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Results for “STREPTODORNASE AND STREPTOKINASE”

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At least 1,459 records · Page 81Linked to original sources
PubMed1970

Specificity of antigen recognition by human lymphocytes in vitro.

Delayed hypersensitivity reactions in vivo are exquisitely specific, in terms of both a lack of response after induction of tolerance and a response after sensitization. These studies in vitro demonstrate that this specificity, at least at the level of antigen recognition, is probably derived from different populations of cells, each responding to different antigens.

Antibody Specificity↗
PubMed1974

Cell-mediated immunity in humans during viral infection. I. Effect of rubella on dermal hypersensitivity, phytohemagglutinin response, and T lymphocyte numbers.

Phytohemagglutinin-induced lymphocyte deoxyribonucleic acid synthesis, dermal hypersensitivity, and peripheral blood thymus-derived lymphocyte numbers were assessed in nine men with experimentally induced rubella infection. Five of these men and two additional volunteers received treatment with tilorone dihydrochloride, an antiviral drug. Response to phytohemagglutinin was not changed during rubella; T lymphocyte numbers in peripheral blood were not influenced by the viral illness. However, dermal hypersensitivity was markedly impaired in all volunteers during the height of the illness. Tilorone alone, or with rubella, had no effect on any of the parameters studied.

Anti-Bacterial Agents↗
PubMed1975

Antigenic response to topically applied proteins.

Six different proteins varying widely in molecular weight, ribonuclease, lysostaphin, ovalbumin, penicillinase, collagenase, and Varidase were tested for their ability to induce circulating antibody formation in rabbits after repeated topical application of the proteins in a water-soluble gel vehicle. After a 12-week exposure period, significant hemagglutinin titers were noted in rabbits treated with ovalbumin, lysostaphin, or ribonuclease; markedly elevated, passive cutaneous anaphylaxis-reacting sera were obtained only from collagenase- or lysostaphin-treated animals. Precipitin antibodies as evidenced by gel diffusion were also found in sera from collagenas- and lysostaphin-treated animals. Topical application of penicillinase was only marginally effective and Varidase was totally ineffective in elicting a positive circulating antibody response. In all cases, topical application of proteins for periods in excess of 3 weeks was required for induction of circulating antibody formation.

Administration, Topical↗
PubMed1972

In vitro response of human lymphocytes to Mycoplasma pneumoniae.

In vitro culture and stimulation of human peripheral lymphocytes were employed to investigate the role of cellular immunity in Mycoplasma pneumoniae disease. Subjects with documented natural infections served as donors. The lymphocyte response to whole M. pneumoniae organisms was determined as incorporation of tritiated thymidine in a semimicro culture system. The range of cellular reactivity stimulated by specific antigen was within the range stimulated by phytohemagglutinin. The difference between responses of subjects with documented infection and serologically negative controls was highly significant. Specific reactivity of peripheral lymphocytes correlated closely with the presence of serum growth-inhibiting antibodies, and both persisted for several years following infection. Serum complement-fixing titers correlated well with lymphocyte stimulability during the first year but antibody, as measured by this technique, tended to disappear in later convalescence. In light of previous studies, which revealed a lack of correlation between humoral antibodies and resistance to reinfection, these results suggest that immunity to M. pneumoniae infection is mediated by circulating small lymphocytes.

Antibodies, Bacterial↗
PubMed1970

Enzymes for trauma.

Explore the source record for details and available documents.

Cataract Extraction↗
PubMed1986

Enzymatic wound cleaning and absorbable sutures. An experimental study on Varidase and Dexon sutures.

The effect of an enzymatic preparation for wound cleaning (Varidase) on the mechanical properties of absorbable sutures (Dexon) was studied in vitro and in vivo in a rat model. In vitro the sutures demonstrated a significant decrease in strength (breaking strength and energy absorption) and extensibility after 12 days of incubation in saline. Incubation in Varidase, however, further decreased the mechanical properties significantly. The stiffness of the sutures was independent of treatment and time. In vivo changes of mechanical properties of the sutures resemble those of the in vitro study, except for a decrease in stiffness of the sutures. The sutures in a primary closed wound had the same strength (energy absorption) as the sutures of an open wound treated by saline, while the sutures of an open wound treated by Varidase tended to have a decreased strength (p = 0.08). This study supports the hypothesis that an enzymatic process may be involved in the degradation of Dexon. The continuous use of Varidase in Dexon-sutured wounds for a period longer than a few days is, therefore, questioned.

Animals↗
PubMed1975

T-lymphocytes and serum inhibitors of cell-mediated immunity in renal insufficiency.

In acute as well as chronic renal insufficiency significant immunological abnormalities were found: diminution of delayed hypersensitivity skin reactions, lymphopenia, reduction of the absolute but not relative number of peripheral blood T-lymphocytes. Responses of lymphocytes from uremic patients to PHA, allogeneic cells, or antigens were normal when lymphocyte cultures were preformed in allologous serum from a healthy individual. Sera from uremic patients had an inhibitory or toxic effect on stimulation of normal lymphocytes. Such an in vitro inhibitory activity was found not only in the whole serum but also when certain substances retained in renal failure (methylguanidine, larger molecules, etc.) were added in the lymphocyte cultures.

Acute Kidney Injury↗