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PubMed2002

[Relation between levels of acute phase proteins and copper and the parameters of systolic and diastolic left ventricular function in patients with chronic heart failure].

BACKGROUND: Acute phase protein concentrations and serum copper levels in patients in acute phase of myocardial infarction were significantly higher in subjects with heart failure compared to patients with non-complicated course of myocardial infarction. Acute phase protein concentrations correlated with the parameters of the left ventricular systolic function in patients in acute phase of myocardial infarction. The aim of the study was to evaluate the relation of acute phase protein concentrations and serum copper levels with the parameters of left ventricular systolic and diastolic function in patients with chronic heart failure out of the acute phase post myocardial infarction. METHODS AND RESULTS: Authors analysed relation between the acute phase proteins, C-reactive protein, fibrinogen, and copper concentrations and the left ventricular systolic and diastolic function assessed by echocardiography in 38 patients (26 men and 12 women, average age 68 years) with chronic heart failure and advanced left ventricular systolic dysfunction post myocardial infarction with ejection fraction lower or equal to 35%. Serum C-reactive protein concentrations correlated significantly with the left ventricular ejection fraction (r = -0.38, p < 0.05) and with isovolumic relaxation time IRVT (r = -0.51, p < 0.001)--inverse correlation. C-reactive protein concentration correlated with the ratio of the maximal flow velocity of the early transmitral diastolic filling (E vave) and with the maximal transmitral flow velocity during atrial contraction (A wave)--E/A ration (r = 0.43, p < 0.01). C-reactive protein concentration also correlated with the ration of the time velocity integrals of the E wave and the A wave--TVIE/TVIA (r = 0.45, p < 0.01)--positive correlation. Correlation between the fibrinogen and copper concentrations and the left ventricular ejection, or that with parameters of the diastolic left ventricular function were not statistically significant. CONCLUSIONS: Study revealed significant correlation between C-reactive protein concentration and parameters of the left ventricular systolic and diastolic function in patients with chronic heart failure post myocardial infarction. Correlation between copper and fibrinogen levels and parameters of the left ventricular function was not significant.

Acute-Phase Proteins↗
PubMedDate not supplied

Parenteral inotropic support for advanced congestive heart failure.

Parenterally administered positive inotropic agents remain an important component of the therapeutics of cardiac dysfunction and failure. Dobutamine, a catechol, remains the prototype of this drug group, but recently has been joined by the phosphodiesterase III inhibitor, milrinone. Compared with dobutamine, milrinone has greater vasodilating-unloading properties. The catecholamine, dopamine, is often used as a parenteral positive inotrope; but at moderate to high dose, it evokes considerable systemic vasoconstriction. At lower doses, dopamine appears to augment renal function. Levosimendan and toborinone, new compounds with several mechanisms of action, are under active clinical investigation and review for approval. Parenteral positive inotropic therapy is indicated for short-term (hours to days) treatment of cardiovascular decompensation secondary to ventricular systolic dysfunction, low-output heart failure. More prolonged or continuous infusion of one of these agents may be necessary as a "pharmacologic bridge" to cardiac transplantation, another definitive intervention, or more advanced, intense medical therapy. An occasional patient will require a continuous infusion via indwelling venous catheter and portable pump, simply to be able to be discharged from the hospital setting and function in the home environment. Intermittent parenteral inotropic therapy for chronic heart failure has provoked considerable controversy and passion among cardiologists and heart failure specialists; an attempt is made to present this topic in an objective manner.

Cardiotonic Agents↗
PubMedDate not supplied

BNP in hormone-guided treatment of heart failure.

The pharmacotherapy of heart failure has become complex. Angiotensin-converting enzyme inhibitors (or angiotensin II receptor blockers), beta-blockers, spironolactone, diuretics and digoxin can be prescribed concurrently. Endothelin antagonists and combined inhibitors of converting enzyme and neutral endopeptidase are under investigation. Optimal dosing will become increasingly difficult to judge. Plasma brain natriuretic peptide (BNP) indicates the severity of left ventricular dysfunction. The C-terminal bioactive peptide and N-terminal BNP (N-BNP) circulate at concentrations related to cardiac status. We proposed that plasma levels of N-BNP would provide an index to guide drug treatment in established heart failure. Sixty-nine patients were randomized to treatment adjusted according to clinical criteria or plasma N-BNP. Hormone-guided therapy resulted in fewer clinical end points than did clinical management. This encourages further exploration of hormone guidance of anti-heart failure therapy, which could be extended to patients with preserved ejection fraction, in addition to those with established systolic dysfunction.

Adrenergic beta-Antagonists↗
PubMed2004

Acute comparative effect of right and left ventricular pacing in patients with permanent atrial fibrillation.

We tested the hypothesis that left ventricular (LV) pacing is superior to right ventricular (RV) apical pacing in patients undergoing atrioventricular (AV) junction ablation and pacing for permanent atrial fibrillation. The potential benefit of LV over RV pacing needs to be evaluated without the confounding effect of other variables that can influence cardiac performance. An acute intrapatient comparison of the QRS width and echocardiographic parameters between RV versus LV pacing was performed within 24 h after ablation in 44 patients. Both modes of pacing were also compared with pre-implantation values. Compared with RV pacing, LV pacing caused a 5.7% increase in the ejection fraction (EF) and a 16.7% decrease in the mitral regurgitation (MR) score; the QRS width was 4.8% shorter with LV pacing. Similar results were observed in patients with or without systolic dysfunction and/or native left bundle branch block, except for a greater improvement in MR in the latter group. Compared with pre-ablation measures, the EF increased by 11.2% and 17.6% with RV and LV pacing, respectively; the MR score decreased by 0% and 16.7%; and the diastolic filling time increased by 12.7% and 15.6%.Rhythm regularization achieved with AV junction ablation improved EF with both RV and LV pacing; LV pacing provided an additional modest but favorable hemodynamic effect, as reflected by a further increase of EF and reduction of MR. The effect seems to be equal in patients with both depressed and preserved systolic functions and in those with and without native left bundle branch block.

Aged↗
PubMed2005

[Characteristics of hypertensive cardiomyopathy in a population of hypertensive patients never treated].

BACKGROUND AND OBJECTIVE: Although impaired diastolic function is frequently found in systemic hypertension, the diagnosis of hypertensive heart disease (HHD) is based on the demonstration of left ventricular (LV) growth. The aim of the current work was to investigate the potential interactions between diastolic function and LV growth in patients with arterial hypertension. PATIENTS AND METHOD: One hundred and sixteen never-treated asymptomatic hypertensives underwent an echocardiographic evaluation. Classification of diastolic dysfunction (DD) was based on alterations in parameters assessing transmitral inflow, Doppler tissue imaging of mitral annular motion, and color M-mode propagation velocity. Classification of LV growth was based on alterations in left ventricular mass index and/or relative will thickness. RESULTS: Ninety-four patients (81%) exhibited DD and 22 (19%) exhibited normal diastolic function. Amongst patients with DD, 79 (84%) exhibited a pattern of impaired relaxation and 15 (16%) a pseudonormal pattern. The presence of LV growth was documented in 41% of patients without DD and 75% of patients with DD (p < 0.05). None of the studied patients exhibited echocardiographic signs of systolic dysfunction. CONCLUSIONS: These findings indicate that DD is an early and highly frequent cardiac alteration in arterial hypertension. In addition, our data show that one fifth of hypertensive patients have DD in the absence of LV growth. It is thus suggested that the diagnosis of HHD can not be further based exclusively on morphologic criteria and should include also the evaluation of alterations in LV filling.

Adult↗
PubMed1991

[Hemodynamic response to high-dose nitroglycerin infusion in patients with severe heart failure after pretreatment and clinical stabilization].

It is a common opinion that the use of nitrates may have a harmful effect on cardiac output (CO) in patients (pts) with congestive heart failure (CHF) due to left ventricular (LV) dilatation and systolic dysfunction in whom previous treatment with diuretics and vasodilators considerably reduced LV filling pressure. The aim of the present study was to evaluate the effects on CO and LV filling pressure of high dose intravenous nitroglycerin (NTG) in eight pts with dilated cardiomyopathy and with CHF in functional class IV NYHA; they had previously undergone intensive treatment with diuretics and vasodilators, and at the time of the study were in stable clinical conditions. Hemodynamic monitoring was performed by Swan-Ganz catheterization and CO was determined by thermodilution. NTG was administered at increasing doses (maximal doses 350 +/- 220 microgr./m, range 100-800 microgr./m) until systolic arterial pressure (BPs) less than or equal to 85 mmHg and/or pulmonary capillary wedge pressure (PCWP) less than or equal to 4 mmHg. Our results showed that NTG caused a significant reduction of right atrial pressure (RAP, 4 +/- 3.5 vs -1 +/- 4 mmHg, p less than 0.001), systolic pulmonary artery pressure (36 +/- 8 vs 21 +/- 11 mmHg, p less than 0.001) and PCWP (16 +/- 5 vs 7 +/- 3 mmHg, p less than 0.001). LV transmural pressure (TMP) calculated as the difference between PCWP and RAP, showed a nonsignificant reduction from 12 +/- 5 to 8 +/- 3.75 mmHg.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1994

Characterization of reversible myocardial dysfunction by magnetic resonance imaging.

Some recent cardiovascular applications of nuclear magnetic resonance imaging (MRI) are discussed, on the basis of both literature and personal data. Management of coronary patients has become directed to strategies aiming at salvaging the ischemic myocardium, and MRI can play an important role in providing the necessary data leading to an appropriate assessment. Due to its capability in showing morphofunctional information on wall thickness and thickening, cine-MRI technique can be used to detect myocardial ischemia and infarction, since it allows the acquisition of 16 or more frames of the cardiac cycle which can be displayed in a cine loop format. In an Italian Cooperative Study the role of MRI in discriminating stunned from necrotic areas has been investigated. Comparison of fractional area change by echo versus cine-MR turned out to be almost completely overlapping, but cine-MRI allowed a more accurate measurement of systolic wall thickening due to better visualization of endo- and epicardial borders (more sensitive marker of kinetic damage than wall motion). Other studies have also been performed in order to determine the capability of contrast agents of allowing differentiation between reperfused reversible and irreversible myocardial injury and allowing distinction between reperfused and occlusive myocardial infarction. In a recent study we investigated the MRI possibility of identifying viable myocardium in severely chronic systolic dysfunctioning areas by comparing, in corresponding left ventricular segments, regional perfusion and metabolism at IPPA scintigraphy and regional signal intensity at MR images obtained before and after paramagnetic contrast media administration. The potential role of MRI was shown in the identification of viable myocardium with the use of contrast medium, that is of crucial importance in this respect.

Diagnosis, Differential↗
PubMed2005

Predictors of mortality and morbidity in patients with chronic heart failure.

AIMS: We aimed to develop prognostic models for patients with chronic heart failure (CHF). METHODS AND RESULTS: We evaluated data from 7599 patients in the CHARM programme with CHF with and without left ventricular systolic dysfunction. Multi-variable Cox regression models were developed using baseline candidate variables to predict all-cause mortality (n=1831 deaths) and the composite of cardiovascular (CV) death and heart failure (HF) hospitalization (n=2460 patients with events). Final models included 21 predictor variables for CV death/HF hospitalization and for death. The three most powerful predictors were older age (beginning >60 years), diabetes, and lower left ventricular ejection fraction (EF) (beginning <45%). Other independent predictors that increased risk included higher NYHA class, cardiomegaly, prior HF hospitalization, male sex, lower body mass index, and lower diastolic blood pressure. The model accurately stratified actual 2-year mortality from 2.5 to 44% for the lowest to highest deciles of predicted risk. CONCLUSION: In a large contemporary CHF population, including patients with preserved and decreased left ventricular systolic function, routine clinical variables can discriminate risk regardless of EF. Diabetes was found to be a surprisingly strong independent predictor. These models can stratify risk and help define how patient characteristics relate to clinical course.

Adult↗
PubMedDate not supplied

Is there an expanded role for digoxin in patients with heart failure and sinus rhythm? A protagonist viewpoint.

The evidence supporting the efficacy of digoxin in patients with heart failure who are in sinus rhythm is substantial. Digoxin improves hemodynamics, exercise capacity, symptoms, and quality of life and reduces hospitalizations. All of this is accomplished with a drug that is very inexpensive and can be given once daily. Its safety has been established through the DIG trial. Although digoxin does not decrease mortality beyond that of diuretics and ACE inhibitors, it does not increase mortality, unlike many positive inotropes. Furthermore, digoxin, in addition to ACE inhibitors and a diuretic, decreases the hospitalization rate due to worsening of heart failure. From a managed care perspective, as well as that of the patient, this is of enormous benefit. A pharmacoeconomic analysis estimated that continuation of digoxin in patients with stable congestive heart failure could save the healthcare system an estimated $ 400 million, based on costs from one hospital. The issue is not whether to use digoxin in these patients, but rather, how early to initiate therapy. From some of the recent data in patients with systolic dysfunction and mild heart failure, as well as knowledge of the neurohormonal activation that occurs early in these patients, it could be suggested that early use of neurohormonal modulators, including digoxin, would decrease the progression of heart failure. Thus, rather than waiting for symptoms despite optimal doses of an ACE inhibitor and diuretic, as suggested by the AHCPR practice guideline for heart failure, initiation of digoxin therapy in patients as early as NYHA class II at a dosage that will achieve a serum concentration of 1.0 ng/mL or less should occur. With the understanding of digoxin's effect on the neurohormonal systems, its role in patients with preserved systolic function needs to be reexplored. The debate can now focus on asymptomatic patients or those with preserved systolic function. Could these patients benefit from therapy with digoxin as well?

Angiotensin-Converting Enzyme Inhibitors↗
PubMed1998

Evaluating the use of angiotensin-converting enzyme inhibitors for older nursing home residents with chronic heart failure.

BACKGROUND: Despite their well noted therapeutic benefits for heart failure (HF), angiotensin-converting enzyme (ACE) inhibitors may be underprescribed and underdosed among older nursing home patients. OBJECTIVES: To assess the use of ACE inhibitor therapy in older (> or =70 years) nursing home residents with systolic heart failure (HF). DESIGN: A cross-sectional, retrospective analysis. SETTING: Five long-term care facilities in Providence, Rhode Island. SUBJECTS: Adults aged 70 years or older with left ventricular (LV) ejection fractions < or =40%. MEASUREMENTS: New York Heart Association (NYHA) class, comorbid diseases, and cardiac medications with logistic regression analysis to clarify their bearing on the prescription of ACE inhibitors. RESULTS: Of the 819 nursing home residents who were evaluated, 119 (24 men, 95 women) fulfilled exacting entry criteria, i.e., heart failure signs/symptoms and documented LV systolic dysfunction. Forty-one of these 119 (35%) older persons were receiving ACE inhibitor therapy, predominantly in doses (< or =50 mg captopril/day or < or =5 mg enalapril/ day) less than those of proven therapeutic efficacy. Compared with older residents not receiving ACE inhibitors, those receiving ACE inhibitors included fewer with NYHA Class I HF (0 vs 21%, P = .017), more men (58 vs 28%, P< or =.01), and more people with hypertension (61 vs 35%, P< or =.01). In contrast, diuretics were prescribed more frequently among those not receiving ACE inhibitors (83 vs 56%, P< or =.001). CONCLUSIONS: ACE inhibitors are underprescribed and underdosed among elderly nursing home patients carefully screened to include systolic HF and no contraindications to the medication. ACE inhibitors are particularly underused in those elderly with NYHA Class I HF and in those receiving diuretics.

Aged↗
PubMed2004

[Relationship between Doppler indices of diastolic function and exercise capacity in patients with congestive heart failure].

UNLABELLED: Exercise intolerance is a major symptom in patients (pts) with congestive heart failure (CHF). A lack of correlation between the left ventricular systolic dysfunction and exercise capacity was found. Recently, it has been proposed that diastolic dysfunction may contribute to significant impairment of exercise tolerance in pts with CHF. The aim of the study was to compare the relationship between Doppler indices of diastolic function and exercise capacity in patients with CHF. MATERIAL AND METHODS: The study included 29 pts (20 M, 9 F) 14 with idiopathic and 15 with ischaemic cardiomyopathy. The mean left ventricular ejection fraction (LVEF) was 31 +/- 8%, VO2peak was 16.4 +/- 4.6 ml/kg/min. The mean age was 55.4 +/- 12.1, ranged from 30 to 73 years. All pts underwent complete echocardiography study. Diastolic performance was estimated using conventional Doppler mitral inflow (E, A) velocities, E/A ratio, deceleration time of E velocity (E-DT), isovolumetric relaxation time (IVRT) and color Doppler M-mode flow propagation velocity (Vp). Resting spirometry and cardiopulmonary exercise test (CPX) were performed in all pts. Exercise capacity was measured as oxygen consumption at peak exercise (VO2peak). The association between echocardiography parameters and VO2peak was evaluated by Spearman's correlation coefficients (r). RESULTS: We found that VO2peak correlated significantly with the LV filling pattern estimated by the transmitral Doppler E/A ratio (r=-0.4, p=0.03), A-wave velocity (r=0.4, p=0.03) and velocity flow propagation (r=0.4, p=0.05). There was no correlation between VO2peak and following mitral inflow parameters: (E-wave, DT, IVRT). There was no correlation between VO2peak and LVEF. CONCLUSIONS: 1. Doppler indices of diastolic function are important determinants of exercise capacity in CHF pts. 2. Assessment of transmitral flow velocities holds a substantial diagnostic potential, which may be utilized in everyday clinical practice as a alternative in routine monitoring of systolic heart failure.

Adult↗
PubMed1990

Electrocardiographic abnormalities and left ventricular systolic function in Chagas' heart disease.

In chagasic patients, the electrocardiogram becomes abnormal very late in the course of the disease. Most clinical studies concerning cardiac autonomic function of chagasic patients have been carried out in this very late stage of the disease. The purpose of this study was to assess accurately the left ventricular systolic function of chagasic patients with abnormal electrocardiograms. We performed left ventricular contrast cineangiography in 44 patients with positive complement fixation test for Chagas' disease and abnormal electrocardiograms. On the basis of the electrocardiographic abnormalities found in the electrocardiogram taken the night before the hemodynamic procedure, we divided our patients into three subgroups; those with rhythm disturbances, those with ventricular conduction abnormalities, and those with rhythm disturbances plus ventricular conduction abnormalities. The chagasic patients with only cardiac rhythm disturbances, had left ventricular volumes and ejection fractions which were similar to those of controls. On the other hand, the left ventricular volumes of the chagasic patients with ventricular conduction defects, although slightly larger, were still not different from those of controls. Finally, the chagasic patients, with cardiac rhythm disturbances and left ventricular conduction defects, had the largest left ventricular volumes (P less than 0.05), and the lowest ejection fractions (P less than 0.001) of all three subgroups. These findings clearly indicate that chagasic patients, in this very late stage of the disease, have a very variable degree of left ventricular systolic dysfunction. Furthermore, our results show a distinct tendency for the left ventricular volumes to increase, and for the ejection fraction to decrease; when the electrocardiogram becomes progressively more abnormal, and "mixed" electrocardiographic abnormalities appear.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed2006

The effect of altering heart rate on ventricular function in patients with heart failure treated with beta-blockers.

BACKGROUND: Beta-blockers are effective for the treatment of heart failure, but their mechanism of action is unresolved. Heart rate reduction may be a central mechanism or a troublesome side effect. METHODS: A randomized, double-blind, parallel group study comparing chronic higher-rate (80 pulses per minute) with lower-rate (60 pulses per minute) pacing in pacemaker-dependent patients with symptomatic left ventricular (LV) systolic dysfunction, receiving beta-blockers. Gated radionuclide ventriculography (RNVG) was performed at baseline and after at least 9 months. The primary outcome was change in LV volumes, as a marker of beneficial reverse remodeling, from baseline to follow-up. RESULTS: Forty-nine patients were randomized. Mean age was 74 +/- 6 years and with LV ejection fraction of 26% +/- 9% at baseline. During 14 +/- 13 months of follow-up, 21 patients (43%) died and 25 (51%) completed the study protocol: 12 in the higher-rate and 13 in the lower-rate group. Mean LV end-diastolic (higher rate +20 +/- 104 mL vs lower rate -65 +/- 92 mL, P = .03) and systolic (higher rate +29 +/- 83 mL vs lower rate -60 +/- 74 mL, P = .006) volumes increased with higher-rate versus lower-rate pacing, whereas LV ejection fraction declined (higher rate -4.2% +/- 4.4% vs lower rate +2.2% +/- 5.4%, P = .002). CONCLUSION: Reversal of beta-blocker-induced bradycardia has deleterious effects on ventricular function, suggesting heart rate reduction is an important mediator of their effects. The prognosis of patients with pacemakers and heart failure is poor.

Adrenergic beta-Antagonists↗
PubMedDate not supplied

High prevalence of target organ damage in young, African American inner-city men with hypertension.

Young, urban, African American men are at particularly high risk of hypertension and its cardiovascular complications. Left ventricular hypertrophy and renal dysfunction are manifestations of target organ damage from hypertension that predict adverse cardiovascular events. The subjects of this study were 309 African American men, age 18-54 years, with hypertension, residing in inner-city Baltimore. Echocardiograms, electrocardiograms, serum creatinine, and the urinary albumin-creatinine ratio were obtained to evaluate hypertensive target organ damage. Fifty-three percent of the men reported use of antihypertensive medications, of whom 80% were on monotherapy. Calcium channel blockers were used most frequently. The mean echocardiographic left ventricular mass was 211+/-68 g, with a prevalence of echocardiographic left ventricular hypertrophy of 30%. There were 14 men (5%) with extremely high left ventricular mass, >350 grams. Left ventricular systolic dysfunction was seen in 9% of the men with uncontrolled hypertension, and none of the men with controlled hypertension (p=0.02). Renal dysfunction was found in 12% of the subjects, and microalbuminuria or gross proteinuria in 34%. The authors conclude that there is a high prevalence of cardiac and renal abnormalities in inner-city African American men with hypertension, especially in men on antihypertensive therapy with uncontrolled hypertension. It is imperative that cost-effective medications and culturally acceptable health care delivery programs be developed, tested, and integrated into health systems, with strategies specifically relevant to this high-risk population, to decrease the largely preventable morbidity and mortality associated with hypertension.

Adolescent↗
PubMed2004

Plasma brain natriuretic peptide levels in coronary heart disease with preserved systolic function.

We evaluated the circulating levels of brain natriuretic peptide (BNP) in stable angina, unstable angina, and myocardial infarction relating hormone levels to extension of coronary disease and number of vessels involved after angiographic examination. We studied 86 patients consecutively undergoing angiographic coronary examination and echocardiographic evaluation for coronary heart disease. These included 15 control subjects (group 0), 21 with stable angina (group I), 26 with unstable angina (group II), and 24 with non-Q myocardial infarction (group III). Patients with heart failure, a history of myocardial infarction, or recent myocardial damage with electrocardiographic S-T elevation were excluded. BNP levels in patients with unstable angina and myocardial infarction were significantly increased with respect to the group with stable angina (P<0.01). There were no differences between the groups with unstable angina and myocardial infarction. Analysis of peptide levels in relation to the number of involved vessels demonstrated a significant increase in patients with three-vessel disease compared with subjects with one or two vessels involved (P<0.03); among subjects with mono-vessel disease, patients with left descendent anterior stenosis had a more-marked BNP elevation than subjects with stenosis in other regions (P<0.01). Hence, BNP levels appear to be elevated in coronary disease, especially in acute coronary syndromes, even in the absence of systolic dysfunction. BNP levels also seem to be related to the severity of coronary atherosclerosis and number of vessels involved. BNP could prove a novel marker for risk stratification, not only in heart failure but also in coronary heart disease.

Aged↗
PubMed1990

Coronary atherosclerosis is associated with left ventricular dysfunction and dilatation in aortic stenosis.

Patients with aortic stenosis develop widely variable patterns of left ventricular hypertrophy and dysfunction. We postulated that coronary atherosclerosis (CAD) may be associated with impaired left ventricular function and chamber dilatation in patients with aortic stenosis. Left ventricular mass and volumes were quantified from two-dimensional echocardiography and correlated with coronary angiography in 78 patients with severe aortic stenosis and no previous myocardial infarction or regional wall motion abnormalities. Eighteen patients (group 1) had smooth coronary arteries, 25 patients had irregular coronary arteries with 50% or less stenosis (group 2), and 35 patients had obstructive CAD (group 3). Even though the calculated valve area was similar in all three study groups, group 1 patients had higher values for ejection fraction (65 +/- 9%, 51 +/- 17%, and 48 +/- 13%; p = 0.0002), systolic mass-to-volume ratio (9.2 +/- 3.9, 5.6 +/- 2.8, and 5.2 +/- 2.2; p = 0.0001), and cardiac index (2.9 +/- 0.7, 2.5 +/- 0.7, and 2.3 +/- 0.6 l/min.min2; p = 0.015) than patients in groups 2 and 3, respectively (mean +/- SD). Mean circumferential wall stress was inversely related to severity of CAD. Multivariate analysis showed that CAD is an independent predictor of ejection fraction and mass-to-volume ratio in this group of patients. Thus, in an elderly population with severe aortic stenosis, patients with both obstructive and nonobstructive CAD have an increased incidence of left ventricular enlargement and systolic dysfunction.

Aged↗
PubMedDate not supplied

Cardiac and cardiopulmonary disorders in patients with ankylosing spondylitis and rheumatoid arthritis.

One hundred patients suffering from ankylosing spondylitis (AS) and one hundred patients suffering from rheumatoid arthritis (RA) were examined by clinical, non-invasive cardiological, radiological and laboratory methods to determine the prevalence of their cardiac and cardiopulmonary disorders. Fourteen patients with AS and 24 patients with RA had several valvular abnormalities. Among the patients not having any valvular abnormality, systolic dysfunction of the myocardium was detectable in 15 and 11 cases respectively, and cor pulmonale was diagnosed in 16 and 7 cases respectively. Conduction disturbances were demonstrated in 17 patients suffering from AS and in 14 patients suffering from RA.

Adult↗
PubMed2007

Myocardial perfusion and ventricular function assessed by SPECT and Gated-SPECT in end-stage renal disease patients before and after renal transplant.

BACKGROUND: Cardiovascular disease is a major cause of morbidity and mortality in end-stage renal disease (ESRD). Renal transplant is known to improve left ventricle hypertrophy and systolic dysfunction in selected groups of patients. METHODS: We assessed myocardial perfusion, wall motion and functional parameters by single photon emission computed tomography (SPECT) and Gated-SPECT in 30 consecutive ESRD patients with normal coronary angiograms before and after renal transplantation. RESULTS: Uremic cardiomyopathy improved significantly after the transplant. The proportion of patients with angina decreased from 26 to 0%; the frequency of cardiomegaly decreased from 57 to 20% (p <0.01); the frequency of segments with perfusion defects decreased from 42.7 to 10.2% (p <0.001); the proportion of patients with low left ventricular ejection fraction (LVEF) dropped from 53.3 to 20% (p <0.001); and mean LVEF increased from (48.0 +/- 9.7% to 58.2 +/- 8.2%). Similarly, the proportion of segments showing systolic wall thickening, hypokinesia and dyskinesia also decreased significantly after renal transplant (p <0.01). CONCLUSIONS: Uremic cardiomyopathy may be potentially reversible in patients with normal angiographic coronary arteries after renal transplant in a relatively short period of time. SPECT and Gated-SPECT are objective gateway methods to determine myocardial perfusion, hypokinesia, dyskinesia, and functional parameters (left ventricular ejection fraction and systolic wall thickening) and may be useful to establish diagnostic, coronariographic, prognostic, and therapeutic indications.

Adolescent↗