Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Musculoskeletal Development”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,459 records · Page 81Linked to original sources
PubMed2006

Integrating modelling and experiments to assess dynamic musculoskeletal function in humans.

Magnetic resonance imaging, bi-plane X-ray fluoroscopy and biomechanical modelling are enabling technologies for the non-invasive evaluation of muscle, ligament and joint function during dynamic activity. This paper reviews these various technologies in the context of their application to the study of human movement. We describe how three-dimensional, subject-specific computer models of the muscles, ligaments, cartilage and bones can be developed from high-resolution magnetic resonance images; how X-ray fluoroscopy can be used to measure the relative movements of the bones at a joint in three dimensions with submillimetre accuracy; how complex 3-D dynamic simulations of movement can be performed using new computational methods based on non-linear control theory; and how musculoskeletal forces derived from such simulations can be used as inputs to elaborate finite-element models of a joint to calculate contact stress distributions on a subject-specific basis. A hierarchical modelling approach is highlighted that links rigid-body models of limb segments with detailed finite-element models of the joints. A framework is proposed that integrates subject-specific musculoskeletal computer models with highly accurate in vivo experimental data.

Animals↗
PubMed2004

Radiologic evaluation of the shoulder girdle.

The radiologic evaluation of the shoulder girdle is an important adjunct to the clinical history and physical examination. Close collaboration between musculoskeletal clinicians and musculoskeletal radiologists improves the diagnostic performance of imaging studies. Technologic advantages, especially in MRI, have improved appreciation of shoulder anatomy, biomechanics, and injury patterns, allowing for the development of more targeted surgical and nonsurgical treatment strategies. This article reviews imaging considerations of the major clinical entities related to the shoulder.

Diagnosis, Differential↗
PubMed1994

Nerve injuries.

Sports medicine physicians should be able to recognize and manage peripheral nerve injuries in athletes. Most often, the injury is a result of repetitive microtrauma, linking peripheral nerve injury to other musculoskeletal injuries in athletes. As with other musculoskeletal injuries, rest and a modification of the athlete's regimen often lead to clinical improvement. If the physician is uncertain about the diagnosis, if the athlete develops a rapid worsening of symptoms and signs, or if the athlete is refractory to treatment, a physician who specializes in peripheral nerve injuries should be consulted.

Athletic Injuries↗
PubMed2003

AGEing and osteoarthritis: a different perspective.

PURPOSE OF REVIEW: Across the world, osteoarthritis is the most commonly occurring musculoskeletal disease of the elderly, affecting more than 25% of the population older than 60 years of age. By far the single greatest risk factor for the development of osteoarthritis is age, but a mechanism to explain this relation has not yet been identified. If such a mechanism is identified, this potentially also provides a novel target for osteoarthritis therapy. The identification of new therapeutic targets is of utmost importance, because a disease-modifying treatment for osteoarthritis is not available and, because of the graying of the population, the number of patients with osteoarthritis will continue to increase, which will pose an enormous social and economic burden on society. RECENT FINDINGS: Advanced glycation end products accumulate in human articular cartilage with increasing age, and affect biomechanical, biochemical, and cellular characteristics of the tissue. As an illustration, accumulation of advanced glycation end products increase cartilage stiffness and brittleness while decreasing the synthesis and degradation of cartilage matrix constituents. Articular cartilage becomes more prone to damage, and thus osteoarthritis, at elevated concentrations of advanced glycation end products. SUMMARY: The reviewed literature demonstrates that the age-related accumulation of advanced glycation end products in articular cartilage may provide a molecular mechanism capable of (at least in part) explaining the age-related increase in the incidence of osteoarthritis. This conclusion paves the way for new strategies to prevent or treat osteoarthritis via inhibition and/or reversal of this process.

Aging↗
PubMed1997

An overview of the issues: physiological effects of bed rest and restricted physical activity.

Reduction of exercise capacity with confinement to bed rest is well recognized. Underlying physiological mechanisms include dramatic reductions in maximal stroke volume, cardiac output, and oxygen uptake. However, bed rest by itself does not appear to contribute to cardiac dysfunction. Increased muscle fatigue is associated with reduced muscle blood flow, red cell volume, capillarization and oxidative enzymes. Loss of muscle mass and bone density may be reflected by reduced muscle strength and higher risk for injury to bones and joints. The resultant deconditioning caused by bed rest can be independent of the primary disease and physically debilitating in patients who attempt to reambulate to normal active living and working. A challenge to clinicians and health care specialists has been the identification of appropriate and effective methods to restore physical capacity of patients during or after restricted physical activity associated with prolonged bed rest. The examination of physiological responses to bed rest deconditioning and exercise training in healthy subjects has provided significant information to develop effective rehabilitation treatments. The successful application of acute exercise to enhance orthostatic stability, daily endurance exercise to maintain aerobic capacity, or specific resistance exercises to maintain musculoskeletal integrity rather than the use of surgical, pharmacological, and other medical treatments for clinical conditions has been enhanced by investigation and understanding of underlying mechanisms that distinguish physical deconditioning from the disease. This symposium presents an overview of cardiovascular and musculoskeletal deconditioning associated with reduced physical work capacity following prolonged bed rest and exercise training regimens that have proven successful in ameliorating or reversing these adverse effects.

Bed Rest↗
PubMed2000

Invited review: what do we know about the effects of spaceflight on bone?

This review of the peer-reviewed literature focuses on the effects of spaceflight on bone. Studies performed in humans and laboratory animals have revealed abnormalities in bone and mineral metabolism that suggest that long-duration spaceflight will have detrimental effects on the skeleton. However, because of large gaps in our knowledge, it is not presently possible to estimate the magnitude of the health risk, individual variations in risk, effective countermeasures, or mechanism(s) of action. Specific recommendations are made for future research to ascertain risk and develop appropriate countermeasures.

Animals↗
PubMed2006

Leg textiloma. A case report.

OBJECTIVE: To report and highlight the potential diagnostic pitfalls and consequences of leg textiloma. CASE REPORT AND INTERVENTION: A soft tissue pseudotumor of the left leg diagnosed in a 58-year-old man is described. The lesion was caused by a retained surgical gauze after surgery for varicose veins. The surgical gauze had remained in the subcutaneous tissue for 3 years and led to the formation of a 3-cm, well-circumscribed, pseudotumoral foreign body granuloma which appeared like a soft tissue tumor. A surgical intervention was performed and the mass was excised. During the procedure an old surgical gauze was found. The histologic examination revealed that a large foreign body granuloma (pseudotumor) had developed in contact with foreign material birefracting under polarized light (gauze). No sign of malignancy was noted. CONCLUSION: Although no fatal complications have been described in the musculoskeletal localization, the diagnosis is difficult and costly. According to clinical presentation, a differential diagnosis should be made between a tumoral lesion, such as a sarcoma, or a pseudotumoral lesion, such as a gossypiboma. Focal myositis or infections should also be suspected.

Female↗
PubMed2003

Effect of 6-month whole body vibration training on hip density, muscle strength, and postural control in postmenopausal women: a randomized controlled pilot study.

UNLABELLED: High-frequency mechanical strain seems to stimulate bone strength in animals. In this randomized controlled trial, hip BMD was measured in postmenopausal women after a 24-week whole body vibration (WBV) training program. Vibration training significantly increased BMD of the hip. These findings suggest that WBV training might be useful in the prevention of osteoporosis. INTRODUCTION: High-frequency mechanical strain has been shown to stimulate bone strength in different animal models. However, the effects of vibration exercise on the human skeleton have rarely been studied. Particularly in postmenopausal women-who are most at risk of developing osteoporosis-randomized controlled data on the safety and efficacy of vibration loading are lacking. The aim of this randomized controlled trial was to assess the musculoskeletal effects of high-frequency loading by means of whole body vibration (WBV) in postmenopausal women. MATERIALS AND METHODS: Seventy volunteers (age, 58-74 years) were randomly assigned to a whole body vibration training group (WBV, n = 25), a resistance training group (RES, n = 22), or a control group (CON, n = 23). The WBV group and the RES group trained three times weekly for 24 weeks. The WBV group performed static and dynamic knee-extensor exercises on a vibration platform (35-40 Hz, 2.28-5.09g), which mechanically loaded the bone and evoked reflexive muscle contractions. The RES group trained knee extensors by dynamic leg press and leg extension exercises, increasing from low (20 RM) to high (8 RM) resistance. The CON group did not participate in any training. Hip bone density was measured using DXA at baseline and after the 6-month intervention. Isometric and dynamic strength were measured by means of a motor-driven dynamometer. Data were analyzed by means of repeated measures ANOVA. RESULTS: No vibration-related side effects were observed. Vibration training improved isometric and dynamic muscle strength (+15% and + 16%, respectively; p < 0.01) and also significantly increased BMD of the hip (+0.93%, p < 0.05). No changes in hip BMD were observed in women participating in resistance training or age-matched controls (-0.60% and -0.62%, respectively; not significant). Serum markers of bone turnover did not change in any of the groups. CONCLUSION: These findings suggest that WBV training may be a feasible and effective way to modify well-recognized risk factors for falls and fractures in older women and support the need for further human studies.

Aged↗
PubMed2003

Reactive metabolites and adverse drug reactions: clinical considerations.

Idiosyncratic reactions can affect many different organ systems, either as -an isolated event (e.g., hepatitis) or as part of a syndrome (e.g., drug hypersensitivity syndrome). Formation of reactive metabolites of drugs in conjunction with a decreased ability for detoxification is believed to be the initiating step in many idiosyncratic reactions. The drug hypersensitivity syndrome, defined by the presence of fever, rash and internal organ involvement, is estimated to occur in approx 1 in 1000 to 1 in 10,000 exposures with drugs such as anticonvulsants sulfonamide antibiotics, allopurinol, and dapsone. Symptoms usually start within 2-8 wk of drug initiation. Serum sicknesslike reaction, most frequently found after 7-14 d of drug exposure, is distinguished by a fever, cutaneous eruption and arthralgias. Medications such as cefaclor, minocycline and bupropion are most frequently implicated in this reaction. In contrast, drug-induced lupus can occur l-2 yr after initiation of medication. Drug-induced lupus is characterized by musculoskeletal complaints and fever and weight loss. Drugs most commonly associated with drug-induced lupus include procainamide, hydralazine, chlorpromazine, isoniazid, and minocycline. Management of patients who develop idiosyncratic reactions includes discontinuation of the implicated drug, initiation of corticosteroids (when appropriate), and symptomatic relief as required. Internal organ involvement, which may initially be asymptomatic, should be monitored. Confirmatory or diagnostic tests are not readily available in most areas, except for research purposes.

Drug Hypersensitivity↗
PubMed2003

The accuracy of the Palpation Meter (PALM) for measuring pelvic crest height difference and leg length discrepancy.

STUDY DESIGN: Test-retest reliability and validity. OBJECTIVE: To determine the validity and reliability of the Palpation Meter (PALM). BACKGROUND: Leg length discrepancy (LLD) has been associated with a variety of musculoskeletal disorders. Therefore, the clinical measurement of LLD has become a routine and important part of the physical examination. The PALM is an instrument that was recently developed to indirectly measure LLD, but little is known about its measurement properties. METHODS AND MEASURES: Fifteen healthy and 15 symptomatic subjects with suspected LLD participated in this study. Measurements of pelvic crest height difference (PD) were obtained by 2 examiners using the PALM. A standing antero-posterior (AP) radiograph of each subject's pelvis was taken, and PD and LLD (femoral head height difference) were determined from the radiograph for comparison with the PALM values. Intraclass correlation coefficients (ICCs) were calculated to determine the validity and reliability estimates of the PALM. RESULTS: For all subjects, the validity estimates (ICC2,3) of the PALM for PD were excellent (0.90 for rater 1 and 0.92 for rater 2) when compared with the standing AP radiograph of the pelvis. The PALM was less accurate (ICC2,3 of 0.76 and 0.78 for rater 1 and 2, respectively) as an indirect estimate of LLD. Intrarater reliability for each rater was excellent (ICC3,3 = 0.97 and 0.98) and interrater reliability was very good (ICC2,3 = 0.88). CONCLUSION: The PALM is a reliable and valid instrument for measuring PD. Clinicians should consider this convenient, cost-effective clinical tool as an alternative to radiographic measurement of pelvic crest height difference.

Adult↗
PubMedDate not supplied

Image-guided percutaneous needle biopsy: an overview.

Image-guided percutaneous needle biopsy (IGPNB) is a valuable tool for diagnosis of nonpalpable or deep-seated lesions that cannot be characterized definitively with diagnostic imaging alone. The procedure entails inserting a needle through the skin into an area of suspected pathology under the guidance of various imaging techniques to retrieve a sample of tissue or fluid for analysis. This article discusses the historical development, indications, contraindications, patient preparation, equipment and possible complications of IGPNB, with particular attention to biopsies of the thorax, breast, abdominal organs, head and neck and the musculoskeletal system.

Biopsy, Needle↗
PubMed2004

The effects of exercise on skeletal muscle in the aged.

Age-related sarcopenia leads to muscle weakness and a concomitant increase in gait problems and the risk of hip fracture due to falling in the elderly. Muscle weakness reduces general activity levels in elderly individuals which in turn elevates the risk of osteoporosis due to a decrease in overall mechanical loading of the skeleton. At the same time, age-related sarcopenia is also linked to an increase in the risk of metabolic disorders such as adult onset (Type II) diabetes. However, it is widely accepted that increased mechanical loading of the musculoskeletal system (e.g., resistive exercise) can have a beneficial effect on both skeletal muscle and the supporting skeleton resulting in a significant reduction in the risk of developing all of the above age-related problems. As such, unloading models that exhibit many if not all of the same responses observed in aged muscle, including the capacity of exercise to reverse these responses, may provide valuable insight into the skeletal muscle aging process.

Aged↗
PubMed2005

Headache pain.

The headache problem with its debilitation and pain has been noted throughout medical history. It is one of the most common outpatient complaints and affects more than 45 million Americans. The lost days to work and family and the immeasurable suffering of patients can be lessened with the understanding and knowledge of a caring physician. Osteopathic physicians with expertise in holistic and musculoskeletal concepts are particularly well prepared to help. The establishment of an accurate diagnosis through a careful history and physical examination is essential before the physician can develop an effective treatment plan. Treatment can be abortive, prophylactic, or symptomatic, or a combination. Abortive treatment is geared to reverse the headache once begun; prophylactic treatment usually involves the use of daily medications to prevent, decrease frequency, or lessen severity of attacks; and symptomatic treatment is for relief of pain or accompanying symptoms. Most headaches experienced are of the tension type, whereas most debilitating headaches are of the migraine type. Cluster headache, though experienced by a small percentage of sufferers, is especially severe, and is useful in differential diagnosis.

Headache Disorders, Primary↗
PubMedDate not supplied

Pattern of congenital malformations in Nigerian children.

A series of 252 abortuses, stillbirths and neonates at the University of Ilorin Teaching Hospital and ECWA Hospital, Egbe, in Nigeria, were examined by autopsy dissection between 1983 and 1985. Their clinical cohorts in the nurseries, pediatric wards and those subjected to operations were also reviewed. Primary school children volunteers in two Ilorin schools were also examined in 1987 for cardiopulmonary malformations and umbilical hernia. Incident rates for congenital malformations ranged from 0.08 to 38.27% for congenital groin hernia, 2.39 to 8.73% for umbilical hernia, and 0.21 to 21.05% for the entire gastrointestinal tract. Other incident rates are 0.10 to 7.14% for genitourinary tract, 0.33 to 6.69% for CNS, 0.16 to 5.55% for musculoskeletal system, 0.26 to 4.76% for cardiovascular and 0.06 to 3.9% for bronchopulmonary malformations. The scope of the study is expected to make it adaptable in other developing countries.

Adolescent↗
PubMedDate not supplied

[Tissue bank for the musculoskeletal system. Clinical applications].

From June 1987 to June 1990, the musculoskeletal system tissues bank of the Orthopaedics and Traumatology Department of the University Clinic of Navarra has used 310 allografts. Of this, 219 has been used in our Department, 142 of cancellous bone and 42 of cortical bone. 24 of patellar tendon and 11 of fascia lata. The other 91 grafts have been sent to other hospitals in the country. In the present work we make a retrospective study that included the patients who were operate with allograft. We observe the differences between several types of allografts comparing them with conventional surgery technics. Within the complications we distinguished a 10.52% of infection in cortical bone allografts used in patients with neoplastic treatment. In the other type of allograft we didn't present this complication. We concluded that a bone bank or a musculoskeletal system tissues bank has a great usefulness in different reconstructive surgery technics and arthrodesis. They are used more frequent in orthopaedics and traumatology surgery improving the development of this surgery.

Adolescent↗
PubMed1997

An agenda for clinical research in geriatrics.

The health of the older segment of the population is affected by two types of problems: those that cause death and those that cause disability. Both types need to be studied. All levels of investigation, from basic clinical research to applied health services research, are needed. Areas of investigation must include the killer diseases (cardiovascular disease, cerebrovascular disease, and cancer) and disability-causing conditions, such as Alzheimer's disease and metabolic, genitourinary, musculoskeletal, and special sense disorders. Pharmacotherapeutics and disease management are also subjects that deserve attention. Problems related to race and gender differences, health services research, and technology development and assessment need to be addressed. Clinical investigators in geriatrics must be recruited and trained, and funding for their activities must be increased.

Aged↗
PubMedDate not supplied

Health hazards in the meatpacking industry.

Workers in the meatpacking industry face many health risks. Musculoskeletal disorders, including both acute injuries and repetitive strain injuries, are the most commonly reported problem in these workers. Other health hazards include infectious diseases, skin and respiratory disorders, and problems caused by environmental stressors such as cold, heat, noise, chemical exposures, explosions, fires, and work stress. Several studies are reviewed to show strengths and weaknesses of the purported association between work in the meatpacking industry and the development of cancer. Workplace programs designed to decrease health risks in this industry and governmental initiatives and legislation are discussed.

Communicable Diseases↗
PubMedDate not supplied

Identification of relevant ICF categories by patients in the acute hospital.

PURPOSE: To describe functioning and health of patients in the acute hospital and to identify the most common problems using the International Classification of Functioning, Disability and Health (ICF). METHODS: Cross-sectional survey in a convenience sample of neurological, musculoskeletal and cardiopulmonary patients requiring rehabilitation in the acute hospital. The second level categories of the ICF were used to collect information on patients' problems. For the ICF components Body Functions, Body Structures and Activities and Participation absolute and relative frequencies of impairments/limitations in the study population were reported. For the component Environmental Factors absolute and relative frequencies of perceived barriers or facilitators were reported. RESULTS: The mean age in the sample was 57.6 years with a median age of 60.5, 49% of the patients were female. In 101 patients with neurological conditions, 115 ICF categories had a prevalence of 30% and more: 32 categories of Body Functions, 13 categories of Body Structures, 32 categories of Activities and Participation and 38 categories of Environmental Factors. In 105 patients with cardiopulmonary conditions, 80 categories had a prevalence of 30% and more: 36 categories of Body Functions, eight categories of Body Structures, 10 categories of Activities and Participation and 26 categories of Environmental Factors. In 90 patients with musculoskeletal conditions, 61 categories had a prevalence of 30% and more: 14 categories of Body Functions, five categories of Body Structures, 16 categories of Activities and Participation and 26 categories of Environmental Factors. CONCLUSION: This study is a first step towards the development of ICF Core Sets for patients in the acute hospital.

Activities of Daily Living↗