Topical Fucidin.
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Forty-two infants and young children with skin diseases of various kinds were treated by the simultaneous application of a combination of three creams, the respective ingredients of which were beclomethasone dipropionate, sodium fusidate and ketoconazole. The treatment produced good results in 97.6% of cases, with eradication of pathogenic agents and satisfactory relief of symptoms. The combination was well tolerated in almost all cases, both locally and systemically, and no adverse reactions were reported.
Forty patients with skin diseases of various origins were treated with a combination of three creams, the respective bases of which were clobetasone butyrate, sodium fusidate and ketoconazole. Satisfactory results were obtained in 97.5% of cases, with remission of symptoms and good healing of lesions. Tolerance was excellent in 97.5% of cases, with only one patient complaining of burning sensations after the applications.
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The authors have previously shown the role of antibiotic loaded plaster-of-Paris pellets in the treatment of bone loss. In the present paper, a study has been made of the effects of osteogenesis of added decalcified bone matrix in powder. The experiment was made by the implantation of pellets in the muscles of rabbits. It was shown that bone induction by pellets of bone matrix was slightly lower when Rifamycin was added and was not modified by the addition of Fucidin or Gentamycin. The exudation of antibiotics was not diminished by the addition of bone matrix to plaster-of-Paris pellets. The double action, on infection and on bone induction, of composite pellets of plaster-of-Paris with antibiotics and bone matrix may lead to their use in the treatment of septic bone cavities since the pellets are absorbable.
Forty outpatients with skin diseases were treated with an extempore combination of three creams, the respective bases of which were beclomethasone dipropionate, sodium fusidate and ketoconazole. Positive results were obtained in 97.5% of the cases with good relief of symptoms and excellent local tolerance in all cases treated.
Forty-two patients undergoing cryosurgery for skin diseases were treated by means of the simultaneous application of three creams, the respective bases of which were beclomethasone dipropionate, sodium fusidate and ketoconazole. The treatment produced excellent results, preventing bacterial and/or mycotic superinfections and relieving the edema and erythema caused by the operation in 97.6% of cases. Local tolerance was optimal in all cases; no adverse reactions of any kind being reported.
For the otolaryngologist (ENT specialist), too, antibiotics are among the most frequently prescribed drugs. This article gives the essential fundamentals for the antibiotic treatment of patients with restricted kidney functions, as well as advice for antibiotic therapy in clinics and in medical practice.
Thirty-eight patients suffering from dermatological conditions of various natures were treated by means of the simultaneous application of a combination of three creams, the bases of which were sodium fusidate, ketoconazole and clobetasone butyrate respectively. Positive results, in the form of remission of symptoms, were obtained in 86.7% of the cases. Local tolerance was excellent in all cases and no adverse reactions were observed.
Forty out-patients suffering from a variety of skin diseases were treated over a period of 7 to 14 days (mean 9.6 days) with twice-daily applications of an extempore combination of sodium fusidate, clobetasone butyrate and ketoconazole creams. The severity of symptoms was assessed before, after 5 days and at the end of treatment and an overall evaluation made of response to therapy. The findings indicated that there was clinical cure or significant improvement in 37 (92.5%) of the patients, with excellent tolerance and no reports of any adverse reactions.
Forty-one patients with skin diseases of various origins were treated with an extempore combination of three creams containing clobetasone butyrate, sodium fusidate and ketoconazole. A mixture of the creams was applied once to 3-times daily for periods ranging from 5 to 15 days (mean 8.5 days). Assessments were made before, during and at the end of the treatment period using a symptom severity rating scale. The results showed that all symptoms regressed to a significant extent and by the end of the treatment period there had been complete disappearance or improvement with satisfactory remission in 97.6% of the patients. Local tolerance was excellent or good in all patients and there were no reports of any side-effects.
Forty-three patients with skin diseases of poorly defined natures, often related to lengthy periods of hospitalization, were treated for 10 days with a combination of three creams, the active ingredients of which were beclomethasone dipropionate (0.025%), ketoconazole (2%) and sodium fusidate (2%), respectively. Positive results were obtained in 81.4% of the patients treated with good remission of symptoms and good healing of initial lesions. Local tolerance was excellent, and no adverse effects were observed.
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