Sympathetic dystrophy: new name, new concepts, new treatment?
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68 patients have been treated by regional intravenous blocks with guanethidine. 251 blocks have been realized. The majority of the patients received 3 blocks of one week. Some of them got a second series of 3 blocks after a minimum interval of one month. The study included 3 groups of patients. The first group showed 12 patients in the first stage of Sudeck; the second group 22 patients in the second stage. The third group included 34 patients for which the indication to blockade had been a chronic painful stage (19 cases), an ankylosis (8 cases), a Dupuytren post-traumatic contracture (3 cases) a stage before the operation predisposing to dystrophy reflex (3 cases) and one case of hyperhidrosis of the hand. Considering the three groups it can be stated that the first one responded the best to the treatment with a success in 80% of the cases. This success confirms the necessity of intervening as soon as possible in case of an algoneurodystrophy. The third group reveals that this therapeutical method can be useful in other situations than the dystrophy reflexes. The indication herewith is more founded on a possible sympathetic origin of the troubles as on the comportment psycho-affective of the patient.
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The results of studies are presented on the determination of aldosterone accumulation by mineralocorticoid receptors on cytoplasm and nuclei of normal rat renal tubules as well as in disturbed neurotrophic supply of the kidney including that against the background of activation and deprivation of the sympathetic nervous system function. It was shown that a pharmacological stimulation of sympathetic nervous system potentiated functional disturbances of the renal mineralocorticoid receptor apparatus in reflex dystrophy of the kidney. A simultaneous pharmacological blockade both of neural and of humoral transmission of pathological stimuli from damaged sciatic nerve to the kidney prevented the development of these disturbances. A belief is stated that there is a possibility of using adrenoceptor blockers as means to prevent or inhibit the development of dystrophic alterations in the organism which appear under the lesion of one or other part of the nervous system.
Concerning course, symptomatology and morphology the clinical picture of Sudeck's dystrophy is commented unanimously. Different views of pathogenesis, terminology, and therapy are still existing. Among multifarious contributing factors, vasomotor reflexes as well as endogenous factors are of particular significance. Methods of treatment and their benefits within different stages are pointed out and discussed. Besides physical treatment, application of calcitonin or neurostimulation are viewed to be effective. In cases of progressing dystrophy blocking of the sympathetic ganglia or (periarterial) sympathectomy are still measures of benefit. Prophylaxis is of great importance, though Sudeck's dystrophy is not always avoidable.
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