Woman, moon and menstruation.
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The purpose of this study was to determine and describe the chronological age, age at menarche (AM), age at initiation of training (AIT), years dedicated to training (YDT), selected menstrual characteristics, use of oral contraceptives, family size (FZ), birth order (BO), martial status, and number of children relative to sport of Puerto Rican women athletes. Fifty five (55) women athletes (track and field n = 6, basketball n = 7, gymnastics n = 5, synchronized swimming n = 9, swimming n = 5, softball n = 14, tennis n = 4 [field tennis n = 2, table tennis n = 2], and volleyball n = 5) members of the Puerto Rico Olympic Committee delegation to the XV Central American and Caribbean Games were interview. The M +/- sd of the variables were as follows: age = 21.0 +/- 5.3 years, AIT = 11.4 +/- 4.3 years, YDT = 9.6 +/- 4.4 years, AM = 13.2 +/- 1.6 years, BO = 2.7 +/- 1.3, y FZ = 3.7 +/- 1.9. Five percent of the sample (gymnasts = 2, swimmers = 1) had not attained menarche at the time of the study. The prevalence for menstrual irregularity and dysmenorrhea was 44.2 and 40.4%, respectively. With respect to the degree of certainty in the recall of age of menarche: 61.5% were very certain, 25% certain, and 13.5% uncertain. The prevalence of the use of oral contraceptives was 7.3%. In conclusion, the results are within the range of those reported for olympic athletes.
We studied 150 women with primary/secondary amenorrhea and/or oligomenorrhea; in 61 cases we found an abnormal karyotype (i.e. 40.7%): 51 cases in the first group of 110 patients with amenorrhea (i.e. 46%) and 10 cases in the second group of 40 patients with oligomenorrhea and/or secondary amenorrhea (i.e. 25%). The chromosome aberrations we found consisted in X aneuploidy, male karyotype and the different structural changes as mono- and dicentric X isochromosomes, dicentric, ring, deleted or inverted X chromosomes. Our results suggest a cytogenetic examination in patients with primary amenorrhea as well as in patients with oligomenorrhea and/or amenorrhea secundaria.
Levels of estradiol (E2), progesterone (P0), androstenedione (A), testosterone (T), follicle stimulating hormone (FSH), luteinizing hormone (LH) and prolactin (PRL) in ovarian follicles of different sizes and at different phases of normal menstrual cycles were determined and, their relationships with those in peripheral blood were studied. According to the diameters, the follicles were divided into large (greater than 14 mm), median (8-14 mm) and small (less than 8 mm) ones. The results showed that the levels of E2, P0, FSH and LH were lower, whereas those of A and T were higher in small and median follicles, as compared with the large follicles. In the large follicles, particularly at the preovulatory phase, E2, P0, FSH and LH reached maximum levels. The concentration of E2 was 9815 nmol/L, P0, 3316 nmol/L, FSH 1.34 IU/L and LH 3.91 IU/L at the preovulatory phase. The concentrations of A and T were much lower in large follicles, being 280 nmol/L and 137 nmol/L respectively. No significant difference was found in PRL levels in follicles of different sizes. The steroid hormones in the follicular fluid were about 7-20,000 times higher than those in the peripheral blood, while FSH and LH were only about 10-80% and PRL was slightly higher than in peripheral blood.
CA-125 is a glycoprotein associated with various ovarian tumors. A commercial radioimmunoassay involving a monoclonal antibody is available for it. In our laboratory, a normal-value study was conducted as part of a routine evaluation of this assay. One healthy subject had a serum CA-125 concentration greater than 300 kU/L, more than eightfold the upper limit of normal (35 kU/L). This increase, which coincided with the onset of the menstrual period, subsided to within the normal range by the end of the menstrual cycle. The half-life of CA-125, calculated from this decrease, was 6.4 days. Similar observations were made in the same subject over several menstrual cycles. Results of clinical and ultrasound examinations of the subject for ovarian tumors were negative. No clinical evidence of malignancy was present eight months after the initial discovery of an increased CA-125. None of the other 39 healthy subjects had a CA-125 value greater than 51 kU/L. Five of these subjects had CA-125 determined several times during their menstrual cycles; none exhibited pronounced variations in CA-125 concentrations. Evidently CA-125 can be extremely increased in a healthy woman, and possible effects of the menstrual period on serum CA-125 concentrations should be considered in pre-menopausal patients.
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