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PubMed2006

Personality profile of depressive patients with a history of suicide attempts.

AIM: To examine the dimensions and appropriate aspects of personality according to the five-factor model of personality of depressive patients with a suicide attempt history compared to depressive patients without a suicide attempt history and healthy persons. METHOD: Sample of 35 outpatients of both gender (< 60 years), with a diagnosis of ICD-10 non-psychotic recurrent depression in remission (F 33.4) and a group of healthy persons (N = 20) were included in the study. Patients were classified into a group of patients with a suicide attempt history (N = 15) and a group of patients without a suicide attempt history (N = 20). The exclusion criteria were determined. The NEO PI-R (240 self-report items) has been used to evaluate personality dimensions and aspects. RESULTS: Both patient groups had a significantly higher score on the dimension of Neuroticism (p < 0.001), as well as significantly lower scores on the dimensions of Extroversion, (p < 0.001) Openness (p < 0.01) and Conscientiousness (p < 0.001; p < 0.01) compared with a group of healthy persons (ANOVA; Fisher's test-LSD). CONCLUSIONS: Depressive patients with a suicide attempt history were significantly different in all personality domains except in Agreeableness from healthy persons (higher Neuroticism and lower Extroversion, Openness and Conscientiousness). There were no considerable differences in personality domains when major depressives with and without suicide attempt history were compared.

Adult↗
PubMedDate not supplied

P16 is overexpressed in cutaneous carcinomas located on sun-exposed areas.

BACKGROUND: Recently, an increased expression of P16, a cell cycle regulatory tumor suppressor protein, has been demonstrated in cervical squamous neoplasms as a marker of malignancy. In contrast, studies performed in skin carcinomas led to contradictory results. OBJECTIVES: Our first aim was to evaluate P16 expression in different types of non-melanoma skin cancers compared with normal skin and benign tumors. The second aim was to evaluate the relationship between P16 expression and the location of skin tumors (i.e. exposed versus non exposed sites). Finally, we also studied Ki67 expression in skin carcinomas and control biopsies. METHODS: Skin biopsy specimens with typical histologic features of squamous cell carcinoma (SCC; n = 30), Bowen's disease (BD; n = 17), basal cell carcinoma (BCC; n = 10), seborrheic keratosis (SK; n = 10) and normal human skin (NHS; n = 9) were obtained from 76 patients seen at our institution between 2001 and 2003. In all cases, P16 and Ki67 expression were evaluated by immunohistochemistry and image analysis. RESULTS: P16 overexpression was observed in 58% of cutaneous carcinomas (SCC: 60%; BD: 58%; BCC: 50%) versus 0% of SK or NHS (0%) (p = 0.006). Ki67 expression in over 5% of tumour cells was observed in 69% of cutaneous carcinomas (SCC: 54%; BD: 76%; BCC: 80%) versus 16% in the group including SK (30%) and NHS (0%) (p = 0.04). Overexpression of P16 was associated with a high rate of Ki67 positive tumour cells in 23/57 malignant skin tumors (40%). Both P16 was associated and Ki-67 were negative in 7/57 cases (12%). Sixty-eight percent of tumors located on sun-exposed areas versus 23% of those located on non sun-exposed areas overexpressed P16 (p = 0.02). CONCLUSION: Our study demonstrated that the expression of P16 and Ki67 is associated with skin carcinomas. No difference was observed according to histological types of carcinomas, suggesting that P16 and Ki67 expression did not correlate with the degree of proliferation and malignancy. Within cutaneous carcinoma specimens, P16 overexpression was significantly associated with the location on sun-exposed areas, suggesting a possible induction of P16 overexpression by UV radiation.

Adult↗