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At least 1,459 records · Page 81Linked to original sources
PubMed2006

Balance marks cognitive changes in old age because it reflects global brain atrophy and cerebro-arterial blood-flow.

In healthy old age biomarkers such as Balance robustly correlate with measures of mental abilities such as scores on tests of intelligence, reaction times and memory. A plausible explanation is that balance reflects general physiological fitness and so also neurophysiological integrity, but direct evidence is lacking. Brain scans measured age-associated loss of brain volume and cerebro-arterial blood flow (CBf) in 69 volunteers aged from 62 to 81 years who also took the Tinetti Balance test battery, 3 tests of fluid intelligence, 3 tests of decision speed and a memory test. Balance, but not atrophy or CBf, predicted intelligence test scores. Balance, atrophy, and CBf all independently predicted speed and memory scores but, after variance in atrophy and CBf had been considered, predictions from Balance were no longer significant. It appears that in these tests Balance marks cognitive performance in old age because it reflects gross age-related neurophysiological changes.

Aged↗
PubMed1988

Cannabis and cognitive functions: a prospective study.

Psychological tests measuring intelligence, memory and other cognitive functions were given to 26 heavy cannabis users (mean duration of cannabis use 6.76 years; average daily intake 150 mg THC). Compared with a control group, the cannabis users were found to react slowly in perceptuo-motor tasks, but not to differ in intelligence or memory tests. The users suffered disability in personal, social and vocational areas and indicated higher psychoticism and neuroticism scores.

Adolescent↗
PubMedDate not supplied

Correlations between nonverbal intelligence and peripheral nerve conduction velocity in right-handed subjects: sex-related differences.

The speed hypothesis of intelligence was tested in relation to median nerve conduction velocity (NCV) in right-handed subjects. In total, NCV did not significantly correlate with IQ (Cattell's Culture Fair Intelligence test). The motor and sensory median NCVs correlated with IQ positively linearly in men and negatively linearly in women. These results supported the general, unqualified speed hypothesis of intelligence only for men. It was concluded that the conduction speed of the input-output channels of brain as an information processing unit may differentially contribute to nonverbal intelligence, depending upon sex. The male hormone, testosterone, was suggested to be the main factor responsible for sex-related differences in the IQ-NCV relationships.

Adolescent↗
PubMed2000

Recent advances in the assessment of intelligence and cognition.

In this paper, we review current issues in cognitive assessment. After addressing important definitional and theoretical issues, we discuss some recently developed cognitive assessment instruments as well as some recently revised instruments. Tests that are scheduled for revision will also be mentioned. As most readers are generally familiar with the widely used and nationally standardized IQ tests, we will summarize these tests according to their general usage. The testing of intelligence has been a major focus and contribution since the early days of Psychology, when the birthplace of the intelligence testing movement began in France with the work of Alfred Binet toward the end of the 19th century. Many of the most widely known and used IQ tests have been developed in the U.S.A. and are used internationally. In addition, other IQ tests have been developed in many other countries outside the U.S.A. The use of IQ tests and selected assessment considerations will be reviewed. Finally, we make some predictions about the future role of cognitive assessment in the coming century.

Child↗
PubMed2001

[Practical application of the CERAD test battery as a neuropsychological dementia screening test].

The CERAD neuropsychological test battery is becoming the standard measure for screening cognitive deficits associated with dementia. The seven subtests of the CERAD battery (Mini-Mental State Examination or MMSE, verbal fluency, Modified Boston Naming Test or MBNT, construction ability, learning of word lists, recall, and recognition), a short test of crystallized intelligence (vocabulary test or WST), and a simple test of visuo-motor tracking (number relation test-G or ZVT-G) were applied to 30 healthy control subjects, 49 depressed patients, and 98 mildly to severely demented patients. All subtests of the CERAD battery separated controls from mildly demented patients. Overall, depressed patients scored between controls and mildly demented patients. Score differences between depressed patients and mildly demented patients were significant for MMSE, learning and recall of the word list, verbal fluency, and MBNT. This paper contains a profile sheet for the CERAD battery developed according to published norms that allows rapid transformation of test results into a scaled graphical representation.

Aged↗
PubMed1998

Visual information processing in infants with focal brain lesions.

Visual information processing for faces were tested by means of the Fagan test of infant intelligence (FTII) in six infants of approximately 12 months of age affected by congenital unilateral brain lesions. Magnetic resonance imaging (MRI) was used to determine the side and size of the lesions. In addition to the FTII, all infants were submitted to a psychometric evaluation using the Griffiths scales. Visual acuity, visual field, and ocular motility were also assessed. Three infants showed damage in the left hemisphere and three in the right. The severity of the lesions, as revealed by MRI scan, was similar in the two groups. All infants except one had normal or borderline cognitive scores on the Griffiths scales. Conversely, four infants showed abnormal results on the FTII, which were not associated with the severity of the lesions, psychometric scores, or the presence of visual deficits. A preference for stimuli presented on the left side of the screen was found, independent of the side of the lesions. This effect was stronger for novel stimuli. The results of this study confirm the importance of early assessment of neuropsychological functions in infants with focal brain lesions.

Cerebral Hemorrhage↗
PubMed1992

Testing by artificial intelligence: computational alternatives to the determination of mutagenicity.

In order to develop methods for evaluating the predictive performance of computer-driven structure-activity methods (SAR) as well as to determine the limits of predictivity, we investigated the behavior of two Salmonella mutagenicity data bases: (a) a subset from the Genetox Program and (b) one from the U.S. National Toxicology Program (NTP). For molecules common to the two data bases, the experimental concordance was 76% when "marginals" were included and 81% when they were excluded. Three SAR methods were evaluated: CASE, MULTICASE and CASE/Graph Indices (CASE/GI). The programs "learned" the Genetox data base and used it to predict NTP molecules that were not present in the Genetox compilation. The concordances were 72, 80 and 47% respectively. Obviously, the MULTICASE version is superior and approaches the 85% interlaboratory variability observed for the Salmonella mutagenicity assays when the latter was carried out under carefully controlled conditions.

Artificial Intelligence↗
PubMed2004

Fetal rate of behavioral inhibition and preference for novelty during infancy.

BACKGROUND: Correlations between infant measures of information processing and later IQ have been established, and a few studies have extended this continuum by examining links between various fetal measures and cognitive measures during infancy. AIMS: This study compared fetal rate of behavioral habituation among infants identified as at high or low cognitive risk. STUDY DESIGN: This study was a retrospective examination of differences in fetal rate of behavioral habituation as a function of cognitive risk status at 6.5 and 9 months postpartum, using an independent two-group design. SUBJECTS: Participants were 32 infants who were born between 36 and 42 weeks gestational age at normal birth weight and had normal APGAR scores. OUTCOME MEASURES: The Fagan Test of Infant Intelligence (FTII) was used to obtain a measure of preference for novelty, which served as the basis for identification of infants at high or low risk for cognitive difficulty. These infants had undergone up to three habituation trials using a vibroacoustic stimulus during fetal development. RESULTS: Infants who were classified as being at high cognitive risk at 6 months had required more trials to habituation as fetuses. CONCLUSIONS: Fetal rate of behavioral habituation is associated with information processing during the first 6 months of infancy. We suggest that fetal habituation may be influenced by early cognitive mechanisms and therefore represents an immature but real form of information processing.

Acoustic Stimulation↗
PubMed2004

Cognitive and psychological predictors of everyday memory in children with intractable epilepsy.

Children with epilepsy have known deficits on objective measures of learning and memory. Parents and children report that memory deficits have a negative impact on everyday functioning. In adults with epilepsy, self-report of memory is more strongly associated with depression than performance on memory tests. We investigated the cognitive and psychological predictors of everyday memory in 37 children with medically intractable epilepsy, using children's self-report and parent ratings of everyday memory performance and standard tests of attention, intelligence, visual and verbal memory, working memory, and mood/emotional state. Standard multiple regressions demonstrated that only a parent report measure of attention uniquely and significantly (P< or =0.05) predicted estimates of everyday memory performance, accounting for 33% of variance in children's own ratings and 27% of variance in parents' ratings. Findings suggest that everyday memory in children with intractable epilepsy differs from that of adults; attentional problems may underlie everyday memory problems in these children.

Adolescent↗
PubMedDate not supplied

Differential effects on cognitive functioning in 13- to 16-year-olds prenatally exposed to cigarettes and marihuana.

Cognitive performance was examined in 145 thirteen- to sixteen-year-old adolescents for whom prenatal exposure to marihuana and cigarettes had been ascertained. The subjects were from a low-risk, predominantly middle-class sample participating in an ongoing, longitudinal study. The assessment battery included tests of general intelligence, achievement, memory, and aspects of executive functioning (EF). Consistent with results obtained at earlier ages, the strongest relationship between prenatal maternal cigarette smoking and cognitive variables was seen with overall intelligence and aspects of auditory functioning whereas prenatal exposure to marihuana was negatively associated with tasks that required visual memory, analysis, and integration. The interpretation of the results is discussed in terms of the differential observations related to in utero exposure to cigarettes and marihuana and the nature of the cognitive variables associated with the two drugs.

Adolescent↗