[Longitudinal study of changes in heart activity and peripheral circulation during the learning stage of autogenic training (author's transl)].
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Adolescent↗
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Relation of smoking and low-to-moderate alcohol consumption to change in cognitive function: a longitudinal study in a defined community of older persons.
To determine whether smoking habits and alcohol consumption are related to changes in cognitive function, the authors conducted a prospective, community-based study of persons aged 65 years and over in East Boston, Massachusetts. In 1982 and again in 1985, the subjects were given three brief tests of cognitive function: immediate memory, digit span, and a mental status questionnaire, which primarily assessed orientation. The 1,201 individuals who performed well in 1982 were included in linear regression analyses of 3-year change in performance, adjusted for age, sex, education, and income. Relative to nonsmoking, current smoking, past smoking, and pack-years were not significantly related to change in immediate memory. None was significantly related to change in orientation. Only pack-years was significantly related to normal change score in digit span (normal change score change per unit of predictor = 0.001, 95% confidence interval 0.0003-0.002). Low-to-moderate alcohol consumption during the month preceding baseline testing was not significantly related to a subsequent 3-year change in performance in two of the three tests. However, people who consumed a very small amount of alcohol had a normal change score that was 0.088 (95% confidence interval 0.015-0.160) better for digit span than did nondrinkers. This study provides evidence that the reported levels of smoking and alcohol use among older persons are not consistent or substantial predictors of the longitudinal change in cognitive function observed in a community.
Aged↗
[Changes in the locomotor activity of muscles of the forelimb of the guinea pig during translation of the animal with respect to the longitudinal axis].
Changes in spontaneous locomotor activity of forelimb muscles evoked by adequate stimulation of vestibular system were investigated in decerebrated guinea pigs. Extensor activity in stance phase increased and flexor activity in swing phase decreased during a tilt ipsilateral to the prepared limb, opposite changes were observed during the contralateral tilt. The alternation pattern of antagonist muscle activity was not changed. Revealed changes in the locomotor activity were more pronounced during cyclic shifts than during fixed tilts.
Animals↗
Longitudinal dento-skeletal changes in UCLP patients following maxillary distraction osteogenesis using RED system.
Longitudinal dento-skeletal changes in unilateral cleft lip and palate (UCLP) patients following maxillary distraction osteogenesis using the rigid external distraction device (RED) were analyzed. Twelve Japanese non-syndromic UCLP patients who underwent maxillary distraction at the mean age of 16.4 years were used as subjects. Serial sets of lateral cephalograms, taken at 4 stages: 1) before osteotomy, 2) immediately after distraction, 3) 6 months and 4) 12 months post-osteotomy, were analyzed. Statistical analyses, including a paired t test, Pearson correlation analysis and stepwise linear regression analysis, were performed to distill characteristic dento-skeletal changes. In accordance with maxillary advancement, significant amounts of up-forward movement of the nasal bone, mandibular rotation and maxillary dental changes were observed. Maxillary dental changes were significantly related to the amount of mandibular rotation and force system of maxillary traction. Significant dento-skeletal relapse was found to occur during the 0-to-6-month follow-up period, but not in the 6-to-12-month follow-up period. Maxillary relapse was significantly related to the amount of maxillary advancement and severity of pre-surgical maxillary hypoplasia, while mandibular relapse was significantly related to maxillary dento-skeletal relapse. Successful clinical application of this procedure therefore requires consideration of both the surrounding dento-skeletal changes and the traction force system.
Adolescent↗
Pubertal development in Caracas upper-middle-class boys and girls in a longitudinal context.
Changes between pubertal stages (PS) are best analyzed in a longitudinal context. A sample of 67 boys and 48 girls from the Caracas Longitudinal Study who presented data for the full range of pubertal development: genitalia (G2-G5), breast (B2-B5), pubic hair (PH2-PH5), axillary hair (AH2-AH3), and age at menarche (AM) during follow-up, were assessed at clinical examination. Medians and standard errors for ages at each stage were estimated with the logit method. For length of intervals between stages of genitalia, breast, pubic hair and axillary hair, intervals B2-M and PH2-M, survival analysis was used according to life tables and Cox regression analysis. In boys, G2 occurred at 11.61 years; in girls, B2 occurred at 10.35 years and AM at 12.55 years of age. In both sexes, length of the intervals PS 2-3 and 3-4 were approximately 1 year, while PS 4-5 was 1.5 years. Duration of puberty reached 3.7 years in boys (G2-G5) and 3.3 years in girls (B2-B5); corresponding intervals for PH2-PH5 were 3.1 and 3.0 years in boys and girls, respectively. B2-AM was 1.8 years (with a range of 0.3-3.6 years) and PH2-AM was 1.5 years (with a range 0.3-3.5 years). These results are useful for screening and monitoring: identifying abnormal pubertal patterns in subjects who are advanced or delayed with respect to their peers, together with other pubertal events such as age at peak height and weight velocity and skeletal age. Am. J. Hum. Biol. 12:88-96, 2000. Copyright 2000 Wiley-Liss, Inc.
Journal Article↗
Changes in reversal of cupping in experimental glaucoma. Longitudinal study.
BACKGROUND: The authors prospectively and longitudinally studied changes in optic disc topography during spontaneous reduction of intraocular pressure (IOP) in five monkeys with experimental glaucoma, using a computerized image analyzing system (Topcon IMAGEnet). METHODS: Glaucomatous optic neuropathy was produced in one eye of each animal by repeated argon laser photocoagulation of the trabecular meshwork. The duration of follow-up was 12 months. After laser treatment, IOP fluctuated and tended to increase. Spontaneous reduction in IOP was frequently observed during follow-up. Changes in optic disc parameters (vertical and horizontal cup-to-disc ratios, rim area/disc area, cup volume/disc area) that accompanied a given magnitude of spontaneous reduction in IOP at the early stage of glaucoma (first 4 months of follow-up) were compared with those at the later stage of glaucoma (last 4 months of follow-up). RESULTS: All optic disc parameters improved significantly during IOP reduction at each stage of glaucoma. Although there was no significant difference between the two stages in the magnitude of IOP reduction, the extent of improvement in each disc parameter was significantly less in the later stage than in the early stage. In both stages, reversal of cupping occurred symmetrically in the vertical and horizontal dimensions. Expansion of the cup occurred symmetrically in the early stage, but this was predominantly vertical in the later stage. CONCLUSION: These results suggest that the extent of cupping reversal after IOP reduction may decrease with progressive glaucomatous damage in primate glaucoma.
Animals↗
[Variations in blood lipid levels in adolescents: relation to changes in lifestyle. A longitudinal approach].
In order to assess the relationship between changes in life style (taking up smoking, giving up sporting activity) and plasma lipids, 3,650 young subjects aged 14 to 18 years, from the Lorraine region, were examined on two occasions separated by a 5 year interval. At the second examination, 39% of the boys and 33.8% of the girls had taken up smoking, and 52% of the boys and 68% of the girls had given up strenuous physical activity. These changes in life style were associated with a significant change in total cholesterol in boys and also of triglycerides after adjustment of values for age and variation in body mass: starting smoking or the giving up of sporting activities was associated with a greater increase in cholesterol and triglyceride levels. These results underline need for increasing efforts in the prevention of cardiovascular disease in young subjects, and emphasise the importance of maintaining physical activity and of not smoking.
Adolescent↗
[Longitudinal study of the changes in glycosylated hemoglobin in normal pregnancy].
A longitudinal study of HbA1c levels during normal pregnancy was carried out on 54 women. Three measurements were systematically performed around the 14th, the 24th and the 33rd weeks of gestation. On average, an initial decrease was observed in the first period, followed by a significant increase in the second period. The latter increase was negatively related to age (r = -0.33; p less than 0.05) and to prepregnancy weight (r = -0.26; p = 0.06), but neither to the birth weight of the offspring nor to total weight gain. The variation of HbA1c in the first period was not related to any of these four factors.
Adult↗
Age-associated changes in blood pressure in a longitudinal study of healthy men and women.
BACKGROUND: Current knowledge of age-associated increases in blood pressure is based primarily on unscreened population studies that may not be representative of healthy men and women. We examined longitudinal patterns of change in blood pressure in healthy male and female volunteers from the Baltimore Longitudinal Study of Aging (BLSA). METHODS: Longitudinal mixed-effects regression models are used to estimate the age-associated changes in blood pressure in 1307 men (age 17-97) and 333 women (age 18-93) who have been followed for up to 32 years (mean: 8.4 years for men and 3.4 years for women) and who have been screened for health problems or medications that affect blood pressure. RESULTS: On average, systolic pressure is relatively stable in men and women until approximately age 45, increases at 5-8 mm Hg per decade in middle age, then accelerates in men and stabilizes in women. Diastolic pressure increases at 1 mm Hg per decade at all ages in men, whereas in women the rate of change in diastolic pressure increases in middle age and then plateaus and may decline after age 70. Additional findings include: (a) BLSA cross-sectional and longitudinal findings are more similar than has been observed in studies of unscreened samples; (b) there is no evidence of a gender cross-over in this group of healthy men and women; and (c) compared to previous studies of unscreened samples, healthy BLSA men and women show a weaker association between baseline blood pressure and subsequent rate of blood pressure change. CONCLUSIONS: These findings suggest that several previously described age-associated patterns of blood pressure change partially reflect the effects of hypertension and its treatment, rather than intrinsic age changes in the blood pressure of healthy individuals.
Adolescent↗
Childhood and pubertal growth changes of the human symphysis.
Longitudinal growth changes of the human symphysis were evaluated for 75 children (37 males and 38 females) between 6 and 15 years old. Childhood growth was described by mean yearly rates of change between 6 and 10 years for females and between 7 and 11 years for males; pubertal changes pertain to growth between 10 and 14 for females and between 11 and 15 for males. Cephalometric tracings of the mandible were superimposed using stable reference structures. Vertical growth changes, particularly for landmarks located in the upper 20% of the symphysis, were most pronounced. Annual rates of vertical growth ranged between 0.9 mm/yr for the lingual incisor contact point to -0.2 mm/yr for gnathion. Males showed significantly greater rates of vertical growth than females, especially for the upper half of the symphysis. Vertical growth rates were also greater during puberty than during childhood. The horizontal growth changes indicated lingual movement of most symphyseal landmarks. Annual rates of growth were greatest for landmarks located in the upper half of the symphysis. B-point showed the greatest lingual drift. During puberty, the mandibular incisors in females moved lingually as the upper anterior half of the symphysis remodeled; in males, the incisors maintained their horizontal position as the labial sulcus developed.
Adolescent↗
The assessment of fetal brain morphology and circulation by transvaginal 3D sonography and power Doppler.
OBJECTIVE: The objective of this article is to describe the use of transvaginal 3D ultrasound in prenatal neuroimaging and to investigate its clinical usefulness. METHODS: Firstly, 18 fetuses with hydrocephalus, ventriculomegaly and/or space occupying lesion were examined by transvaginal 3D sonography, and fetal CNS abnormalities were evaluated. Multiplanar image analysis and volumetric assessment were performed off-line. Longitudinal volume changes of target structure were evaluated, and usefulness of transvaginal 3D ultrasound was evaluated. Secondly, in 56 normal cephalic fetuses of between 18 and 32 weeks, 3D Doppler volume acquisition and reconstruction of the intracranial vascular structure were performed. RESULTS: Longitudinal changing appearance in the same cutting section of the enlarged ventricle or cystic lesion could be demonstrated in all cases and volumetric assessment was also successful in all cases. Longitudinal objective data were useful in the brain assessment, consultation and counselling. 3D Doppler acquisition time was 5.6-26 seconds and symmetrical 3D reconstruction was successful in 51.8%. CONCLUSION: Transvaginal 3D imaging technology provides us with not only comprehensive intracranial images in exactly the right sections, but also with objective volume data. Prenatal information with objective data analyses is useful in consultation for both specialists and parents, and leads to proper management of CNS diseases.
Brain↗
Evidence that the apolipoprotein E-genotype effects on lipid levels can change with age in males: a longitudinal analysis.
We previously reported that change, with age, in plasma levels of total cholesterol (TC) and LDL cholesterol (LDL-C) differed between apolipoprotein E (APOE) genotypes epsilon 3 epsilon 3 and epsilon 3 epsilon 4, in a sample of 77 older, unrelated males. By use of a larger sample from that cohort, followed longitudinally during 1969-87, the change in TC and in LDL-C, between the epsilon 3 epsilon 3 and epsilon 3 epsilon 4 APOE genotypes, over three exams, was reanalyzed. Additionally, the change in triglycerides (TG) and in HDL-cholesterol (HDL-C), between the epsilon 3 epsilon 3 and epsilon 3 epsilon 4 APOE genotypes-as well as the differences between the epsilon 3 epsilon 3 and epsilon 3 epsilon 2 genotypes, for TC, LDL-C, TG, and HDL-C-were contrasted over the three exams. At exam 1 TG was higher in the epsilon 3 epsilon 4 group than in the epsilon 3 epsilon 3 group (mean age 48 years), and at exams 2 and exam 3 (mean ages 58 and 63 years, respectively) it was similar (P = .009 for the exam-by-genotype-interaction effect in the repeated-measures analysis). A similar trend was seen for TC (P = .03), yet previously detected LDL-C effects were not apparent (P = .46). Those with the epsilon 3 epsilon 2 genotype had higher TG and lower LDL-C and TC at each exam than were seen in those with the epsilon 3 epsilon 3 genotype, although the differences in the values were not always statistically significant. Differences in TC, LDL-C, and TG, between the epsilon 3 epsilon 2-genotype and epsilon 3 epsilon 3-genotype groups, did not significantly change over the three exams. HDL-C levels were relatively stable over the exams; however, the exam-by-genotype interaction was significant for the epsilon 3 epsilon 2 genotype versus the epsilon 3 epsilon 3 genotype (P = .02). The epsilon 4 allele effects on TG and TC changed between longitudinal exams and may be age dependent. Changes, with age, in the effect of the epsilon 3 epsilon 4 genotype on lipids may impact the risk of developing atherosclerotic disease.
Aged↗
Physiological age-related changes: cross-sectional and longitudinal studies.
Physiological age-related changes were investigated by cross-sectional and longitudinal studies. The data of the study were derived from volunteers admitted to the Gerontology Center in Budapest. In the follow-up study 864 subjects took part, and in the cross-sectional study 2,281 individuals. The 20-year longitudinal study and the cross-sectional examination showed that from a clinical standpoint the most important observation is that several biochemical data do not change with age. No changes were found in the values in erythrocyte sedimentation, hemoglobin, hematocrit, serum total protein, albumin, liver function, glucose, creatinine, triglyceride, and HDL-cholesterol levels. Changes were observed in the levels of HDL-cholesterol, immunoglobulins, rheumatoid factors, antinuclear factors, morphology of lymphocytes, serum TSH and T3 concentration, and systolic blood pressures.
Aged↗
Longitudinal patterns of regional change on volumetric MRI in frontotemporal lobar degeneration.
The aim of this study was to assess the longitudinal patterns of regional change in the different syndromic variants of frontotemporal lobar degeneration (FTLD). Ten patients with semantic dementia, 7 with progressive non-fluent aphasia and 29 with frontotemporal dementia had two serial volumetric MR scans. Fluid registration was used to match serial scans from each individual. Voxel-level analysis of change across subject groups was performed using statistical parametric mapping. The analysis showed patterns of increased rates of volume loss (atrophy) in frontal, temporal and parietal regions in the whole FTLD group compared with controls. The different FTLD syndromes displayed different patterns of change. This technique gives an insight into disease evolution over time in these disorders and may be useful as a method of tracking change in clinical trials.
Aged↗
A prospective longitudinal study on periodontal bone height changes in a Swedish population.
BACKGROUND, AIMS: This investigation was performed to assess longitudinal changes in periodontal bone height in an adult population over a period of 17 years. METHODS: In 1973, a random sample of 1000 individuals aged 3-70 years in the city of Jönköping, Sweden, was examined clinically and radiographically to assess dental status and treatment needs. Out of the 574 dentate individuals 15-60 years, 433 accepted the invitation and were re-examined in 1989-91, 4 were edentulous and the study therefore finally included 429 dentate individuals. The examination included full mouth plaque and gingivitis scores and bone height measurements on full mouth intra-oral radiographs. All age groups except the youngest had very good oral hygiene with 50% or more having plaque and gingivitis scores below 20%. RESULTS: From the age of 20, there was a general pattern of bone height reduction over time corresponding to an annual loss of around 0.1 mm. From the age of 30 years, about 80% of the population had one or more sites with bone loss of 10% or more. Very few individuals, about 5%, exhibited an individual mean bone loss of 2 mm or more. 17% had > or =6 such sites indicating destructive periodontal disease. These individuals and sites could not be identified in advance based only on previous disease experience.
Adolescent↗
Professional socialization in dentistry. A longitudinal analysis of attitude changes among dental students towards the dental profession.
In a longitudinal study conducted as part of a broad project dealing with socialization of health professionals in Israel, it was observed that during the course of professional socialization several major transformations occur in the dental student's image of the 'competent' dentist and in his self-image as a professional. Although students initially emphasized people-oriented traits as important to the competent dentist, this emphasis gradually decreased as their professional socialization advanced, concomitant with an increase in importance placed on status-oriented traits. The people-oriented elements likewise decreased in importance with regard to the student's self-image as professionals as they became more accustomed to professional reality. The correlation between these variables indicates the changes occurring in the students' acceptance or rejection of various aspects of their chosen profession throughout their years of study.
Attitude of Health Personnel↗
Premenarcheal expectations and postmenarcheal experiences of positive and negative menstrual related changes.
PURPOSE: Longitudinal examination of early adolescent girls' premenarcheal expectations and postmenarcheal experiences of positive and negative menstrual related changes. METHOD: Ratings of 14 positive and negative changes were made by 80 girls on three occasions: (1) in grade 6 when girls were premenarcheal, (2) at the test occasion within six months after each girls' own menarche, and (3) in grade 9 when girls were postmenarcheal. Premenarcheal girls rated expectations of changes, and postmenarcheal girls rated experiences of changes, for both premenstrual and menstrual phases. Girls also rated preparation for, and emotional response to, menarche and mothers' helpfulness on the first two occasions. RESULTS: Ratings for positive and negative changes were at similar levels premenarcheally and decreased at menarche; once menstruation became established, ratings of negative changes increased while those of positive changes decreased. Ratings for negative changes were higher in the menstrual phase, while ratings for positive changes were higher in the premenstrual phase. Premenarcheal expectations of changes contributed to the prediction of menarcheal experiences of changes. Premenarcheal expectations and menarcheal experiences, along with anticipated emotional response to menarche, contributed to the prediction of longer-term experience of negative changes; menarcheal experiences, along with preparation for and emotional response to menarche, contributed to the prediction of longer-term experience of positive changes. CONCLUSIONS: Both expectations about, and initial experiences of, menstrual cycle-related changes were associated with longer-term menstrual experiences. The different outcomes for positive and negative changes have implications for menstrual socialization, and provide the basis for some optimism about facilitating a more complex and multidimensional understanding of menstruation.
Adolescent↗
Accuracy of equations for predicting stature from knee height, and assessment of statural loss in an older Italian population.
We determined the applicability of deriving the stature from knee height in an older Italian population, and, in the same population, we assessed longitudinally the change in stature over a 6-year interval. The standing stature and knee height in a supine position were measured in the entire home-dwelling older (65 + years) population of a small Italian town (N = 606). Stature measured in 1989 and in 1995 was used to assess longitudinal changes in 258 subjects of the same population. Stature derived from knee height was greater than measured stature in this population and in the two sexes. This difference disappeared when subjects with evident kyphosis were excluded. From 1989 to 1995, stature decreased by 1.7+/-3.0 cm, with women showing a larger decrement than men. Stature estimated from knee height is more accurate than measured stature in subjects with kyphosis. In accordance with previous studies, stature decreases with aging, and such height loss is greater in women than in men.
Aged↗