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PubMed2001

[The connection between sports and spores. The foot, its mycoses and onychomycoses].

The epidemiological survey Achillus on over 76,000 subjects has highlighted the high prevalence of foot diseases. In particular, the risk of contracting skin and nail infections of the foot by fungi is quite important during some sport practices. The interhuman transmission is due to propagules commonly called spores. It often occurs by indirect contamination from the soil. Clinical presentations are diverse, largely depending upon the identity of the pathogen fungus. Prevention and treatment of these infections require both patience and perseverance. Boosting the transformation of spores into an active growing phase might paradoxically increase the clinical efficacy of antifungals.

Disease Transmission, Infectious↗
PubMed2002

[Identification and antifungal susceptibility of Candida spp isolated from invasive mycoses. Influence of growth inhibition percentage to determine minimal inhibitory concentration].

BACKGROUND: An increase in the frequency of resistant strains to antifungal drugs has been detected in the last decade. AIM: To report the minimal inhibitory concentration (MIC) to amphotericin B, fluconazole, ketoconazole and itraconazole. To compare the MIC obtained with 80% and 50% of growth inhibition to the azoles. MATERIAL AND METHODS: Fifty yeast strains isolated between 1998 and 1999, from 17 adults and 33 children with invasive mycosis were studied. Susceptibility was determined by broth microdilution method with RPMI 1640 plus glucose 2% according to the National Committee for Clinical Laboratory Standards (1997). RESULTS: The most frequently isolated strains were C albicans in 27 cases and C parapsilosis in 12. All isolates were susceptible to amphotericin B. According to the MICs obtained with 80% of inhibition, 12 strains had MICs considered as resistant to azoles. Five strains were resistant both to fluconazole and itraconazole. Considering MICs obtained with 50% of inhibition, only five strains were found resistant to azoles (p < 0.05). Using this criterion, only one C glabrata strain was found to be simultaneously resistant to fluconazole and itraconazole. CONCLUSIONS: Similar results in the pattern of susceptibility of Candida spp to azoles, to those reported abroad, are obtained when the MIC is calculated using 50% inhibition.

Adult↗
PubMed2002

Butenafine: an update of its use in superficial mycoses.

Butenafine is a synthetic benzylamine antifungal agent that may be fungicidal against susceptible organisms, e.g., dermatophytes. Butenafine may be effective and safe in the treatment of interdigital tinea pedis (apply twice daily for 1 week or once daily for 4 weeks), tinea corporis/tinea cruris (apply twice daily for 2 weeks), and pityriasis versicolor (apply once daily for 2 weeks). The effectiveness of the drug persists for at least 4 weeks following the discontinuation of therapy suggesting that there is some retention of the drug in the skin following termination of active therapy.

Administration, Topical↗