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PubMed2006

Macrophage populations and cardiac sympathetic denervation during L-NAME-induced hypertension in rats.

The rat model of hypertension induced by prolonged treatment with Nomega-nitro-L-arginine methyl ester (L-NAME) has been extensively used. However, the effects on cardiac autonomic innervation are unknown. Here, the cardiac sympathetic innervation is analyzed in parallel with myocardial lesions and leukocyte infiltration during L-NAME (40 mg/Kg body weight/day, orally) treatment. The occurrence of cardiomyocyte hypertrophy, a controversial matter, is also addressed. Degenerating cardiomyocytes and focal inflammation occurred one day after treatment. Inflammatory lesions became gradually more frequent until day 7. At day 14 fibroblast-like cells were outstanding. Interstitial and perivascular connective tissue increased from day 28 on. In the left ventricle, cardiomyocyte hypertrophy occurred only around the damaged area during the first 14 days. After 28 days, it became more widespread. In the right ventricle, the hypertrophic cardiomyocytes were restricted to damaged areas. Significant reduction of the noradrenergic nerve terminals occurred from day 3 to 28. The area occupied by ED1+ (hematogenous) macrophages increased until day 7, and dropped to control levels by day 10. ED2+ (resident) macrophages increased from day 3 to 7 and remained higher than control values up to day 77. Animals receiving both L- NAME and aminoguanidine (AG), an inducible nitric oxide synthase (iNOS) inhibitor (65 mg/Kg body weight/day, orally), showed significant decrease in the nitrite serum levels, sympathetic denervation and macrophage infiltration at day 7. No denervation was detectable at day 14 of double treatment, using subcutaneous AG. Our findings favor a role for ED1+ macrophages and iNOS in the hypertension-induced denervation process.

Animals↗
PubMed2006

Restoring cerebral blood flow reveals neural regions critical for naming.

We identified areas of the brain that are critical for naming pictures of objects, using a new methodology for testing which components of a network of brain regions are essential for that task. We identified areas of hypoperfusion and structural damage with magnetic resonance perfusion- and diffusion-weighted imaging immediately after stroke in 87 individuals with impaired picture naming. These individuals were reimaged after 3-5 d, after a subset of patients underwent intervention to restore normal blood flow, to determine areas of the brain that had reperfused. We identified brain regions in which reperfusion was associated with improvement in picture naming. Restored blood flow to left posterior middle temporal/fusiform gyrus, Broca's area, and/or Wernicke's area accounted for most acute improvement after stroke. Results show that identifying areas of reperfusion that are associated with acute improvement of a function can reveal the brain regions essential for that function.

Aphasia, Broca↗
PubMed2003

Evaluation of the clinical and economic impact of a brand name-to-generic warfarin sodium conversion program.

BACKGROUND: Substitution of generic warfarin initially was discouraged because of concerns regarding therapeutic failure or toxicity. Although subsequent research with AB-rated (i.e., bioequivalent) warfarin did not confirm initial concerns, the issue is not settled for all clinicians. OBJECTIVES: We sought to provide additional information regarding the clinical and economic impact of warfarin conversion by analyzing a real-life sample of patients receiving long-term anticoagulation therapy who were switched from brand name to generic warfarin. METHODS: Patients who had been taking warfarin for at least 180 days and had received uninterrupted oral anticoagulation 90 days before and 90 days after switching to generic warfarin were included. The switch date was based on the first time generic warfarin was dispensed from our pharmacies. The primary end point was the calculated amount of time each patient's international normalized ratio (INR) values were within the patient-specific target INR range in the 90 days before and after the switch. Data regarding adverse events and medical resource utilization were also collected. Pharmacoeconomic analyses were performed. RESULTS: The analysis included 2299 patients. The overall difference in calculated time INR values were below (22.6% before vs 26.1% after switch, p<0.0001) and within (65.9% before vs 63.3% after switch, p=0.0002) the therapeutic INR range was statistically but not clinically significant. Only 28.0% of patients experienced a change in therapeutic INR control of 10% or less, 33.1% experienced INR control that improved by greater than 10%, and 38.9% experienced INR control that worsened by more than 10%. The difference in total treatment costs associated with brand name and generic warfarin was 3128 dollars/100 patient-years in favor of the generic product. Sensitivity analyses revealed that cost savings associated with warfarin conversion in this health care system were highly dependent on the difference between warfarin costs and cost of treating anticoagulation-related adverse events. CONCLUSIONS: Most of these patients were successfully switched from brand name to generic warfarin. However, supplemental INR monitoring is warranted when one warfarin product is substituted for another to allow timely detection of those patients who experience significant changes in anticoagulation response.

Aged↗
PubMed1998

Genetic differences define severity of renal damage after L-NAME-induced hypertension in rats.

Genetic factors are important in determining the susceptibility to renal damage. In a backcross of the hypertensive and proteinuric fawn-hooded Erasmus University Rotterdam (FHH/EUR) rat with the normotensive, nonproteinuric August Copenhagen Irish (ACI/EUR) rat, two genes (denoted Rf-1 and Rf-2) were genetically mapped for parameters of functional and structural renal damage. The aim of the present study was to investigate the susceptibility to functional and structural renal damage in heterozygous (FHH X ACI) F1 rats compared with the parental FHH and ACI strains at similar levels of systolic BP (SBP). BP elevation was induced by chronic treatment with NG-nitro-L-arginine methyl ester (L-NAME) in either a low dose (LD, 75 to 100 mg/L) or a high dose (HD, 175 to 250 mg/L) in the drinking fluid. Survival of FHH rats and, to a lesser extent, F1 rats, was adversely affected by L-NAME treatment. All ACI rats except for one ACI-HD animal survived. In all strains, L-NAME caused a dose-dependent increase in SBP. At similar levels of SBP, the increase in functional renal damage, as indicated by the level of albuminuria, was higher in F1 compared with ACI, but lower compared with FHH. The same differences were found for the level of structural renal damage, as indicated by the incidence of glomerulosclerosis. Both the SBP and the average BP burden (SBP-Av), defined as SBP averaged over the period of follow-up, directly correlated with the level of albuminuria and incidence of glomerulosclerosis in all strains. However, the increase in the degree of renal damage per mmHg increase in SBP or SBP-Av was significantly higher in the F1 rats compared with ACI, but lower compared with FHH rats. Values for these F1 rats were closer to the ACI rats than to values for the FHH rats and increased above an SBP level of 180 mmHg. The F1 rats, being heterozygous for Rf-1 and Rf-2, as well as for other potential genes responsible for renal disease, were largely, but not completely, protected from hypertension-induced renal damage. It is concluded that complete susceptibility to hypertension-associated renal damage in rats primarily depends on the presence of predisposing genes for renal failure even after a significant increase in BP.

Animals↗
PubMedDate not supplied

Product-line extensions and pricing strategies of brand-name drugs facing patent expiration.

OBJECTIVE: This study proposed an alternative to brand loyalty as the explanation for the continued price rigidity of patent-expired brand-name prescription drugs despite the increase in market entry of generic drugs facilitated by the 1984 Drug Price Competition and Patent Term Restoration Act. Study hypotheses were to test (1) whether market entries of new-product extensions are associated with market success of original brand-name drugs before generic drug entry, and (2) whether original brand-name drugs exhibit price rigidity to generic entry only when they are extended. METHODS: The design is a retrospective follow-up study for the prescription drug brands that lost their patents between 1987 and 1992. The drug brands were limited to nonantibiotic, orally administered drugs containing only 1 active pharmaceutical ingredient. Information on patent expiration, entry of a product extension, and market success were determined from the U.S. Food and Drug Administration.s Orange Book, First DataBank, and American Druggist, respectively. Market success was defined as whether an original drug brand was listed in the top 100 prescriptions most frequently dispensed before facing generic entry. Product-line extension was defined as the appearance of another product that a company introduces within the same market after its existing product. Drug prices were average wholesale prices from the Drug Topics Red Book. The relationship between product-line extension and market success was examined using a logistic regression analysis. The price rigidity to entry was tested using a panel regression analysis. RESULTS: A total of 27 drug brands lost their patents between 1987 and 1992. Drug brands that achieved market success were 16 times more likely to be extended than were those that did not (OR=16, 95% confidence interval, 2.12-120.65). The price rigidity to entry existed in drug brands with extensions (beta=2.65%, P <0.033), but not in those brands without extensions (beta=-2.40%, P <0.001). CONCLUSION: This study provided some support for the alternative explanation to brand loyalty that a new product-line extension introduced for an original brand helps the original price be rigid despite the entry of generic drugs facilitated by the 1984 Drug Price Competition and Patent Term Restoration Act.

Costs and Cost Analysis↗
PubMed1980

A comparison of three strategies for teaching object names.

Researchers in applied behavior analysis have been charged to provide large-scale demonstration of the outcomes of evaluations. In this research, three experiences were conducted to examine the relative efficacy of three methods of presenting stimuli in object naming tasks. Stimuli were introduced successively, simultaneously, or using a combination of the two procedures. College adults, mentally retarded children and adolescents, and preschool children were taught to produce the names of five Hebrew letters, English words, or American coins, respectively. Presentation method was a between-subjects treatment in a factorial design. Results from the series of systematic replications were consistent showing better posttest for subjects in the Simultaneous and Combined conditions. Further, follow-up data in Experiment III showed that retention was also superior for subjects trained by the Simultaneous or Combined methods. Although the acquisition criterion was met in fewer trials by subjects in the Successive condition, only several minutes more training time was required by the Simultaneous and Combined conditions. From a cost-effectiveness point of view, either of the latter two techniques should be favored over the Successive procedure for testing verbal naming skills.

Adolescent↗
PubMed1980

Generalization of naming responses to objects in the natural environment as a function of training stimulus modality with retarded children.

Picture-cards, photographs, and real objects were compared as training stimuli in order to determine which best facilitated the generalization of naming responses learned in a special training room to real objects in the natural environments of four retarded children. The amount of transfer of naming behavior between the three stimulus modes and the average amount of training time required per stimulus mode were also assessed. Three of the four children displayed considerably more generalization to the real objects in the natural environment when they were trained with real objects. The fourth child displayed substantial generalization regardless of the training stimulus mode. No particular training stimulus mode clearly facilitated the transfer of naming responses to other modes or greatly reduced training time. The results of two supplementary procedures conducted with one child showed that: (1) training in several environments facilitated generalization to real objects in the natural environment when real objects were used as training stimuli but not when picture-cards were used, and (2) transfer from picture-cards to real objects was facilitated by training other picture-cards and the real objects portrayed by them at the same time.

Adolescent↗
PubMed1996

Naming, the formation of stimulus classes, and applied behavior analysis.

The methods used in Sidman's original studies on equivalence classes provide a framework for analyzing functional verbal behavior. Sidman and others have shown how teaching receptive, name-referent matching may produce rudimentary oral reading and word comprehension skills. Eikeseth and Smith (1992) have extended these findings by showing that children with autism may acquire equivalence classes after learning to supply a common oral name to each stimulus in a potential class. A stimulus class analysis suggests ways to examine (a) the problem of programming generalization from teaching situations to other environments, (b) the expansion of the repertoires that occur in those settings, and (c) the use of naming to facilitate these forms of generalization. Such research will help to clarify and extend Horne and Lowe's recent (1996) account of the role of verbal behavior in the formation of stimulus classes.

Attention↗
PubMed1971

Color-naming functions for the pigeon.

Six pigeons were trained to match wavelengths in a three-key matching-to-sample paradigm. Test trials were occasionally presented, where probe wavelengths appeared on the center key and choices were made to the training stimuli presented on the side keys. Color naming functions were obtained by plotting the percentage of test trials that each training stimulus wavelength was chosen for each center key probe wavelength. The wavelength where the functions intersected was interpreted as a transition point between pigeon hues. Three experiments employed different wavelengths as training stimuli. The first two experiments demonstrated that the intersection of the color-naming functions occurred in all cases at 540 nm and 595 nm. The third experiment employed 540 nm and 595 nm as two of the three training stimuli, and the relatively slow acquisition, together with the resulting color-naming functions, supported the proposition that 540 nm and 595 nm may be transition point wavelengths between pigeon hues.

Journal Article↗
PubMed2006

Equivalence relations, contextual control, and naming.

This paper reports two experiments that investigated the role of verbal behavior in the emergence and generalization of contextually controlled equivalence classes. During both experiments, participants were trained with two different combinations of the same easily nameable, yet formally unrelated, pictorial stimuli. Match-to-sample baselines for eight four-member classes were established under the contextual control of two colors. In the presence of one color, conditional relations were established between stimuli whose normative names rhymed. In the presence of the other color, conditional relations were established between stimuli whose normative names did not rhyme. Although, during Experiment 1, all participants demonstrated equivalence classes involving rhyming stimuli, none demonstrated the formation of nonrhyme equivalence classes. To investigate this finding, Experiment 2 evaluated whether participants would demonstrate both rhyme and nonrhyme equivalence classes given more extensive exposure to the experimental contingencies. All participants demonstrated contextually controlled rhyme and nonrhyme equivalence classes, although rhyme classes were demonstrated with greater facility than nonrhyme classes. Results indicate that visual stimuli are named, that verbal bases for stimulus classification can affect the emergence of contextually controlled equivalence classes, and that untrained contextually controlled conditional discriminations involving novel stimuli can emerge on the basis of participants' verbal behavior.

Adolescent↗
PubMed1999

Name-based reporting of HIV-positive test results as a deterrent to testing.

OBJECTIVES: This study evaluated attitudes toward name-based reporting of HIV. METHODS: One hundred thirty high-risk, male repeat testers received information on the public health benefits of name-based reporting and reported their intentions to test. RESULTS: Of the 67 men who were randomly selected and asked their intentions before hearing the benefits, 63% said they would not test if reporting were required. After hearing the benefits, 19% changed their minds (P < .014). Of the 63 men who were asked only after hearing the benefits, 44% would not test. CONCLUSIONS: Implementing name-based reporting without working before-hand to change attitudes could undermine the benefits of both testing and HIV surveillance.

AIDS Serodiagnosis↗
PubMed1989

Lateralization differences for color-naming and color-matching in men and women.

The relationship between accuracy of color-naming and color-matching in both visual fields (LVF and RVF) as a function of sex was investigated. Subjects were 19 men and 15 women who ranged in age from 18 to 32 yr. Each subject was tested on both a color-naming task and a color-matching task presented tachistoscopically. Accuracy measures for each task were obtained separately for both left and right visual fields. A two-factor analysis of variance with repeated measures on one factor followed by a t test for simple main effects showed significant right visual-field advantage for the color-naming task, a significant sex main effect for the color-matching task (in the left visual field only), and a significant interaction of sex by visual field for the matching task. Men performed in a more strongly lateralized fashion on the color-matching task than did women, supporting the notion of greater lateralization among males.

Adolescent↗
PubMed1995

Hemispheric picture-naming hierarchies in stuttering subjects.

The present study was done to investigate the linguistic organization of the right hemisphere of stuttering subjects and the interhemispheric interactions that underlie verbal output in this population. Naming reaction times of 14 stuttering adults were measured to unilaterally presented pictures corresponding to vocabulary levels of < 5.5, 9.5-10.5, and > 18.0 years of age. An analysis of variance of latencies showed a significant main effect for picture vocabulary-age. Post hoc tests were interpreted as suggesting that the right hemisphere of stuttering subjects was capable of differential picture-encoding operations in a manner similar to the left hemisphere of normal speakers. Also, naming latencies favored left visual-field stimulations by 34 msec. Taken with significant and high correlations between visual fields for each level of picture vocabulary score, the right hemispheres of the stuttering subjects appeared responsible for picture-encoding operations. Left-hemispheric stimulus processing was not predicted, suggesting differences may exist in interhemispheric interactions underlying picture-naming functions in stuttering populations.

Adult↗
PubMed2002

Visual and lexical factors in naming speed by children with reading disorders.

Reaction times of 12 reading disordered and 12 normally reading children and 12 adults were investigated with a visual half-field tachistoscopic picture-naming task. Analysis indicated slower picture-naming times for children with reading disorders. Hemispheric processing models suggested neurolinguistic maturation for rapid picture-naming speed.

Brain↗
PubMed2003

Measurement errors in voice-key naming latency for Hiragana.

This study makes explicit the limitations and possibilities of voice-key naming latency research on single hiragana symbols (a Japanese syllabic script) by examining three sets of voice-key naming data against Sakuma, Fushimi, and Tatsumi's 1997 speech-analyzer voice-waveform data. Analysis showed that voice-key measurement errors can be substantial in standard procedures as they may conceal the true effects of significant variables involved in hiragana-naming behavior. While one can avoid voice-key measurement errors to some extent by applying Sakuma, et al.'s deltas and by excluding initial phonemes which induce measurement errors, such errors may be ignored when test items are words and other higher-level linguistic materials.

Adult↗
PubMed2002

Cortical stimulation mapping of language cortex by using a verb generation task: effects of learning and comparison to mapping based on object naming.

OBJECT: Cortical stimulation mapping has traditionally relied on disruption of object naming to define essential language areas. In this study, the authors reviewed the use of a different language task, verb generation, in mapping language. This task has greater use in brain imaging studies and may be used to test aspects of language different from those of object naming. METHODS: In 14 patients, cortical stimulation mapping performed using a verb generation task provided a map of language areas in the frontal and temporoparietal cortices. These verb generation maps often overlapped object naming ones and, in many patients, different areas of cortex were found to be involved in the two functions. In three patients, stimulation mapping was performed during the initial performance of the verb generation task and also during learned performance of the task. Parallel to findings of published neuroimaging studies, a larger area of stimulated cortex led to disruption of verb generation in response to stimulation during novel task performance than during learned performance. CONCLUSIONS: Results of cortical stimulation mapping closely resemble those of functional neuroimaging when both implement the verb generation task. The precise map of the temporoparietal language cortex depends on the task used for mapping.

Adolescent↗
PubMed2006

Are age-of-acquisition effects on object naming due simply to differences in object recognition? Comments on levelt (2002).

Levelt (2002) argued that apparent effects of word frequency and age of acquisition (AoA) reported in recent picture naming studies might actually be confounded effects operating at the level of object recognition, rather than relevant to theories of lexical retrieval. In order to investigate this issue, AoA effects were examined in an object recognition memory task (Experiments 1 and 2) and a word-picture verification task (Experiment 3) and compared with those found in naming tasks using the same pictures. Contrary to Levelt's concerns, the results of the three experiments show that the AoA effect on picture naming has a lexical origin and does not simply result from a possible confound of object identification times.

Adolescent↗
PubMed2005

Effect of uncertainty on the time course for selection of verbal name codes.

Response selection takes time. Hick's law (Hick, 1952) predicts that the time course of response selection is a logarithmic function of the number of equally likely response alternatives. However, recent work has shown that oculomotor responses constitute noteworthy exceptions in that the latencies of saccades (Kveraga, Boucher, & Hughes, 2002) and smooth pursuit movements (Berryhill, Kveraga, Boucher, & Hughes, 2004) are completely independent of response uncertainty. This finding extends to the case in which the required response was known in advance (i.e., simple reaction times [RTs] were equivalent to choice RTs). In view of these results, we reevaluated reports that latencies to name visually presented digits (Experiment 1) and/or repeat aurally presented digits (Experiment 2) are similarly independent of the size of the response set. We found that naming latencies were equivalent for response set sizes from one to eight, but simple RTs (response set of one) were faster. Thus, the overlearned task of digit naming is indeed highly automatic but has not reached the level of automaticity characteristic of the oculomotor system.

Adolescent↗