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At least 1,477 records · Page 82Linked to original sources
PubMed1980

[Morphology of late hepatic lesions after thorotrast (author's transl)].

Late lesions of the liver after longstanding exposure to thorotrast are the following: adaptive and degenerative alterations of hepatocytes, proliferation and atypical morphology of sinusoidal cells, ectasia of sinusoids, portal fibrosis due to inflammatory as well as non-inflammatory changes with transition to complete cirrhosis. Pronounced changes of sinusoidal cells and sinusoidal shape occur most frequently in the immediate vicinity of angiosarcomas. Just as in chronic vinyl chlorid intoxication these changes may represent an early stage of angiosarcoma, or may be due to the fact, that an angiosarcoma is close to the hepatic area, where the biopsy specimen was taken from. However, liver tissue surrounding carcinoma induced by thorotrast usually shows only noncharacteristic alterations, except in cases, where cirrhosis of the liver is present.

Adult↗
PubMed1981

[Thorotrast cancer following vesiculography in chronic prostatitis].

33 years after vesiculography using the X-ray contrast remedy Thorotrast on transurethral way in a patient with chronic prostatitis a carcinoma developed in the region of the vesical neck. Histologically the tumour imposed now as a differentiated urothelium carcinoma of medium degree. By autoradiography in the region of the tumour structures radioactive Thorotrast could be proved. On account of the close topographical relations and the long time of latency the development of the carcinoma seems to be ascertained by the then application of Thorotrast. The connections are discussed.

Aged↗
PubMed1978

Determination of thorium series nuclides in thorotrast patients.

Application of gamma-ray spectrometry with a Ge(Li) detector and then instrumental neutron activation analysis to tissue samples from a Thorotrast patient using the same standard reference sample makes it possible to determine both 232Th concentrations and activity ratios of the descendant nuclides to 232Th in living tissues. This analytical method is nondestructive, being simpler and more reliable than the methods previously used. In the present study, the activity ratio of 228Ra/232Th in living tissue was estimated at 0.37 to 0.44, being somewhat lower than the value reported by Kato. As for the activity ratio of 228Th/228Ra, our value agreed fairly well with Kato's value. A stomach sample from a Thorotrast patient was found to contain the same level of 232Th as liver and spleen samples; trace amount of 232Th was also found in kidney and brain samples.

Brain Chemistry↗
PubMed1981

[Radiophages and aseptic microsequestration of bone].

Using thorotrastosis for a model we showed that corpuscular radiating substances after entering the vascular space are also being accumulated in the RES (radiophages) of the bone marrow. Redistribution of these substances over the years leads first to mobile and later to immobile deposits of radiophages. This results in a reduction of bone marrow mass in the affected areas as well as myelosclerosis and sometimes in the development of so-called embryonic bone formation (a potentially presarcomatous lesion) and later in the formation of aseptic microsequesters of preexisting spongiosa spicules. Reference is also made to the infrequently observed phagocytosis of osteoblasts and osteocytes.

Aged↗
PubMed1981

[Carcinoma of the kidney and generalised thorotrastosis after retrograde pyelography (author's transl)].

A 70 years old patient is presented who was nephrectomized because of carcinoma of the kidney following retrograde pyelography with Thorotrast in 1940. Despite of local application of the contrast medium thorotrastosis was also seen in liver, spleen and probably in bone marrow. Possible causal connections are discussed. Thorium was identified in the kidney and in the liver with an electron beam microprobe.

Aged↗