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At least 1,477 records · Page 82Linked to original sources
PubMed1995

[Influence of oral isosorbide dinitrate (ISDN) on parameters of blood flow in the coeliac trunk evaluated with doppler sonography].

Blood flow in the coeliac trunk was measured before and after oral application of ISDN (isosorbitol dinitrate) 10 or 20 mg. Clinical prognostic value of this test was evaluated. Investigation were carried out with a duplex-Doppler pulsatory wave. The quantitative hemodynamic method with estimation of PI and RI was applied to exclude the effect of angle and the vessel diameter. 44 healthy volunteers were examined. The ultrasonograph ACUSON 128 was used with the linear and sectorial head 3.5 MHz enabling measurement of the pulsatory wave (Doppler). All persons were divided into 4 groups: according to sex, the age, the dose of nitrate and the groups given placebo. Application of the ISDN led to increase values PI and RI. Application of placebo had no influence on the blood flow.

Adolescent↗
PubMed1998

[Time-dependent hemodynamic effects of monosan (Isosorbide-5-mononitrate) in anginal patients].

Chronosensitivity to monosan was studied in acute clinicopharmacological tests at 7.00, 11.00, 15.00, 19.00 and 23.00 in 20 patients with ischemic heart disease, angina pectoris (class II-III). Arterial pressure, heart rate, hemodynamic parameters were measured before monosan intake, 1.5, 2, 3 and 21 hours after the intake of 20 mg. The findings indicate the existence of chronosensitivity of hemodynamics to monosan, circadian rhythm of sensitivity of the heart rate, systolic pressure, peripheral resistance. Acrophase of the sensitivity rhythm of the heart rate occurred at 13.42, systolic pressure at 21.54, mean arterial pressure at 00.41, total and peripheral resistance at 14.13, 15.18, respectively.

Angina Pectoris↗
PubMed1998

[Comparative efficacy, safety, cardio-hemodynamic effects of isosorbide dinitrate (ID) aerosol and sublingual tablets of nitroglycerin].

AIM: To study efficacy, safety, cardiohemodynamic effects of ID aerosol--isoket--for relief of anginal attacks and their prevention in long-term treatment. MATERIALS AND METHODS: 15 patients with ischemic heart disease suffering from stable angina class II-III. Isoket was tried for efficacy, tolerance, hemodynamic parameters, morphofunctional status of the heart, exercise tolerance. RESULTS: Isoket aerosol in a dose 1.25 mg as a single oral spray arrested anginal attacks in all the patients. In long-term regimens good antianginal effect was achieved in 60% of cases. The ID aerosol produces a fast antianginal effect, improves morphofunctional cardiac parameters and exercise tolerance. CONCLUSION: Isoket spray is effective and safe antianginal drug.

Administration, Inhalation↗