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Biomedical Technology↗

Nanostructured Ti-based multi-component alloys with potential for biomedical applications.

A group of Ti(60)Cu(14)Ni(12)Sn(4)M(10) (M=Nb, Ta, Mo) alloys was prepared using arc melting and copper mold casting. The as-prepared alloys have a composite microstructure containing a micrometer-sized dendritic beta-Ti(M) phase dispersed in a nanocrystalline matrix. These new alloys exhibit a low Young's modulus in the range of 59-103 GPa, and a high yield strength of 1037-1755 MPa, together with large plastic strains. The combination of high strength and low elastic modulus offers potential advantages in biomedical applications.

Alloys↗

Poly(alkylcyanoacrylates) as biodegradable materials for biomedical applications.

This review considers the use of poly(alkylcyanoacrylates) (PACAs) as biomedical materials. We first present the different aspects of the polymerization of alkylcyanoacrylate monomers and briefly discuss their applications as skin adhesives, surgical glues and embolitic materials. An extensive review of the developments and applications of PACAs as nanoparticles for the delivery of drugs is then given. The methods of preparation of the nanoparticles are presented and considerations concerning the degradation, in vivo distribution, toxicity and cytotoxicity of the nanoparticles are discussed. The different therapeutic applications are presented according to the route of administration of the nanoparticles and include the most recent developments in the field.

Absorbable Implants↗