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Results for “AMINOISOBUTYRIC ACID”

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PubMed1979

The effect of diamide on amino acid transport by rat renal cortex slices.

Diamide directly added to renal cortical slices inhibits the uptake of amino acids. Steady-state kinetic analysis indicates an inhibition of alpha-amino acid influx without effect on efflux. The effect could be reversed by addition of pyruvate to the incubation medium. Although there was a good correlation of the transport effect of diamide with its ability to decrease cellular reduced glutathione concentration, there did not appear to be a necessary connection between them. This was shown by the fact that renal cortical slices stored at 4 degrees C have no alteration in amino acid uptake despite the fact that GSH concentration is as low as that seen with diamide. Diamide was shown to have a direct effect on the uptake of glycine by isolated renal brush border membrane vesicles.

Amino Acids↗
PubMed1984

Photodynamic effects of hematoporphyrin-derivative on transmembrane transport systems of murine L929 fibroblasts.

Photodynamic treatment of murine L929 fibroblasts with hematoporphyrin-derivative causes deterioration of various membrane functions. Most sensitive to photodynamic inactivation are the energy-coupled transport systems for aminoisobutyric acid and for Rb+. The facilitated diffusion system for 2-deoxy-D-glucose is slightly less sensitive. After longer illumination periods also the membrane barrier function is impaired, as reflected by K+ leakage and increased passive Rb+ uptake. After still longer illumination periods intermolecular protein crosslinking can be observed. This makes it unlikely that intermolecular protein crosslinking is causally involved in the deterioration of these membrane functions.

Animals↗