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At least 1,477 records · Page 82Linked to original sources
PubMed1991

[The criteria for choosing the surgical approach to cervicomediastinal goiters].

The retrospective analysis of a series of 350 cases of intrathoracic goiters, out of a total of 5,000 thyroid operations derived from the joined case records of the 3rd General Surgery Institute (Director: Prof. G. Di Matteo) and the 8th Chair of Surgical Pathology (Director: Prof. F.P. Campana), has induced the authors to reconsider the surgical approach to this pathology on the basis of anatomo-surgical factors.

Goiter, Substernal↗
PubMedDate not supplied

[Individual immunogenetic characterization of patients with diffuse toxic goiter and autoimmune thyroiditis].

Statusmetry as a variant of a method of collective image recognition was used for evaluation of integral immunogenetic characterization of patients with toxic goiter (TG) and autoimmune thyroiditis (AT). Typing of 40 HLA antigens, class I, was performed in 114 TG patients, 106 AT patients and 500 healthy subjects, however this analysis employed the frequency of expression of 26 most informative specificities (9 alleles of locus A and 17 alleles of locus B of the HLA system). Functional models and decision rules to recognize TG, AT, remission and recurrence (decompensation) of TG were worked out. Recognition probability by the zero threshold was 68.4-78.3%. It was proposed that individual immunogenetic statusmetry should be used as part of diagnostic methods for TG and AT, their differential diagnosis, and a long-term prognosis of medicinal recurrence (decompensation) of TG.

Alleles↗
PubMedDate not supplied

[HLA antigens in diffuse toxic goiter].

The paper is concerned with some data of investigation of the association of the HLA-system with the development of diffuse toxic goiter (DTG). An attempt was made to predict clinical variants of a course of DTG using HLA-antigens. Comparative analysis of the distribution of HLA-antigens was performed in 50 patients with various degrees of DTG severity, different therapeutic methods (operative and conservative) and outcomes of disease (postoperative hypothyrosis, DTG recurrence and euthyroid condition). The data obtained confirmed a high informative value of HLA-markers not only for predicting clinical variants of a DTG course, therapeutic methods but also for outcomes of therapy.

Adult↗
PubMedDate not supplied

[Morphofunctional features of the thyroid gland in patients with diffuse toxic goiter].

A study was made of the morphometric, ultrastructural and functional features of the thyroid in patients with diffuse toxic goiter (DTG) (women aged 16 to 12) with positive and negative dynamics of body mass (groups 1 and 2, respectively). Proliferation of the thyroid epithelium, detected in DTG patients of the 1st group, can be regarded as a morphological criterion for making a decision of a necessity of surgical intervention.

Adolescent↗
PubMed1990

[Nodular forms of goiter as a cause of cancer of the thyroid gland].

The experience with diagnosis and treatment of struma maligna in 267 (5.5%) of the 4876 patients operated on for nodular forms of goiter is summarized. In the diagnosis, the puncture biopsy was widely used. Extrafascial resection of the thyroid gland with subsequent replacement therapy with thyroidin is a method of choice.

Adolescent↗
PubMed1990

[Role of Yersinia infection in the pathogenesis of diffuse toxic goiter].

Antibodies to Yersinia enterocolitica were tested in 87 patients with diffuse toxic goiter. They were detected in 32.1% of the patients and only 4.8% of the control group patients (p less than 0.01). The role of Yersinia infection in breakdown of natural tolerance to autologous thyroid tissue is discussed.

Adolescent↗
PubMedDate not supplied

Lack of response of peripheral blood mononuclear cells to thyroid microsomal antigen in nontoxic nodular goiters.

The production of interferon gamma (IFN gamma) by peripheral blood mononuclear cells (PBMC) from patients with nontoxic nodular goiter (NTNG), autoimmune thyroid disease (AITD), and normal persons (NL) has been studied in vitro, with the express object of comparing NTNG and AITD. PBMC were cultured with thyroid microsomal antigen (TMc), thyroglobulin (Tg), and liver microsomal antigen (LMc) at concentrations of 0, 1, 10, 100, and 1000 ng/ml for two days. IFN gamma was measured by a spot-ELISA technique which determines the number of cells secreting IFN gamma. There were no significant differences in the basal numbers of IFN gamma secreting cells between NL, AITD, and NTNG PBMC in this study. In AITD PBMC, TMc antigen caused a significant increase in the number of IFN gamma secreting cells, compared with the numbers in unstimulated AITD PBMC (percent IFN gamma secreting cells), whereas Tg and LMc antigen caused a significant decrease in all groups. The maximal percentage change in IFN gamma secreting cells (i.e., compared to unstimulated PBMC) did not increase significantly in NTNG in response to TMc antigen, in contrast to the AITD PBMC. Based on these findings, it is concluded that NTNG PBMC are not sensitized to the thyroid antigens tested; this is unlike the findings from AITD PBMC.

Adolescent↗
PubMed1990

[Two cases of mediastinal goiter with progressive deviation of the trachea by its growth and their thyroid hormone values in the fluid of the cystic lesions].

We reported two operated cases (a 35-year-old male and 52-year-old male) of mediastinal goiter accompanied by marked tracheal deviation. The two patients did not have any clinical symptoms. CT, MRI, ultrasonography and angiography finding of the two cases are presented. Fluid was obtained from the cystic lesions by ultrasonically guided needle aspiration. The levels of thyroid hormones (T3, T4) in the fluid were not high in comparison with serum levels. Surgical resection was performed on the 35-year-old male case by collar incision and on the 52-year-old male case by median sternotomy.

Adenoma↗
PubMed1986

[Effects of enzymatic deglycosylation of human goiter thyroglobulin on its immunochemical properties].

Thyroglobulin (Tg), isolated from soluble iodoproteins by ammonium sulphate fractionation, was enzymatically deglycosylated in vitro and analyzed by polyacrylamide gel electrophoresis, double immunodiffusion and non-commercial RIA. Carbohydrate and iodine content was chemically determined. By PAAGE deglycosylated Tg (dTg) showed the appearance of a major band in the 12S region and three slower migrating bands corresponding to higher aggregates than 19S Tg. In immunodiffusion by testing native and deglycosylated Tg against anti-native Tg antiserum it was shown the appearance of a spur of native on deglycosylated Tg. By RIA of native and deglycosylated Tg against anti-deglycosylated Tg antiserum it was shown a minor binding capacity of the anti-deglycosylated antibody against native Tg at high dilutions. The results demonstrate that the enzymatic deglycosylation release almost all the carbohydrates of goiter Tg and that the removal of the carbohydrates of Tg produces a loss of antigenic determinants of the molecule.

Electrophoresis, Polyacrylamide Gel↗
PubMed1989

A case of methimazole-induced hypothyroidism in a patient with endemic goiter: effects of endogenous TSH hyperstimulation after discontinuation of the drug.

Serum thyroid hormone and TSH concentrations were monitored in a patient with multinodular endemic goiter and severe methimazole (MMI) induced hypothyrodism up to 190 days after drug withdrawal. Serum concentrations of TT3, TT4 and TSH returned to normal values at the 6th., the 140th, and the 120th. day respectively. Within the first 20 days after MMI withdrawal the increase of serum T3 levels was correlated with the observed decrease of serum TSH concentrations. Successively T3 values decreased and T4 levels progressively increased. Six months after MMI withdrawal basal serum TSH concentration was normal while an exaggerated response to TRH was observed. We think that this peculiar hormone pattern is due to iodine depletion. In this case TSH hyperstimulation increases predominantly T3 secretion demonstrating the reduced thyroidal ability to produce T4 when hyperstimulated.

Female↗
PubMed1989

[Role of surgery in the treatment of simple nodular goiter].

On the basis of the pathophysiological data and their experience, the Authors believe that the medical treatment of non-toxic nodular goiter has many limitations. Furthermore, thyroid nodules may progress uncontrollably till to cancer. Surgery is safe in skilled hands, but in many cases it is necessary to remove the gland extensively. Thus, the best treatment is both medical and surgical, because prevention and cure are associated that way.

Female↗
PubMed1989

Frequency of medullary thyroid carcinoma in an endemic goiter area.

A series of 41 poorly differentiated follicular carcinomas of the thyroid gland without histopathological features of medullary or papillary carcinoma and 9 cases of undifferentiated thyroid carcinoma of the small cell type (diagnosed between 1967 and 1983) were investigated immunohistochemically. Two poorly differentiated follicular carcinomas showed a considerable number of calcitonin-positive cells in addition to the weakly thyroglobulin-positive tumor cells. One of these cases revealed several areas with calcitonin-positive tumor cells with additional squamous metaplasia with keratinization. No medullary carcinomas could be demonstrated among the 9 cases previously diagnosed as undifferentiated thyroid carcinomas of the small cell type. From the epidemiological point of view the application of immunohistochemistry does not significantly increase the proportion of medullary carcinomas detected in our endemic goiter area. The incidence of medullary carcinoma remains surprisingly low when compared with nonendemic areas.

Adenocarcinoma↗
PubMed1989

[Experimental goiter formation].

Nodules formation in goiter is still poorly understood due to the lack of an adequate animal model. The key role of iodine in the increased heterogeneity of iodine metabolism and in cold follicle formation has been demonstrated. Administration of iodide excess to goitrous mice induces follicle cell necrosis and thyroiditis. Necrosis and inflammation can be prevented by reducing the iodine dose, giving T3 or T4, or combining iodide with antithyroid drugs or vitamin E. This suggest that iodide toxicity is related to excessive production of free radicals. During inflammation, Ia positive interstitial cells were increased in number whereas no Ia expression was seen in follicular cells.

Animals↗
PubMed1989

[An epidemiological survey of goiter caused by excessive iodine in potable water in Cangzhou region].

This article describes a relationship between iodine and function and shape of thyroid gland. There was positive correlation between the prevalence rate of goiter and iodine content in drinking water [ln (10x)] and urine [ln (5x)]. Their curve fitting regression equations were y = 36.36 - 10.94 x + 0.83x2 and y = 22.39 - 6.36 x + 0.48x2 respectively. Use 3 per cent as criterion of disease area, threshold upper limit value of water and urinary iodine content should be 400 micrograms/L and 890 micrograms/gCr respectively.

Adolescent↗
PubMedDate not supplied

[Unusual tumor of the thyroid: amyloid goiter].

The goiter amyloid is an infrequent complication in the expanded symptomatic range of the generalized amyloidosis. Much more habitual alteration among the reactive secondary amyloidosis: it's characterized by a fast and progressive growth of the thyroid which can bring about compressive problems over the closest cervical structures. In the same way, it can be observed regarding to neoplastic process of the thyroid gland; either carcinoma medullary or another type. It is necessary its with a clear differentiation. We present you a case of a male suffering systematic reactive amyloidosis, secondary to bronquiectasys in the bosom of a pneumoconiosis, with an increase of serum figures of IgA.

Amyloidosis↗
PubMed1989

[Nodular goiter and cancer of the thyroid].

Among 3229 patients with diseases of the thyroid gland aged from 6 to 83 years there were 2924 patients who had nodular forms of goiter and 71 patients who had malignant tumors of the thyroid. Thyroidolymphography with aimed trepanbiopsy was used to make more exact diagnosis. Complex clinico-radiological examination, thyroidolymphography with aimed biopsy before operation are considered to facilitate making more exact diagnosis and choosing the adequate treatment.

Adolescent↗