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Results for “Retinal Neovascularization”

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At least 1,477 records · Page 82Linked to original sources
PubMed1989

[Keratopathy following vitrectomy with silicone oil injection].

We present a retrospective study on keratopathy following vitrectomy and injection of SF96 silicone oil (viscosity 1000 centipoise, n = 232 eyes) and the purified OP 1000 silicone oil (viscosity 1000 centipoise, n = 129 eyes). In cases with aniridia, with closed inferior basal iridectomy (IBI) or without IBI, keratopathy was found in 74 of the 166 eyes (45%) injected with silicone SF96 and in 14 of the 30 eyes (47%) injected with silicone OP 1000. An intact IBI reduced the incidence of keratopathy to 0% (SF96, 0/45 eyes) or 6% (OP1000, 5/88 eyes) when the anterior chamber was free of silicone. When silicone oil was in contact with the corneal endothelium (due to periretinal reproliferation, hypotony, overfilling or droplet formation), there was corneal decompensation in 66% (SF96, 14/21 eyes) or 55% (OP1000, 6/11 eyes). The keratopathy presents as calcified band keratopathy or diffuse bullous corneal edema as in "endothelial decompensation." These variations in keratopathy are in agreement with the following basic diagnoses: 77% (43/56 eyes) of trauma patients (n = 130) develop calcified band keratopathy, and 47% (24/51 eyes) of patients with idiopathic proliferative vitreoretinopathy (n = 182) present with diffuse bullous corneal edema.

Cornea↗
PubMedDate not supplied

[Photocoagulation in diabetes mellitus--our results].

Fifty six diabetic patients aged 25-74 were under ophthalmological control in the period 1984-87. The mean time of duration of diabetes amounted 14 years. In 29 persons diabetes was insulinodependent and in the remaining insulino-independent. In 11 eyes the fundus exhibited diabetic changes with characteristics of angiopathy, in 43 eyes--of exudative retinopathy and in 58 eyes of proliferative retinopathy. Photocoagulation with a xenon-arc lamp of the diabetic changes was performed in all the patients. In dependence of the extent of the changes one used either a focused or a panretinal photocoagulation. In the majority of cases one could stop the progress of the diabetic changes on the fundus and preserve a fair visual acuity.

Adolescent↗
PubMedDate not supplied

[Preventive laser coagulation of the retina in children with uveitis].

Presented are cases of proliferative uveitis in which a laser coagulation of the retina has been performed in order to separate the fibrous changes. The authoresses discuss 2 groups: treated without coagulation and with the use of an argon laser coagulation. They see better anatomical and functional results in group in which prophylactical coagulation has been performed. They draw on this basis the conclusion that it should be used earlier, before the complications which hinder this operation come forth.

Adolescent↗
PubMedDate not supplied

[Factors determining the presence and predicting the development of diabetic retinopathy].

In a group of 329 diabetics aged 35-56 years with diabetes duration 1-30 years 134 cases were found diabetic retinopathy (40.7%). After 7 years funduscopy was repeated in 136 out of 248 patients and 50 new cases of retinopathy were disclosed. After multivariate analysis it was found that retinopathy was associated most closely with diabetes duration, while arterial hypertension was most surely predicting during 7 years future retinopathy, particularly in the case of higher level of glycosylated haemoglobin at the final examination.

Adolescent↗
PubMed1989

[New occult choroidal vessels in age-related macular degeneration].

We studied the clinical characteristics and the natural course of occult choroidal new vessels (CNV) in 78 eyes with age-related macular degeneration (AMD). Cases were included in 2 groups characterized respectively by ill-defined subretinal ooze (group 1) and serous detachment of the retinal pigment epithelium (RPE) with adjacent areas of mottled pigmentation (group 2). Both these forms of occult CNV showed to have a slower evolution compared to the classic CNV occurring in AMD, but they also led to disciform scar and severe visual loss. Occult CNV of group 2, contrary to those of group 1, were often multifocal and extrafoveal. They had a greater tendency to hemorrhages and a faster and less gradual progression to fibrovascular scarring and visual loss. Fluorescein angiography showed choroidal filling delay in the macular region of 47% of eyes of group 1. A perfusion defect of the macular choroid could be the basis of the low perfusion pressure and the consequent low activity of CNV with the angiographic pattern of ill-defined ooze.

Aged↗
PubMed1989

[Does cataract surgery with lens implantation influence the course of age-related macular degeneration?].

To evaluate the influence of cataract surgery with posterior chamber lens implantation on preexisting macular degeneration we divided 60 eyes of 54 patients in a group with 1) preoperative non exudative macular degeneration (50 eyes/47 patients) and 2) preoperative exudative macular degeneration (10 eyes/9 patients). Postoperatively, we found in the first group a visual improvement in 64%, an unchanged vision in 28%, and a deterioration in 8% of the cases. In the late postoperative course all eyes showed a visual acuity at least as preoperative values (6 eyes). In the second group, vision improved in 30%, remained unchanged in 30%, and deteriorated in 40% immediately after surgery. In 2 of these 4 cases vision showed no improvement even in the late postoperative period. A sudden increase of subretinal fluid in the macular region due to the operation trauma seems to be responsible.

Aged↗
PubMed1995

Insulin-like growth factor I (IGF-I) receptor/binding protein in human diabetic epiretinal membranes.

Insulin-like growth factor I (IGF-I) is thought to play a role in the development of proliferative diabetic retinopathy. Proliferative diabetic retinopathy is characterised by the formation of fibrovascular epiretinal membranes, and IGF-I may initiate and/or potentiate this epiretinal proliferation. To evaluate further the part played by IGF-I in the development of epiretinal tissue, we investigated the presence of IGF-I receptor/binding protein in proliferating diabetic fibrovascular epiretinal membranes. Five fibrovascular epiretinal membranes were obtained by vitrectomy from five patients with proliferating diabetic retinopathy. The presence of IGF-I receptors was investigated by autoradiography using 125I-labeled IGF-I on frozen sections. To characterise binding specificity, some sections were preincubated with either insulin or unlabeled IGF-I. Sections of post-mortem liver were used as controls. Strong labeling of cells with 125I-labeled IGF-I was observed in all epiretinal membranes and in liver cells. Almost no autoradiographic labeling was observed in sections that had been blocked with non-radioactive IGF-I, and very little labeling was found following blockage with insulin. Our preliminary study suggests the presence of IGF-I receptor/binding protein in human diabetic epiretinal membranes. These results support the hypothesis that IGF-I may be involved in the formation of proliferative diabetic membranes.

Autoradiography↗
PubMed1994

Proliferation and activation of vascular endothelial cells in epiretinal membranes from patients with proliferative diabetic retinopathy. An immunohistochemistry and clinical study.

In the present study, we investigated the status of proliferation and activation of vascular endothelial cells in epiretinal membranes from patients with proliferative diabetic retinopathy (PDR) by means of immunohistochemical techniques and compared the findings with the main clinical features of the patients. The results showed that of 21 vascularized membranes, 17 (81%) contained proliferating endothelial cells (positive for proliferating vascular endothelial cell marker EN 7/44) and 19 (90%) were positive for endothelial cell activation marker anti-VCAM-1; Furthermore, by using a double-staining technique we found that in 15 of the 17 cases (88%) the proliferating vascular endothelial cells were activated (expressing VCAM-1). Of the 18 type I diabetics, 15 (83%) contained activated proliferating endothelial cells, whereas in the 3 type II patients, only 1 membrane contained activated proliferating endothelial cells, Preoperatively, 18 patients had severe vitreous hemorrhage, among whom 15 (83%) contained proliferating endothelial cells, which were activated in 13 cases, and 16 patients had tractional retinal detachment, among whom 12 contained proliferating endothelial cells, which were activated in 11 cases. In all, 7 patients (33%) had vitreous rebleeding within 8 months postoperatively, whose membranes in 6 cases contained proliferating and activated endothelial cells. In contrast, of the 4 patients who were negative for EN 7/44, none had rebleeding, and of the 6 patients who were negative for EN 7/44 and anti-VCAM-1, only 1 had rebleeding.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1995

Natural course of retinal development in preterm infants without threshold retinopathy.

In a consecutive series, 209 preterm infants with birth weights below 1501 g or a gestational age of < or = 32 weeks were observed. Stage 3 retinopathy of prematurity (ROP) developed in 48 infants (23%) of between 32 and 46 weeks postconceptional age (PCA; mean, 37 weeks). Stage 3 ROP was not seen before 6 weeks after birth. Threshold ROP was seen and treated at between 34 and 42 weeks PCA (mean, 38 weeks PCA; n = 22, 10.5%). A subgroup of 126 untreated infants were followed until complete retinal vascularisation. At estimated term, 38.7% of eyes with vessels ending in zone 3 at the first examination showed complete vascularisation as compared with 17.6% of eyes with vessels ending in peripheral zone 2 and none of those with vessels ending in central zone 2. Occurrence of ROP delayed retinal development. At estimated term, no eye with any stage of ROP showed complete vascularisation as compared with 35.4% of eyes without ROP. Regression of stage 3 ROP below threshold started in all cases before 56 weeks PCA.

Cryosurgery↗
PubMed1995

[Hemorrhagic macular choroidopathy in young adults. Apropos of a case].

We report a case of haemorrhagic macular choroidopathy in young adult occurring in a 24-year-old woman. The aetiology of the affection remains unknown in Europe, but many authors suggest arterial dissemination of an infectious agent may be involved, as in the American form. In the case described here, it could be Chlamydia Psittaci.

Adult↗
PubMed1994

The blinding mechanisms of incontinentia pigmenti.

The ocular and cerebral abnormalities associated with incontinentia pigmenti, an X-linked dominant disease with characteristic cutaneous features, are far worse than the name would indicate. Although some patients have normal vision, total blindness or permanent visual deficiency may occur. Retinal vascular abnormalities, involving the periphery as well as the macula, appear to represent the primary disease process in the eye. Retinal detachment may then ensue, due to mechanisms that seem analogous to those of retinopathy of prematurity. Optic nerve atrophy and occipital lobe infarction are additional causes of severe visual dysfunction in some patients. For the first time, neonatal infarction of the macula is documented in this disease. The purpose of this report is to describe the visually disabling ocular and cerebral manifestations in five selected cases of incontinentia pigmenti.

Adult↗
PubMed1994

Ocular toxoplasmosis in the fetus. Immunohistochemistry analysis and DNA amplification.

PURPOSE: Ocular toxoplasmosis is often the result of a congenital infection. However, the earlier stages of the ocular lesions in the fetus have not been well studied. The purpose of the present study is to analyze the ocular findings in four aborted fetuses that were infected congenitally with Toxoplasma gondii. METHODS: Eight eyes from four fetuses of 22 to 27.5 weeks with T. gondii infection were studied by routine and immunohistochemical techniques. Two of the four were also examined by polymerase chain reaction (PCR). RESULTS: In two cases, the results of gross and histopathologic of the eyes were normal; marked retinal necrosis was present in the other two cases. Although no toxoplasmic cysts were identified by routine histopathologic examination, antigens of the tachyzoite were detected by immunohistochemistry analysis in the areas of retinal necrosis. In one of the cases with ocular lesions, the presence of T. gondii was confirmed by PCR. The presence of ocular lesions correlated with the severity of pathologic changes in the central nervous system. Large numbers of T cells were observed in the retinal lesions and in the choroid. CONCLUSION: Retinal necrosis, neovascularization, and marked chorioretinal inflammations despite the absence of bradyzoites are characteristic findings in the fetal eyes infected with T. gondii, and infiltrating T lymphocytes play a role in early recognition of the toxoplasma organism.

Adult↗
PubMed1994

[Selective vascular occlusion by repetitive short laser pulse].

The occlusion of arterioles and venules (30 microns in diameter) by means of repeated dye laser pulses (577 nm, 160 microseconds, 0.5 Hz) was studied in the hamster cheek pouch model. Microscopically visible changes during and after irradiation were recorded and monitored by a video system. The energy necessary per pulse for vessel occlusion with a single pulse (arterioles 5 J/cm2, venules 3.5 J/cm2) can be lowered more than 50% with 100 pulses (1.8 J/cm2, 1.2 J/cm2). Rupture of vessels, which regularly occurs with a single pulse, can be totally avoided with 100 repetitive laser pulses. Investigations of the temperature dependence of the occlusion rate of arterioles showed different interaction mechanisms with one pulse and 100 pulses (mechanical and thermal respectively). Light and electron microscopic investigations supported this concept of selective occlusion using repeated short laser pulses. Possible clinical applications are portwine stains of the eyelid, neovascularisation on the cornea and subretinal neovascularisation.

Animals↗
PubMed1994

[Hypertensive choroid angiography. Initial results].

A new method for the examination of choroidal morphology and hemodynamics by SLO-ICG videoangiography under induced hypertension by ocular ophthalmodynamography is presented. In 17 normal subjects, 32 patients suffering from exudative age-related macular degeneration and 13 patients suffering from subretinal fibrosis, the arterial blood vessels of the choroid were demonstrated in detail angiographically. Perfusion pressures of posterior ciliary arteries at their entry into the eye were also estimated. In the majority of patients in each group the central retinal artery was first filled with dye; in the central 40 degrees field 5-8 posterior ciliary arteries were detected; the arterial branches of the submacular choroid were supplied by a submacular ciliary artery in more than half of the cases; however, dye filling of the submacular choroid occurred later than in the surrounding choroid during reduction of intraocular pressure. ICG fluorescence angiography is compared to other angiographic examination methods of choroidal morphology and hemodynamics.

Adult↗
PubMed1994

[Color duplex ultrasound. A new procedure in the study of orbital blood vessels in diabetic retinopathy].

Color Doppler imaging is a new noninvasive technique that allows the measurement of flow velocity in small orbital vessels (both arteries and veins). We compared 59 eyes with proliferative, 47 eyes with nonproliferative and 24 eyes with preproliferative diabetic fundus changes with a control group of non-diabetic patients. The central retinal artery, short ciliary artery and ophthalmic artery of each patient were examined. The systolic, diastolic and mean velocity was obtained for each vessel. Differences between the groups were most prominent in the central retinal artery. The perfusion velocity was significantly lower (P < 0.01) in proliferative eyes (Vsyst 5.7 +/- 1.9 cm/s) than in the control group (Vsyst 9.4 +/- 1.4 cm/s) or the nonproliferative eyes (Vsyst 8.3 +/- 1.9 cm/s). In the preproliferative group the velocity distribution varied widely. Consequently, no statistically significant difference could be deduced in relation to either the control group or the group with proliferative diabetic changes. In the ophthalmic artery and ciliary artery no group showed significant differences from normal. Our measurements indicate a definite correlation between the severity of diabetic retinopathy and a decreased flow velocity, particularly in the central retinal artery. Thus, color Doppler imaging may help to identify those diabetic patients who are at high risk of developing severe diabetic retinopathy so that early photocoagulation treatment can be initiated.

Adult↗