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[Stress echocardiography and mitral stenosis: what interest?].

The stress echocardiography is used extensively as a diagnostic and prognostic tool and the assessment of ischemic cardiopathies. Its use in valvulopathies is more limited, but is increasing with time. The discrepancies between the functional symptoms and hemodynamics at rest is frequently met in patients with mitral stenosis. By assessing changes of pressures, gradients and surface stress echocardiography helps to identify the real hemodynamic conditions permitting to recommend a more aggressive approach in certain situations.

Blood Pressure↗

Spontaneous coronary artery dissection in mitral stenosis.

Spontaneous coronary artery dissection is a rare disease that occurs most commonly in young people, especially in peripartum or postpartum women. It has rarely been diagnosed during life and has never before been observed associated with any other non-ischaemic heart disease. We report a case associated with mitral stenosis, in which successful valvular and coronary surgery were carried out. We speculate whether rheumatic coronary arteritis was a cause of the dissection.

Aortic Dissection↗

Acute and delayed hormonal changes in mitral stenosis treated by balloon valvulotomy.

The role of left atrial and aortic pressures on the secretion of the main hormones controlling blood volume is still subject to debate in humans. Because of increased mean left atrial pressure and decreased mean aortic pressure produced by balloon inflation in patients with mitral stenosis treated with balloon valvulotomy, the hormonal changes occurring acutely (group II of patients) were measured. The same studies (group I patients) were also performed 48 hours after this treatment, a period at which left atrial pressure permanently diminished. Inflation of the balloon resulted in a decrease in plasma renin activity and increases in plasma atrial natriuretic factor (ANF) and plasma arginine vasopressin (AVP). Forty-eight hours after balloon valvulotomy, which had produced a decrease in left atrial pressure, plasma ANF was lower (58.9 +/- 7.9 vs 95.3 +/- 11.9 pg/ml; p < 0.001), and plasma renin activity (2,575 +/- 533 vs 960 +/- 113 pg/ml/hour; p < 0.01), plasma angiotensin II (25.0 +/- 4.1 vs 9.3 +/- 1.3 pg/ml; p < 0.001) and plasma aldosterone (181.7 +/- 36.7 vs 139.9 +/- 19.8 pg/ml; p < 0.05) were higher than their respective control levels 24 hours before treatment of the stenosis. In contrast, plasma AVP (3.7 +/- 0.25 vs 4.4 +/- 0.31 pg/ml; p = 0.001) diminished moderately along with plasma osmolality (282.4 +/- 0.1 vs 286.2 +/- 0.6 mOsm/kg; p < 0.001). Urinary sodium excretion was also examined before and after balloon valvulotomy.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗

The hemodynamic effects of severe mitral stenosis and pulmonary hypertension during labor and delivery.

Pregnancy represents a hyperdynamic state characterized by increased cardiac output, blood volume, and oxygen consumption. Valvular heart disease may blunt this response and, especially when associated with pulmonary hypertension, carries a high mortality. We report the hemodynamic variables as measured through the completion of labor, delivery and postpartum period in a woman with severe mitral stenosis and pulmonary hypertension.

Adult↗

Plasma cytokine levels in cardiac chambers of patients with mitral stenosis with congestive heart failure.

To ascertain whether elevated levels of circulating proinflammatory cytokines in patients with advanced heart failure are due to congestive heart failure or due to cachexia or infection complicating heart failure, we measured prospectively plasma concentrations of tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), interleukin 2 (IL-2), and interleukin-6 (IL-6) in 12 patients with mitral stenosis with moderate congestive heart failure, but not with cachexia or infection. Blood samples were obtained from the peripheral vein and right and left atria of the patients during percutaneous mitral valvuloplasty. Levels of TNF-alpha, IL-1 beta, IL-2, and IL-6 in the plasma form the peripheral vein and right and left atria of these patients were not elevated compared with those from the peripheral vein of a control group of 10 normal subjects. On the other hand, plasma levels of TNF-alpha but not IL-1 beta, IL-2 or IL-6, were elevated in 4 of 9 patients with congestive heart failure complicated with cachexia and/or infection. Our results suggest that proinflammatory cytokine levels are not elevated in congestive heart failure uncomplicated with cachexia or infection.

Adult↗

Acquired mitral stenosis in children under fifteen.

The clinical and hemodynamic studies of acquired MS in 30 children under the age of 15 are reviewed. There are 13 male and 17 female patients with an age range from 9 to 14 (mean 12.6) years. The majority of the patients (78%) are in New York Heart Association functional class 3 or 4. Only 55% of the patients had a history suggestive of previous rheumatic fever. All patients had pulmonary hypertension and 41% had severe pulmonary hypertension. A closed mitral commissurotomy was performed in all patients. There were 3 deaths and 2 patients required reoperation because of restenosis. The early onset of mitral stenosis in our population was suggestive of a very early onset of valvulitis with subsequent fibrosis and narrowing of the mitral valve. This is in contrast to the acute fulminating form of rheumatic fever with valvulitis manifested by severe mitral and or aortic insufficiency.

Adolescent↗