats.

The functional integrity of the local immune system in vitamin A-deficient (A-) rats was investigated. Secretory IgA levels in the intestinal fluid of A- rats were significantly lower than in controls. This and the decrease in intensity of immunofluorescent staining for secretory component (SC) in the intestinal cells was related to the duration of vitamin A deprivation. IgG levels in the intestinal fluid, and serum IgA and IgG levels were unaffected in deficiency. Moreover, when the response of animals to DNP50-BGG was evaluated, the local anti-DNP response in the intestine was markedly depressed. These defects may result from impaired synthesis of SC by epithelial cells. On the other hand, the serum antibody response in deficient animals was not noticeably different from that of the controls; if any, htere was a slight reduction in the affinity of antibody.

Animals↗