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Pulpal and radicular response to maxillary osteotomy in monkeys.

The purpose of this study was to examine the pulpal and radicular response to total maxillary osteotomy. The osteotomy was performed on four adult Macaca irus monkeys. Monkeys were killed after a postsurgical observation period of 150 days. Tissue blocks of the maxilla with teeth were cut and examined histologically. The pulp of the majority of the teeth from experimental animals showed cellular and circulatory pathologic changes, even in the presence of collateral circulation.

Animals↗

Soft-tissue calcifications of the dental follicle in regional odontodysplasia: a structural and ultrastructural study.

Soft-tissue calcifications of the dental follicle in regional odontodysplasia were studied via the correlated techniques of light microscopy, scanning electron microscopy (SEM), calcium x-ray cartography, and high-resolution transmission electron microscopy (TEM). The study revealed several types of calcification, mostly located within an area normally occupied by enamel formation. Some of them are produced without collagen being involved; others result from the mineralization of collagen fibers. Sometimes they were surrounded by a structureless homogeneous zone and resulted from the fusion of several smaller globules. High-resolution TEM revealed two different types of calcifications: a few composed of platelike crystallites, presenting a "sheath" characteristic of apatite formation, most of them poorly crystallized. The calcifications were in close contact with the cytoplasm of the neighboring connective tissue cells in which an abundance of microfilaments was found. It is suggested that these filaments might be involved in the formation of dystrophic soft-tissue calcifications.

Adolescent↗

Hemifacial hypertrophy affecting the maxillary dentition. Report of a case.

A case of hemihypertrophy affecting part of the right maxilla was followed for 8 years with sequential radiographs. The effects of this unusual condition on the developing dentition were documented. Advanced root formation prior to active resorption, increased deposition of secondary dentin, and the histopathologic description of a tooth have not been previously recorded.

Child↗

A panoramic radiographic analysis of Air Force basic trainees.

In a comprehensive study of 1,059 panoramic radiographs of Air Force recruits, the following findings were noted: 10% of the recruits had no restorations, no radiographic decay, and no teeth missing; 10% had at least one endodontically treated teeth; and 5% had at least one metallic crown. The typical recruit averaged five restorations, one impaction, and one missing tooth.

Adolescent↗

The dental management of patients with bipolar disorder.

Bipolar disorder (manic depressive disease) affects 1% of the United States population. These persons suffer from prolonged episodes of extreme elation and depression. There is a significant incidence of dental pathosis and a need for dental care among these patients. The medications used for the treatment of this disease, their physiologic effects, and their interactions with the drugs used in dentistry are reviewed.

Anesthetics↗

Autotransplanted teeth with early-stage endodontic treatment: a radiographic evaluation.

Autotransplantation of teeth has been performed for many years and with varying degrees of success. The present report concerns the long-term results of autotransplantation of 36 teeth with completed root formation. Endodontic treatment was started before or within 12 weeks after transplantation. At the final check-up 32 teeth were present, 24 of them without signs of inflammation, replacement, or internal resorption. Careful radiographic examination during the follow-up period and adequate therapeutic measures with inter alia renewed endodontic treatment are of importance for successful autotransplantation.

Adult↗

Dentinal candidiasis in cancer patients.

Two examples of an unusual presentation of oropharyngeal candidiasis in cancer patients are offered. The light and scanning electron microscopic appearances of candidiasis involving the dentin of teeth are described. The potential significance of recognition of this form of candidiasis in cancer patients is discussed.

Adenoma, Pleomorphic↗

Intracoronal radiolucencies within unerupted teeth. Case report and review of literature.

A panoramic radiograph obtained during orthodontic treatment revealed an intracoronal radiolucency within an unerupted permanent second molar. This unusual entity was successfully treated by surgical and endodontic intervention, followed by restorative and orthodontic treatment. These treatments enabled the tooth to maintain pulpal vitality, erupt, complete root formation, and function. This report will review the proposed etiologies for this condition, discuss the need for surgical intervention, and present the details of the case.

Calcium Hydroxide↗

Functional glycoproteins expressed in Schwann cell membrane.

Certain types of glycoproteins expressed in Schwann cell appear to play specific roles in neurite growth and neural migration. Peripheral myelin protein-22 (PMP-22) is a glycoprotein down-regulated in nerve damage and is involved in both trembler mouse mutation and human Charcot-Marie-Tooth disease, type 1A. PMP-22 now appears to be a homologue of previously reported PASII. The homology of PASII/PMP-22 to the growth arrest-specific protein (Gas-3) suggests its role in Schwann cell development. P0, a major protein in peripheral myelin, mediates cell adhesion and promotes neurite outgrowth. In cell adhesion mediated by P0, its unique carbohydrate chain plays an important role. A special isoform of L1 (L1cs), with a short deletion in the intracellular domain, is localized in Schwann cells, whilst the complete L1 is exclusively located in neurons. L1cs in Schwann cells may function differently from L1 in neurons.

Amino Acid Sequence↗

Referred otalgia.

Referred otalgia is a challenging symptom, with the burden on the physician to identify the source. Only by careful patient history and physical examination can all causes in this extensive differential diagnosis be excluded. In the absence of primary otologic pathology, referred pain from a head and neck carcinoma must be considered foremost and ruled out.

Ear↗

Distribution of PASII/PMP22 and connexin 32 proteins in the peripheral nervous system.

Various mutations of PO, PASII/PMP22 and connexin 32 genes were recently reported in hereditary neuropathies, such as Charcot-Marie-Tooth disease (CMT) and Dejerine Sottas disease (DS). However, physiological roles of the proteins in PNS are not well understood. To address the functions of the proteins, we examined their localization in PNS comparatively by immunohistochemical methods. In Western blotting, a polyclonal antibody against the carboxyl terminal peptide of PASII/PMP22 reacted to 20-24 kD bands of PASII/PMP22 in mammalian PNS myelin, but produced no reaction in either mammalian or carp CNS myelin proteins. Monoclonal anti-connexin 32 antibody recognised connexin 32 of a dimer or monomer form in rat and human PNS myelin. By histological examination, PASII/PMP22 expressed dominantly in rat PNS compact myelins, while connexin 32 localized exclusively in the nodes of Ranvier, but not in compact myelins. In cell culture, axonal contact induced a remarkable increase of PASII/PMP22 in the Schwann cell in contrast to faint staining in immature Schwann cells. While localization of connexin 32 is quite different from that of PASII/PMP22, the mutations of the two proteins often induce similar phenotypes of hereditary neuropathies.

Animals↗

Cervicofacial sinuses.

One hundred consecutive cases of cervicofacial sinuses are reviewed in terms of aetiology, diagnosis and subsequent management. One hundred and thirty-eight cases recorded in the world literature are reviewed for comparison.

Adolescent↗

Secondary retention of permanent molars: an assessment of ankylosis by scanning electron and light microscopy.

Secondary retention refers to the cessation of eruption of a tooth after emergence. This may be the result of pathological changes in the periodontal ligament. The aim of this study was to describe the morphological and histological aspects of the radicular surface of secondarily retained permanent molars. The roots of 12 secondarily retained molars and two control molars, were examined by means of scanning electron microscopy (SEM) and light microscopy (LM) in order to analyse the occurrence and localisation of ankylosis. With SEM it was observed that the root surface of retained molars showed local areas covered with bonelike tissue. LM of these areas showed that this tissue was bone in direct contact with the root surface (ankylosis). In 11 cases, the areas of ankylosis were observed in the bifurcation area and at the interradicular root surface. In the remaining case, ankylosis was located at the outer root surface. The results of this study endorse the assumption that focal ankylosis is an important factor in secondary retention. Treatment recommendations must be based on this fundamental principle, because orthodontic movement of ankylotic molars is not possible.

Adolescent↗

Early surgical management of cleidocranial dysplasia: a preliminary report.

Cleidocranial dysplasia is an interesting syndrome for the dental practitioner. The failure of eruption of the permanent teeth is secondary to both a mechanical obstruction and a lack of resorption of the overlying bone. Various modes of treatment have been suggested to manage this problem. We feel that early surgical management with serial uncovering of the permanent teeth is the best choice. This treatment will probably need to be combined with orthodontics or prosthetic care, depending on the success of the surgical procedures. In both of our cases the erupting teeth have been malaligned and malrotated, necessitating subsequent use of orthodontic appliances. To our knowledge these patients are among the youngest patients with cleidocranial dysplasia to undergo this treatment. Our preliminary results are encouraging.

Child↗

The microbiology and chemotherapy of odontogenic infections.

This article reviews the complexity of the microbiological environment of odontogenic infections. With an understanding of the organisms involved, the appropriate antibiotic can be chosen. A review of current antibiotic choices and the rationale for their selection is also presented.

Anti-Bacterial Agents↗

Treatment of the retained permanent molar.

The effect of five different treatments for retained permanent molars was evaluated in 59 patients to develop a rational guideline for adequate therapy. The results showed that a prosthetic buildup is the proper treatment if retention develops after the growth spurt, because in these cases the extent of infraocclusion is slight and relatively stable. If retention develops before the growth spurt, immediate removal of the retained molar followed by orthodontic treatment is the way to maximal success. When retention develops during the growth spurt, the tooth affected has to be observed at 6-month intervals. In such a case, no active treatment is indicated if the neighboring teeth show no tilting and the extent of infraocclusion is minor and stable. In all other cases, the teeth affected have to be removed, followed by orthodontic closure of the edentulous space. Finally, all patients must be screened regularly, because in this investigation, new cases of retention were observed relatively frequently.

Adolescent↗