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At least 1,459 records · Page 81Linked to original sources
PubMed1990

[Detection of coagulation factor XIII in the vitreous body and periretinal membranes in proliferative retinal diseases].

The human blood coagulation factor catalyses the cross-linking of fibrin monomers at the end of the coagulation cascade. Additional functions are the coupling of fibronectin and collagen to each other and fibrin. Therefore we tried to investigate the significance of factor XIII in the development of intraocular membranes. Using gel electrophoresis and western blotting, both subunits (A and B) of factor XIII could be detected in vitreous aspirates from patients with "idiopathic" proliferative vitreoretinopathy (PVR) (n = 5), traumatic PVR (n = 5), and proliferative diabetic retinopathy (n = 5). In contrast the vitreous of five human "normal" post mortem eyes did not contain the subunits of factor XIII. Furthermore, we observed immunofluorescence staining for both subunits of factor XIII in 20 surgically obtained periretinal membranes. In early cellular as opposed to late hypocellular membranes we observed stronger labeling for both subunits of factor XIII. With double label staining techniques, the fibroblastic cells recognized by vimentin staining did not contain factor XIII. About 50% of the macrophages stained positive for the A-subunit of factor XIII. We observed no labeling for the B-subunit in macrophages. Therefore, we hypothesize that factor XIII in proliferative vitreoretinal disorders (PVR, PDR) is derived from the exudation of plasma and platelets through disrupted blood-retinal barriers.

Diabetic Retinopathy↗
PubMed1990

[Dye lasers: experimental histopathologic study of the effects of various wavelengths on the macular region].

Pathological experimental study of dye laser photocoagulation simulating the confluent treatment of subretinal new vessels in the macular area of a Macacas Cynomolgus monkey. 38 days after treatment the lesions become similar on the choriocapillaris and retinal pigment epithelium whatever the wavelength; the choriocapillaris is always occluded and the pigment epithelium destroyed. The internal limiting membrane is ondulated only with yellow and orange colors. These results are compared to those of similar experimental studies.

Animals↗
PubMedDate not supplied

[Pathomorphology of the retina and the pathogenesis of retinopathy of prematurity].

Pathomorphologic examinations of 74 preterm fetuses and newborns evidenced that retinopathy of preterm infants occurred in 33.7 percent of these. The development of retinopathy starts in utero. The leading factors in the pathogenesis of this condition are too early untimely delivery and chronic intrauterine hypoxia due to various diseases of the mother and fetal and pregnancy-associated abnormalities.

Endothelium, Vascular↗
PubMed1990

[Visual acuity and binocular vision following surgery of extreme retinal detachment].

Retinal surgery with implantation of silicone oil was performed in 33 patients presenting with idiopathic or traumatic proliferative vitreoretinopathy. Following removal of the oil patients were on average followed-up for 6 to 29 months (14 months). Sixteen patients had had buckling procedures prior to endosurgery. Improvement of vision up to 4 rows of optotypes was noted in 21 patients following silicone oil removal. Three cases showed a large, organic, central scotoma. Ten patients suffered from diplopia; 3 of whom were known to have had a preexisting strabismus. Suppression of the visual impression of the operated eye was seen in 4 cases. Eye muscle surgery was necessary in 4 cases. Sixteen patients demonstrated normal binocular vision as far as possible taking the visual acuity into account.

Adolescent↗
PubMed1990

[Quantitative determination of 5 vitreal proteins in the normal vitreous body and proliferative retinal diseases].

While progress in vitreoretinal surgery has been very rapid in recent years, our understanding of the biochemistry of normal and pathological vitreous is still limited. Therefore, we developed non-competitive ELISA techniques for the quantification of five vitreal proteins which, together with vitreal collagen (300 mg/l), account for more than 70% of the total vitreal protein. Physiological levels of the individual proteins were determined as follows: albumin 293 +/- 18 mg/l, IgG 34 +/- 3 mg/l, transferrin 74 +/- 7 mg/l, alpha 1-antitrypsin 14 +/- 3 mg/l, alpha 1-acid glycoprotein 4 +/- 0.7 mg/l. Mean values for these proteins were also obtained in vitreous aspirates from patients with traumatic proliferative vitreoretinopathy (PVR) (n = 10), idiopathic PVR (n = 10) and proliferative diabetic retinopathy (PDR) (n = 15). Significant differences were found for total vitreal protein and alpha 1-antitrypsin between the control groups and the three vitreoretinal disorders, between the PDR and control group for transferrin, and between both types of PVR and controls for alpha 1-acid glycoprotein. Given the high plasma levels of the individual proteins quantified in this study and the uniform rise in total vitreal protein, a disturbancee of blood-retinal and blood-vitreal barriers seems to be an essential features of proliferative intraocular disorders. No disease-specific change in the protein pattern could be detected for the three disorders examined.

Blood Proteins↗
PubMed1990

[Daunomycin in vitrectomy of complicated diabetic retinal detachment].

Fourteen eyes with combined traction and rhegmatogenous retinal detachments from proliferative diabetic retinopathy were treated with pars plana vitrectomy (PPV) and daunomycin applied to the vitreous cavity using the technique described by Wiedemann et al. for the treatment of proliferative retinopathy. The operations were completed by filling the vitreous with silicone. The aim of our study was to investigate the effect of daunomycin and the reproliferation rate. After a follow-up period of at least 3 months, the post-operative results were compared with a control group of similar eyes treated with PPV and silicone tamponade alone. No evidence was found to the effect that daunomycin affects the rate of reproliferation.

Adult↗
PubMed1990

[Morphological study on the intraocular proliferative membrane of proliferative diabetic retinopathy and proliferative vitreoretinopathy].

The membranes from 42 eyes with PDR and 8 eyes with PVR were removed during vitreous surgery. In 12 of those with PDR and 3 of the cases with PVR, the reproliferated membranes formed beneath silicone oil (SO) were removed and were histologically and immunohistochemically examined, using morphometrical quantitative analysis. In each case, area coefficient, fibrous content and the number of new vessels, and thick basement membranes, increased wall cells and multilayer basement membranes of new vessels were studied. In both PDR and PVR, the number of cells per unit area tended to be increased with the period of time after SO was injected, while the percentage of fibrous components did not change. The Percentage of occurrence of each type of new vessels was almost the same in both primary and reproliferative PDR membranes. In the primary proliferative PDR membranes, endothelial cell proliferation was found predominantly, while glial hyperplasia was predominant in the primary proliferated PVR membranes and the reproliferated membranes under SO of PDR and PVR.

Basement Membrane↗
PubMed1989

[Ocular sarcoidosis].

Sarcoidosis is a multisystem granulomatous disorder of unknown origin that most commonly affects young adults. Ocular involvement occurs in about 30% of patients. Acute or chronic anterior uveitis are the most common ocular manifestations of sarcoidosis but all the ocular tissues can be involved. Diagnosis is based on several investigations which the most interesting are biopsy of sarcoid granuloma and bronchoalveolar lavage. Treatment is topical or systemic corticosteroid therapy.

Adrenal Cortex Hormones↗
PubMed1989

Venous stasis retinopathy of stenotic or occlusive carotid origin.

Venous stasis retinopathy is an uncommon sign of carotid artery obstruction. It is found in those patients who have very severe stenosis, or complete occlusion, of the arterial lumen. Affected patients usually have advanced multivessel disease with compromise of both carotid arteries. The retinopathy is ipsilateral to the more severely compromised artery; it is caused by progressive, chronic hypoxic injury to retinal tissues, which causes an ophthalmoscopic picture of venous dilation and tortuosity, retinal hemorrhages, macular edema, and eventual neovascular proliferation. The retinal findings are quite similar to those found in diabetic retinopathy, except for unilaterality corresponding to the more obstructed artery and early onset in the retinal midzone rather than the posterior pole. The primary treatment is panretinal photocoagulation to ischemic areas, followed by either medical or surgical management of obstructive carotid disease or carotid endarterectomy alone.

Carotid Artery Diseases↗
PubMed1989

[Long-term results of the treatment of Coats disease].

Fluorescein angiographies and clinical data of 265 patients (292 eyes) with primary retinal teleangiectasis were retrospectively evaluated. If patients showed the typical pathology of the fundus and were less than or equal to 20 years, they were summarized under the diagnosis Coats' disease (125 eyes). These patients revealed significantly more severe vascular changes and exudates compared with older patients with retinal teleangiectasis. The treated and untreated course was compared in the group of patients with Coats' disease. Coagulation treatment and in some cases additional retina detachment surgery resulted in a significantly better course of the disease in contrast to the untreated group. The degree of the pathology of the fundus was the main factor for successful therapy. If the vascular changes regressed, the situation was stabilized for the following years.

Adolescent↗