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MR detection of mechanical vibrations using a radiofrequency field gradient.

A new method for NMR characterization of mechanical waves, based upon radiofrequency field gradient for motion encoding, is proposed. A binomial B1 gradient excitation scheme was used to visualize the mobile spins undergoing a periodic transverse mechanical excitation. A simple model was designed to simulate the NMR signal as a function of the wave frequency excitation and the periodicity of the NMR pulse sequence. The preliminary results were obtained on a gel phantom at low vibration frequencies (0-200 Hz) by using a ladder-shaped coil generating a nearly constant RF field gradient along a specific known direction. For very small displacements and/or B1 gradients, the NMR signal measured on a gel phantom was proportional to the vibration amplitude and the pulse sequence was shown to be selective with respect to the vibration frequency. A good estimation of the direction of vibrations was obtained by varying the angle between the motion direction and the B1 gradient. The method and its use in parallel to more conventional MR elastography techniques are discussed. The presented approach might be of interest for noninvasive investigation of elastic properties of soft tissues and other materials.

Magnetic Resonance Spectroscopy↗

Vocal fold vibration in simulated head voice phonation in excised canine larynges.

In order to establish precise vibratory patterns and their clinical implication for phonation, the mode of vibration of the vocal folds around the time of register transition in excised canine larynges was analyzed multi-directionally according to various acoustic parameters. Phonation was simulated by artificially tensing the cricothyroid muscles. Vibration of the vocal folds around the time of register transition was filmed from above using ultra-high-speed cinematography and in a frontal plane using X-ray stroboscopy. Acoustic parameters included subglottic pressure, pitch, intensity and tension and were recorded simultaneously during register transition. The fundamental vibration patterns observed during vocal phonation were the same as that involved in chest voice phonation in excised canine larynges, with respect to the traveling wave of the vocal fold vibration. Changes in the physical properties of the vocal folds were considered to occur at register transition. These changes were probably strongly dependent upon changes in the structure of the lamina propria. Head voice phonation requires adaptability of the lamina propria and is less efficient than chest voice phonation. Hence, head voice phonation would be one method for assessing the condition of the vocal folds.

Animals↗

Changes in auditory evoked brain potentials during ultra-low frequency whole-body vibration of man or of his visual surround.

Auditory evoked brain potentials (AEP) were recorded from nine healthy male subjects during three types of condition: A - subject and visual field stationary; B - subject vibrated (z-axis, 0.6 Hz, 1.85 ms-2 rms), visual field stationary; C - subject stationary, visual field vibrated (as for B). The visual surround was confined to a checkerboard pattern in front of the subject. Auditory stimuli (1000 Hz, 86 dB, interstimulus interval 7 s) were delivered via headphones to evoke AEP. Vibration-synchronous activity in the EEG was eliminated by a subtraction technique. In comparison with condition A, conditions B and C caused an attenuation of P2 and N1P2 components of AEP together with an increased latency of N1. Effects of conditions B and C did not differ. Direct vestibular stimulation and mechanisms specific for whole-body vibration were rejected as modes of action. The AEP-changes and the subjective evaluation of experimental conditions, arousal and performance, as well as symptoms of kinetosis (motion sickness) suggest a sensory mismatch, leading to a "latent kinetosis" with de-arousal, as the dominating mechanism by which the processing of information was affected. This suggestion was supported by an additional pilot study. Under real working conditions a similar effect can be expected during relative motion between the driver and his visual surround, i.e. even with perfect vibro-isolation of the driver's seat.

Adult↗

Medical and occupational preconditions for vibration-induced spinal disorders: occupational disease no. 2110 in Germany.

The current state of scientific knowledge of the biodynamic behaviour of the vertebral column under the influence of whole-body vibration whilst sitting and results from epidemiological studies caused the medical board of experts on occupational health of the Federal Ministry of Labour in Germany to add a new occupational disease to the official list of occupational diseases. The occupational disease "diseases of the lumber spine from disc degeneration caused by long-term (mainly vertical) whole-body vibration exposure" has been introduced. The medical preconditions with the symptoms and the diagnostic methods are presented. With regard to the occupational preconditions for the acknowledgement of this occupational disease, a procedure is suggested which leads to the determination of the total occupational vibration exposure dose. Another requirement for recognition is that the chronic recurrent complaints have caused the patient to avoid any form of vibration exposure.

Biomechanical Phenomena↗

Validity of various function tests performed in Japan as a screening test for vibration syndrome.

In Japan, various function tests on the upper extremities are widely performed for the early diagnosis of vibration syndrome. The validity of these function tests was investigated by discriminant function analysis. The correct classification rate of the 120 workers exposed to vibration and the 40 control workers was 83.1%, when including the exposure-to-cold test. Therefore, the function tests were confirmed to be of diagnostic significance as a screening test for vibration syndrome. However, the rate is not sufficient to make a diagnosis only with the function tests. When not including the exposure-to-cold test, the rate was reduced by 10% because insidious functional disorders were missed in the early stage. For the early diagnosis of vibration syndrome, the exposure-to-cold test should be included in the function tests. Furthermore, to enhance the validity of the diagnosis, the results of the function tests should be evaluated together with subjective symptoms and the findings on bones and joints, the central nervous system and the endocrine system.

Adult↗

Effect of vibration on red cell metabolism.

In investigating the influence of vibrational energy on the metabolism of the erythrocyte, it was hypothesized that under conditions of normal PaO2 and SaO2 in arterial blood, vibration induced vasoconstriction would decrease local blood flow and induce hypokinetic hypoxia. This decreased blood flow and therefore decreased delivery of oxygen to the tissue would markedly lower tissue PO2 (hypokinetic hypoxia), which would influence the energetics and metabolism of the erythrocyte. The metabolism of the red blood cell (RBC) was evaluated by measuring the enzymatic activities of PFK (2.7.1.11), PGI (5.3.1.9), PK (2.7.1.40), and aldolase (4.1.3.13) from the anaerobic glycolytic cycle and D-G-6-P (1.1.1.49) from the pentose cycle. Also measured were the levels of ATP and 2,3 DPG and the in-vitro production of lactic acid. In the group of workers showing early changes (vibration angioneurosis) associated with the vibration syndrome, changes in RBC metabolism were demonstrated. Statistically significant were increases of PFK, PK and the production of lactic acid, indicating the activation of anaerobic glycolysis. Furthermore statistically significant were the increased 2,3 DPG and decreased ATP levels.

2,3-Diphosphoglycerate↗

Central and peripheral nervous system effects of hand-arm vibrating tool operation. A study of brainstem auditory-evoked potential and peripheral nerve conduction.

To examine the effects of hand-arm vibrating tool operation on the central and peripheral nervous system, the brainstem auditory-evoked potential (BAEP), median nerve conduction velocity and hearing level were measured in twelve chain saw operators (6 operators had a history of white finger attack) and in eight brush saw operators (none had a history of the attack). Control subjects, matched to each chain saw and brush saw operator by sex and age, were selected randomly from healthy adults without otitis, deafness and tinnitus. The I-V interpeak latency (conduction from cochlear nerve to brainstem) and V peak latency of BAEP were significantly prolonged in chain saw operators; the I-V interpeak latency was significantly correlated with working years in brush saw operators. The median nerve conduction velocity was significantly slowed in both chain saw and brush saw operators. Moderate hearing loss was observed in the two groups. It is suggested that vibrating tool operation, i.e. the combined stressors of local vibration, noise, climate and heavy work, affected not only the peripheral nervous system but also the brainstem portion of the auditory pathway; the brainstem effect, if any, is less advanced than the peripheral nervous system effect of local vibration.

Adult↗

Epidemiological survey of shipyard workers exposed to hand-arm vibration.

All 169 caulkers employed at a ship yard were examined to determine the prevalence of vibration syndrome due to pneumatic portable tools (chipping hammer and grinders). Vibration measurements and medical investigations were performed in the field between September 1977 and July 1978. Vibration spectra recorded on pneumatic tools were compared to ISO Draft Proposal No. 5369. The chipping hammer produced the highest acceleration levels and exceeded the maximum ISO limits even for a short exposure time (30 min per shift). The results of medical investigations pointed out that 78.7% of caulkers experienced paresthesia in their hands, 31.3% Raynaud's phenomenon (or VWF), 20.1% presented with radiological signs of osteoarthritis at wrist and shoulders, 10.0% with olecranon exostoses, and 31.3% with cysts of the carpal bones. To diagnose VWF the skin temperature of the hands were recorded in all 169 caulkers and 60 controls at the shipyard. The basal skin thermometric map (recorded in 16 positions per hand) demonstrated an average difference of 2-2.5 degrees C between the two populations. The thermometric curve, monitored every 3 min for 40 min after a provocative cold-test (immersion of hands and wrists in melting ice for 2 min), well differentiated workers exposed and not exposed to vibrations. The authors emphasize that skin temperature (before and after the cold-test) are suitable for epidemiological purposes to compare the prevalence rates of VWF in control-experimental groups.

Adult↗

Mechanical energy absorption in human hand-arm exposed to sinusoidal vibration.

A possible basis for risk assessment of human exposure to vibration when using hand-held tools may be to determine the amount of mechanical energy that is absorbed by the hand-arm system. The aim of this investigation was to study the absorption of mechanical energy in the human hand-arm system during exposure to sinusoidal vibration within the frequency range of 20 to 1500 Hz. A handle, specially designed for this type of experiments, was used during the measurements. The influence of various experimental conditions, such as three different hand-arm postures, grip force (25-75 N) and vibration levels (27-53 mm/srms), were studied on eight subjects. The outcome clearly shows that the energy absorption properties of the human hand-arm system are more or less dependent on all of the experimental conditions studied, but mainly to the frequency of the vibration stimuli. Furthermore, the results indicate a non-linear relationship between the energy absorbed and all other variables studies.

Arm↗

Back disorders in crane operators exposed to whole-body vibration.

In The Netherlands so far little research has been carried out to investigate the health effects of exposure to whole-body vibration at work. In a retrospective (10-year) follow-up study, the incidence of permanent work disabilities in crane operators exposed to vibration was compared to that of a control group. The emphasis in this presentation is on disablement because of back disorders. Among the crane operators with more than 5 years of exposure to vibration, more disability due to back trouble occurred than in the control group. The incidence density ratio (IDR) exceeded 2 for disability because of degeneration of the intervertebral disc, after adjustment for age, nationality, shift work and calendar year. With increasing years of exposure, the risk ratio for disability because of intervertebral disc disorders also increased. The risk ratio for a disability pension due to disease of the intervertebral disc for crane operators with more than 5 years of exposure was almost 3 compared to the control group. A combination of exposure to whole-body vibration, an unfavorable posture, and climatic conditions is responsible for the development of these health effects.

Adult↗

Temporary threshold shift of temperature sensation caused by vibration exposure.

The temporary threshold shift of temperature sensation due to vibration exposure was studied to clarify the significance of frequency and acceleration on it. The discrete frequencies of the vibrations tested were 32, 63, 125, 250 and 500 Hz, and the accelerations were at the level of 2, 4, 8 and 16 g. The threshold shift of warm sensation (TTSw) was markedly, but that of cool sensation was small and not significantly different from the control value. TTSw increased with a rise in the level of acceleration and was largest at 125 Hz among the frequencies examined. The most effective frequency among the vibrations tested for warm sensation was inferred to be lower than that for vibratory sensation. After exposure, TTSw or the increment of the neutral zone decayed exponentially but bounced slightly in the later period. These patterns of TTSw are similar to those of the vibration-induced TTS of vibratory sensation.

Adult↗

An immunoserological study of patients with vibration syndrome.

In a study undertaken to investigate the relationship between vibration syndrome and collagen disease, 90 Japanese patients with vibration syndrome (all men aged 41-86 years) were examined immunologic abnormalities, mainly by a set of immunoserology tests. Of these 90 patients, 25 had examinations at yearly intervals for 3 consecutive years, while the other 65 underwent examinations once. The results indicate that, of all the patients studied, 10 (11.1%) gave a positive RA test, 6 (6.7%) had leukopenia, 5 (5.6%) had hypergammaglobulinemia, and 15 (16.7%) had hypocomplementemia (CH50). Worthy of particular note are the 21 patients (23.3%) who were positive for nuclear-specific antibodies (1: greater than or equal to 40) (using Hep-2 cells as the nuclear substrate), with some of them suspected of having Sjögren's syndrome, progressive systemic sclerosis, or systemic lupus erythematosus. During a 3-year follow-up period, 10 (40%) of 25 patients exhibited rising titers of nuclear-specific antibodies with conversion to seropositivity for these antibodies. The facts that the positivity rate for nuclear-specific antibodies was significantly higher in these patients with vibration syndrome (23.3%) than in healthy adult men over 40 years of age (1.8%) (P less than 0.05) and that a progressive elevation of nuclear-specific antibody titer was noted in a high percentage of the patients were suggestive of some causal relationship between the appearance of nuclear-specific antibodies and the use of vibrating tools.

Adult↗

Acute effects of transient vertical whole-body vibration.

The question as to whether shock-type whole-body vibration causes increasingly acute strain was investigated. Random vibrations were superimposed with shocks differing in amplitude and in number per unit of time in a systematic manner. The weighted root mean square (rms) acceleration was kept constant in all over the varied experiments. A total of 17 men were exposed to vibration from an electrohydraulic simulator. The following strain criteria were used: biodynamic behavior of the trunk and the head, electrical activity of the muscles of the back and the neck, subjective sensation, skin temperature in the lumbar area and visual and tracking performance. It was found that increasing shock amplitude and, in some experiments, also increasing numbers of shocks led to increasingly acute effects that varied, depending on the kind of shock used. New methods should be developed for the assessment of transient vibration that are better than the existing standards.

Acceleration↗

Activation of blood coagulation and fibrinolysis in vibration syndrome.

The pathophysiology of peripheral circulatory disturbance in patients presenting with vibration syndrome was studied from the viewpoint of blood coagulation. Plasma levels of fibronectin (FN), vitronectin (VN), thrombin-antithrombin III complex (TAT), and alpha 2-plasmin inhibitor-plasmin complex (PIC) were measured in 23 subjects who showed no evidence of vibration-induced white finger [VWF(-) group] and in 24 patients who presented with VWF [VWF(+) group]. In the VWF(-) group, plasma FN concentrations were elevated but plasma TAT and PIC levels were within the normal ranges. In the VWF(+) group, plasma FN concentrations were normal but plasma TAT and PIC levels were significantly elevated. In both groups, plasma VN concentrations were similar to those in normal controls. For purposes of comparison, 32 patients presenting with diabetes mellitus were also studied. They were divided into 2 groups, 13 subjects who showed no evidence of angiopathy [complication(-) group] and 19 patients who presented with angiopathy [complication(+) group]. In the complication(+) group, plasma TAT and PIC concentrations were significantly elevated, as in the VWF(+) group. These results suggest that in vibration syndrome, vibration, cold stimulus, or other factors first injure the vascular endothelium, resulting in a rise in plasma FN, and that in the VWF(+) group, augmentation of coagulation and fibrinolysis induces a state of compensated disseminated intravascular coagulation (DIC).

Adult↗

Raynaud's phenomenon of fingers and toes of miners exposed to local and whole-body vibration and cold.

In a study of 27 underground miners exposed to hand or whole-body vibration, cold or other vasoconstrictive environmental factors, higher prevalences of Raynaud's phenomenon in both fingers and toes were found than in a control group not exposed to vibration. There were no Raynaud-like phenomena among miners not exposed to vibration. There was a positive correlation between the two locations. This may mean a general susceptibility of vasospasm, but it seems more probable that the disorders are caused by vibration exposure to fingers and toes.

Adult↗

Whole-body vibration and disorders of the spine.

This cross-sectional study is based on interviews and medical examinations of 352 operators of earth-moving machines who had been exposed to whole-body vibrations for at least three years. In addition, available X-rays showing different parts of the spines of 251 machine operators who had been exposed to vibration for at least ten years were used for evaluation. One hundred and forty-nine of the operators were asked about discomfort occurring immediately after an eight-hour work shift. The group of exposed persons was compared with a control group of 215 non-exposed persons. The percentage of subjects reporting spinal discomfort was much higher for the exposed group than for the non-exposed group. 68.7% of the operators complained of spinal discomfort in the lumbar spine, 6.8% in the thoracic column and 18.2% in the cervical column. The discomfort reported immediately after an eight-hour exposure to whole-body vibration was highly age-dependent. The epidemiological study resulted in an objective conformation of the spinal discomfort reported, 2/3 of which were related by the operators to the lumbar syndrome. Lumbar syndrome (81%) accounted for by far the highest number of spinal disorders. Examinations of the operators with at least ten years of exposure to whole-body vibrations showed that morphological changes in the lumbar spine occur earlier and much more frequently than in the case of non-exposed persons. Problems of etiology and pathogenesis are discussed.

Adult↗

Effect of whole body vibration on the rat brain content of serotonin and plasma corticosterone.

To investigate the effects of whole body vibration on the central nervous system, rats were exposed to various whole body vibrations and changes in whole brain levels of Serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) were then determined. Changes in plasma corticosterone levels were also determined and related to the changes in the whole brain levels of 5-HT and 5-HIAA. The dose-related changes in the 5-HT and 5-HIAA levels were observed as acceleration increased from 0.4G to 5.0G. Changes in vibration frequency also affected the 5-HT and 5-HIAA levels of brain: they were significantly elevated at a frequency of 20 Hz (P less than 0.05). Plasma corticosterone levels increased as acceleration increased from 0.4G to 5.0G. As the vibration frequency was changed from 5 Hz to 30 Hz, plasma corticosterone levels also rose significantly (P less than 0.05) but the extent of elevation was approximately the same at each frequency. The correlation between brain 5-HT and plasma corticosterone levels with increasing acceleration (r = 0.93, P less than 0.01) was significant.

Animals↗

Electrophysiological study of reticulo-limbic interrelationships during prolonged action of vibration.

Phasic changes in the bioelectrical activity of the dorsal hippocampus (field CA3), the mesencephalic reticular formation, and several regions of the neocortex and the reticulo-cortical evoked potentials were measured under conditions of the action of prolonged vibration (3 months) in electrophysiological experiments with rabbits. Daily three-hour vibration during the first month of the experiment evoked an activation reaction in the EEG, characterized by a desynchronization effect in the neocortex and hippocampus and by the stabilization of the v rhythm in the mesencephalic reticular formation. Noted against this background was a certain facilitation in the reticulo-cortical evoked potentials, more pronounced in the neocortex, and a decline in the ascending activational influence of the mesencephalic reticular formation. The three-month action of vibration exerted an inhibitory influence on reticulo-cortical interrelationships, expressed in a decline in the compound bioelectrical activity of the cortex and subcortical formations, the excitability of the mesencephalic reticular formation, and the suppression of reticulo-cortical evoked potentials. At the same time an elongation of the latent periods of the positive phases of the evoked potentials, a decline in their amplitude, and a reduction of the negative phase in limbic structures was noted. The question of the physiological mechanism of development of vibrational pathology is discussed.

Animals↗