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A placebo controlled trial of ultrasound therapy in chronic leg ulceration.

A controlled study of the effects of ultrasound on healing chronic leg ulcers was carried out in conjunction with standard treatment on 38 patients divided randomly into two groups. All patients received standard treatment (paste impregnated bandage and a self-adhesive elastic bandage plus placebo ultrasound or ultrasound (1.0 watt/cm2 at 1 MHz, for 10 min) twice weekly for 8 weeks. Percentage healed ulcer area and number of healed ulcers were compared after 2, 4, 6 and 8 weeks. There were no significant differences in the proportion of healed ulcers or ulcer area in the ultrasound group as compared with the placebo group.

Adult↗

Effects of a proprietary topical medication on wound healing and collagen deposition in horses.

Full-thickness skin wounds were created on the dorsum of both metacarpi in 8 horses. Three topical treatment regimens were studied. All wounds were bandaged with a nonadherent dressing, which was held in place with a snug elastic wrap. Group-A wounds were treated with a proprietary topical wound medication that consisted of a spray and an ointment. Group-B wounds were treated with the same regimen, except the putative active ingredients in the ointment were omitted. Group-C wounds were treated with a dry nonadherent bandage only. Wound dressings were changed every day and the limbs were photographed every other day until the wounds were healed. Specimens of normal skin and biopsy specimens of healed wounds were examined histologically and were assayed for hydroxyproline content. Wound healing measurements quantitated for each wound were number of days to healing, maximal wound size attained, day wound contraction commenced, day epithelium first noticed, rate of wound contraction, final wound size, and fraction of the wound that healed by contraction. The cosmetic appearance of the healed wounds was also graded. Significant differences were not noticed in hydroxyproline content, histologic appearance, or any of the wound healing measurements between treatment groups. The cosmetic appearance of healed group-A and -B wounds was significantly better than the appearance of group-C wounds. The topical treatment regimens studied neither enhanced nor inhibited wound healing in this study.

Administration, Topical↗

Effects of mechanical and pharmacologic manipulations on portal pressure, central venous pressure, and heart rate in dogs.

Central venous pressure (CVP), portal pressure (PP), and heart rate (HR) were monitored in 6 female, sexually intact, middle-age Beagles during temporary portal vein obstruction, anesthetic recovery, abdominal bandaging, and propranolol administration. Intraoperative baseline PP was 7.3 mm of Hg (+/- 1.7 SD). Portal pressure was significantly increased throughout portal vein occlusion, but returned to baseline values 2 minutes after release of the ligature. Central venous pressure was significantly decreased throughout portal vein occlusion, but did not differ significantly from baseline values 3 minutes after release of the portal vein ligature. Portal pressure increased significantly (8 +/- 3.3 mm of Hg) over baseline values after application of an abdominal bandage; however, CVP did not change significantly. During postoperative monitoring, CVP and PP did not change significantly from respective 18-hour mean postoperative values in resting dogs. At 60 and 75 minutes after surgery, heart rate was significantly increased over the 18-hour mean. Portal pressure and CVP, respectively, were significantly increased over intraoperative baseline values in the first hour and the first 8 hours after surgery. Postoperative CVP and HR were significantly correlated. Individual measurements of PP in dogs that were abdominal pressing during barking or defecation were significantly increased (9 +/- 3 mm of Hg) above measurements taken after cessation of abdominal press. Portal pressure measurements in standing dogs decreased 7.5 +/- 2 mm of Hg, compared with measurements of the same dog in lateral recumbency. Central venous pressure was inaccurate in dogs performing abdominal press. Portal pressure did not decrease significantly from baseline after injection of propranolol (2 mg/kg, IV).(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗

[Colles' fracture. Therapeutic results and use of resources. A comparative study between 2 departments in the same county].

A comparison between the functional end results of Colles' fractures, treated in two different hospitals, was performed by a follow up study of 100 patients from each hospital 18-24 months after fracture. The difference between the requirements of resources in the two hospitals were mainly: treatment of patients as outpatients or during admission and the method of anaesthesia. No significant difference in functional end result between the two groups was found. It was concluded that local anaesthesia in the fracture haematoma often is insufficient and is unpleasant for the patient. A more effective anaesthesia which can be applied polyclinically is preferable, as anaesthesia, which demands admission to the hospital, is an expensive solution and does not give a better functional end result. The "sandwich" type plaster of Paris bandage is more comfortable, safer to use with outpatients and is therefore preferable to the circular plaster of Paris bandage.

Adult↗

The role of sclerotherapy as an adjunct to Unna's boot for treating venous ulcers: a prospective study.

Ankle ulcers associated with venous disease have been traditionally treated by Unna's compressive bandages. However, successful healing of an ulcer with this therapeutic modality is slow and tedious. The purpose of this study is to investigate whether adjunctive sclerotherapy of large venous channels near the ulcers enhances healing. Twenty-eight patients with perimalleolar venous ulceration were entered into this study. Ulcer size ranged from 6.0 to 25 cm2. All were examined for the presence of large venous channels adjacent to the ulcer bed. A portable continuous-wave Doppler supplemented digital examination of the area. Twenty-five out of 28 patients had easily detectable venous channels, and these were randomized into two groups: group I, treated by weekly changes of Unna's compressive boots; group II, treated by weekly change of Unna's compressive boots and sclerotherapy with 3% sodium tetradecyl sulfate (Sotradecol). All patients had the size of the ulcer measured during their weekly visits. Patients in group II took a mean of 2.1 weeks to exhibit 50% healing and 4.3 weeks to fully heal. Conversely patients in group I took a mean of 3.2 weeks to achieve 50% healing and 6.1 weeks to fully heal. Thus, healing was significantly faster (p less than 0.05) in group II. In conclusion, the therapeutic efficiency of Unna's compressive bandaging is significantly enhanced by the adjunctive sclerotherapy of adjacent venous channels.

Adult↗

Surgical treatment of tarsal sheath effusion associated with an exostosis on the calcaneus of a horse.

A 2-year-old Thoroughbred colt was referred for evaluation of effusion within the tarsal sheath and associated lameness of the right hind limb. Conservative treatment consisting of needle aspiration and pressure bandaging had been unsuccessful. Radiography of the right tarsus revealed proliferative periosteal reaction along the distal caudal border of the sustentaculum tali and medial aspect of the calcaneus. The owners elected conservative treatment, using a local injection of corticosteroid and pressure bandaging the tarsus. Five months later, the severity of the effusion and lameness had increased. Radiography revealed increased reactive bone along the sustentaculum tali and mineralization of the plantar tarsal ligament and tarsal sheath. Surgical exploration revealed fibrous adhesions between the medial aspect of the calcaneus and the flexor tendon and associated soft tissue mineralization. The adhesions were broken down and the reactive bone along the calcaneus was removed. The mineralized soft tissue within the tarsal sheath was excised. Five months after surgery, the horse was sound at the trot, with only minimal tarsal sheath effusion. The response to treatment for tarsal sheath effusion and lameness caused by bony changes of the sustentaculum tali is often unsatisfactory. After responding poorly to conservative treatment, the horse in this report had a favorable outcome to the surgical intervention of this condition.

Animals↗

[Conservative treatment of chronic lymphedema].

Decongestion of chronic lymphedema can be achieved by supportive bandages without elasticity, manual lymph drainage (especially in cases of secondary lymphedema after treatment of cancer), and remedial exercises performed while wearing bandages. Hygienic skin care is necessary to avoid attacks of recurrent erysipelas. In order to preserve the reduction of the edema once achieved, the patients have to wear elastic sleeves or stockings daily.

Bandages↗

Varicose veins: optimum compression after surgery and sclerotherapy.

Graduated compression stockings are used in both surgical and non-surgical treatment of varicose veins. In a trial of high versus low compression stockings (40 mmHg vs 15 mmHg at ankle) after varicose vein surgery, both were equally effective in controlling bruising and thrombophlebitis, but low compression stockings proved to be more comfortable. In a further trial after sclerotherapy, high compression stockings alone produced comparable results to Elastocrepe bandages with stockings. It is concluded that after varicose vein surgery low compression stockings provide adequate support for the leg and that after sclerotherapy, bandaging is not required if a high compression stocking is used.

Adult↗

Whitehead's varnish and Jelonet--a better dressing for skin graft donor sites than Jelonet alone.

Two methods of skin autograft donor site management were evaluated in 40 patients in a prospective randomised double-blind clinical trial. Donor sites were dressed using either a standard dressing of Jelonet, gauze, wool and a crêpe bandage or Jelonet, Whitehead's varnish (compound iodoform paint BPC), gauze, wool and a crêpe bandage. Donor site pain was assessed daily using a linear analogue scale, and the healing time of the donor area was recorded. Whitehead's varnish significantly reduced donor site pain compared to the standard dressing (P = 0.0006). Although overall healing time was not statistically different in the two groups, larger donor sites treated with Jelonet and Whitehead's varnish healed more quickly than those treated with the standard dressing alone.

Bandages↗

[Compression in lymphedema].

The author discusses the indications and contraindication of compression. The study of auto-immune complexes in the circulating blood has shown a significant increase in lymphedema patients with erysipeloid inflammations and a definite increase, but less marked, in lymphedema patients without a past history of fever. Then, the compression values are studied in the 5 stages of the treatment of lymphedema by compression: elevation with Thuasne 18 bandages, Lymphapress and if necessary Tubing (always general anesthesia) limited to the leg. For the thigh, lymphatic "drainage" is recommended. Then comes the walking bandage (non elastic !). Once the edema has disappeared, elastic stockings (compression e.g. 60 mm at the level of the malleolus) are custom made. Statistics of 57 cases, where the regular replacement of the stockings after 9 to 13 years was controlled, conclude the study.

Bandages↗

The effect of external pressure on intramuscular blood flow at rest and after running.

Local blood flow in the thigh was measured with 133Xe clearance technique in eight male distance runners after compression with a foam rubber compress and a standard elastic bandage. Two degrees of compression were tested, and an initial experiment with rested subjects was followed by a similar experiment immediately after running. Maximum compression exerted a cutaneous pressure of 85 (+/- 8) mm Hg and caused an immediate cessation of intra-muscular blood flow in the compressed area. Moderate compression gave a cutaneous pressure of 40 (+/- 5) mm Hg and resulted in a reduction of blood flow by approximately 50%. During compression, there were no significant differences in the blood flow of rested subjects compared to subjects immediately after running. In acute soft tissue injuries, a maximum compression bandage should effectively reduce or eliminate the formation of an intra-muscular hematoma, and an additive effect on blood flow of ice should not be expected.

Adolescent↗

The pressure distribution under tourniquets.

We measured the detailed pressure distribution under pneumatic tourniquets and Esmarch bandages in canine limbs. The results showed that pressure concentration can occur in the tissue under the tourniquet. The Esmarch-bandage tourniquet was shown to be capable of producing pressures in excess of 1000 millimeters of mercury immediately beneath the tourniquet. There is a wide variation between cuff pressure and the pressures in the underlying tissues.

Animals↗

[Effect of exogenous collagen on the metabolism of burns in rats; the collagen treatment of large superficial excision wounds].

In an animal experiment study the effect of collagen sponge treatment on skin wounds was examined. In a test for defense mechanism, the bandage material was accepted without any disturbance of the surrounding tissue. It could also be removed without any damage to the wound area while renewing the covering bandage. In contrast to the controls, there was a statistically significant difference in the decreasing wound area. No tract formation of the wound edges was observed in the experimental group, and histologically the wounds showed an earlier fiber formation with functional orientation toward the wound surface. The advantages of treatment using collagen instead of inert material include better compatibility, a positive cosmetic effect, and a stimulation of wound healing without the necessity of a two-stage transplantation.

Animals↗

[Morphology of healed burns treated by different methods].

The dynamics of burn wound healing was studied on biopsies from the wound area in 30 patients treated by open methods (treatment under conditions of abacterial environment and in a cabinet with laminar air). Twenty patients were treated by applications on the wound of ointment bandages. Under the bandages, the crust formed on the burn surface was infiltrated with polymorphonuclear leukocytes. When patients with burns over 10-25% of the body surface were treated in abacterial environment, a thin dry crust developed on the burn wound surface with small accumulations of microflora in its external layers. The granulation tissue filling the wound after early necrectomy contains numerous vessels and cell elements. In extensive burns (35-50% of the body surface) the granulation tissue fills the wound cavity incompletely, as separate islets.

Bandages↗

Treatment of dogs with wounds of the limbs caused by shearing forces: 98 cases (1975-1993).

Medical records of 98 dogs with wounds of the limbs caused by shearing forces (shearing wounds) were reviewed. Shearing wounds were reported most often in young dogs of many breeds, and most often resulted from trauma received during an encounter with an automobile. Wounds were located mainly on the distal portion of the limbs, with the most common site being the medial aspect of the tarsus and metatarsus. All injuries resulted in exposure of subcutaneous soft tissues, about three fourths of all injuries resulted in bone or joint exposure, and slightly more than half of the dogs had joint instability. All wounds were lavaged and debrided. Wounds were sutured, using primary closure techniques or methods that allowed the wound to remain partially or totally open to heal by second intention. Bandages were applied in all dogs. Most bandages were reinforced with a splint device. Grafting procedures or internal fixation devices were not used in initial treatment of the injuries. In the study reported here, healing time ranged from 2.0 to 8.7 weeks, depending on the size and depth of the wound and type of closure used. Mean number of anesthetic and surgical procedures was 1.7 per dog, and the mean number of rechecks after discharge from the hospital was 5.5 per dog. Outcome was considered excellent or good in 89 of 98 (91%) dogs; these dogs were clinically normal or had only minor functional abnormalities after their injuries healed. Outcome was poor in 9 of 60 (15%) dogs.

Accidents, Traffic↗

Psychosocial benefits of postmastectomy lymphedema therapy.

The effect of a comprehensive lymphedema management program was assessed in 25 patients in whom moderate to severe lymphedema had developed after surgery and/or radiotherapy for carcinoma of the breast. Intensive treatment (4 weeks) involved massage, compression bandaging, and sequential pneumatic compression, with an adjunct program of education to provide skills in exercise, massage, bandage, and containment garment use. The intensive treatment phase was followed by a self-management phase based on the skills that had been acquired. A significant reduction in limb circumference and volume, with continuing improvement over 12 months of self-management, was observed. There was a decrease in need for physical assistance. Quality of life generally remained high and stable throughout the 12 months. Quality of life specific to lymphedema, however, declined during the intensive phase of treatment, but recovered and surpassed pretreatment levels during the self-management phase of treatment. Perceived comfort and strength in the lymphedematous limb improved, and perceived size decreased. The study confirmed that the combination of multimodal physical therapy and education for self-management reduces lymphedema and its adverse subjective consequences and maintains the improvement thus achieved.

Adult↗

[Ambulatory treatment of postphlebitic ulcers of lower limbs. Physiopathological bases and clinical results].

Venous ulceration is a troublesome and disabling complication, representing one of the most difficult problems to be treated by the vascular surgeon. Venous insufficiency is a widespread condition, the prevalence of venous ulceration being 0.5 - 1 per cent in European populations. Although all venous ulcers will heal if the limb is elevated above heart level for an extended period of time, patients need a safe, effective, not disabling and quick therapy. Hence, the competent vascular surgeon must be familiar with venous pathophysiology and possess a thorough understanding of the treatment options available for a discouraged patient in need of an acceptable and effective approach. The aim of the present study was to assess the efficacy and the speed of healing of venous ulcer using an outpatient ambulatory treatment protocol. This protocol consisted of elastic compression bandage allowing deambulation, local dressing using lyophilized heterologous collagen (Condress, Gentili) and systemic profibrinolytic drugs. Exclusion criteria were coexisting arterial insufficiency, ulcer area greater than 25 cm2, coexisting disabling diseases (congestive cardiac failure, hepatic insufficiency, malignancy). From December 1990 to June 1993, 37 patients affected by venous ulcer were treated, according to the aforementioned protocol, at the Surgical Department of Montecchio Maggiore Hospital (VI). There were 16 male and 21 female patients, mean age was 66 years (range 59-91). Results show the complete healing of the venous ulcer in 94.5% of patients; mean time for ulcer healing was 128 days (range 45-91). The Authors conclude that the outpatient ambulatory treatment protocol is safe, quick, and effective for the therapy of chronic venous ulcer; once obtained the healing of the ulcer, elastic compressive bandage with elastic stockings is mandatory to prevent recurrences.

Aged↗

The efficacy of compression immobilization technique in retarding spread of radio-labeled Russell's viper venom in rhesus monkeys and 'mock venom' NaI131 in human volunteers.

The efficacy of the modified compression immobilization technique in retarding spread of radio-labeled Russell's viper venom in 3 rhesus monkeys (Macaca mulata) and "mock venom" NaI131 in 14 human volunteers was studied. 0.1 microgram of Russell's viper venom having 10 microCi radioactivity in 0.2 ml normal saline containing 0.5% bovine serum albumin was injected subcutaneously at the lateral aspect of the right hind limb of a rhesus monkey. A hand-tight bandaging of a rubber pad measuring 55 x 28 x 16 mm over the injection site and splinting effectively retard spread of radio-labeled venom for the entire length of time applied, although complete immobilization was not achieved. In human volunteers, application of a pad measuring 60 x 50 x 17 mm over the subcutaneous injection site of 20 microCi or 12 microCi/0.2 ml NaI131 with a hand-tight bandaging (60 +/- 10 mmHg) and immobilization of limb was found to be effective in retarding the movement of radioactive NaI131. These results suggested that the compression pads tried in this study effectively retard the spread of radio-labeled Russell's viper venom (MW ranging from 20,000-90,000) and radioactive NaI131 (MW 150) from the site of injection. Thus, it is highly likely that the present compression pad will be useful as a first-aid measure in Russell's viper bite victims.

Adult↗