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PubMedDate not supplied

Carotid endarterectomy in young adults.

The results of carotid endarterectomy in 521 patients were analyzed to verify whether the early and late outcome in young patients is worse than in older patients, such as the results observed in peripheral arterial reconstruction in young adults. The patients were subdivided into 3 groups: 105 under 55 years, 397 aged between 56 and 74 years and 19 over 75 years. Young patients presented less risk factors and associated diseases than older ones, with the exception of smoking-habit; on the other hand, they presented a higher incidence of early post-operative thrombosis, myocardial infarction and of recurrent stenosis at follow-up. This trend has already been observed in other series. Young age and smoking habit have also been significantly related with recurrent carotid stenosis. In spite of these complications, carotid endarterectomy is indicated in severe stenosis or complicated carotid plaques, in young adults, because of a low operative mortality and a better trend in the follow-up period; however, the pre-operative evaluation needs a more accurate study and, when possible, the normalization of metabolic risk factors and the elimination of smoking.

Adult↗
PubMed1991

[A method of endarterectomy of carotid artery bifurcation].

A new method for endarterectomy of the bifurcation of the carotid artery is described. The author applied it in 25 operations. It allows qualitative one-stage open endarterectomy from the common, internal, and external carotid arteries. By means of this method new orifices of the external and internal carotid arteries, lined with a normal intima, can be created, which reduces the possibility of their restenosis. The essence of the method consists in complete separation of the internal carotid artery from the bifurcation of the common carotid artery, longitudinal cutting in the distal direction of the internal and external carotid arteries and their side-to-side anastomosis, as a result of which their lumina are integrated and the bifurcation of the common carotid artery is artificially transposed distally.

Anastomosis, Surgical↗
PubMed1991

Angiographic assessment of graft patency after coronary endarterectomy.

Fifty-one consecutive patients underwent 68 manual core endarterectomies between April 1985 and May 1987. There were 42 men and nine women, mean age 60 years (range 39 to 81). All patients underwent coronary bypass grafting alone. There were no reoperations. There was one operative death (2%). Forty patients consented to early (mean 19 days) and 27 to late (mean 19 months) repeat angiography. At the early restudy 47 of 52 (90%) grafts to endarterectomized vessels were patent. This rate fell to 27 of 42 (64%) at late restudy. There was considerable variation in the angiographic appearance of the endarterectomized vessels, ranging from a large caliber, smooth walled vessel to an attenuated vessel with irregular walls. In general, there was a tendency toward "shrinkage" of these vessels by the late restudy, suggesting fibrosis in the walls. We conclude that, although endarterectomy can be done on most atheromatous vessels with excellent early graft patency, these vessels tend to show an accelerated deterioration with time, resulting in a low late patency rate. We suggest that the procedure be reserved for vessels that are truly inoperable by other means and only for vessels that supply a coronary bed of at least moderate size.

Adult↗
PubMed1990

[Modification of non-hemispheric symptoms by carotid endarterectomy].

In case of multi-locular supra-aortic lesions the correction of a hemodynamic carotid stenosis has priority over any reconstruction of another supra-aortic lesion. Thus carotid endarterectomy leads to an improvement of the global cerebral perfusion. Patients with a classical vertebro-basilar insufficiency profit most by these operations. A subclavian or vertebral reconstruction or PTA is indicated only if the patient is not symptom-free after the carotid endarterectomy.

Brain Ischemia↗
PubMed1991

[Carotid endarterectomy for prevention of stroke: comparison of surgical and conservative therapy].

The incidence of TIA, stroke and death among 689 patients with a narrowing of the internal carotid artery exceeding 50% was investigated in a follow-up study. Patients were assigned according to their initial status to one of the following groups: asymptomatic, transient ischemic attacks (TIA) and minor stroke. Patients subjected to carotid endarterectomy (n = 206) were compared to those treated by oral medication only. The follow-up time averaged 2.1 years. The incidence of stroke and death among the initially asymptomatic persons was not significantly different in those who underwent surgery (n = 46) and those who did not (n = 234). The incidence of TIA however was significantly higher in the operated patients. Among patients with TIA the incidence of repeated TIA, stroke and death was similar in those who were operated (n = 90) and those who were not (n = 61). The same was true for subsequent TIA and strokes in patients who had suffered from a first stroke prior to the initial examination. Patients who underwent surgery (n = 70) did not differ in this respect from the 188 patients who were not operated on. The death rate, however, was significantly higher in the non-operated patients (24.5% versus 7.2%). Due to the retrospective character of the study, operated and non-operated groups of patients were not directly comparable. We therefore selected comparable groups of patients by a stratification procedure. These subgroups showed no differences in the incidence of TIA and stroke between operated and non-operated patients. The result indicates, that the decision to perform carotid endarterectomy should be made with great caution.

Adult↗
PubMedDate not supplied

Division and reanastomosis of the internal carotid artery for endarterectomy.

In an attempt to meet superior hemodynamic criteria without patch angioplasty and to prevent recurrent stenosis, Division-Endarterectomy-Reanastomosis (D.E.R.) was used as a routine technique in a prospective study on 26 consecutive interventions in 25 patients. One patient had a residual technical stenosis of less than 30%. Eight patients died during the one and a half year follow-up from nonstroke-related causes. After on an average 14 months flow parameters were evaluated with Color Duplex Sonography to detect recurrent stenosis. One (5.5%) mild asymptomatic recurrent stenosis of less than 50% was diagnosed. The residual stenosis remained unchanged and all other sites showed normal flow patterns. Division-Endarterectomy-Reanastomosis of the internal carotid artery, as described, meets all requirements for safe carotid restoration.

Aged↗
PubMedDate not supplied

Monitoring cerebral perfusion during carotid endarterectomy.

Transcranial pulsed Doppler ultrasound was used to monitor blood velocity in the middle cerebral artery (MCA) of two patients during ipsilateral carotid endarterectomy. In the first patient the ultrasound data demonstrated a non-functioning shunt which was corrected by repositioning the distal end of the shunt. In the second patient MCA blood velocity data demonstrated that clamping of the external carotid artery would have resulted in complete cessation of MCA flow throughout endarterectomy. These cases illustrate the benefit that this technique offers to the individual patient undergoing carotid surgery.

Aged↗
PubMed1990

The influence of neutralizing heparin after carotid endarterectomy on postoperative stroke and wound hematoma.

The influence of neutralizing or not neutralizing heparin after carotid endarterectomy on postoperative stroke and wound hematoma is unknown. During the past 6 years some of the authors frequently gave protamine sulfate to neutralize heparin, whereas others did not unless a patch was used or wound hemostasis was not readily obtained. To determine the influence of protamine sulfate on stroke and wound hematoma the records of 697 patients having a carotid endarterectomy from January 1984 to September 1989 were reviewed. Protamine sulfate was given to 328 patients, and 369 did not receive protamine sulfate. The incidence of stroke in the two groups was 1.8% (n = 6) and 2.7% (n = 10), respectively, and the difference was not significant (p = 0.6019). Excluding three strokes that could not be related to neutralizing or not neutralizing heparin, the difference remained insignificant (1.5% vs 2.2%, p = 0.7290). The incidence of wound hematoma was 1.8% (n = 6) in patients given protamine sulfate and 6.5% (n = 24) in patients not given protamine sulfate, and this difference was significant (p = 0.0044). The difference remained significant when three hematomas not related to protamine sulfate were excluded (1.2% vs 6.2%, p = 0.0013). In patients not given protamine sulfate draining the wound lessened the incidence of wound hematoma (4.4% vs 8.6%), but this difference was not statistically significant (p = 0.1475). In patients given protamine sulfate the dose of protamine sulfate (15 to 45 mg vs 50 to 75 mg) had no statistically significant effect on the incidence of stroke (0.8% vs 2.0%, p = 0.6530) or wound hematoma (1.6% vs 1.0%, p = 1.000).

Aged↗
PubMed1990

Carotid endarterectomy under local anesthesia.

Carotid endarterectomy has been used increasingly in the management of cerebrovascular disease. However, morbidity and mortality statistics for this procedure have caused criticism. The authors believe neurologic and medical complications can be reduced with the use of regional anesthesia for carotid endarterectomy.

Arteriosclerosis↗
PubMed1990

Symptomatic carotid endarterectomy trials.

The possible benefit of carotid endarterectomy in stroke prevention is being evaluated in three major clinical trials. To date, the European Carotid Surgery Trial has randomized 2,200 patients, 30% of whom have a carotid stenosis of greater than 70% appropriate to their symptoms. The North American Symptomatic Carotid Endarterectomy Trial has randomized 1,000 patients, of whom more than half have this severity of appropriate stenosis. Quality control and the evaluation of outcome events in this trial is achieved by a three-tier review, including review by medical and surgical adjudicators who are blinded to the treatment arm of each patient. Baseline characteristics of the patients eligible but not randomized are similar to those of patients who have been randomized. Two percent of the patients randomized to the surgical arm have declined surgery and crossed over to the medical arm, and 3% have elected surgery after randomization to the medical arm. Both of these studies, as well as a Veterans Administration trial, are continuing to randomize patients.

Aged↗
PubMed1990

Rupture of the vein patch: a rare complication of carotid endarterectomy.

Vein patch closure after carotid endarterectomy has been used to reduce the incidence of residual and recurrent stenosis at the carotid bifurcation. A rare but potential serious complication is rupture of the vein patch during the early postoperative period. In our experience of 2359 carotid operations performed from 1962 through 1986, saphenous vein was used for closure in 2275 (96.5%) operations. In three patients out of 75 in whom the vein patch had been harvested from the ankle, rupture of the patch occurred 2 to 5 days after uneventful carotid surgery. At emergency reoperation, the central portion of the vein was necrotic, with no evidence of infection. In each case the carotid artery was closed again with fresh thigh saphenous vein, and recovery was uneventful. The use of ankle vein was discontinued in December 1983 in favor of groin saphenous vein, and similar complications have not occurred in more than 600 carotid endarterectomies performed since. Early noninfectious ruptures of the saphenous vein patches have been mentioned in other reported series of carotid operations and have often been related to the use of ankle vein, but they remain unexplained.

Carotid Arteries↗
PubMed1990

Hollenhorst plaques: retinal manifestations and the role of carotid endarterectomy.

The ocular examinations and hospital records of 64 patients with Hollenhorst plaques were retrospectively reviewed to document any associated visual defects and to determine if carotid endarterectomy prevented the occurrence of new plaques or symptoms. One hundred nine Hollenhorst plaques were seen in 75 eyes; 18 had multiple plaques simultaneously. Visual field defects were noted in 14 eyes, four of which corresponded to the location of Hollenhorst plaques. Twenty-eight carotid endarterectomies were performed ipsilateral to a Hollenhorst plaque: 24 patients had no symptoms; four patients developed new ipsilateral asymptomatic Hollenhorst plaques at 1 to 50 months after operation. Two late strokes occurred, one of which was ipsilateral to a new Hollenhorst plaque, during a mean follow-up of 50 months (range 8 to 102 months). Thirty-seven eyes with asymptomatic Hollenhorst plaques did not undergo ipsilateral operation. Two eyes developed new Hollenhorst plaques during a mean follow-up of 23 months (range 1 to 132 months). Eight eyes in patients with no symptoms had multiple Hollenhorst plaques, one of which was associated with a subsequent stroke. Of the 29 eyes with a single Hollenhorst plaque, one subsequently experienced an ipsilateral stroke, and another had a transient ischemic attack (1 and 3 years later, respectively). Visual field defects infrequently corresponded to locations of Hollenhorst plaques. The cerebral hemisphere ipsilateral to asymptomatic plaques had a slightly increased risk of subsequent transient ischemic attack or stroke compared to the contralateral side without Hollenhorst plaques. The number of simultaneous Hollenhorst plaques in the retinal circulation did not predict clinical outcome.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗
PubMed1990

[False aneurysm: a complication of carotid endarterectomy].

False aneurysm of the carotid artery is a rare complication of carotid endarterectomy. We present a 65-year-old woman and a 68-year-old man with this condition. In 1 the artery had been closed with a Dacron patch graft, and in the other by direct suture. In the first case the aneurysm was successfully repaired with an expanded GoreTex (PTFE) patch graft sutured with monofilament nylon. In neither case was an organism grown from cultures taken at operation. The incidence of false carotid aneurysm as a complication of endarterectomy is only 0.3%. Usually infection is the main cause. It is therefore surprising that closure with a synthetic patch-graft is not a predisposing factor in the development of false carotid aneurysms, neither according to the literature nor in our own very limited experience with this complication.

Aged↗
PubMed1990

[A case of aortitis syndrome with left coronary ostial stenosis and aortic regurgitation treated by transaortic coronary endarterectomy and aortic valve replacement].

A case, 23-year-old female of aortitis syndrome with left coronary ostial stenosis and aortic regurgitation was reported. The coronary angiography showed critical stenosis of the left coronary ostium with intact main stem and its branches. The aortogram revealed aortic regurgitation of grade III, and multiple obstructive or stenotic lesions on the left common carotid artery, the origin of the left renal artery, the inferior mesenteric artery and the abdominal aorta. After improvement of inflammatory findings by steroid therapy during 2 months, transaortic coronary endarterectomy and aortic valve replacement with 21 mm Björk-Shiley valve were performed successfully. Postoperative course was uneventful. Coronary angiography performed at the 57th day after the operation showed complete removal of the left coronary ostial stenosis, and aortography showed no evidence of perivalvular leakage of the aortic valve prosthesis. The indication of transaortic coronary endarterectomy and the technique used to avoid aortic valve detachment which may be caused by recurrence of aortitis were discussed in this paper.

Adult↗
PubMed1990

The training of carotid endarterectomy during an era of controversy. A personal experience.

One hundred carotid endarterectomy (CEA) procedures were performed in this teaching institution from August, 1984 to January, 1989 under the direction of the author. Presenting symptoms were TIA (36), CVA (25), amaurosis fugax (17), and asymptomatic carotid stenosis greater than 80 per cent (22). The average age was 61.8 years and 68 per cent were male. The operation was performed through a transverse neck incision with the use of flaps, a shunt was used (96%) and the artery closed primarily (95%). The heparin given was not reversed. There was no operative mortality and the stroke morbidity consisted of one permanent (1%) and one temporary (1%) deficit. Hematoma evacuations were required in four cases; one had a demonstrable bleeding point. The long-term stroke rate was 1.62 per cent, with overall survival of 94 per cent at 42 months. Restenosis following repair was noted in only 5.5 per cent of the cases at one year. When carotid endarterectomy is performed in a teaching institution, excellent early results (2% combined stroke/mortality rate) are maintained long-term. Furthermore, a 50-plus per cent decrease in the risk of stroke at 42 months is demonstrated when this study's results are compared to estimates of the natural history of significant carotid disease.

Adult↗
PubMed1975

Manual coronary endarterectomy. Clinical experience in 315 patients.

From July, 1970, to December, 1973, manual endarterectomies were performed on 330 coronary arteries in 315 patients. The procedures were performed on either an elective or nonelective basis. The over-all hospital mortality rate was 1.27 per cent. Postoperative myocardial infarction occurred in 4.8 per cent of these patients. Postoperative catheterization was performed on 186 endarterectomized arteries; the average time of postoperative catheterization was 13.1 months after surgery. The over-all patency rate was 76.3 per cent. This experience suggests that endarterectomy is a safe and useful adjunct to saphenous vein bypass grafting procedures when used in a restricted fashion as detailed in this presentation.

Adult↗
PubMed1987

Increased intraocular pressure following endarterectomy.

Two patients are presented with neovascularization of the iris due to ischemia secondary to decreased blood flow through the carotid arteries. Panretinal photocoagulation was followed by regression of the new iris blood vessels to a greater extent in one patient than in the other. Following carotid endarterectomy, intraocular pressure increased, and, in one case, filtering surgery was required. Possible mechanisms for the rise in intraocular pressure following carotid endarterectomy are discussed.

Carotid Artery Diseases↗
PubMed1988

[Carotid endarterectomy: an intervention not without risk].

The authors report the result of 141 carotid endarterectomies, 6 of which were done for total occlusion, performed on 128 patients (97 men and 31 women). Mortality was 4.9%, decreasing to 2.9% after a more rigorous selection of the patients. Morbidity was 11.3% without evolution along the years and local complications were 12%. 83 patients were controlled with ultrasounds from 12 to 123 months after operation (mean delay: 50.6 months). There were 15% of more than 50% restenosis and 7.6% of occlusions. These results are compared with those of literature. They make the necessity of endarterectomy very controversial. At the moment, as long as the results of randomised multicenter studies are not known, each case must be thought of very cautiously before deciding any operation.

Adult↗