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Effect of naproxen on IUD-induced hypermenorrhea.

48 volunteers using either a Lippes Loop D or a T Cu 220C IUD who subjectively observed an increase in menstrual bleeding associated with IUD use received 250 mg naproxen 3 times/day during, or for 5 days of, their menstrual period. Results were compared with those on administration of placebo. Of the 48 women studied, 14 had hypermenorrhea (average 133.4 ml/menstrual cycle; heavy bleeding group) and 34 had blood loss within the normal range (average 47 ml; normal group). The study consisted of measuring menstrual blood loss (MBL) during the 1st (control cycle). During the 2nd cycle, the women received placebo medication 3 times/day for the 5 days of menses; results were not significantly different from control values. Naproxen was administered during the 3rd and 4th cycles (treatment); a significant reduction in the amount of MBL was observed in the group of women with heavy bleeding. During the 1st treatment cycle, a reduction of 42.8% was observed and during the 2nd treatment cycle, the reduction was 24.2%. In the group of women with MBL within the range of normal, no significant change in the amount of menstrual bleeding was observed in the treatment cycles as compared with the control cycle or placebo administration.

Contraception↗

Copper IUDs.

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Chemical Phenomena↗

A comparative study of the nylon T and copper T 200.

The nylon T IUD is identical to the copper T 200 except for the composition of nylon/copper. A study conducted at the Family Planning Institute in Ljubljana, Yugoslavia compared the nylon T with the copper T. Devices were randomly administered to women who had not been pregnant during the month prior to insertion. The pregnancy rate for the nylon T group was 13.0 at 12 months, significantly higher (Por= 0.01) than the rate of 0.0 for the copper T group. Effectiveness of copper devices is related to the copper itself, rather than being an effect of the increased surface area alone.

Birth Rate↗

A comparison of the initial pain response following insertion of the Copper 7 and combined Multiload Copper 250-short IUDs.

The immediate postinsertion and 3 minute postinsertion pain response in nulliparous women undergoing insertion of either the Copper 7 (Cu 7) or the Multiload Copper 250-short (ML Cu 250-short) IUD has been studied. 35 women were fitted with a Cu 7 device and 23 with the ML Cu 250-short. The immediate postinsertion pain scores were significantly higher in the ML Cu 250-short group than in the Cu 7 group. There was no significant difference between the 3 minutes postinsertion scores for the 2 groups. The 3 minute pain scores were significantly lower than the immediate pain scores for each individual device group. Immediate postinsertion IUD pain may be related to the presenting diameter and insertional mechanism of the device. This pain is of short duration and after 3 minutes, the level of pain is independent of the type of device which has been inserted. The rapid diminution of pain at 3 minutes postinsertion indicates that the routine use of certain analgesic techniques, e.g., paracervical block before IUD insertion, is not justified. Pain following IUD insertion may provide a useful model for the study of various types of peripheral and centrally acting analgesics.

Chemical Phenomena↗

Comparison of T Cu 200 and Progestasert IUDs.

Insertions of the T Cu 200 and the Progestasert IUDs in a total of 400 postpartum women were compared. Insertions were carried out within 10 minutes of delivery, either manually or with an inserter. There was a significant difference in the 6 and 12 month expulsion rates (P0.05) between the 2 groups, but no differences were found related to type of insertion. 12 month expulsion rates for the T Cu hand and inserter groups were 9.0 and 8.1, respectively, and 35.8 and 35.2 for the Progestasert hand and inserted groups, respectively. Overall, significantly fewer Progestasert users reported dysmenorrhea at follow-up and the specific 12 month dysmenorrhea rate was significantly lower for the Progestasert users than for the T Cu users. More women in the Progestasert groups reported intermenstrual spotting and bleeding, but specific 12 month rates of intermenstrual pain, spotting, and bleeding showed no differences between the groups.

Contraception↗