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[Computer program for medical records of patients with diabetic retinopathy].

The purpose of this study was to point out the advantages or the computerised evidence in patients with diabetic retinopathy examined in "Diabetic Eye Department" from Ophthalmology Clinic Craiova. This program represents a new national performance regarding the evidence of the diabetic patients clinic examination. The main characteristics of our program are the accessibility and the coherence; the utility of this program has been demonstrated by long term use and the big number of patents recorded.

Diabetic Retinopathy↗

GENESRCH: a computer program for restriction fragment analysis.

We describe a program GENESRCH which has been written to enable the design of efficient restriction fragment analysis of DNA from patients with hereditary disorders. The program identifies homology of DNA sequences up to 20 base pairs in length, calculates the fragment sizes and indicates the position of enzyme restriction sites within the gene of interest. GENESRCH is written in the BASIC language and will run on any IBM-compatible PC with a parallel printer. A hard disc is recommended for efficient storage and retrieval of data. An example of the use of the program is cited.

Base Sequence↗

The Gene Construction Kit: a new computer program for manipulating and presenting DNA constructs.

The Gene Construction Kit is a new tool for manipulating and displaying DNA sequence information. Constructs can be displayed either graphically or as formatted sequence. Segments of DNA can be cut out with restriction enzymes and pasted into other sites. The program keeps track of staggered ends and notifies the user of incompatibilities and offers a choice of ligation options. Each segment of a construct can have its own defined thickness, pattern, direction and color. The sequence listing can be displayed in any font and style in user defined grouping. Nucleotide positions can be displayed as can restriction sites and protein sequences. The DNA can be displayed as either single- or double-stranded. Restriction sites can be readily marked. Alternative views of the DNA can be maintained and the history of the construct automatically stored. Gel electrophoresis patterns can be generated and can be used in cloning project design. Extensive comments can be stored with the construct and can be searched rapidly for key words. High quality illustrations showing multiple editable constructs with added graphics and text information can be generated for slides, posters or publication.

Amino Acid Sequence↗

REFERENCE UPDATE and REFERENCE MANAGER: personal computer programs for locating and managing references.

REFERENCE UPDATE (a trademark of Research Information Systems, Inc.) is a diskette-based service which provides subscribers with a weekly update on the latest publications in biology and medicine. REFERENCE MANAGER (a registered trademark of Research Information Systems, Inc.) is a microcomputer-based software package developed to manage selected references for quick retrieval and bibliography generation. These two systems allow scientists to build and update a personalized data base of references. The following article gives an overview of REFERENCE UPDATE and REFERENCE MANAGER and provides a description of the various functions each system offers.

Bibliographies as Topic↗