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PubMed2006

A clear response.

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Anti-Bacterial Agents↗
PubMed1991

Nontuberculous mycobacterial sternal osteomyelitis in a patient without predisposing condition.

A woman is reported with a ten-year history of nonspecific chest pain. Bone scintigraphy showed increased local uptake, suggesting isolated sternal osteomyelitis. Radiographic investigations were positive 18 months later. Cultures of needle aspirations of the sternal bone marrow isolated Mycobacterium fortuitum as well as Mycobacterium simiae. Due to its indolent nature, nontuberculous mycobacterial disease is easily missed, especially in non-compromised hosts.

Adult↗
PubMed1990

Comparative post-antibiotic effect of five antibiotics against ten aerobic gram-positive cocci.

The post-antibiotic effect (PAE) is the persistent suppression of bacterial growth after a short antibiotic exposure. It is well documented with a variety of antibiotics and micro-organisms and may have important therapeutic implications. The authors have evaluated the PAE produced by teicoplanin, fucidin, gentamicin, rifampicin and ciprofloxacin against a total of ten Gram-positive organisms (S. aureus (2), MRSA (2), S. epidermis (2) S. haemolyticus (2) and E. faecalis (2)). All the organisms were clinical isolates with variable sensitivity patterns confirmed by disc and MIC testing. MICs were performed by the broth dilution method using a final inoculum of 10 x 5 cfu/ml. The PAE was estimated by adding 5 x MIC of each antibiotic to a log phase of growth of approximately 10 x 7 cfu/ml, and incubating at 37 degrees C for 1 h. Antibiotic was removed by 1000-fold dilution in nutrient broth, and total viable counts were carried out hourly by the Miles and Misra method for a further 9 h. All the antibiotics tested showed a PAE against the organisms tested, except for fucidin and ciprofloxacin against the enterococci. Overall, teicoplanin showed a maximum PAE of 5 h against MSRA and a minimum of 0.6 h against E. faecalis. Gentamicin, rifampicin and ciprofloxacin also showed a variable range. Fucidin showed the least PAE against the ten organisms, ranging from 0-1.3 h, except for S. epidermidis (FUC-R) which had a PAE of up to 4.5 h. The duration of PAE of each antibiotic/organism combination varied and was associated with the sensitivity pattern of the organism.(ABSTRACT TRUNCATED AT 250 WORDS)

Anti-Bacterial Agents↗
PubMed1979

[Epidermolysis bullosa dystrophica inversa, a review and case report].

An additional case of epidermolysis bullosa dystrophica inversa is reported. A review of the literature shows that until now reports about probably 15 patients from seven families were published, although the first 13 patients were not investigated by electron microscope [3]. By blistering beneath the basal lamina similar to the Hallopeau-Siemens type these patients develop bullae predominantly at the trunk and the inverse sites of the axillar and genitoanal regions continuously or at close intervals starting shortly after birth. The mucous membranes of the mouth, the esophagus, and the cornea and conjunctiva of the eye are very often involved. By bacterial infection of the skin lesions the patients develop hpochrome anemia. The web-like structures in the esophagus following blistering can be successfully treated by careful dilatation because of the low tendency to scar formation. An autosomal recessive mode of inheritance seems to be most likely.

Adolescent↗
PubMed1989

[Treatment of chronic osteomyelitis in Africa with plaster implants impregnated with antibiotics].

Nineteen African patients with osteomyelitis were treated by curettage of the lesions and packing of the bone cavities with plaster of Paris pellets containing antibiotics (Fucidin and Amoxycillin). Of 18 patients followed, 16 showed wound healing in an average of 3 to 6 weeks. Eight patients had regular roentgenographic examinations during a minimum of two months. In six of these patients, healing of the lesions and a significant osteogenic reaction were observed. The plaster pellets were resorbed in 3 to 6 weeks in all patients, and no signs of rejection were noted. In spite of insufficient follow-up due to medical conditions in Africa (Zaire), the study confirms the advantages of this simple treatment of osteomyelitis in underdeveloped countries.

Adolescent↗
PubMed1989

Rectal absorption enhancement of cefoxitin and desglycinamide arginine vasopressin by sodium tauro-24,25-dihydrofusidate in conscious rats.

The effects of sodium tauro-24,25-dihydrofusidate (STDHF), an enhancer of nasal insulin absorption, on the rectal absorption of cefoxitin and desglycinamide arginine vasopressin (DGAVP) were evaluated in the rat. Cefoxitin and DGAVP proved to be poorly absorbed rectally without STDHF, but their bioavailability was considerably increased by STDHF in concentrations of 0.15 to 8% w/v. Both rectal infusion and rectal bolus delivery resulted in complete cefoxitin absorption at 4% w/v of STDHF. Delivery rate appeared to be an important factor in the effect of 4% w/v of STDHF on DGAVP bioavailability; on infusion a mean DGAVP bioavailability (+/- S.D.) of 47 +/- 12% was obtained, whereas after bolus delivery it amounted to 27 +/- 6%. For both compounds the effect of STDHF was significant at 0.5% w/v. It is concluded that STDHF is capable of actively enhancing the rectal absorption of poorly absorbed drugs, including small peptides.

Animals↗
PubMed1988

Antistaphylococcal activity of teicoplanin in Riyadh, Saudi Arabia.

The antistaphylococcal activity of teicoplanin, a new glycopeptide antibiotic, has been evaluated in vitro and compared with that of vancomycin, fucidin, rifampicin and gentamicin. Teicoplanin was found to be as active as vancomycin against clinical isolates of Staphylococcus aureus (both methicillin-resistant and methicillin-sensitive strains). Teicoplanin was found to be more active than vancomycin against Staphylococcus epidermidis. The minimum inhibitory concentration (MIC) of teicoplanin was 2- to 4-fold lower than that of other drugs tested. The minimum bactericidal concentration (MBC) of both teicoplanin and vancomycin either equalled or exceeded by 2-fold the respective MIC's. The rate at which staphylococci were killed showed that teicoplanin at 4 X MIC produced rapid killing in 10 h and no growth was detected after 24 h.

Fusidic Acid↗
PubMed1988

A study of fucidin uptake in ischaemic tissues.

Twenty-five patients undergoing vascular surgery were given Fucidin 500 mg t.d.s. for the 3 days prior to surgery. Serum and fat levels obtained at the time of surgery show that the antibiotic is well absorbed and penetrates relatively ischaemic tissues. The levels obtained greatly exceed the MIC for Staphylococcus aureus.

Adipose Tissue↗
PubMed1978

[Chemotherapy of experimental lactational mastitis in mice].

More severe mastitis on infection with Proteus was shown on a standardized model of experimental lactation mastitis of mice caused by Staphylococcus, Proteus and their mixture. Significant differences in the morphological pictures of the staphylococcal and Proteus mastitis were noted. A pronounced effect was observed with the use of kanamycin in combination with fuzidin in treatment of experimental mastitis of various etiology.

Animals↗
PubMed1986

Treatment of skin diseases of mixed aetiology in outpatients.

Forty patients with skin diseases were treated by the simultaneous application of three creams, the respective bases of which were beclomethasone dipropionate, sodium fusidate and ketoconazole. The treatment yielded positive results in 92.5% of the treated cases with good relief of symptoms, arrest of growth of pathogenic agents, and good local and systemic tolerance. No adverse reactions of any kind were observed.

Administration, Topical↗