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At least 1,459 records · Page 81Linked to original sources
PubMed1993

Randomized trial comparing cryopreserved cultured epidermal allografts with hydrocolloid dressings in healing chronic venous ulcers.

BACKGROUND: Cultured epidermal allografts have been successfully used to treat a variety of wounds. Their postulated mechanism of action is through release of cytokines that stimulate epithelialization. On the basis of previous experience we expected ulcers treated with cryopreserved cultured allografts (CCAs) to be healed by 6 weeks. Hydrocolloid dressings (HCDs) have also been reported to be effective in the treatment of venous ulcers. OBJECTIVE: Our purpose was to compare the effectiveness of CCAs with HCDs in healing chronic venous ulcers. METHODS: Forty-three patients with 47 ulcers were enrolled in a randomized controlled trial. Ulcers not healed by 6 weeks were changed to the other treatment. RESULTS: No difference in the number of healed ulcers between the two groups was observed at 6 weeks. Healing rate, percent reduction of initial ulcer size, and radial progression toward wound closure were significantly greater for CCAs than for HCDs. Pain relief was not significantly different. CONCLUSION: CCAs achieve more rapid healing and greater reduction in ulcer size than HCDs.

Adult↗
PubMed1984

A comparison of the in-vitro antibacterial and complement activating effect of 'OpSite' and 'Tegaderm' dressings.

Two readily available semipermeable polyurethane dressings, 'OpSite' and 'Tegaderm', were tested for their in vitro ability to kill potential bacterial pathogens and activate complement C3. In bacterial killing tests, 'OpSite' was superior to 'Tegaderm' and in addition only 'OpSite' activated C3. It is concluded that in the practical situation, 'OpSite' could well confer a greater margin of safety.

Bacteria↗
PubMed1987

'Tegaderm' dressings prevent recolonization of chlorhexidine-treated skin.

'Tegaderm', a semi-permeable, self-adhesive dressing made of polyurethane film, applied to intact upper arm skin in Intensive Care Unit (ICU) patients reduced the aerobic skin flora compared to adjacent exposed skin sites. We also applied 'Tegaderm' to skin disinfected with chlorhexidine; the aerobic skin flora remained unchanged at a low level for 5 days.

Adult↗
PubMed1983

Report on evaluation of hydron film as burn wound dressing.

Hydron Burn Dressing, an amalgam of Polyethylene Glycol-400, and Polyhydroxyethyl methacrylate formed directly on the burn wound has been used in 50 cases with comparable control areas on the same patients which were managed by Polybactrin spray and exposure. The 4-layer film was found to be easily applicable in indoor patients and was pain-free during application and reduced pain after application in superficial burns. It was found to be translucent, pliable, less liable to crack and did not peel off once dried. The rate of infection was found to be 12.5 per cent more than the controls but the healing time was shorter by 2.8 days. Patient's comfort and compliance was better than the scab of the control areas.

Adolescent↗
PubMed1984

Preliminary report on the use of a new hydrocolloid dressing in the treatment of burns.

Twenty-four patients who were referred to our outpatient clinic for treatment of burns were included in a study to evaluate the clinical effectiveness of a new hydrocolloid dressing (HCD). The depth of their burns ranged from superficial partial thickness to full thickness burns and the average size was 1.63 per cent of the total body surface. Seven patients had similar burns on other areas of their body which served as control areas. In six patients healing occurred slightly faster in the HCD treated wounds as compared to silver sulfadiazine (1 per cent), and at least as fast as compared with human allografts in these patients. Two patients were removed from the study; in the remaining non-control group (15 patients) healing progressed rapidly and the patients reported the treatment to be very comfortable. Follow-up visits after 1, 3 and 6 months showed excellent healing and there were no signs of hypertrophic scarring.

Adult↗
PubMed1985

Variables determining the amount of microbial contamination on cadaveric allograft skin used as a biological wound dressing.

The increased availability and use of cadaveric allograft skin as a temporary burn wound dressing has emphasized the need for a complete understanding of the parameters affecting the contamination level of this material. We undertook a prospective evaluation of the allograft skin obtained from 300 cadaveric donors over 5 years. We evaluated the contribution to skin contamination of eight parameters: sex, age, race, cause of death, elapsed time postmortem before skin removal, total refrigerated storage time of the skin prior to cryopreservation, donor body area from which the skin was removed, and choice of surgical operators or teams. The only parameters significantly related to skin contamination level were the choice of surgical operator or team which prepared the body and removed the skin (P = 0.0001) and the acceptance of skin from donors when the cause of death was unknown but presumed to be from natural causes (PNC) such as myocardial infarction or cerebral vascular accident (P = 0.006). In the case of the PNC deaths, there was only a small 3.4 per cent increase in bacterial contamination and no increase in fungi or yeast, while some surgical operators were associated with five-fold more bacterial contamination and nearly 13-fold more fungal contamination than other surgical operators. We conclude that the performance of surgical operators appears to be the major determinant of the microbiological cleanliness of skin from cadaveric allograft donors.

Age Factors↗
PubMed1990

Experiences using silicone gel tie-over dressings following skin grafting.

Twenty-six patients with 27 skin grafts treated with tie-over dressings using silicone gel sheets containing 0.02 per cent Ofloxacin are described. This method ensured direct in-progress inspection of healing of the grafted skin. Although the silicone gel tie-over procedure without any additional pressure resulted in haematoma and congestion in four out of 12 grafts (33.3 per cent), in the group with additional pressure (approximately 20-30 mmHg) limited to the early period after surgery there was no haematoma and congestion of the grafts in 15 grafts (P less than 0.05, Chi-square test). It is surmised that adequate pressure applied to the graft for a few days after surgery would be beneficial in preventing haematoma formation.

Adolescent↗
PubMed1992

Benefits of silicone cream occlusive dressing for treatment of meshed skin grafts.

A side-by-side evaluation of a silicone cream occlusive dressing technique for grafted meshed skin on the extremities of 10 patients is described. The site treated by silicone cream showed less congestion in the interstices of the mesh, less visible diamond pattern, and less hardness of the skin in all patients compared with the control site, which was treated by application of petroleum jelly ointment. The general appearance of the silicone cream-treated site showed better cosmetic results when compared with the control site.

Adolescent↗
PubMed2005

The biocompatibility of dibutyryl chitin in the context of wound dressings.

Dibutyryl chitin (DBC) is a modified chitin carrying butyryl groups at 3 and 6 positions; its peculiarity is that it dissolves promptly in common solvents, while being insoluble in aqueous systems. The high biocompatibility of dibutyryl chitin in the form of films and non-wovens has been demonstrated for human, chick and mouse fibroblasts by the Viability/Cytotoxicity assay, In situ Cell Proliferation assay, Neutral Red Retention assay, Lactate Dehydrogenase Release assay, MTS cytotoxicity assay, and scanning electron microscopy. DBC was hardly degradable by lysozyme, amylase, collagenase, pectinase and cellulase over the observation period of 48 days at room temperature, during which no more than 1.33% by weight of the DBC filaments (0.3 mm diameter) was released to the aqueous medium. DBC non-wovens were incorporated into 5-methylpyrrolidinone chitosan solution and submitted to freeze-drying to produce a reinforced wound dressing material. The latter was tested in vivo in full thickness wounds in rats. The insertion of 4x4 mm pieces did not promote any adverse effect on the healing process, as shown histologically. DBC is therefore suitable for contacting intact and wounded human tissues.

Amylases↗
PubMed2007

A silver-impregnated antimicrobial dressing reduces hospital costs for pediatric burn patients.

PURPOSE: Since using a novel silver-impregnated antimicrobial dressing (Aquacel Ag, ConvaTec, Princeton, NJ) in our pediatric patients with partial-thickness burns, hospital LOS has been significantly reduced. Here we investigated whether there was concomitant cost-effectiveness of this approach. METHODS: We retrospectively reviewed Burn Registry Data from a large Children's Hospital Burn Unit from January 2005 through August 2005 for inpatients with partial-thickness burns treated with Aquacel Ag. A comparison group was composed of patients from the same period the previous year treated with silver sulfadiazine cream (SSD, Par Pharmaceuticals, Woodcliff, NJ) and matched for age and %TBSA burned. Patients with inhalation injury or full-thickness burns were excluded. Intent-to-treat analysis was limited to patients with less than 22% TBSA burn. Direct costs and total charges were compared statistically after log transformation due to the skewedness of the data. RESULTS: Total charges and direct costs were significantly lower for Aquacel Ag-treated patients (n = 38) than for SSD-treated patients (n = 39) (P = .004 and P < .001, respectively). In addition, Aquacel Ag-treated patients had a shorter LOS than SSD-treated patients. DISCUSSION: These data strongly support our findings that the application of Aquacel Ag reduces hospital LOS which results in a significant cost savings in the care of pediatric patients with partial-thickness burns.

Anti-Infective Agents, Local↗
PubMed2002

Photocrosslinkable chitosan as a dressing for wound occlusion and accelerator in healing process.

Application of ultraviolet light (UV-) irradiation to a photocrosslinkable chitosan (Az-CH-LA) aqueous solution resulted in an insoluble, flexible hydrogel like soft rubber within 60 s. The chitosan hydrogel could completely stop bleeding from a cut mouse tail within 30 s of UV-irradiation and could firmly adhere two pieces of sliced skins of mouse to each other. In order to evaluate its accelerating effect on wound healing, full thickness-skin incisions were made on the back of mice and subsequently an Az-CH-LA aqueous solution was added into the wound and irradiated with UV light for 90 s. Application of the chitosan hydrogel significantly induced wound contraction and accelerated wound closure and healing. Histological examinations also have demonstrated an advanced granulation tissue formation and epithelialization in the chitosan hydrogel treated wounds. The chitosan hydrogel due to its accelerating healing ability is considered to become an excellent dressing for wound occlusion and tissue adhesive in urgent hemostasis situations.

Animals↗
PubMed1997

Novel method to investigate kinetics of rat skin cells by means of an occlusive dressing method using bromodeoxyuridine.

We developed a novel technique to detect S-phase skin cells by applying bromodeoxyuridine (BrdU) epicutaneously using an occlusive dressing (OD) method. BrdU was scarcely absorbed from the skin with a simple epicutaneous application, whereas the incorporation of BrdU was very well promoted with the use of our OD method. We applied BrdU on the backs of rats using this method and investigated the conditions required for an optimal response, with a special focus on the period of application, the concentration of BrdU used and vehicles suitable for the immunocytochemical staining of this agent. From these experiments, we were able to determine that an application time of at least 60 min was necessary to liable S-phase cells, a 2% concentration of BrdU was needed to obtain consistent labeling and aqueous vehicles are satisfactory solvents for BrdU preparations. Epidermal keratinocytes and S-phase cells in the upper portion of dermis were clearly labeled after either intraperitoneal injection of BrdU or after administration by means of the OD method. To ascertain whether this latter method could provide an effective alternative to intraperitoneal injection, we compared the labeling patterns of both methods with respect to the speed of migration of BrdU-labeled basal cells from the basal layer to the horny layer of epidermis. Using either of these two methods, basal keratinocytes were labeled immediately after administration. Three days after the first administration, BrdU-labeled cells were detected in the middle layer of the epidermis, but after 8 days, they were no longer evident in epidermal tissue. As another means of comparing both methods, we used antibody to proliferating cell nuclear antigen (PCNA) and compared the ratio of PCNA-positive basal cells to BrdU-labeled basal cells. The number of PCNA-positive cells was about 4.6 times greater than the number of BrdU-labeled basal cells by both methods. We concluded that the OD method could be used as a substitute for intraperitoneal injection in order to observe cell kinetics using bromodeoxyuridine.

Administration, Topical↗
PubMed2002

Experimental study of reparative regeneration processes in the wound treated with bioactive dressings.

Quantitative and structural functional analysis of granulation tissue cells during treatment with protein-polysaccharide dressing Collahit F was carried out. The preparation effectively cleansed the wound from detritus, prevented secondary infection due to stimulation of the functional activity of macrophages and due to the effect of its antiseptic component (furagin), and stimulated proliferative activity of fibroblasts and granulation tissue microvessels on day 5 of treatment, thus promoting repair processes in the wound.

Animals↗
PubMed2000

Investigation of amine and polyol functionality in extracts of polyurethane wound management dressings using MALDI-MS.

Polyurethane (PU) foams used in wound management are produced by a reaction between aromatic diisocyanates and polyether polyols. There is concern that residues of these starting materials, which may contain aromatic amine functionality, may leach from the finished polymer during in vivo applications. Furthermore, oligomers and additives may be leached from the PU system after the polymerization process is complete. Finished polymers have, therefore, been extracted with a range of solvents, such as water, diethyl ether and dilute HCl. The extracts were subjected to MALDI-MS (matrix-assisted laser desorption ionization mass spectrometry) analysis in an attempt to determine the amine and polyol functionality. Direct MALDI-MS analysis of the wound dressing extracts indicated the presence of components based on the polyols [corrected] used in the formulation of the foam. The spacing between the peaks identified the base monomer used in the polyol. MALDI-MS analysis of the fluorescamine derivatives of model amine compounds has demonstrated the anticipated increase in mass (278 for monoamines and 278 and 556 for diamines). Similar results were obtained from the derivatization of model polyols with phenyl isocyanate, where the mass shift (n x 119) was a direct measure of the number of active hydroxyl groups. Fluorescamine labelling of PU foams shows the colour change which could be [corrected] indicative of the presence of an amine, but the subsequent MALDI-MS analysis was unable to demonstrate the anticipated increase in mass.

Amines↗
PubMed1996

The effects of adding chlorhexidine and polyhexamethylene bisguanide to a light-cured periodontal dressing material.

The effect of adding two bisguanide antimicrobial agents (chlorhexidine and PHMB) on some physical properties of the light-cured periodontal dressing material Barricaid are reported. The physical properties tested were elastic modulus, initial and 10 min recovery strains, and tear stress. The addition of both chlorhexidine and PHMB solutions reduced the elastic modulus as did water. The addition of PHMB to Barricaid produced greater initial recovery in the strain test than either the addition of chlorhexidine or water, but there were no differences between the treatments after 10 min. Tear stress was also reduced by the addition of water and the chlorhexidine and PHMB solutions. These results suggest that as far as the physical properties of Barricaid are concerned the addition of the antimicrobial agent PHMB had no long-term advantages over chlorhexidine.

Anti-Infective Agents, Local↗
PubMed2001

[Treatment of 3rd degree fingertip frostbite in a mountain climber with semi-occlusive dressings].

Deep frostbites of the fingertips mostly result in some form of amputation. To preserve functional length and to achieve good sensibility, we managed deep frostbites of five fingertips of a mountain climber with semiocclusive dressings. The method was described by Mennen and Wiese (1993) for the management of fingertip injuries. To our knowledge, the method has not been used so far in the treatment of frostbites. The two fingertips presenting only deep soft-tissue damage achieved a nearly normal recovery of pulp shape and sensibility. The three fingers with bone involvement required a long period of time for complete healing. In two of these fingers, additional bone shortening had to be performed.

Finger Injuries↗
PubMed2004

[The treatment of heel pressure ulcer with V.A.C. therapy using the new V.A.C. GranuFoam "Heel-Dressing"].

The treatment of heel pressure ulcer represents one od the difficulties in treatment of pressure ulcer, because of its pressure load conditional on the calcaneus, the missing of muscle buffer and the huge number of tender insertions. With the V.A.C.-Therapy based upon interdisciplinary pretreatment (debridement, control of infection, circulation and metabolism and pressure relief) the growth of granulation tissure succeeds in a very fast time. The new V.A.C.-GranuFoam Heel Dressing contains the possibility to apply the V.A.C.-Therapy safe and very quick, in spite of the difficult ulcer location at the heel. Moreover it includes the necessary transfer of the T.R.A.C-Pad on the top of the foot to prevent new increase of pressure.

Aged↗
PubMed2004

Wound dressings for office-based surgery.

Since the turn of the 20th century, our understanding of wound healing has changed completely. Because of this, we now realize that wounds heal better under occlusive or semi-occlusive conditions. This revelation has led to the creation of a vast array of wound-dressing techniques and products that any office-based surgeon must use on a daily basis. This article reviews these techniques and products and offers the reader a framework of techniques that will help to achieve optimal surgical outcomes while at the same time maximize patient comfort and convenience.

Bandages↗