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[Surgical treatment of a patient with carotid and renal artery stenoses].

A case report presents successful surgical treatment of a patient with multifocal atherosclerosis, impaired carotid arterial territory and renovascular hypertension resulted from subtotal renal artery stenosis. Clinical picture of the case is given in detail, as well as diagnostic examination results and surgical treatment plan, Optimal surgical strategy for such lesions is simultaneous surgery of carotid and renal arteries or staged correction beginning with carotid arteries. In the described case the staged intervention was chosen, but it was complicated by iliac arterial thrombosis during the attempt of renal artery angioplasty. From thoracophrenoperitoneal access simultaneous grafting of left renal artery with synthetic prosthesis and recanalization of blood flow in right lower limb were executed.

Angioplasty↗

Biphasic sarcomatoid carcinoma or carcinosarcoma of the breast: prognosis and therapy.

Biphasic sarcomatoid carcinoma of the breast represents only 0.2% of all breast cancer. Due to its rarity and repetitive reclassifications little is known about optimal treatment modalities. These tumours form a diagnostic and therapeutic challenge. The present report describes our experience with a case of biphasic sarcomatoid carcinoma of the breast and a review of the relevant literature is discussed.

Breast Neoplasms↗

[Control of exposure time of a roentgenodiagnostic unit by the radiation method].

The authors word the main requirements to the measuring channel of an outfit for measuring the time of exposure of a roentgeno-diagnostic unit by the radiation method. Define optimal conditions of radiation filtering within the range of 40-125 kV. The measuring channel permits recording exposures in roentgenography made within the limits of 0.001-5 s.

Humans↗

[Selection of correct treatment in patients with low cardiac output after open-heart surgery].

In operations of the open heart inadequate cardiac output can lead to the so-called syndrome of a low cardiac output. The main indicator of cardiac function is the cardiac index. In patients in a critical state reduction of the cardiac index below 1.9 l/min q.m. suggests the presence of this syndrome. The submitted paper deals with the early detection of a low cardiac output which makes it possible to select optimal treatment before clinical signs of failure as well as further complications develop. The submitted paper deals with a group of 115 operated patients incl. 53 operated on account of IHD and 62 on account of rheumatic heart disease. Treatment was according to haemodynamic values divided into four groups: 1. Insurance of an optimal intravascular volume without pharmacological support, 2. pharmacological support of vasodilatating agents (nitroglycerine, sodium nitroprusside), 3. positive inotropic support by dobutamine, 4. support by a combination of vasodilatating agents and positive inotropic pharmaceutical preparations (dobutamine, dopamine). The favourable effect of treatment in the above groups is apparent already after four hours, and after 20 hours the investigated values shift to an optimal zone. The authors emphasize the high diagnostic value of comprehensive extensive monitoring which influences and controls therapy by retrospective informations.

Cardiac Output, Low↗

[Functional roentgen diagnosis of the upper cervical spine].

For evaluation of the function of the upper cervical spine, especially assessment of the range of motion, functional X-rays films are useful in addition to the clinical examination. For the diagnosis of segmental instability, passive motion should be induced in order to obtain the full range. If anterior instability of the upper cervical spine is suspected, flexion-extension X-rays in the lateral view are appropriate. If a lesion of the alar ligaments is suspected, then lateral flexion X-rays films should be taken. In the normal situation, the atlas glides in the direction of bending, coupled by forced rotation of the axis. In cases with rotatory instability of the upper cervical spine, functional computed tomography should be performed. Atlantoaxial rotation of more than 52 degrees should be considered pathological as a result of a lesion of the alar ligaments. For examination of the relationship between the spinal cord and bony structures or inflammatory tissue in patients with rheumatoid arthritis, functional MRIs are helpful. Not only the exact diameter of the spinal canal can be measured during flexion and extension, but the degree of basilar impression or cranial migration of the axis can also be assessed. Optimal use of functional X-ray diagnostics, including functional the CT and MRI, is not only helpful for clinical diagnoses, but also for the planning of surgical procedures.

Cervical Vertebrae↗

[Diagnostic criteria for respiratory infection in intensive care patients].

The optimal technique for diagnosing nosocomial bacterial pneumonia in critically ill patients cared for in an Intensive Care Unit remains unclear. Firstly, fever, purulent secretions and new pulmonary infiltrates can be associated with a variety of other common pathological processes. Secondly, microscopic and culture of tracheal secretions are frequently unrewarding since the upper respiratory tract of most ventilated patients is colonized with potential pulmonary pathogens, wether or not deep pulmonary infection is present. Thus, the results of studies evaluating the clinical diagnosis of nosocomial pneumonia in this setting have been very disappointing. An important advance has been the development of the protected specimen brush technique. We and others have demonstrated that the secretions obtained using this technique and evaluated by quantitative cultures are useful in distinguishing patients with and without pneumonia. However, this procedure has important limitations in that results are not available immediately and in that a few false negative or false positive results may be observed. Recently, the use of bronchoalveolar lavage has been suggested to be of value in establishing the diagnosis of pneumonia since the cells recovered by lavage may provide a sensitive and specific means for early and rapid diagnosis of pneumonia in this setting and that the lavage technique can be conveniently incorporated into a protocol along with the quantitative culture of samples obtained using the protected specimen brush.

Bronchoalveolar Lavage Fluid↗

[Equipment and methodologic parameters of radiation exposure in digital subtraction angiography].

The mutual dependence of various parameters--frame rate, radiation dose per frame, size of the image intensifier field, photon energy, frame mode, and patient diameter--is investigated systematically on a modern DSA equipment. The software programme of the DSA machine widely modifies these parameters according to the individual conditions, which may influence both radiation exposure and image quality. IV DSA requires low photon energies to exploit the low iodine signal. Higher frame rates, oblique views and small image intensifier fields should be used restrictively especially in the abdomen, as they tend to lower the radiation doses per frame and to increase photon energies, thus impairing contrast resolution. Full understanding of the physical and technical basics and familiarity with the software programme of own DSA machine are mandatory to allow appropriate selection of the various parameters, according to the individual patient and his/her diagnostic problems. They are the key to optimal imaging quality at a tolerable radiation exposure.

Angiography↗

Current problems of the diagnostics of the retroperitoneum.

The authors discussed the examinations yielding optimal results in revealing the pathological retroperitoneal processes. Among those were bilateral dorsopedal lymphography, ultrasonography and computed tomography. They evaluated these examinations in detecting the retroperitoneal lymph node metastases of 15 non-seminoma patients. They describe their 4 cases of extragonadal germ-cell and testicular tumours and speculate on their development. They suppose that the 'unexplainable' renal colics of the older male patients can possibly be due to primary retroperitoneal germ-cell tumours.

Aged↗

[Special diagnostic and therapeutic procedure for the incomplete form of primary varicosis].

The difference between the incomplete and complete form of the primary varicosis of the internal saphenous vein is that the saphenofemoral valve is still intact in the incomplete form. There are two types of the incomplete form, one caused by a perforating vein and the other by a lateral branch of the saphenous vein. The preoperative diagnostic procedure is particularly important for the optimal choice of treatment.

Humans↗

Use of the acoustic reflex threshold at 3 kc/s for setting optimal click-presentation level in ABR testing.

Ten otoscopically and tympanometrically normal young men with noise-exposed hearing loss (mn HTL at 1 kc/s = 25 db, and at 3 and 4 kc/s = 50 db) were examined for threshold of acoustic reflex (AR) at 3 kc/s. Wave V latency was then determined to a click of which the peak SPL was equivalent to the AR threshold at 3 kc/s, and at 4 additional levels +/- 5 and +/- 10 db. At the equivalent AR threshold level, 6 Ss yielded Wave V latency within normal limits, while at +5, and also at +10 db, all 10 Ss did so. It was concluded that an optimal setting of click level for ABR diagnostic use was +5 db re AR threshold at 3 kc/s, at least for the shielded circumaural earphone/cushion unit used here.

Adolescent↗

[Complications and liver transplantation: diagnostic strategy].

Liver transplantation is currently the treatment of choice for end-stage liver failure in children and adults. 670 liver transplantations were performed in France in 1990. The 2-year survival rate in adults is 65%. Significant progress in terms of survival has been achieved as a result of improvement of surgical techniques and postoperative surveillance, the development of effective immunosuppressant therapy and a better organization of donor organs. Surgical techniques depend on the recipient and the transplant available. Imaging is useful in pretransplantation assessment, but especially during the immediate and long-term follow-up to assess transplant vitality and to detect any complications, which are of four types: vascular, biliary, or related to rejection or infection. Postoperative surveillance of the transplant must be based on a diagnostic approach conducted according to the following optimal sequence: laboratory parameters, histological examination and imaging, performed systematically from the 1st day onwards, including examination of the hepatic parenchyma, bile ducts, hepatic vessels and search for effusions and collections. The role of imaging in the context of rejection is not so much to visualize of rejection, as to eliminate a vascular, biliary or even infectious cause for the altered laboratory parameters. In the context of surgical vascular, biliary, infectious or complex complications, the examination sequence always includes clinical and laboratory findings, histology, angiography in the context of vascular complications and CT scan to assess the vitality of the hepatic parenchyma and to identify any intrahepatic or perihepatic collections. Interventional radiology plays an important role in the treatment of these vascular, biliary and infectious complications and should be considered prior to any surgical revision.

Angiography↗

Fostering learners' reflection and self-assessment.

In most medical schools and residency programs, little or no attention is given to fostering learners' reflection or self-assessment. Yet learners who do not value or who are not effective at these skills are unlikely to extract the maximum benefit from their education. They are at risk of becoming unsafe physicians. To be optimally helpful, teachers need access to the diagnostic information about learners that is provided by their reflections and self-assessments. There are major barriers to learners being reflective and self-assessing. Medicine is dominated by unreflective doing. In the fiercely competitive environment of many teaching programs, many learners correctly perceive that it is unsafe to reveal their fears and deficiencies. Learners often retain this cautious posture even after moving to programs where it is unnecessary. Many learners and teachers have grown accustomed to authoritarian educational approaches in which teachers decide what the learners need and unilaterally evaluate their performance. In this review of the available literature, we summarize the compelling reasons for fostering reflection and self-assessment and for helping learners become their own coaches. Specific strategies and tools for creating programs that foster these values and activities are presented.

Clinical Competence↗

The role of ERCP in patients after laparoscopic cholecystectomy.

OBJECTIVES: The goal of this study was to evaluate the feasibility of endoscopic management of complications encountered in patients undergoing laparoscopic cholecystectomy. Special attention was given to establishing the optimal timing, success rate, and complications of diagnostic and therapeutic endoscopic retrograde cholangiopancreatography (ERCP) after laparoscopic cholecystectomy. METHODS: Fifty-six consecutive patients referred from two major medical centers were evaluated with ERCP after laparoscopic cholecystectomy. The patient population included 22 men and 34 women 16-87 yr of age. Indications included common bile duct stones seen on operative cholangiography or ultrasound, persistently elevated liver enzymes and abdominal pain, evidence of biliary injury, and other, All endoscopic procedures were carried out by experienced endoscopists using standard ERCP techniques and equipment. Endoscopic papillotomy was performed with 2- to 2.5-cm cutting wire papillotomes and all biliary stones were removed with 8.5- to 14-mm balloons. Small biliary leaks were first treated with 3-7 days of nasobiliary drainage, and if persistent with 10-Fr internal stents for 1 month. One patient with a biliary stricture was dilated with placement of progressively larger biliary stents over 9-month period. RESULTS: ERCP was performed within 6 h to 2 yr after laparoscopic cholecystectomy (LC). In 12 patients, it was performed within the first 24 h after LC. A cholangiogram was obtained in all patients. No complications were encountered. Thirty patients underwent therapeutic endoscopy. Common bile duct stones were found and were successfully removed from 23 patients. One patient required an emergent ERCP and sphincterotomy for gallstone pancreatitis 3 days after LC. Fourteen patients had common bile duct injuries, cystic duct stump leaks, or leakage from ducts of Luschka (one patient). All leaks were successfully treated with temporary stenting. Six patients with bile duct transection or complete obstruction by clips required surgical therapy. One patient with a common bile duct stricture was managed with endoscopic stents alone. Two patients had unsuspected malignancies, one each with ampullary and pancreatic carcinoma. Fourteen patients had a normal ERCP. CONCLUSIONS: Diagnostic and therapeutic ERCP can be done within 24 h of LC with safety and a high degree of success. Delay in removal of CBD stones may lead to complications. Cystic duct stump leaks are easily corrected with nasobiliary drainage, and some post-LC strictures may be amenable to therapy with biliary stents. Finally, malignancy must be excluded in patients with unexplained recurrent symptoms.

Adolescent↗

[Enuresis in childhood: what should one know? What should one do?].

Bladder control is a developmental process which is determined by somatic, individual psychological and psychosocial factors. It depends on the maturation of bladder capacity and of adequate neuromuscular coordination, on the quantity of urine and on appropriate recognition of bladder expansion. The latter especially is clearly correlated to healthy individuation and psychosocial integration of the child. Statistically, 80-90% of children have successfully developed bladder control at the age of 4-6 years. In the remaining 10 or 20% who do not attain dryness during daytime or at night, wetting is often felt to be disturbing state, sometimes more by the parents than by the children. The state is called enuresis. The physician is expected to master the problem of night or daytime enuresis diagnostically as well as therapeutically. Although in most cases enuresis represents a retardation of normal development, it is important not to miss the rare, but, if present, important disturbing factors. Disorders can occur at all above mentioned levels, either in isolation or combined. Although proposing the simplest diagnostic measures, the present paper represents an optimal workup during which none of the rare somatic or complicated psychological disturbances, which would need specialized attention, should be missed. After this workup the therapeutic pathways are clear. On the one hand, relevant somatic and/or psychological disorders must be treated specifically (often in collaboration with the specialist). On the other side, there is the large number of enuretics who are, by all criteria, normal children. In these it is possible to accelerate the developmental process by performing an elaborate micturition protocol which has a good chance of success, provided, however, there is optimal cooperation between physician, parents and child.

Adolescent↗

[Diagnosis and treatment of fetal and neonatal tachycardia].

Severe intrauterine cardiac failure due to supraventricular tachycardia in a 29 week fetus was diagnosed using 2 dimensional and Doppler echocardiography. The prenatal tachycardia was successfully treated, the postnatal finding suggested Wolff-Parkinson-White syndrome. The fetal echocardiography by providing information on cardiac structure and haemodynamics may provide diagnostic and therapeutic useful informations. For the optimal pre- and perinatal management of this life-threatening condition absolutely essential a brief collaboration between the pediatric cardiologist and obstetricians.

Adult↗

Digital subtraction angiography in the diagnosis of congenital heart diseases: analysis of 60 cases.

Ninety-one IVDSA and/or IADSA examinations with 192 injections were performed in 60 patients with congenital heart disease (CHD), including 31 anatomic anomalies. Axial projection was used in 23 patients. Analysis of the results of this series showed that accurate diagnosis by DSA confirmed by cardiac surgery together with definite diagnosis by DSA were obtained in 54 cases (90%). Two cases of nondiagnosis by DSA resulted from a suboptimal DSA method; four cases of partially accurate or mistaken diagnosis determined by cardiac surgery occurred because the axial view was not used and/or the anomalies were too small to be visualized by DSA. To increase the diagnostic accuracy of DSA in CHD, an optimal method of DSA must be selected according to the position of the anomaly and the hemodynamic data, and the axial view should be used to visualize the anomaly clearly in complex cases. In addition, DSA may fail to define a mild anomaly because of its lower spatial resolution.

Adolescent↗

Beta 2-microglobulin amyloidosis: why and how to look for it.

Thirty years after the introduction of chronic dialysis into clinical practice, amyloidosis based on the precursor molecule beta 2-microglobulin (beta 2m-A) has emerged as an important complication of end-stage renal disease in patients on renal replacement therapies other than transplantation. For the individual patient, diagnosis of beta 2m-A is important to exclude other treatable causes of the symptoms, initiate symptomatic treatment, prevent possible life-threatening complications, and assign a high priority for transplantation. For the ESRD population as a whole, early specific diagnosis should help to assess the influence of various therapeutic modes on the development and course of beta 2m-A and to guide further the optimization of renal replacement therapy. Besides, sophisticated diagnostic techniques may yield valuable information on underlying pathogenetic mechanisms of beta 2m-A. Morphology, including immunohistochemistry, as the most definitive and specific diagnostic proof must rely on invasive procedures to obtain the appropriate material from clinically affected sites. Clinical assessment and imaging techniques such as x-ray and joint sonography suffer from non-specificity. Scintigraphic imaging of beta 2m-A after injection of radiolabelled beta 2-microglobulin is a non-invasive, specific, and highly sensitive way of diagnosis. Further refinement and more widespread use of this method can be expected to enhance the understanding of beta 2m-A pathogenesis and promote therapeutic and preventive efforts against this complication.

Amyloidosis↗