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PubMed2005

Corticofugal modulation of directional sensitivity in the midbrain of the big brown bat, Eptesicus fuscus.

In our recent study of corticofugal modulation of collicular amplitude sensitivity of the big brown bat, Eptesicus fuscus, we suggested that the corticofugal modulation is based upon the best frequency (BF) differences and the relative amplitude sensitivity difference between collicular (IC) and cortical (AC) neurons but not the absolute amplitude sensitivity of IC and AC neurons. To show that corticofugal modulation is systematic and multiparametric, we studied corticofugal modulation of directional sensitivity in 89 corticofugally inhibited IC neurons in the same bat species under free field stimulation conditions. A neuron's directional sensitivity was expressed with the azimuthal range (AR) at 50% below the maximum of each directional sensitivity curve and the best azimuth (BAZ) at which the neuron discharged maximally. Cortical electrical stimulation did not affect the directional sensitivity of 40 (45%) neurons with BF(IC-AC) differences of 7.3+/-4.4kHz but sharpened the directional sensitivity of other 49 (55%) neurons with BF(IC-AC) differences of 2.3+/-1.8kHz. Corticofugal modulation sharpened directional sensitivity curves of IC neurons by decreasing the AR and shifting collicular BAZ toward cortical BAZ. The decrease in AR and the shift in BAZ increased significantly with AR(IC-AC) and BAZ(IC-AC) differences but not with absolute AR and BAZ of IC and AC neurons or BF(IC-AC) differences. Corticofual modulation also shifted collicular BF toward cortical BF. The shift in BF increased significantly with BF(IC-AC) differences but not with the BF of IC and AC neurons or BAZ shift. Consonant with our previous study, these data indicate that corticofugal modulation of collicular directional sensitivity is based on topographic projections between the IC and the AC and the difference in directional sensitivity but not the absolute directional sensitivity of IC or AC neurons.

Acoustic Stimulation↗
PubMed2005

Cellular and spatial changes in the anuran superior olive across metamorphosis.

In many vertebrate species, the superior olive in the auditory brainstem plays an essential role in sound source localization. Little is known, however, about the structural and functional changes in this nucleus during development when alterations in head size and shape as well as in inner ear projections are expected to affect the perception of binaural cues. Using stereological techniques, we investigated the changes in several cellular and spatial features of the bullfrog superior olive across metamorphosis, the time period during which the animal transforms from a totally aquatic larva to a semiterrestrial adult. The total number of cells shows a strongly linear increase from hatchling through late larval stages. The number of neurons decreases during metamorphic climax stages, and recovers to pre-metamorphic climax levels in the early post-metamorphic froglet stage. The number of glial cells increases during the early larval period, and remains relatively stable, with no systematic variation, from late larval to froglet stages. The volume of the superior olive increases rapidly in early larval stages, followed by a much-attenuated rate of growth between late larval and froglet stages. These morphological changes may provide a substrate for the functional restructuring of the bullfrog superior olive, shortly before the switch from aquatic to mostly atmospheric hearing.

Animals↗
PubMed2005

Interaction in the perceptual processing of interaural time and level differences.

Phillips and Hall [Psychophysical evidence for adaptation of central auditory processors for interaural differences in time and level, Hear. Res., 202 (2005) 188-199.] recently described the frequency-specific, selective adaptation of perceptual channels for interaural differences in level (ILD) and time (ITD). Psychometric functions for laterality based on ITD or ILD were obtained before and after exposure to adaptor tones of two frequencies presented alternately and highly lateralized to opposite sides. Following adaptation, points of perceived centrality (PPCs) were displaced towards the sides of the adaptor tones, and in opposite directions for the two frequencies. That is, laterality judgements showed a shift away from the adapted side, particularly for test cue values near the middle of the range. These data were congruent with a two-channel, opponent-process model of sound laterality coding. The present study used the same general paradigm to explore the independence of perceptual ITD and ILD processing. Psychometric functions for laterality based on ITD or ILD were obtained for each of two frequencies concurrently, before and after exposure to adaptor tones lateralized using the complementary cue. Once again, PPCs derived from the psychometric functions were displaced towards the sides of the adaptor tones, consistent with an opponent-process account of sound laterality coding. The size of the adaptation effect was at least as great as that described in the earlier study. Thus, a quarter cycle ITD adapting stimulus effected a 3 dB shift in the mean ILD-based PPC, and a 12 dB ILD adapting stimulus effected a 100 micros shift in the mean ITD-based PPC. These data offer new evidence concerning interaction in the processing of ITDs and ILDs.

Adaptation, Physiological↗
PubMed2006

Interaural delay-dependent changes in the binaural difference potential of the human auditory brain stem response.

Binaural difference potentials (BDs) are thought to be generated by neural units in the brain stem responding specifically to binaural stimulation. They are computed by subtracting the sum of monaural responses from the binaural response, BD = B - (L + R). BDs in dependency on the interaural time difference (ITD) have been measured and compared to the Jeffress model in a number of studies with conflicting results. The classical Jeffress model assuming binaural coincidence detector cells innervated by bilateral excitatory cells via two delay lines predicts a BD latency increase of ITD/2. A modification of the model using only a single delay line as found in birds yields a BD latency increase of ITD. The objective of this study is to measure BDs with a high signal-to-noise ratio for a large range of ITDs and to compare the data with the predictions of some models in the literature including that of Jeffress. Chirp evoked BDs were recorded for 17 ITDs in the range from 0 to 2 ms at a level of 40 dB nHL for four channels (A1, A2, PO9, PO10) from 11 normal hearing subjects. For each binaural condition 10,000 epochs were collected while 40,000 epochs were recorded for each of the two monaural conditions. Significant BD components are observed for ITDs up to 2 ms. The peak-to-peak amplitude of the first components of the BD, DP1-DN1, is monotonically decreasing with ITD. This is in contrast with click studies which reported a constant BD-amplitude for ITDs up to 1 ms. The latency of the BD-component DN1 is monotonically, but nonlinearly increasing with ITD. In the current study, DN1 latency is found to increase faster than ITD/2 but slower than ITD incompatible with either variant of the Jeffress model. To describe BD waveforms, the computational model proposed by Ungan et al. [Hearing Research 106, 66-82, 1997] using ipsilateral excitatory and contralateral inhibitory inputs to the binaural cells was implemented with only four parameters and successfully fitted to the BD data. Despite its simplicity the model predicts features which can be physiologically tested: the inhibitory input must arrive slightly before the excitatory input, and the duration of the inhibition must be considerably longer than the standard deviations of excitatory and inhibitory arrival times to the binaural cells. With these characteristics, the model can accurately describe BD amplitude and latency as a function of the ITD.

Acoustic Stimulation↗
PubMed2006

Hearing in large (Eidolon helvum) and small (Cynopterus brachyotis) non-echolocating fruit bats.

Comparing the hearing abilities of echolocating and non-echolocating bats can provide insight into the effect of echolocation on more basic hearing abilities. Toward this end, we determined the audiograms of two species of non-echolocating bats, the straw-colored fruit bat (Eidolon helvum), a large (230-350 g) African fruit bat, and the dog-faced fruit bat (Cynopterus brachyotis), a small (30-45 g) bat native to India and Southeast Asia. A conditioned suppression/avoidance procedure with a fruit juice reward was used for testing. At 60 dB SPL, the hearing range of E. helvum extends from 1.38 to 41 kHz with best sensitivity at 8k Hz; the hearing range of C. brachyotis extends from 2.63 to 70 kHz with best sensitivity at 10 kHz. As with all other bats tested so far, neither species was able to hear below 500 Hz, suggesting that they may not use a time code for perceiving pitch. Comparison of the high-frequency hearing abilities of echolocating and non-echolocating bats suggests that the use of laryngeal echolocation has resulted in additional selective pressure to hear high frequencies. However, the typical high-frequency sensitivity of small non-echolocating mammals would have been sufficient to support initial echolocation in the early evolution of bats, a finding that supports the possibility of multiple origins of echolocation.

Animals↗
PubMed2006

Changes in interaural time sensitivity with interaural level differences in the inferior colliculus.

We measured interaural time difference (ITD) sensitivity of 72 cells in the inferior colliculus of the anaesthetised guinea pig as a function of frequency and interaural level difference (ILD). For many units there was a "null" frequency, where varying the ILD made no difference to the position of the peak of the ITD sensitivity. This null frequency was not necessarily at the characteristic frequency (CF): it occurred at CF in less than a third of the neurons for which we had sufficient data (14/50). Equally often, the null occurred below (15/50) and less often, above CF (8/50). The remaining (13/50) neurons showed clear phase changes, but these were erratic or parallel and no null could be attributed. In 33 of the 37 neurons with an identifiable null frequency, the peak ITD moved towards the recording side with increasing ILD, for frequencies above the null, and away for frequencies below the null. The changes in ITD sensitivity expressed as phase were maximally about 0.2-0.3 cycles. Many of the changes in response phase with ILD are in the same direction and magnitude as changes in the phase locking with sound level in auditory nerve fibres. Thus, these changes in phase sensitivity at the basilar membrane and auditory nerve are maintained through to ITD tuning in the IC. This is consistent with a coincidence detection mechanism. However, some of the more complex phenomena which we observe are consistent with convergence at the IC.

Acoustic Stimulation↗
PubMed2007

The effects of lateralized adaptors on lateral position judgements of tones within and across frequency channels.

Two experiments examined the effect of highly lateralized adaptor tone pulses on the perceived intracranial location of subsequent test tones. In Experiment 1, adaptor tones of each of two frequencies, highly lateralized to opposite sides by a quarter-period interaural time difference (ITD), were found to shift the perceived intracranial location of test tones of each adaptor frequency away from the side of the adaptor. The shift in perceived location was seen for all test tone ITDs with the same sign as the adaptor tone, and sometimes extended to include test tones with small ITDs favoring the opposite ear. The generality of the effect across test tone ITDs of the same sign as the adaptor suggests that the human auditory lateralization system is built of two (left, right) hemifield-tuned azimuthal channels, and that perceived lateral location depends on the relative outputs of those two channels. In Experiment 2, the perceived location of test tones lateralized by ITD was studied in the same listeners at each of the same two frequencies, but after selective adaptation with tone pulses of only one frequency and laterality. The perceived lateral position of test tones with the same frequency as that of the adaptor underwent the same changes as seen in Experiment 1. The perceived lateral position of test tones of the nonadapted frequency usually shifted weakly in the opposite direction, i.e., in the direction expected if the second adaptor from Experiment 1 had actually been present. These data have implications both for the processes mediating selective adaptation using contingent stimuli, and for the azimuthal tuning of auditory spatial channels in man.

Acoustic Stimulation↗
PubMed2003

Effects of otitis media with effusion (OME) on central auditory function.

Conductive hearing loss attenuates and delays sound passing through the middle ear. This impairs binaural hearing and other central auditory functions dependent on high fidelity sound transmission. Persistent conductive loss leads to central impairments that persist after the peripheral loss has resolved. For example, children who have had multiple episodes of otitis media with effusion (OME) in the first few years of life may have poor detection of sounds in noisy environments, evidenced by reduced binaural unmasking (BU). Recent research shows that a 'threshold' level of OME is required to produce impaired BU. Children who had OME in one or both ears for more than about 50% of the first 5 years had reduced BU. Animal research, using long-term ear plugging, suggests that total OME duration, rather than age at the time of having the disease, determines its effect on BU. Animals reared with bilateral (but not unilateral) ear plugs also have poor auditory temporal resolution, and reduced sensitivity to short tones in the presence of background noise, after plug removal. However, given time (6-24 months) and training, all animals regained normal temporal resolution.

Auditory Diseases, Central↗
PubMed2004

Does the adjustment cavitate the targeted joint? An investigation into the location of cavitation sounds.

BACKGROUND: The cavitation sounds heard during chiropractic adjustments of the spine are common phenomena; yet, their location relative to the technique used is relatively untested. OBJECTIVE: The purpose of this study was to locate the cavitation sounds during the L5 spinous hook adjustment and a lower sacroiliac adjustment. The sounds were analyzed for significant difference in location relative to the 2 techniques. METHODS: Thirty asymptomatic volunteers were randomly divided into 2 equal groups. Each group represented either the spinous hook adjustment or lower sacroiliac adjustment. Subjects had 8 microphones taped to their skin, over the relevant facet and sacroiliac joints. Radiographic confirmation was used to ensure optimal placement of the microphones. Sound signals produced during the adjustments were digitized, recorded, and analyzed statistically. RESULTS: The results indicated that no statistically significant correlation existed between the anatomical location of cavitation sounds and the adjustment technique selected. CONCLUSION: Location of cavitation sounds does not appear to have a relationship with type of manipulative technique selected. Further studies using other techniques need to be performed.

Adult↗
PubMedDate not supplied

Coding interaural time differences at low best frequencies in the barn owl.

In birds and mammals, precisely timed spikes encode the timing of acoustic stimuli, and interaural acoustic disparities propagate to binaural processing centers. The Jeffress model proposes that these projections act as delay lines to innervate an array of coincidence detectors, every element of which has a different relative delay between its ipsilateral and contralateral excitatory inputs. Thus, interaural time difference (ITD) is encoded into the position of the coincidence detector whose delay lines best cancel out the acoustic ITD. Neurons of the avian nucleus laminaris and mammalian MSO phase-lock to both monaural and binaural stimuli but respond maximally when phase-locked spikes from each side arrive simultaneously, i.e. when the difference in the conduction delays compensates for the ITD. McAlpine et al. [Nat. Neurosci. 4 (2001) 396] identified an apparent difference between avian and mammalian ITD coding. In the barn owl, the maximum firing rate appears to encode ITD. This may not be the case for the guinea pig, where the steepest region of the function relating discharge rate to interaural time delay (ITD) is close to midline for all neurons, irrespective of best frequency (BF). These data suggest that low BF ITD sensitivity in the guinea pig is mediated by detection of a change in slope of the ITD function, and not by maximum rate. We review coding of low best frequency ITDs in barn owls and mammals and discuss whether there may be differences in the code used to signal ITD in mammals and birds.

Acoustic Stimulation↗
PubMed2005

Neural cross-correlation and signal decorrelation: insights into coding of auditory space.

The auditory systems of humans and many other species use the difference in the time of arrival of acoustic signals at the two ears to compute the lateral position of sound sources. This computation is assumed to initially occur in an assembly of neurons organized along a frequency-by-delay surface. Mathematically, the computations are equivalent to a two-dimensional cross-correlation of the input signals at the two ears, with the position of the peak activity along this surface designating the position of the source in space. In this study, partially correlated signals to the two ears are used to probe the mechanisms for encoding spatial cues in stationary or dynamic (moving) signals. It is demonstrated that a cross-correlation model of the auditory periphery coupled with statistical decision theory can predict the patterns of performance by human subjects for both stationary and motion stimuli as a function of stimulus decorrelation. Implications of these findings for the existence of a unique cortical motion system are discussed.

Acoustic Stimulation↗
PubMed2004

Illusory sound shifts induced by the ventriloquist illusion evoke the mismatch negativity.

The ventriloquist illusion arises when sounds are mislocated towards a synchronous but spatially discrepant visual event. Here, we investigated the ventriloquist illusion at a neurophysiological level. The question was whether an illusory shift in sound location was reflected in the auditory mismatch negativity (MMN). An 'oddball' paradigm was used whereby simultaneously presented sounds and flashes coming from the same location served as standard. The deviant consisted of a sound originating from the same source as the standard together with a flash at 20 degrees spatial separation, which evoked an illusory sound shift. This illusory sound shift evoked an MMN closely resembling the MMN evoked by an actual sound shift. A visual-only control condition ruled out that the illusory-evoked MMN was confounded by the visual part of the audiovisual deviant. These results indicate that the crossmodal interaction on which the ventriloquist illusion is based takes place automatically at an early processing stage, within 200 ms after stimulus onset.

Acoustic Stimulation↗
PubMed2005

Auditory evoked fields to variations of interaural time delay.

Auditory motion can be simulated by presenting binaural sounds with time-varying interaural time delays. Human cortical responses to the rate of auditory motion were studied by recording auditory evoked magnetic fields with a 122-channel whole-head magnetometer. Auditory motion from central to right and then to central was produced by varying interaural time differences between ears. The results showed that the N1m latencies and amplitudes were not affected by the fluctuation of interaural time delay; however, the peak amplitude of P2m significantly increased as a function of fluctuation of the interaural time delay.

Acoustic Stimulation↗
PubMed2005

Mismatch negativity evoked by stationary and moving auditory images of different azimuthal positions.

The present study has been designed to evaluate the pre-attentive detection of the location changes for stationary and moving sound sources. Auditory event-related potentials to the click trains simulating stationary and moving fused auditory images were recorded from healthy subjects using an oddball paradigm. The spatial characteristics of stimuli were created by introducing constant or variable interaural time delay (ITD) into the click trains. Repetitive standard auditory images (0 or 800 micros ITD, p=0.9) were interspersed by infrequent deviants (p = 0.1) of three types: stationary and moving to or from standards. The deviants moving to standards elicited similar mismatch negativities (MMNs) as compared to the stationary ones. The deviants moving from standards evoked the lowest and latest MMNs depending on standard location. Results suggest that pre-attentive ITD discrimination is essentially dependent on the pattern of ITD changes at the moment of the deviant onset.

Acoustic Stimulation↗
PubMed2005

Lights can reverse illusory directional hearing.

Adding brief flashes of light to a train of auditory clicks [R. Hari, Illusory directional hearing in humans, Neurosci. Lett. 189 (1995) 29-30] can alter the sounds perceived location within the head. In an experimental procedure adopted from Hari [R. Hari, Illusory directional hearing in humans, Neurosci. Lett. 189 (1995) 29-30], 16 observers listened over headphones to 8 binaural clicks (i.e., 4 left-ear leading followed by 4 right-ear leading) separated by one of three ISIs (8, 64 and 120 ms), then reported the perceived location of each click-pair within the head. Flashing a light rightward across a CRT screen during temporally coincident click-pairs made observers report the location of the sounds in roughly equally spaced steps from left-to-right through the head. In contrast, light flashes originating on the right of the CRT and moving leftward reversed the perceived location of the clicks, so that the sound appeared to originate on the right side of the head and shift leftward. These effects were diminished when the first four lights were all presented on one side of the CRT and the last four lights were all presented on the other side of the CRT. This multimodal phenomenon occurs although the light was perceived external to the head while the sounds presented over headphones were perceived within the head.

Acoustic Stimulation↗
PubMed2006

Impairment of online control of reaching movements with aging: a double-step study.

This study investigated the influence of aging on the online control of goal-directed arm movements through visual feedback of target position. Two groups of human adults, aged 28 and 56 years on average, reached with their unseen hand for targets that were unexpectedly displaced sideways at movement onset. Both stationary and displaced targets were continuously illuminated, briefly lit or not visible. When no visual information of target position was available, only an auditory signal indicated the location of the target. Results showed that when the target remained stationary, visual information enhanced movement accuracy for both age groups. When the target was displaced, visual information contributed to greater and earlier corrections for both groups. However, young adults corrected for more of the 21 degrees target displacement than older adults (95% versus 72%). Moreover, first adjustments of movement trajectory were triggered faster by young adults as compared to older adults (339 ms versus 538 ms after movement onset). Therefore, the present results highlight the impairment of older adults to monitor online movement trajectory through visual feedback processes. The detrimental effect of aging is evident when large adjustments of trajectory are necessary to reach the target.

Acoustic Stimulation↗
PubMed2006

Auditory cortical change detection in adults with Asperger syndrome.

The present study investigated whether auditory deficits reported in children with Asperger syndrome (AS) are also present in adulthood. To this end, event-related potentials (ERPs) were recorded from adults with AS for duration, pitch, and phonetic changes in vowels, and for acoustically matched non-speech stimuli. These subjects had enhanced mismatch negativity (MMN) amplitudes particularly for pitch and duration deviants, indicating enhanced sound-discrimination abilities. Furthermore, as reflected by the P3a, their involuntary orienting was enhanced for changes in non-speech sounds, but tended to be deficient for changes in speech sounds. The results are consistent with those reported earlier in children with AS, except for the duration-MMN, which was diminished in children and enhanced in adults.

Acoustic Stimulation↗
PubMed2003

Binaural specialisation in human auditory cortex: an fMRI investigation of interaural correlation sensitivity.

A listener's sensitivity to the interaural correlation (IAC) of sound plays an important role in several phenomena in binaural hearing. Although IAC has been examined humans, little is known about the neural basis of sensitivity to IAC in humans. The present study employed functional magnetic resonance imaging to measure blood oxygen level-dependent (BOLD) activity in auditory brainstem and cortical structures in human listeners during presentation of band-pass noise stimuli between which IAC was varied systematically. The stimuli evoked significant bilateral activation in the inferior colliculus, medial geniculate body, and auditory cortex. There was a significant positive relationship between BOLD activity and IAC which was confined to a distinct subregion of primary auditory cortex located bilaterally at the lateral extent of Heschl's gyrus. Comparison with published anatomical data indicated that this area may also be cytoarchitecturally distinct. Larger differences in activation were found between levels of IAC near unity than between levels near zero. This response pattern is qualitatively compatible with previous measures of psychophysical and neurophysiological sensitivity to IAC. extensively in neurophysiological studies in animals and in psychophysical studies in

Acoustic Stimulation↗