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At least 1,477 records · Page 82Linked to original sources
PubMed1999

Merck Frosst Award Lecture 1998. Molecular dissection of the human multidrug resistance P-glycoprotein.

The human multidrug resistance P-glycoprotein is an ATP-dependent drug pump that extrudes a broad range of cytotoxic agents from the cell. Its physiological role may be to protect the body from endogenous and exogenous cytotoxic agents. The protein has clinical importance because it contributes to the phenomenon of multidrug resistance during chemotherapy. In this review, we discuss some of the results obtained by using molecular biology and protein chemistry techniques for studying this important and intriguing protein.

ATP Binding Cassette Transporter, Subfamily B, Mem↗
PubMed1999

Armstrong Lecture: Opening the envelope: the continuing legacy of Maj. Gen. Harry G. Armstrong, USAF, MC (Ret.).

From 1929-1957, Harry Armstrong, M.D., rose from first lieutenant in the U.S. Army to the rank of major general in the U.S. Air Force. He founded the aeromedical research laboratory at Wright Field, Dayton, OH, founded the Central Medical Establishment, England, became command flight surgeon, U.S. 8th Air Force, England, and founded the Department of Space Medicine (1947), Randolph Field, TX, and served as Surgeon General, USAF (1949-54). Armstrong worked throughout his career on the most advanced aeromedical problems and personally directed breakthrough programs for which he received the highest national and international awards. Applying Armstrong-like projections, one can forecast faster, larger aircraft for the coming decades as well as 21st century habitations on the moon and Mars.

Aerospace Medicine↗
PubMed1999

The Mason Brown Lecture. Scots and paediatric surgery.

Scotland and Scots paediatric surgeons have been in the forefront of the development of surgical services for children. Development has occurred at different rates in sections of society. Progress or obstruction has seldom been for 'scientific' reasons but much more according to the personal interests or drive of individuals. The Scots can justifiably claim some influence in the overall evolution of paediatric surgery. It is no wonder that Henley wrote after his visit to Walter Scott in Edinburgh, "The conceit of these bloody Scotsmen is atrocious".

General Surgery↗
PubMed1999

1998 Andre Allard Lecture. Aerospace medicine in the 21st century--reaching for the stars.

The 21st century will be an era of unprecedented scientific achievements, one in which man will continue to overcome limits rather than be overcome by them. Aerospace medicine will continue to make significant contributions as aviation and space activities intensify, and as new technologies pose new aeromedical challenges. More than that, aerospace medicine's role will prove decisive in man's quest for his ultimate destiny in the universe.

Aerospace Medicine↗