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[Metastasis to the small intestine of malignant melanoma as a rare cause of intestinal hemorrhage].

This is the case report of a 63 year old female patient, who was admitted to the hospital due to an unexplained anemia. A malignant melanoma of the cheek was excised four years previously (stage II, Clark level V, TNM classification: pT4, pNl, MO), followed by chemotherapy. By x-ray and CT examination an intestinal malignant growth was assumed. Laparotomy revealed a metastasis of the malignant melanoma, situated in the middle of the jejunum as cause of the occult bleeding. Complete resection of the tumor was successfully carried out. A second look laparotomy one year later revealed no further tumor growth in the abdominal cavity.

Facial Neoplasms↗

[Y1 receptors mediate inhibitory and stimulatory effects of peptide YY in isolated small intestine and large intestine muscles of the rabbit].

Peptide YY has been shown to have stimulatory and inhibitory effects on gastrointestinal motility. However, the receptors mediating these effects are unknown. To determine if specific YY receptor agonists can mediate the effects on gastrointestinal motility we studied the effects of peptide YY (PYY), of Pro34PYY, a selective Y1 agonist, and of PYY 3-36, a selective Y2 agonist, on the motility in isolated smooth muscle strips from rabbit small and large intestine. In strips from distal colon, PYY stimulated spontaneous motility whereas it inhibited spontaneous contractions in circular strips from distal ileum. In distal circular colon maximal inotropic response (10.1 +/- 2.1% of a maximal response to carbachol 10(-5) M) was found at PYY 10(-8) M; (ED50 3.1 +/- 1.2 x 10(-9) M). In distal circular ileum maximal inhibition (by 39 +/- 20% of basal motility index) was found at 10(-7) M; (ID50 6.2 +/- 1.4 x 10(-9) M). PYY caused a dose-dependent inhibition of the on-contraction induced by electrical field stimulation. This inhibition could not be reversed by alpha- or beta-adrenergic blockade. PYY had no influence on the inotropic response evoked by carbachol. Both the stimulatory effect of PYY observed in distal colon and the inhibitory effect in distal ileum could be reproduced by the Y1 agonist Pro34PYY, but not by the Y2 agonist PYY 3-36. In distal circular colon the maximal inotropic response evoked by the Y1 agonist was 10 +/- 1.4%; (ED50 1.2 +/- 0.5 x 10(-8) M).(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗

[Intestinal autograft: creation of an isolated intestinal segment by entero-enteropexy].

An isolated bowell segment (IBS) was created in rats by a two-stage procedure. Initial lateral entero-enteropexy between small and colonic bowell was performed. Six weeks later, the small bowell mesentery was divided. After four weeks, the survival animals were killed, the viability of the segment is maintained by developing vascular collateral across the coaptation between both intestinal segments, under light microscopy the willi were atrophied on 50% of animals.

Animals↗

Hyperoxaluria and intestinal disease. The role of steatorrhea and dietary calcium in regulating intestinal oxalate absorption.

Hyperoxaluria was documented in patients with pancreatic insufficiency, adult celiac disease, regional enteritis after ileectomy and partial colectomy, and jejunoileal bypass. The degree of hyperoxaluria correlated directly with the severity of the steatorrhea and inversely with the dietary calcium content. High-calcium diets suppressed oxalate excretion to normal when fecal fat excretion was approximately 30 g/day or less. In patients with more severe steatorrhea, decreasing dietary fat and oxalate content further reduced urinary oxalate excretion. These data suggest that, while steatorrhea is the most important determinant for enhanced absorption of dietary oxalate, variations in dietary calcium content modulate the amount of oxalate absorbed.

Adult↗