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[Colonoscopy in the diagnosis and follow-up of colonic polyps].

Out of 5000 patients examined endoscopically colon polyps were detected in 64%. The polyps were characterized by: higher incidence in 70-79-year-olds, high percentage of tubular adenomas (79%), large sizes of polyps with complex structure and their prevalence in the left colon, signs of malignancy in 0.64% of the removed polyps. The chance to develop cancer from tubular adenoma was 0.28%, tubular-villous, 1.4%, villous 3%. Recurrent polyps following polypectomy arose in 65% of cases. Tumor relapses emerging mainly within the first postoperative year occurred in 14% of cases. In 4 patients with cancer its onset was registered at the site of the removed large adenomas of complex histological structure. Colonoscopy proved an adequate method of diagnosis and follow-up of colon polyps. Endoscopic polypectomy can be considered as a measure to prevent colon cancer.

Aged↗

[Bowel cleansing prior to colonoscopy. A prospective, randomized, blind comparative study].

A randomized, prospective, single blind study was performed in 90 hospital inpatients to compare the effect of three different bowel preparatory regimens prior to total colonoscopy. The extend of bowel cleansing, acceptance by the patients, side effects as well as body weight, blood pressure, pulse rate and various laboratory parameters served as major assessment criteria. Peroral colonic lavage was superior to a senna preparation and a combined laxative agent with regard to the extend of bowel cleansing (p less than 0.001). The study failed to detect significant differences in terms of acceptance by the patients between the three study groups. Minor deviations were found after the combination laxative (slight decrease of serum potassium levels by 0.32 mmol/l), after the senna preparation (minimal decrease of the heart rate), and after peroral lavage (slightly less weight reduction) as compared with the other study groups, respectively. We conclude that peroral lavage is significantly more effective with regard to the extend of bowel cleansing, when compared with two other bowel preparatory regimens, which use a senna preparation or a laxative combination, respectively. Likewise, this study failed to detect significant differences in terms of acceptance by the patients.

Adult↗

[Role of colonoscopy in the diagnosis of ischemic colitis as a complication of surgery of aneurysms of the abdominal aorta].

Ischaemic colitis is one of the complications following aortic reconstruction for abdominal aortic aneurysm. The diagnosis and monitoring of this complication can be helped by a left colonoscopy. Through an endoscopic valuation of 18 patients, the Authors value the incidence of colonic mucosal or mucosal and muscularis ischaemia following aortic aneurysmectomy with inferior mesenteric arterial ligation.

Aged↗

[The role of colonoscopy in screening for tumors of the large intestine].

In 1986-1988, 6434 patients underwent colonoscopy in general hospital: 2076 were at risk for large bowel cancer whereas in 4358 the procedure was used for prophylaxis. Benign polyps or polyposis were detected in a total of 1699 (26.4%) patients: 856 (41.2%) in the risk group and 843 (19.3%) in the prophylactic one. Malignancy was diagnosed in 248 (11.9%) and 41 (0.9%) patients, respectively. It was found that small and early tumors made up 22% of the total number of cancers in the prophylactic group and 16.9% in the high risk group only. Colonoscopic screening carried out under general hospital condition is psychologically and economically justified since it allows to form a risk group and diagnose early cancer whereas timely removal of polyps assures secondary prophylaxis of large bowel cancer.

Adult↗

[Retrograde ileography. Contrast imaging of the terminal ileum by colonoscopy].

The distal ileum, the segment most frequently affected by small intestinal disease, may be difficult to visualize by conventional x-ray techniques. In recent years various methods have been described for retrograde ileography during or after colonoscopy. However, these methods require special equipment and may be difficult to perform in practice. We have therefore tried out a somewhat modified technique. Patients with suspected distal ileal disease are examined on a fluoroscopy table at the x-ray department. When necessary, biopsies are taken during the introduction of the scope. With the tip of the colonoscope in the terminal ileum (or coecum) a catheter is introduced through the biopsy channel into the distal ileum. Water-soluble contrast (Mixobar) is then instilled under fluoroscopic control and films are taken in the supine, oblique and prone positions. Owing to gas already present in the ileum a double contrast effect is obtained. The ileography is completed in 5-10 minutes and entails no additional discomfort for the patient. The technique is easy to learn and requires no special equipment. It does not obviate the need for conventional small bowel enema, but may be a valuable supplement to this examination when distal ileal pathology is suspected.

Colonoscopes↗

Perforation of the large bowel during colonoscopy in Singapore.

The management of seven patients with colonoscopy-related perforations is described. This study demonstrates the need for an early laparotomy. A high index of suspicion is required to reach an early diagnosis. Patients with no preexisting medical problems who underwent early surgery recovered with little morbidity. In elderly patients (greater than 75 years), colonoscopic perforation can be fatal. Endoscopy should be performed with special care in such patients.

Adult↗

[Colonoscopy: indications, procedure, results].

Colonoscopy in childhood is indicated as a valuable procedure mainly in rectal bleeding and suspected inflammatory bowel disease. Because of high efficiency and low complication rates this procedure should be used more often.

Adolescent↗

[Value of colonoscopy in postoperative care of colorectal carcinoma].

From 1981 to 1986, fiberoptic colonoscopy was performed in 2225 patients, of whom 356 cases (16%) were operated on for colorectal carcinoma and followed up for three months to twenty years. 27 cases were detected to have a second primary cancer and 1 case third primary cancer. In addition, 1 case of carcinoid, 6 cases of in-situ cancers, and 77 cases of adenomas were found. Among the 138 asymptomatic cases, 8 were proved to have a second cancer and 6 to be in early stage. Among the remaining 218 symptomatic cases, 26 with second cancers and 10 in the early stage were detected. The study shows that periodic colonoscopic examinations are mandatory for asymptomatic postoperative patients.

Adenoma↗

Severe hyponatremia after colonoscopy preparation in a patient with the acquired immune deficiency syndrome.

Disseminated infections with cytomegalovirus have become an increasingly important cause of morbidity and mortality in patients with the acquired immune deficiency syndrome. Herein we describe a male homosexual with the acquired immune deficiency syndrome who became severely hyponatremic during bowel preparation for colonoscopy. Biochemical evidence of adrenal insufficiency and clinical evidence for cytomegalovirus colitis was found. We propose that the patient had clinically significant cytomegalovirus adrenalitis. A random urinary sodium concentration is suggested as a potential screening test before bowel preparation in such patients.

Acquired Immunodeficiency Syndrome↗

Procedural skills in flexible sigmoidoscopy and colonoscopy for the family physician.

Procedural skills in flexible sigmoidoscopy and colonoscopy are widely accepted as diagnostic and therapeutic tools that assist physicians as they attempt to understand the biological and behavioral elements of undifferentiated gastrointestinal illness. Data support the ability of family physicians to perform and teach some of these endoscopic skills. Although one major contribution of these procedures is in the prevention of premature colorectal cancer mortality, other important patient care benefits are emerging for the office-based physician. Breadth of care enhances our most important therapeutic tool--the doctor/patient relationship. Unnecessary referral contributes to fragmentation and depersonalization of the health care system. Family physicians are urged to examine and acquire new procedural skills appropriate for their community. The process of privileges is discussed.

Colonoscopy↗

Follow-up colonoscopy in patients with colorectal adenomatous polyps.

Multiple follow-up colonoscopies were performed in 44 asymptomatic patients after polypectomy of colorectal adenomatous polyps. Twenty-six patients (59%) developed new adenomatous polyps. In 81% the new polyps were located in the same segment of the colon where a previous polyp had been totally removed. Polyps removed during follow-up, compared with the initial polyps, revealed significantly more benign and smaller polyps. The number of initial polyps together with occurrence of atypia were factors determining a short time interval for developing new adenomatous polyps. The mean time for developing a 5-mm or larger polyp was significantly longer than polyps less than 5 mm in diameter.

Adenoma↗

Frequency of isolated proximal colonic polyps among patients referred for colonoscopy.

The American Cancer Society now advocates screening asymptomatic populations over the age of 40 to 50 years for colonic malignancy. It is possible, however, that fecal occult blood testing and sigmoidoscopy to 60 cm would fail to identify patients with adenomatous polyps located only in the proximal colon. The purpose of this study was to determine how many patients without polyps in the distal 60 cm of the colon would have more proximal lesions. Ninety-eight consecutive patients with positive fecal blood test results or suspicious barium enema results were studied, using the assumption that if they had been seen six months earlier, when asymptomatic, they would have been candidates for screening examination. Forty-one (42%) of 98 patients had adenomatous polyps or cancer, and 15 (37%) of these patients had isolated proximal lesions. The polyp detection rate from 0 to 60 cm was significantly less than the detection rate for a full colonoscopy (27% vs 42%). We conclude that isolated proximal colonic polyps may be common.

Adenocarcinoma↗

[Results of colonoscopy in surgically relevant diseases of the large intestine].

Colonoscopy has greatly enlarged possible diagnostic, prophylactic, and therapeutic approaches to colonic diseases. The role played by this method for surgically relevant colonic diseases and as an element in precisely defined tumour aftercare programmes as well as for targeted screening of high-risk groups is outlined in this paper with reference to findings obtained from 491 colonoscopic examinations. Endoscopic polypectomy is also described as an important therapeutic approach to precancerous processes and early cancer forms.

Carcinoid Tumor↗

Colonoscopy: its application and merit.

Much has been learned through the development of colonoscopy. This in turn has stimulated interest in roentgenographic studies and has provided a tool for conducting research studies that would not be possible without the ability to obtain tissue sequentially over a period of time. Despite these advances, questions still outnumber answers. As new technologies open doors for research that was not historically possible, commitment to research in endoscopy becomes increasingly important. The opportunities, importance and need for commitment to endoscopic research has recently been emphasized (Silverstein 1984). It is hoped that important research questions in endoscopy will be effectively addressed and this, in turn, will improve our knowledge about cancer of the large bowel and its precursors.

Adenoma↗

High affinity rosette tests in patients having colonoscopy.

Depression of high affinity rosette tests, mediated by serum factors, has been demonstrated previously in pre-malignant disease of the uterine cervix. Patients having colonoscopy were studied to determine whether similar serum changes would permit identification of patients with adenomatous polyps. No clinically useful changes were detected.

Adult↗

[Localization of colon adenomas in relation to age and sex. A colonoscopy study].

The material consists of 318 colonic adenomas in 162 patients - 78 women and 84 men. Patients with partly colonoscopy, polyposis or additional carcinoma are not involved. Distribution of adenomas is influenced by age, sex, and the number of polyps per patient. With increasing age the number of adenomas increases in the proximal parts of the colon. In contrast the number of polyps decreases in the rectum. This change in distribution is caused by age itself and by a greater number of patients with multiple adenomas, in which the number of polyps in proximal parts of the colon is increased independent of age. Women have significant more frequently solitary polyps than men and the rectum is much less involved. There are two parallels between adenoma-disease and carcinoma-disease of the large intestine: With increasing age the number of colonic carcinomas increases in the proximal parts of the large intestine and the rectum is also less involved in women.

Adenoma↗