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PubMed1982

Presence, introduction and removal of mutagenic activity during the preparation of drinking water in the Netherlands.

A survey of the presence of mutagenic activity in drinking water of 18 cities in the Netherlands revealed that in drinking water of 13 cities mutagenic activity could be demonstrated. The activity was detected in the Ames test after concentrating the organic mutagens with a XAD-4/8 procedure. Dose-related responses were observed with concentrates corresponding to 0.5 to 3.0 liters of drinking water. A study of the changes in mutagenic activity during the preparation of drinking water in a few waterworks showed that breakpoint chlorination, transport chlorination and post chlorination increased the mutagenic activity, while ozonation only reduced the activity with metabolic activation. When adsorption on activated carbon powder was used, a certain reduction of mutagenic activity was observed. The use of activated carbon filters, however, removed the activity completely. The majority of organic mutagens present in drinking water concentrates were shown to be nonvolatile and relatively stable and probably consist of compounds with a molecular weight in the order of 200. These mutagens are not identical to the organics identified up till now in drinking water by standard gas chromatography/mass spectrometry analysis. Finally, a group of organic mutagens, which adsorbs only at pH 2-3 on XAD-4/8 (acid fraction), could be demonstrated in Ames-positive drinking waters.

Chlorine↗
PubMed1993

Effects of drinking water monochloramine on lipid and thyroid metabolism in healthy men.

The purpose of this study was to determine whether a 4-week consumption of 1.5L per day of drinking water containing monochloramine at a concentration of 2 ppm (ppm = mg/L) or 15 ppm under controlled conditions would alter parameters of lipid or thyroid metabolism in healthy men. Forty-eight men completed an 8-week protocol during which diet (600 mg cholesterol per day, 40% calories as fat) and other factors known to affect lipid metabolism were controlled. During the first 4 weeks of the protocol, all subjects consumed distilled water. During the second 4 weeks, one-third of the subjects were assigned randomly to drink 1.5 L per day of water containing 2 ppm of monochloramine, to drink 1.5 L per day of water containing 15 ppm monochloramine, or to continue drinking distilled water. Four blood samples were collected from each subject at the end of each 4-week study period. Subjects drinking monochloramine at a concentration of 2 ppm showed no significant changes in total cholesterol, triglycerides, HDL cholesterol, LDL cholesterol, apolipoproteins A1, A2, or B when compared to the distilled water group. Parameters of thyroid function also were unchanged by exposure to monochloramine at this concentration. However, subjects drinking monochloramine at a concentration of 15 ppm experienced an increase in the level of apolipoprotein B. Other parameters of lipid and thyroid metabolism did not change. We conclude that consumption of drinking water containing 2 ppm of monochloramine does not alter parameters of lipid and thyroid metabolism in healthy men. Consumption of water containing 15 ppm monochloramine may be associated with increased levels of plasma apolipoprotein B.

Adolescent↗
PubMed1999

Excretion of arsenic in urine as a function of exposure to arsenic in drinking water.

Urinary arsenic (As) concentrations were evaluated as a biomarker of exposure in a U.S. population chronically exposed to inorganic As (InAs) in their drinking water. Ninety-six individuals who consumed drinking water with As concentrations of 8-620 microg/L provided first morning urine voids for up to 5 consecutive days. The study population was 56% male, and 44% was younger than 18 years of age. On one day of the study period, all voided urines were collected over a 24-hr period. Arsenic intake from drinking water was estimated from daily food diaries. Comparison between the concentration of As in individual urine voids with that in the 24-hr urine collection indicated that the concentration of As in urine was stable throughout the day. Comparison of the concentration of As in each first morning urine void over the 5-day study period indicated that there was little day-to-day variation in the concentration of As in urine. The concentration of As in drinking water was a better predictor of the concentration of As in urine than was the estimated intake of As from drinking water. The concentration of As in urine did not vary by gender. An age-dependent difference in the concentration of As in urine may be attributed to the higher As dosage rate per unit body weight in children than in adults. These findings suggest that the analysis of a small number of urine samples may be adequate to estimate an individual's exposure to InAs from drinking water and that the determination of the concentration of InAs in a drinking water supply may be a useful surrogate for estimating exposure to this metalloid.

Adolescent↗
PubMedDate not supplied

Entertainment and music magazine reading and binge drinking among a group of juvenile offenders.

This study examines the relative contribution of exposure to entertainment and music magazines on binge drinking among a group of teenagers under the supervision of a juvenile court system in a medium-sized western United States community. Despite having a large proportion of adolescent readers, entertainment and music magazines typically include a substantial number of advertisements for alcoholic beverages in each issue. Data were collected via a self-report questionnaire administered to 342 juvenile offenders (ages 12-18 years). Three-quarters of our respondents reported they have used alcohol and about 37% indicated they were binge drinkers. As anticipated, binge drinkers were more frequent readers of entertainment and music magazines than non-binge drinkers. Binge drinkers also estimated that larger portions of their classmates used alcohol and would be more accepting of regular drinking than non-binge drinkers. Results of a multivariate logistic regression analysis to predict whether our subjects typically consumed five or more drinks during a drinking episode indicated that perceived ease of access, age, gender, the number of best friends who drink, parental drinking (inversely), and entertainment and music magazine reading frequency were significant predictors of binge drinking. We conclude that the predictive influence entertainment and music magazine reading frequency may actually reflect a selectivity bias among a segment of the youth sub-culture already inclined toward alcohol use and abuse. We recommend that entertainment and music magazine reading should be considered only within the constellation of other risk factors when assessing risk for potential alcohol abuse.

Adolescent↗
PubMedDate not supplied

Heavy drinking and patterns of sociability at the end of adolescence: a French survey.

UNLABELLED: Many alcohol-related problems at adolescence occur during or as a result of peer-oriented activities, so it is necessary to understand how drinking habits are embedded in sociability and lifestyle. OBJECTIVE: to study patterns of peer-oriented activities among heavy drinkers, and to investigate factors associated with these patterns. STUDY GROUP: A national random sample of 13,623 French adolescents aged 17-18 years, and a subgroup of 762 heavy drinkers (reporting either 20 drinking occasions or more during the prior 30 days, or 20 episodes of drunkenness or more during the previous 12 months). METHODS: Respondents answered to a self-administered closed-ended questionnaire. Questions on peer-oriented activities were used for conducting a cluster analysis among heavy drinkers. Logistic regressions were used for studying factors associated with the resulting clusters. RESULTS: Among heavy drinkers the dominant pattern was characterized by the combination of heavy drinking and peer-oriented activities. But in two other profiles heavy drinking was associated with either strong involvement in formal sporting practice or low participation in peer-oriented activities. The expected relationship between heavy drinking, mood disorders, other drug use, violence and victimization depended on which pattern was considered. CONCLUSIONS: The strong links observed between drinking habits and sociability underline the need to counteract the social acceptability of drinking and focus on the social contexts in which it occurs, but preventive action programs should also take into account the diversity of sociability patterns among heavy drinkers.

Adolescent↗
PubMed1992

Defining patterns of drinking in adolescence: a cluster analytic approach.

Most empirical approaches to defining patterns of adolescent alcohol consumption focus on frequency of drunkenness. In an attempt to define patterns of drinking in a more comprehensive way, the present study used measures of social context in addition to frequency and quantity of alcohol use. Subjects' scores on frequency, quantity and five social context variables were cluster analyzed separately for males and females. Results yielded four socially appropriate drinking patterns and three problem drinking patterns (two for males and one for females). Socially appropriate patterns for both sexes were light drinkers, light party drinkers, family drinkers and dating drinkers. Problem drinking patterns included school drinkers and solitary/stranger drinkers for males, and solitary/school drinkers for females. These groups of subjects showed significant differences on reasons for drinking and on drinking consequences even after differences due to frequency and quantity were statistically controlled. Effects of drinking primarily attributable to frequency and quantity appeared to be limited to differences concerning the physiological effects of alcohol.

Adolescent↗
PubMed1998

Twelve-month abstinence from alcohol and long-term drinking and marital outcomes in men with severe alcohol problems.

OBJECTIVE: Clinical and research data suggest that drinking behavior during the first year following treatment for alcohol problems may predict longer term drinking and functioning in other areas. The purpose of this study was to investigate the relationship between abstinence from alcohol during the first year following group behavioral marital therapy (BMT) for alcohol problems and drinking and marital functioning through 30 months post-group BMT. METHOD: The subjects were 73 white male veterans with severe alcohol problems who participated in a clinical trial of group BMT and individual BMT aftercare. All subjects who entered the clinical trial were classified as either abstinent from alcohol for the full first 12 months following completion of group BMT, or not. Following completion of group BMT, subjects were reevaluated on drinking, marital functioning and related behaviors at 3, 6, 12, 18, 24 and 30 months later. RESULTS: Outcome analyses, taking into account baseline differences between drinker groups on age, marital functioning and number of days light drinking, showed better alcohol use (18, 24 and 30 months) and marital functioning (6, 12, 18, 24 and 30 months) for the first-year abstainers. Furthermore, fewer first-year abstainers than drinkers reported they were hospitalized for alcohol-related reasons at the 18-, 24- and 30-month follow-ups, and the abstainers showed a greater degree of self-efficacy not to drink heavily at each of the 6-, 18- and 30-month follow-ups. CONCLUSIONS: The data are consistent with the literature in showing the prognostic value of first-year post-alcohol treatment abstinence for drinking and functioning in other life areas in the longer term. The findings suggest that at least shorter term abstinence should be considered as an outcome goal for individuals who present to alcohol treatment settings.

Adult↗
PubMed1999

Drinking to cope with negative affect and DSM-IV alcohol use disorders: a test of three alternative explanations.

OBJECTIVE: Previous studies of drinking motives have demonstrated greater levels of drinking to cope with negative affect among problem drinkers relative to nonproblem drinkers. These findings suggest that the use of alcohol to cope with negative affect may place individuals at greater risk for the development of alcohol problems. However, several alternative explanations exist, each with different intervention implications. This study evaluated three alternative explanations or models: risk-factor, generalizing, and epiphenomena. A cross-sectional design was used to compare levels of self-reported drinking to cope with negative affect between individuals who had current DSM-IV alcohol use disorders and those who did not. METHOD: Participants consisted of a sample of community residents (N = 777, 55% men). All participants completed an in-person structured psychiatric interview and a self-report questionnaire assessing alcohol use, drinking motives, depressive affect, and negative alcohol consequences. RESULTS: Linear regression models yielded significant differences in mean drinking to cope with negative affect scores between participants with a DSM-IV alcohol dependence diagnosis and participants with no diagnosis. These differences remained after controlling for depressive affect and frequency of negative alcohol consequences in three of the four adjusted comparisons. No significant differences in adjusted mean drinking to cope with negative affect scores were demonstrated between subjects with a DSM-IV alcohol abuse diagnosis and those with no diagnosis. CONCLUSIONS: The DSM-IV alcohol dependence and no-diagnosis comparisons were most consistent with the predictions of a risk-factor model. These results provide further evidence that drinking to cope with negative affect may have an etiological role in development of alcohol dependence.

Adolescent↗
PubMed2000

Examining drinking patterns and problems among hispanic groups: results from a national survey.

OBJECTIVE: This study examines and compares the drinking patterns and problems of members of four Hispanic groups (Cubans, Mexican Americans, Puerto Ricans and other Hispanics) in the United States, with information presented by gender and age. METHOD: The 1993 National Household Survey on Drug Abuse, a recent national probability sample of the household population aged 18 and over in the United States, is used. Data are obtained through in-person interviews. The sample includes 4,462 Hispanics of Cuban (n = 620), Mexican (n = 2,467), Puerto Rican (n = 619) and Central and South American (n = 756) origin. Analyses are conducted using SUDAAN. RESULTS: There are significant differences across the Hispanic groups in their drinking patterns and problems. Among men, Mexican Americans report the most frequent and heavy drinking, and the greatest prevalence of drunkenness and alcohol-related problems. Cubans report the lowest percentages of such respondents, and Puerto Ricans and other Hispanics are in between the other two groups. For women, fewer ethnic differences are evidenced than for men. In general, Puerto Ricans and Mexican Americans drink more often and heavily and experience more problems than the other groups. Even after controlling for predictors of adult alcohol use, some ethnic differences in drinking persist. CONCLUSIONS: The four Hispanic groups have different drinking patterns. More research is necessary to determine the factors associated with differences in drinking across Hispanic groups.

Adolescent↗
PubMed2001

Successful remission of late-life drinking problems: a 10-year follow-up.

OBJECTIVE: This study sought to determine (1) the rate and predictors of long-term remission among a sample of untreated late-life problem drinkers and (2) whether successfully remitted older problem drinkers attain levels of functioning and life contexts comparable to those of lifetime nonproblem drinkers at a 10-year follow-up. METHOD: We compared 140 older baseline problem drinkers who were successful in achieving long-term remission to 184 baseline problem drinkers whose drinking problems did not remit over the course of 10 years and to 339 lifetime nonproblem drinkers, on functioning and life contexts at baseline and at 4- and 10-year follow-ups. RESULTS: Being female, having more recent onset of drinking problems, fewer and less severe drinking problems, friends who approved less of drinking, and drinking less and drinking less frequently at baseline predicted long-term remission. In many regards, long-term remitted problem drinkers attained levels of functioning and life context similar to those of lifetime nonproblem drinkers. However, remitted problem drinkers continued to report more incipient drinking problems, depressive symptoms, health and financial stressors, psychoactive medication use, reliance on avoidance coping strategies and less social support from friends than did lifetime nonproblem drinkers at the 10-year follow-up. CONCLUSIONS: About a third (30%) of an untreated sample of late-life problem drinkers succeeded in attaining stable, long-term remission. The functioning and life contexts of untreated remitted problem drinkers improved significantly over time; however, some deficits persisted at follow-up.

Adaptation, Psychological↗
PubMed2002

Iodine in drinking water in Denmark is bound in humic substances.

OBJECTIVE: The iodine intake level is important for the occurrence of thyroid disorders in a population. We have previously found that iodine in drinking water is related to iodine excretion but whether iodine is present as iodide or bound in other molecules remains unknown. DESIGN: We measured iodine in drinking water from 22 locations in Denmark. Six locations were selected by iodine content for further tap water analysis (Skagen 140 micro g/l, Samsoe 56 micro g/l, Nykoebing S. 50 micro g/l, Nakskov 40 micro g/l, Ringsted 38 micro g/l, Copenhagen 19 micro g/l). METHODS: HPLC size exclusion before (Skagen) and after (all sites) freeze drying and measurement of absorbance (280 nm) and iodine in fractions, and fluorescence spectroscopy of bulk organic matter in Skagen drinking water. RESULTS: Iodine content was unaltered after 3 Years (P=0.2). All samples contained organic molecules with characteristics similar to humic substances. Most iodine eluted with humic substances (Skagen 99%, Ringsted 98%, Nykoebing S. 90%, Copenhagen 90%, Samsoe 75%, Nakskov 40%). Changing pH and ionic strength and preincubation with iodide indicated that iodine was bound in humic substances. Humic substances may affect thyroid function but differ with geology. Geological and geochemical data agree with tap water humic substances having been released from marine deposits. Iodine is abundant in the marine environment and marine deposits are particularly rich in iodine. Correlation analysis (r=0.85, P=0.03) conform to iodine in drinking water, suggesting marine humic substances at the source rock. CONCLUSION: Iodine in Danish drinking water varied considerably. In drinking water with a high iodine content, the iodine mainly eluted with humic substances derived from marine source rock. We hypothesize that iodine in drinking water in general suggests coexisting humic substances of marine origin.

Denmark↗
PubMed1987

Punishment of schedule-induced drinking in rats by signaled and unsignaled delays in food presentation.

Food-deprived rats were exposed to a fixed-time 60-s schedule of food-pellet presentation and developed schedule-induced drinking. Using an ABA reversal design, three experiments investigated the effects of events then made dependent on licks. In Experiment 1, lick-dependent signaled delays (10 s) in food presentation in general led to decreased drinking, which recovered when the signaled delays were discontinued. The drinking of yoked-control rats, which received food at the same times as those exposed to the signaled-delay contingency, showed much smaller changes. Experiment 2 showed that 10-s lick-dependent signals alone did not reduce drinking. In Experiment 3, when licks produced unsignaled 10-s delays in food there were less marked and more gradual changes in drinking than in Experiment 1, although these effects again were greater than with yoked-control animals. We concluded that both signaled and unsignaled delays functioned as punishers of drinking. These findings support the view that schedule-induced drinking, like operant behavior, is subject to control by its consequences.

Journal Article↗
PubMed2006

Consumption of soft drinks and hyperactivity, mental distress, and conduct problems among adolescents in Oslo, Norway.

OBJECTIVES: We examined whether high levels of consumption of sugar-containing soft drinks were associated with mental distress, hyperactivity, and conduct problems among adolescents. METHODS: A cross-sectional population-based survey was conducted with 10th-grade students in Oslo, Norway (n = 5498). We used the Hopkins Symptom Checklist and the Strengths and Difficulties Questionnaire to assess mental health outcomes. RESULTS: There was a J-shaped dose-response relationship between soft drink consumption and mental distress, conduct problems, and total mental health difficulties score; that is, adolescents who did not consume soft drinks had higher scores (indicating worse symptoms) than those who consumed soft drinks at moderate levels but lower scores than those with high consumption levels. The relationship was linear for hyperactivity. In a logistic regression model, the association between soft drink consumption and mental health problems remained significant after adjustment for behavioral, social, and food-related variables. The highest adjusted odds ratios were observed for conduct problems among boys and girls who consumed 4 or more glasses of sugar-containing soft drinks per day. CONCLUSIONS: High consumption levels of sugar-containing soft drinks were associated with mental health problems among adolescents even after adjustment for possible confounders.

Adolescent↗
PubMed1987

Perceived consequences of drinking caffeinated beverages.

A survey of 238 college students indicated that those who prefer to drink caffeine containing drinks maintain different perceptions about the negative and positive consequences of drinking caffeinated drinks from those who do not prefer to drink caffeinated drinks. 154 of the students reported that the last soft drink they consumed was caffeinated.

Adolescent↗
PubMed1986

Effects of drinking water temperature on physiological responses of lactating Holstein cows in summer.

Nine lactating Holstein cows were offered drinking water of 7.2, 15.6, and 23.9 degrees C in a 3 X 3 Latin square design in Experiment 1. Water was offered for 10 min at 1300 h to simulate time in a milking parlor. Water consumption declined as drinking water temperature decreased. Respiration rates decreased as the drinking water temperature decreased. In Experiment 2, 8 lactating Holstein cows were offered water of 12.8 and 26.7 degrees C in a 2 X 2 changeover design. Results were consistent with Experiment 1. In experiment 3, 16 lactating Holstein cows were offered drinking water of 10, 16, 22, and 28 degrees C in a 4 X 4 Latin square design. Water was offered for 10 min at 1400 h. Respiration rates and deep rectal temperatures were taken before and after watering. Water consumption declined as drinking water temperature decreased, but the cooling effect of the low temperature water was greater. Lower drinking water temperature decreased respiration rates postwatering. Deep rectal temperatures were not affected as drinking water temperature decreased. Both respiration rates and deep rectal temperatures began to increase within 40 min after watering, indicating a transient cooling effect of the chilled water.

Animals↗
PubMedDate not supplied

Drinking locations prior to impaired driving among college students: implications for prevention.

Drinking and driving is perhaps the most serious problem associated with heavy drinking among college students in the United States. In this study, the authors examined drinking locations prior to impaired driving in a college student sample. They administered the Impaired Driving Assessment to 91 college students identified as high risk for drinking and driving. Participants reported an average of 7.98 (SD = 7.67) impaired driving episodes during the past 5 weeks. Using a random effects model, the authors found that location was a significant predictor of blood alcohol content (BAC), F(6,89.6) = 3.62, p = 0.0029. After drinking alcohol at a party, students' average estimated BAC prior to driving (geometric M = 0.089) was significantly greater than all other drinking locations (geometric M = 0.033). The findings of this study provide insight into drinking locations prior to impaired driving and can be used by college health practitioners to develop appropriate interventions to reduce the magnitude of this problem.

Adolescent↗
PubMed1997

[Geographic distribution and exposure population of drinking water with high concentration of arsenic in China].

According to the data obtained from the "National Survey on Drinking Water Quality and Waterborne Diseases", the geographic distribution and exposure population of high arsenic drinking water were reported. From the data of more than 28,800 water samples, we found 9.02 million people drinking the water with As concentration of 0.030-0.049 mg/L, 3.34 million people having their water of 0.050-0.099 mg/L and 2.29 million people having water of > 0.1 mg/L. A total of 14.6 million people, about 1.5% of the surveyed population was exposed to As (> 0.030 mg/L) from drinking water. 80% of high-As-drinking water was groundwater. The situation of As in drinking water in provinces, autonomous regions and municipalities were listed. The locations of sampling site where water As exceeded the national standard for drinking water were illustrated.

Arsenic↗
PubMed2000

Accumulation of hemoglobin-associated acetaldehyde with habitual alcohol drinking in the atypical ALDH2 genotype.

BACKGROUND: Those with the atypical genotypes of low Km aldehyde dehydrogenase (ALDH2) have high blood concentrations of free acetaldehyde, an active metabolite of ethanol, after drinking alcohol. In the present study, we measured acetaldehyde reversibly bound to hemoglobin (HbAA) in Japanese male workers. METHODS: One hundred and sixty Japanese male workers in one plant participated with informed consent. The subjects were genotyped for the ALDH2 polymorphism by polymerase chain reaction method. HbAA levels were measured using a high performance liquid chromatography system with a fluorescence detector. For the study in which we examined accumulation of HbAA, eight Asian male volunteers participated with informed consent. RESULTS: Although HbAA levels were significantly correlated with recent alcohol consumption in both typical (ALDH2*1/*1) and atypical (ALDH2*1/*2) genotypes, the slope in ALDH2*1/*2 was significantly steeper than that in ALDH2*1/*1. Multiple regression analysis on relevant factors for HbAA revealed that not only recent but also daily alcohol consumption increased HbAA levels in those with the ALDH2*1/*2 genotype, which suggests that HbAA accumulates with habitual drinking. We measured HbAA levels before, during, and after alcohol consumption--one drink (0.4 ml/kg) per day--for 7 consecutive days in male volunteers. During the drinking period, HbAA linearly increased in ALDH2*1/*2 (n = 4) but not in ALDH2*1/*1 (n = 4). After reaching peak levels (+76.1 nmol/g hemoglobin) following the seventh drink, HbAA levels gradually decreased but were significantly higher for 3 days after drinking was discontinued. CONCLUSIONS: We demonstrated that HbAA levels accumulate with habitual alcohol drinking in the atypical ALDH2 genotype. HbAA was shown to be a good biomarker for increased internal exposure levels to acetaldehyde.

Acetaldehyde↗