SEARCH · Search PubMed
Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.
Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.
The Authors describe a case of generalised heterotopic ossification (HO) complicating the course of a 31 years old male patient, with a history of Hodgkin's lymphoma and a of long staying in an intensive care unit, where he had been placed on artificial coma. The clinical features, as well as radiological findings and therapy, are discussed.
Symptomatic heterotopic ossification (HO) after total hip arthroplasty (THA) and total knee arthroplasty (TKA) is relatively rare. Patients at high risk for developing HO after THA include men with bilateral hypertrophic osteoarthritis, patients with a history of HO in either hip, and patients with posttraumatic arthritis characterized by hypertrophic osteophytosis. Patients at moderate risk are those with ankylosing spondylitis, diffuse idiopathic skeletal hyperostosis, Paget's disease, or unilateral hypertrophic osteoarthritis. Patients at high risk for developing HO after TKA include those with limited postoperative knee flexion, increased lumbar bone mineral density, hypertrophic arthrosis, excessive periosteal trauma and/or notching of the anterior femur, and those who require forced manipulation after TKA. Preoperative radiation is effective for preventing HO after THA, as are post-operative prophylactic drug regimens and single-dose radiation treatments. Recurrence of HO after surgical excision should be expected unless prophylaxis is administered. Prophylactic measures against HO after THA and TKA should be administered before the fifth postoperative day, optimally within 24 to 48 hours.
Nonsteroidal anti-inflammatory drugs (NSAID) have been proven highly effective as prophylaxis for periarticular heterotopic ossification (HO) following total hip arthroplasty (THA) both when given to patients considered to be at risk for this complication, and in consecutive double-blind studies. Treatment with a standard dosage for 10 days starting on the day of surgery seems to be adequate for the prophylactic effect. Furthermore, NSAID are effective in preventing recurrence of HO after resection.
The first two cases of ossification of the transverse ligament are reported. This abnormality is rare, but it is important to know of its existence to avoid confusion with lesions of the posterior surface of the tooth of the axis.
The authors report a case of severe heterotopic ossifications after a total knee arthroplasty in an 83-year-old woman. She showed a dramatic loss in range of motion between the third and sixth postoperative week, after she had obtained a satisfactory 0 degree to 90 degrees--range of motion at the 14th postoperative day. A treatment program of radiotherapy combined with indomethacin and nonaggressive antiinflammatory physiotherapy resulted in a slow but steady improvement with complete relief of symptoms 6 months postoperatively.
BACKGROUND AND PURPOSE: Cervical myelopathy due to an ossification of the posterior longitudinal ligament (OPLL) is a rare entity in western countries but frequent in Japan. We report on two Lebaneese patients aged 67 and 72 years respectively, who were twins and presented with OPLL. METHODS: Diagnosis was made on myelography in the first case (1989) and on MRI of the cervical spine in the second case (1994). RESULTS: A wide laminectomy was performed in the first case followed by a marked improvement. In the second case, corporectomy of the third, fourth and fifth vertebra with removal of the ligament followed by bone graft didn't improve the clinical symptoms. CONCLUSION: The cause of OPLL remains unknown: genetic factors and metabolic abnormalities are outlined. Treatment options are discussed.
The rate of progression of cervical ossification of the posterior longitudinal ligament (OPLL) was radiologically studied during a 3-year period in three patient populations: (a) after laminoplasty (25 patients), (b) after laminectomy (16 patients), and (c) in patients who were managed without surgery (56 patients). There appeared to be no significant difference between these two surgical procedures in postoperative progression of OPLL. When progression of OPLL was compared between patients treated surgically and nonsurgically, posterior surgery accelerated progression of OPLL.
OBJECTIVE: To compare results of post-meningitic children who had cochlear implantation with partial or complete drill-out to those who had no drill-out. STUDY DESIGN: This study is a retrospective case review. SETTING: The Atlanta Cochlear Implant Group is a private, tertiary, outpatient clinic. PATIENTS: Eligibility included all our post-meningitic patients, 2-17 years, having a cochlear implant between June 1990 and July 1997. INTERVENTIONS: All subjects had a Nucleus 22 cochlear implant surgically implanted, speech processor programming and follow-up testing in our center, and aural rehabilitation in a variety of therapy settings. MAIN OUTCOME MEASURE: Open and closed set speech discrimination tests. RESULTS: Test performance for speech understanding was highest in the non-ossified group and lowest, but above chance, in the ossified group with complete drill-out. CONCLUSIONS: While children with non-ossified cochleas performed best, even children with extensive ossification requiring complete drill-out benefited from cochlear implantation.
Heterotopic ossification after total elbow replacement is a new complication. In this particular case, it resulted in severe limitation of motion. Excision of the heterotopic bone resulted in an excellent functional outcome for the patient.
We report a case of symptomatic Rathke's cleft cyst with ossification. CT scans showed curvilinear calcification on the wall of the cyst. MR images revealed a cystic sellar lesion with a nodular solid mass extending to the floor of the third ventricle. This case shows that calcification of the suprasellar cyst does not always suggest craniopharyngioma. Rathke's cysts should be histologically differentiated from craniopharyngiomas because their treatments are different.
We report two rare cases of prominent ossified ligamenta flava of the thoraco-lumbar junction. The first case presented with thoracic myelopathy diagnosed by spinal MRI. The definite diagnosis and the nature of the T10-T11 compressing process was established by spiral CT with multiaxial reconstruction and the patient was treated by laminectomy. In the second case the ossifications were found on a lateral lumbar X-ray and confirmed by spiral CT with multiplanar reconstructions. The pathology was essentially confined to the lateral portion of the T12-L1 ligamenta flava resulting in stenosis of the formaina only with respect of the central canal. The current literature is reviewed and the major role of CT for the diagnosis of such rare calcifying process of the spine is emphasized.
Radiculopathy resulting from ossification of the ligamentum flavum (OLF) is extremely rare and concerns only intercostal neuralgias. We describe a 37-year-old Caucasian woman with a lumbar radiculopathy revealing an OLF. Her symptoms were completely and definitively relieved by surgery.
Twenty patients with heterotopic ossification were HLA typed. The group consisted of 12 patients with severe cranio-cerebral injury and 8 with spinal cord injury. No significant differences in the frequency of any HLA antigens were found in these patients when compared to 631 healthy matched controls. None of the patients was B27 positive.
A 66-year-old man who had received a diagnosis of ankylosing spondylitis at the age of 50 was referred to our hospital for further evaluation of sleep apnea experienced for the last 3 years. Polysomnography yielded a diagnosis of obstructive sleep apnea syndrome with an apnea index of 41/hr. Computed tomographic scans demonstrated complete closure of the oropharynx during sleep at a site of marked ossification and hypertrophy of the cervical anterior longitudinal ligament. Nasal continuous positive airway pressure (nasal CPAP) with the use of chinstrap, but not nasal CPAP alone, dramatically decreased the patient's apnea index to 2.4/hr. We reported this case because, to the best of our knowledge, it is the first to demonstrate a causative association between ankylosing spondylitis and obstructive sleep apnea syndrome.
Nine cases of heterotopic ossification at the elbow in seven patients who had a cerebral injury and prolonged coma were treated by excision of the extra-articular bone bridge from the humerus to the ulna. The bridge was either anterior or posterior, and did not involve the radius. The articular cartilage in all elbows showed no significant evidence of degeneration in spite of the prolonged immobility of the joints during the period of coma. Two of the patients also had resection of heterotopic bone about the hip joint which resulted in rapid reformation of bone. In all patients there was restoration of satisfactory function in the elbow operated on without reformation of bone. Follow-up was from ten months to 8.7 years.
We describe a case of heterotopic mesenteric ossification presented in a 25 year-old male who underwent laparotomy for a fire-gun injury. Two weeks later he experienced small bowel obstruction and for this reason he has been operated five times with removal of segments of small bowel. Now, nine months later, he needs ileostomy to avoid another obstruction.
A rare extensive ossification occurred in a suprasellar craniopharyngioma of a man who died at 21 years of age. The tumor produced headache, retarded physical and mental development, visual disturbances, and increased intracranial pressure. The neoplasm recurred after surgical and roentgenological treatments. Differentiation of multipotential mesenchymal cells or mesenchymal type cells within the tumor has been suggested as the mode of occurrence of bone in this craniopharyngioma.
Ossification of the posterior longitudinal ligament (OPLL) of the cervical spine associated with diffuse idiopathic skeletal hyperostosis is described in a 70-year-old Caucasian man presenting with a rapidly progressive myelopathy. The acute nature of his myelopathic symptoms and cervical canal stenosis necessitated posterior decompressive surgery. Four other patients with OPLL are presented to illustrate the spectrum of imaging findings. The computed tomographic features of OPLL are distinctive.A 2-5 mm thick linear ossified strip along the posterior vertebral margin usually at mid cervical (C3 to C5) level characterises the condition. Magnetic resonance (MR) imaging is valuable in excluding possible cord damage and associated disc lesions prior to surgery. A calcified central sequestrated disc is the only condition that may be mistaken for the segmental and retrodiscal forms of OPLL In a clinical setting of compressive myelopathy, it is pertinent to distinguish between these two conditions since a sequestrated disc has a more favourable surgical prognosis. The merits and relevance of anterior and posterior surgery together with their possible complications are outlined.