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Comparison of wire-guided cricothyrotomy versus standard surgical cricothyrotomy technique.

We compared a wire-guided cricothyrotomy technique vs. standard surgical cricothyrotomy in terms of accuracy in placement, complications, performance time, incision length, and user preference. We conducted a randomized, crossover controlled trial in which Emergency Medicine (EM) attendings and residents performed cricothyrotomies by both standard and wire-guided techniques (using a commercially available kit) on human cadavers after a 15-min training session. Procedure time, incision length, and physician preference were recorded. Cadavers were inspected for accuracy of placement and complications. Airway placement was accurate in 13 of 15 cases for the standard technique (86.7%), and 14 of 15 cases for the wire-guided technique (93.3%). When comparing wire-guided vs. standard techniques, there were no differences in complication rates or performance times. The wire-guided technique resulted in a significantly smaller mean incision length than the standard technique (0.53 vs. 2.53 cm, respectively, p<0.0001). Overall, 14 of 15 physicians stated that they preferred the wire-guided to the standard technique. Our data suggest that this wire-guided cricothyrotomy technique is as accurate and timely to use as the standard technique and is preferred by our physician operators. In addition, the technique results in a smaller incision on human cadaver models.

Attitude of Health Personnel↗

Farm Financial Standards.

The Farm Financial Standards were developed by a national effort to encourage standardization. Standardization includes financial statement formats, terminology, and calculations for measuring financial position and format. Comparative analysis and education efforts are enhanced greatly by standardization. The Standardization Performance Analysis (SPA) system was developed on the basis of the performance standards for beef cattle and sheep enterprises. This article summarizes the Farm Financial Standards and illustrates the calculations with a worksheet.

Agriculture↗

Standards of radium-226: from Marie Curie to the International Committee for Radionuclide Metrology.

In the early part of the 20th century, the pioneers of radioactivity research, led by Marie Curie, Ernest Rutherford and Stefan Meyer, formed a Commission internationale des étalons de radium. The Commission made arrangements for the preparation and intercomparisons of the international standards of radium, which were identified as the Paris standard and the Vienna standard. Otto Hönigschmid from Vienna prepared a first set of international secondary standards in 1912 and a second set in 1934. In both instances, these secondary standards were compared by gamma-ray measurements with the Paris and Vienna standards. The usage of these international standards of radium in the 20th century is described.

Journal Article↗

Standards of perianesthesia nursing practice: advocating patient safety.

The practice continuum of perianesthesia nursing interacts in concert with other nursing and medical professional organizations. Professional standards of care establish frameworks that guide these practitioners in the delivery of care. ASPAN is charged with the ethical responsibility of defining and promulgating minimum standards of perianesthesia nursing practice. This article discusses the various definitions and uses of standards, as well as the vital importance of using ASPAN Standards. How standards differ from position statements, laws, and regulations, and how standards advocate for patient safety and protect the nurses in their specialty practice are also discussed. In addition, case scenarios will be presented to show how the American Society of Anesthesiologists' (ASA) standards play a major role in the surgical patient's care.

Accreditation↗

["Standards, Options and Recommendations 2001" for radiotherapy in patients with non-metastatic infiltrating breast cancer. Update. National Federation of Cancer Campaign Centers (FNCLCC)].

CONTEXT: The "Standards, Options and Recommendations" (SOR) project, started in 1993, is a collaboration between the Federation of french cancer centers (FNCLCC), the 20 french cancer centers, and specialists from french public universities, general hospitals and private clinics. The main objective is the development of clinical practice guidelines to improve the quality of health care and the outcome of cancer patients. The methodology is based on a literature review and critical appraisal by a multidisciplinary group of experts, with feedback from specialists in cancer care delivery. OBJECTIVES: To develop clinical practice guidelines for non metastatic breast cancer patients according to the definitions of the Standards, Options and Recommendations project. METHODS: Data were identified by searching Medline, web sites, and using the personal reference lists of members of the expert groups. Once the guidelines were defined, the document was submitted for review to 148 independent reviewers. RESULTS: This article presents the chapter radiotherapy resulting from the 2001 update of the version first published in 1996. The modified 2001 version of the standards, options and recommendations takes into account new information published. The main recommendations are: (1) Breast irradiation after conservative surgery significantly decrease the risk of local recurrence (level of evidence A) and the decrease in the risk of local recidive after chest wall irradiation is greater as the number of risk factors for local recurrence increases (level of evidence A). (2) After conservative surgery, a whole breast irradiation should be performed at a minimum dose of 50 Gy in 25 fractions (standard, level of evidence A). (3) A boost in the tumour bed should be performed in women under 50 years, even if the surgical margins are free (standard, level of evidence B). (4) Internal mammary chain irradiation is indicated for internal or central tumours in the absence of axillary lymph node involvement (expert agreement) and in the presence of lymph node involvement (standard, level of evidence B1). (5) Sub- and supra-claviculr lymph node irradiation is indicated in patients with axillary node involvement (standard, level of evidence B1).

Adult↗

[Analysis of the impurity of bacterium source of standard endotoxin by gas chromatography/mass spectrometry].

To analyse the impurity of bacterium source of standard endotoxin, 3-hydroxy fatty acid species in different endotoxin standards was determined by gas chromatography/mass spectrometry (GC/MS) using N, O-bis (trimethylsilyl) trifluoroacetamide as the silanizing reagent. GC/MS analysis was performed using a gas chromatograph equipped with a 60 m x 0.25 mm i. d. DB-5 fused silica capillary column and an injector at 250 degrees C. Helium was used as the carrier gas under a constant pressure of 206 kPa. The oven was programmed at a rate of 5 degrees C /min from 90 degrees C (held for 5 min) to 280 degrees C (held for 5 min). The sample size was 1 microL. The transfer line was kept at 280 degrees C. The quadrupole mass spectrometer was operated in electron impact (EI) ionization mode, and the temperature of the source was kept at 250 degrees C. The kind of 3-hydroxy fatty acids in 9 000 EU/tube national standard endotoxin, 20 EU/tube working standard endotoxin, Escherichia coli, Pseudomonas aeruginosa and deionized water were determined to study the purity of bacterium source of the standard endotoxin. It was shown that 9 000 EU/tube endotoxin standard and Escherichia coli only contained 3-hydroxytetradecanoic acid. There was 3-hydroxydodecanoic acid in 20 EU/tube working standard endotoxin, which indicated the presence of impurity of bacterium source.

Bacteria↗

Standards of holistic nursing practice as guidelines for quality undergraduate nursing curricula.

The accreditation criteria of the Commission for Collegiate Nursing Education (CCNE) direct faculty to select nationally developed standards for professional practice to guide curricula and to articulate curriculum outcomes. Recently, the CCNE proposed that all undergraduate programs should adopt the American Association of Colleges of Nursing (AACN) Essentials of Baccalaureate Education as one set of national standards for undergraduate and prelicensure programs. Standards of Holistic Nursing Practice, developed by the American Holistic Nurses' Association, is an additional set of standards that assists in defining quality for undergraduate nursing education. Standards of Holistic Nursing shares major concepts with Essentials; however, it accentuates the concepts of nurse self-care, articulated nursing theory as a foundation for practice, managing the care environment to promote healing, and care of the environment as essential to professional practice. These standards do not change the care being provided by professional nurses adhering to nursing theory and current evidence, but they do raise awareness and change emphasis of practice to reflect a holistic perspective. Used together, Standards and Essentials provide complementary guidelines for curricula-preparing professional nurses to care for client and self.

Accreditation↗

Comparison of the World Health Organization (WHO) Child Growth Standards and the National Center for Health Statistics/WHO international growth reference: implications for child health programmes.

OBJECTIVES: To compare growth patterns and estimates of malnutrition based on the World Health Organization (WHO) Child Growth Standards ('the WHO standards') and the National Center for Health Statistics (NCHS)/WHO international growth reference ('the NCHS reference'), and discuss implications for child health programmes. DESIGN: Secondary analysis of longitudinal data to compare growth patterns (birth to 12 months) and data from two cross-sectional surveys to compare estimates of malnutrition among under-fives. SETTINGS: Bangladesh, Dominican Republic and a pooled sample of infants from North America and Northern Europe. SUBJECTS: Respectively 4787, 10 381 and 226 infants and children. RESULTS: Healthy breast-fed infants tracked along the WHO standard's weight-for-age mean Z-score while appearing to falter on the NCHS reference from 2 months onwards. Underweight rates increased during the first six months and thereafter decreased when based on the WHO standards. For all age groups stunting rates were higher according to the WHO standards. Wasting and severe wasting were substantially higher during the first half of infancy. Thereafter, the prevalence of severe wasting continued to be 1.5 to 2.5 times that of the NCHS reference. The increase in overweight rates based on the WHO standards varied by age group, with an overall relative increase of 34%. CONCLUSIONS: The WHO standards provide a better tool to monitor the rapid and changing rate of growth in early infancy. Their adoption will have important implications for child health with respect to the assessment of lactation performance and the adequacy of infant feeding. Population estimates of malnutrition will vary by age, growth indicator and the nutritional status of index populations.

Breast Feeding↗

Application of international standards to disasters: summary and action plan.

INTRODUCTION: The need for the application of international standards has been evolving over the last decade. Consistency is needed not just in how we respond, but in when we respond. The discussions in this theme reflected on the progress of standard setting both at the local level and internationally. METHODS: Details of the methods used are provided in the introductory paper. The chairs moderated all presentations and produced a summary that was presented to an assembly of all of the delegates. The chairs then presided over a workshop that resulted in the generation of a set of action plans that then were reported to the collective group of all delegates. RESULTS: Main points developed during the presentations and discussion included: (1) requirement of standards of care for ALL disasters and core parameters, (2) process and procedure is best when there is interagency collaboration and coordination, (3) problems in disasters are management-related, not skill-related, and (4) standards of care must encompass evolving emergencies (e.g., emerging diseases, landmines). DISCUSSION: The action plans for Theme 5 included: (1) develop positions of standards for management, health and public health, education and training, research, psychosocial aspects, and disaster plans; (2) advocate for actions and task forces to deal with evolving and emerging disasters, terrorism, landmines, and emerging infections; (3) proactively work to advocate and facilitate the multidisciplinary and multiorganizational requirements for disaster management; and (4) develop a resource list of interdisciplinary institutions and activities organized by country and topic including the design and maintenance of a website. CONCLUSIONS: There is a clear need for international standards for the management of disasters. Positions and advocacy for these positions are required to define and implement such standards.

Disaster Planning↗

Simultaneous mass bias and fractionation corrections utilizing isotopic solid standards and laser ablation ICPMS.

Homogeneous incorporation of analytes of known isotopic abundance into sol-gel-derived standards that mimic important mineral systems has the potential to contribute significantly to providing solid standard benchmarks for a range of applications. This preliminary study reports on the synthesis of solid glass standards produced via the sol-gel method and their doping with Standard Reference Material (SRM) 981 Common Lead Isotopic Standard and SRM 982 Equal-Atom Lead Isotopic Standard. Custom isotopic materials were also prepared using mixtures of the two isotopic SRMs. Particles from these solid samples were then introduced into an inductively coupled plasma mass spectrometer via laser ablation to determine whether materials of suitable homogeneity could be developed as isotopic reference materials. Preliminary results for Pb isotope ratios show that these solid isotopic reference standards are capable of correcting for instrumental mass bias and laser ablation-induced bias due to fractionation simultaneously. Correction factors generated from the quotient of the certified and measured Pb isotopic ratios in sol-gel disks spiked with SRMs 981 and 982 were successfully applied to produce accurate isotope ratios using comparative control/unknown checks. These correction factors were also used to assign Pb isotopic ratios in NIST SRM 612 Trace Elements in Glass that were in excellent agreement with published measurements, suggesting that tunable matrix sol-gel disks can serve as adequate control matrixes for evaluation of isotope ratios in glass samples.

Journal Article↗

The DICOM image formatting standard: its role in echocardiography and angiography.

Both echocardiography and angiography have traditionally used analog media for long-term storage, but increasingly there is the desire to develop digital storage and exchange methodology. Before digital storage can become a reality, though, standards must be agreed to by the vendor and user community to ensure global intra operability of medical instrumentation. To this end, the National Electrical Manufacturers' Association and various professional organizations from around the world have collaborated to develop the DICOM (Digital Imaging and Communications in Medicine) image formatting standard. This standard specifies the exact way in which digital images are exchanged between instruments, either using a network or storage medium, and distinct standards have been developed for angiography and echocardiography. In angiography, only gray scale images are considered, whereas in echocardiography several different types of image formats are allowed to account for color Doppler echocardiography. Distinct standards have also evolved for disk-based storage. For angiography, only storage on the writable CD-ROM is allowed, whereas echocardiograms may be stored on re-writable magneto-optical disks, floppy disks, and CD-ROMs. Only lossless compression is allowed in the angiographic standard, whereas echocardiography allows the use of the JPEG (Joint Photographic Expert Group) lossy compression algorithm. Currently, all major angiographic and echocardiographic vendors have agreed to support the DICOM standard, and products are beginning to appear, first with disk-based storage but increasingly with network-based exchange of image data.

Coronary Angiography↗

Intracardiac echocardiographic evaluation of ventricular mural swelling from radiofrequency ablation in chronic myocardial infarction: irrigated-tip versus standard catheter.

INTRODUCTION: The production of larger, particularly deeper lesions may improve the success rate for radiofrequency (RF) ablation of post infarction ventricular tachycardia (VT). Therapeutic RF ablation causes left ventricular (LV) mural swelling. This swelling can be detected as increased wall thickness at the ablation site by intracardiac echocardiography (ICE) and correlates with pathologic lesion size. This study compared the extent of mural swelling caused by linear ablation lesions created with irrigated tip and standard RF ablation in a porcine model of healed anterior infarction. METHODS AND RESULTS: In anesthetized closed-chest swine ICE guided multiple RF applications to construct linear lesions at the border zone of the infarct region using an irrigated RF (n=6 swine) and a standard RF (n=6 swine) ablation catheter. 47 individual lesions were created with irrigated RF ablation; 57 lesions created with standard RF ablation. At all sites, wall thickness (measured at end-diastole Pre- and 1 min Post-RF delivery) increased following either irrigated (p<0.0001) or standard (p<0.004) RF deployment. Irrigated RF ablation produced more mural swelling at border zone sites than standard RF ablation (wall thickness increase of 21.2 versus 15.1 %, p<0.003). This difference was more pronounced at RF sites within the infarct (40.7 versus 12.0 %, p<0.0007). Thrombus formation or intramural explosion were not observed; surface crater formation was not more frequent with irrigated compared to standard RF ablation (14/47 versus 12/57 lesions, p=NS). CONCLUSION: Irrigated RF ablation may produce larger lesions than standard RF ablation, particularly for ablation targets within infarcted tissue. ICE imaging provides on line data about the characteristics of the developing lesion which may prove useful in dosing irrigated-tip RF energy application.

Animals↗

Sunscreen standards tested with differently filtered solar simulators.

BACKGROUND: The COLIPA standard for solar simulators permits a range of spectral filtration. Published studies comparing the SPFs of sunscreen formulas show that a range of SPFs is generally expected between laboratories. Specifically, three studies determining the SPFs of sunscreen standards have been performed in a series of laboratories and differences exceeding 50% have been reported. No studies to date have specifically examined potential differences in performance of Standard Sunscreen Test Formulas with varying solar simulator spectra within the permitted range of optical filtration. METHODS: In a paired clinical trial, two SPF standard sunscreen formulas were tested using two solar simulators that complied with the COLIPA standard for solar simulators but were filtered differently. One solar simulator was filtered as supplied by the manufacturer and delivered a high percentage of UVB; the other solar simulator was modified by removing the visible absorbing filter to deliver energy more closely resembling sunlight in the UVA-1 part of the spectrum, with a lower percentage of UVB. RESULTS AND CONCLUSION: The result was that the SPF of each standard sunscreen was almost 50% greater with the unmodified solar simulator than with the modified solar simulator. In vitro evaluation of the sunscreen standards predicted similar differences due to the spectral differences of the solar simulators, which appears to rule out reciprocity failure. However, reciprocity failure of the control MEDs was observed. The total intensity of the modified lamp was approximately 3 times that of the unmodified lamp.

Adult↗

Mental measurement of line length: the role of the standard.

Reaction times were examined for magnitude estimates of line length. In the first two experiments, reaction times increased linearly with judged length. This result is consistent with the hypothesis the judgments are made by laying off a mental image of the standard along the line to be judged. The slope of the function relating judged length to reaction time was not affected by the length of the standard line, suggesting that the rate at which the image of the standard is laid off is not a function of the length of the standard. Reaction time also increased linearly with judged length when subjects judged line length when the standard of 1 in. was suggested but not provided as well as when no standard was suggested. The hypothesized laying-off process was compared to other cognitive manipulations, such as mental rotation and size scaling. Equivalence of judgments based on the representation of the standard in perceptual memory and in imagination is discussed.

Discrimination Learning↗

Survival after reduced-intensity conditioning is not inferior to standard high-dose conditioning before allogeneic haematopoietic cell transplantation in acute leukaemias.

To assess the role of allogeneic stem cell transplantation (SCT) after reduced-intensity conditioning (RIC) in acute leukaemias, we retrospectively compared 25 patients with acute lymphoblastic leukaemia or acute myelogenous leukaemia after RIC to a historical group of 50 matched controls after high-dose conditioning. Engraftment, acute GvHD and severe infections were comparable in both groups. During the observation period, 1/25 patients (4%) after RIC and 14/50 (28%) after standard SCT died due to transplant-related causes; cumulative nonrelapse mortality (NRM) was 4% after RIC and 24% after standard SCT (P=0.029). In total, 15/25 patients (60%) relapsed after RIC and 20/50 (40%) after standard SCT; probability of disease-free survival (DFS) at 3 years was 43% after RIC and 49% after standard SCT (NS). Overall survival (OS) was 40% after RIC and 37% after standard SCT (NS). Stage of disease, cytogenetic risk profile, acute and chronic GvHD, chimerism status at day 90 and severe infections after transplantation were risk factors with significant impact on DFS and/or OS. In retrospective analysis, patients with acute leukaemias who receive RIC because of contraindications against standard SCT have a comparable outcome to standard SCT, but the higher relapse rate warrants further studies.

Acute Disease↗

Comparison of the diagnostic utility of the simplified and standard i.m. glucagon stimulation test (IMGST).

OBJECTIVE: To compare the peak GH and cortisol responses to the simplified and standard i.m. glucagon stimulation test (IMGST) in order to determine whether the use of a simplified form of this test results in a loss of diagnostic utility. PATIENT AND DESIGN: A retrospective study of 35 consecutive patients with pituitary disease who underwent a standard IMGST to measure GH (n = 34) or cortisol (n = 21) reserve at the programmed investigation unit of the Northern General Hospital, Sheffield. MEASUREMENTS: Cortisol, glucose and GH levels were measured at baseline and 30, 60, 90, 120, 150, 180, 210 and 240 min during the standard IMGST. We used the hormone levels at baseline, 150 and 180 min for the simplified IMGST and compared the cortisol and GH responses achieved. RESULTS: The median (range) peak GH and cortisol responses to simplified and standard IMGST were comparable 4.2 (0.5-47.5) vs 5.4 (0.5-47.5) mU/l (P = 0.75) and 635 (306-1669) vs 647 (306-1669) nmol/l (P = 0.801), respectively. Using the standard 'cut-off' points to assess GH (9 mU/l) or cortisol deficiency (580 nmol/l) there was no significant loss of diagnostic utility (P = 0.98 and P = 1.00, respectively). CONCLUSIONS: The simplified and standard IMGST have a similar diagnostic utility. The simplified IMGST could replace the standard IMGST as a screening test for GH and cortisol reserve in pituitary disease. The insulin-induced hypoglycaemia stress test can be reserved for cases in which a second assessment of pituitary reserve is clinically indicated or because of an indeterminate biochemical result.

Adolescent↗

Comparison of one week 0900 h serum cortisol, low and standard dose synacthen tests with a 4 to 6 week insulin hypoglycaemia test after pituitary surgery in assessing HPA axis.

OBJECTIVE: To compare the use of 0900 h serum cortisol and both low and standard dose Synacthen tests, one week after pituitary surgery with an insulin hypoglycaemia test performed 4-6 weeks after surgery in assessing the integrity of the hypothalamic-pituitary-adrenal (HPA) axis. DESIGN: 0900 h basal serum cortisol was measured on days 6 and 7 after pituitary surgery (24 h off replacement hydrocortisone) followed by a low dose Synacthen test (1 microg intravenously) on day 6 and a standard dose Synacthen test (250 microg intramuscularly) on day 7. Three to 5 weeks later an insulin hypoglycaemia test was performed on all patients. Both low and standard dose Synacthen tests were performed on control subjects using an identical protocol. SUBJECTS: Forty-two patients (21 male, 21 female), median age 49 years (range 23-73) who had pituitary surgery (Cushing's disease excluded). One patient had undergone repeat surgery for residual tumour and was studied following each operation. Sixteen healthy normal volunteers, median age 37 years (range 21-55). MEASUREMENTS: Serum cortisol measured by radioimmunoassay. RESULTS: Two standard deviations below the mean serum cortisol (logarithmic transformation) in the normal volunteers 30 minutes after low dose Synacthen (1 microg) was 496 nmol/l and after standard dose Synacthen (250 microg) was 504 nmol/l. A normal response was therefore taken as serum cortisol > 500 nmol/l at 30 minutes in both tests (using 496 and 504 nmol/l did not alter results). 0900 h serum cortisols 1 week after surgery were > 250 nmol/l in 31 patients and 29 of these had a normal response to hypoglycaemia (peak serum cortisol > 550 nmol/l). Of the remaining two patients, one had 0900 h serum cortisol on day 6 and 7 after surgery of 405 and 441 nmol/l with a peak serum cortisol response to hypoglycaemia of 451 nmol/l; the other patient had 0900 h serum cortisols of 416 and 251 nmol/l and a peak cortisol response to hypoglycaemia of 498 nmol/l. All eight patients who had a 0900 h serum cortisol < 100 nmol/l failed a subsequent insulin hypoglycaemia test. Seven discrepancies were noted between the low dose Synacthen test and the insulin hypoglycaemia test in the 41 patients who had both tests. In six of these, a subnormal response to low dose Synacthen was followed by a normal response to hypoglycaemia. Three discrepancies were noted between the standard dose Synacthen test and the insulin hypoglycaemia test in the 40 patients who had both tests. In all three cases a normal response to Synacthen was followed by a subnormal response to hypoglycaemia. CONCLUSIONS: A 0900 h serum cortisol < 100 nmol/l (24 h off replacement hydrocortisone) indicated ACTH deficiency and need for lifelong steroid replacement. A 0900 h serum cortisol > 450 nmol/l one week after pituitary surgery is highly suggestive of a normal cortisol response to hypoglycaemia. A 0900 h serum cortisol between 250 and 450 nmol/l one week after pituitary surgery permits safe withdrawal of steroid therapy pending an insulin hypoglycaemia test 1 month after surgery. Patients with 0900 h serum cortisol between 100 and 250 nmol/l should continue replacement steroids until definitive testing. Low dose and standard dose Synacthen tests 1 week after pituitary surgery are unreliable and should not be used.

Adenoma↗

An Australian mass casualty incident triage system for the future based upon triage mistakes of the past: the Homebush Triage Standard.

BACKGROUND: The purpose of this study was to create a system of mass casualty incident triage that provides a common language platform for both ambulance and hospital personnel based upon standard daily operating procedures for both groups. METHODS: An annotated literature review was conducted. RESULTS: The Homebush Triage Standard taxonomy consists of five categories: immediate, urgent, not urgent, dying and dead, which are given the phonetic alphabet designations of Alpha, Bravo, Charlie, Delta and Echo, respectively, to facilitate radio voice communications. Colours are assigned to each category: red (Homebush Red), yellow (Homebush Gold), green (Homebush Green), white and black comply with Standards Australia AS-2700 1996 Colour Standard for General Purposes, to ensure triage materials have consistent production standards. Numbers are reserved to either quantify or stratify individuals within a particular triage category. The Homebush Triage Standard methodology is based on START (Simple Triage Assessment and Rapid Transport) and SAVE (Secondary Assessment of Victim Endpoint) and documents triage priority using geographic triage with triage flags, instead of triage tags. CONCLUSION: The Homebush Triage Standard provides a basis for both seamless patient reassessment at all points along the casualty evacuation chain and the audit of the medical response to mass casualty incidents. It allows hospital and ambulance staff to keep working using familiar routines and removes fundamental barriers to good communication during a time of crisis.

Australia↗