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PubMed2006

A predictive model for postoperative intraocular pressure among patients undergoing laser in situ keratomileusis (LASIK).

PURPOSE: The aim of this study was to develop a predictive model based on preoperative variables for estimating postoperative intraocular pressure (IOP) of those eyes undergoing LASIK surgery, to predict the amount of underestimated IOP after LASIK for myopia and myopic astigmatism. DESIGN: Pretest-post-test longitudinal study. METHODS: Both eyes of 193 eligible subjects who underwent LASIK procedures at the Department of Ophthalmology, National Taiwan University Hospital, from July 2000 to December 2002 for myopia and myopic astigmatism were identified to build up the predictive models. IOPs were measured with noncontact air-puff tonometry. Information on age, gender, preoperative central corneal thickness (CCT), preoperative central corneal curvature (CCK), preoperative spherical equivalent refractive error, and ablation depth was collected and applied for predicting postoperative IOP after LASIK based on linear mixed model. RESULTS: Significant predictors for postoperative IOP after myopic LASIK procedures included age, gender, preoperative IOP, ablation depth, preoperative CCT, and preoperative spherical equivalent refractive errors. The linear mixed model, taking into account these significant preoperative correlates and the correlation of IOPs between both eyes of the same patient, explained 91% of the variation of postoperative IOP. CONCLUSIONS: A statistical model was developed for predicting the amount of underestimated IOP after LASIK for myopia and myopic astigmatism, which is of clinical importance to uncover ocular hypertension among patients whose information on postoperative IOP immediately after LASIK is not available.

Adult↗
PubMedDate not supplied

Distribution of axial, corneal, and combined ametropia in a refractive surgery unit.

PURPOSE: To group eyes in our refractive surgery unit on the basis of the origin of their ametropia and to assess the percentage of eyes in the different groups. METHODS: Refractive parameters and the axial eye length (AL) of 131 eyes of 131 persons with different refraction were measured. The eyes were initially classified into five groups on the basis of the grade of their ametropia: hypermetropic (> +0.5 D, n = 35), emmetropic (between +/- 0.5 D, n = 24), low myopic (between -0.75 and -4.0 D, n = 24), medium myopic (between -4.25 and -8.0 D, n = 24), and high myopic (over -8.0 D, n = 24). Then a classification scheme was made to group the origin of the ametropia on the basis of AL and corneal refractive power. RESULTS: In the hypermetropic group pure corneal origin was found in 8.6%, pure axial origin in 62.8%, and combined origin in 28.6% of the eyes. In the low myopic group these values were 20.9%, 29.2%, and 45.8%, respectively. In the medium and high myopic groups no pure corneal myopia was found, while axial myopia was found in 16.7% and combined myopia in 83.3% of the eyes. CONCLUSIONS: With the help of the classification scheme, an objective decision could be made as to whether the ametropia of a particular eye had axial, corneal, or mixed origin. The most interesting result was that in 83% of medium and high myopic eyes not only AL but also corneal refractive power contributed to the refractive error instead of the eyes being purely axially myopic.

Adolescent↗
PubMed1988

Explanation of Broca's pupillometer.

Broca's pupillometer offers a simple and effective means of measuring the diameter of the pupil. However, it is often used without proper attention to the limitations of its optics. Errors of measurement may result from uncorrected refractive error, accommodation, spectacle correction, and spherical aberration (SA). A simple means of minimizing these errors is to hold the pinholes (PH's) of the pupillometer as close to the cornea as is feasible.

Accommodation, Ocular↗
PubMed2006

Wavefront analyzers induce instrument myopia.

PURPOSE: To assess the accuracy of three wavefront analyzers versus a validated binocular open-view autorefractor in determining refractive error in non-cycloplegic eyes. METHODS: Eighty eyes were examined using the SRW-5000 open-view infrared autorefractor and, in randomized sequence, three wavefront analyzers: 1) OPD-Scan (NIDEK, Gamagori, Japan), 2) WASCA (Zeiss/Meditec, Jena, Germany), and 3) Allegretto (WaveLight Laser Technologies AG, Erlangen, Germany). Subjects were healthy adults (19 men and 21 women; mean age: 20.8 +/- 2.5 years). Refractive errors ranged from +1.5 to -9.75 diopters (D) (mean: +1.83 +/- 2.74 D) with up to 1.75 D cylinder (mean: 0.58 +/- 0.53 D). Three readings were collected per instrument by one examiner without anticholinergic agents. Refraction values were decomposed into vector components for analysis, resulting in mean spherical equivalent refraction (M) and J0 and J45 being vectors of cylindrical power at 0 degrees and 45 degrees, respectively. RESULTS: Positive correlation was observed between wavefront analyzers and the SRW-5000 for spherical equivalent refraction (OPD-Scan, r=0.959, P<.001; WASCA, r=0.981, P<.001; Allegretto, r=0.942, P<.001). Mean differences and limits of agreement showed more negative spherical equivalent refraction with wavefront analyzers (OPD-Scan, 0.406 +/- 0.768 D [range: 0.235 to 0.580 D] [P<.001]; WASCA, 0.511 +/- 0.550 D [range: 0.390 to 0.634 D] [P<.001]; and Allegretto, 0.434 +/- 0.904 D [range: 0.233 to 0.635 D] [P<.001]). A second analysis eliminating outliers showed the same trend but lower differences: OPD-Scan (n=75), 0.24 +/- 0.41 D (range: 0.15 to 0.34 D) (P<.001); WASCA (n=78), 0.46 +/- 0.47 D (range: 0.36 to 0.57 D) (P<.001); and Allegretto (n=77), 0.30 +/- 0.62 D (range: 0.16 to 0.44 D) (P<.001). No statistically significant differences were noted for J0 and J45. CONCLUSIONS: Wavefront analyzer refraction resulted in 0.30 D more myopia compared to SRW-5000 refraction in eyes without cycloplegia. This is the result of the accommodation excess attributable to instrument myopia. For the relatively low degrees of astigmatism in this study (<2.0 D), good agreement was noted between wavefront analyzers and the SRW-5000.

Adult↗
PubMed1988

[Random dot stereograms and the limits of their detectability].

The influence of contrast reduction combined with aniseikonia on disparities in the TNO test was investigated with monocular induced refractive errors by spherical convex and concave lenses. Single contrast reduction was produced by Bangerter foils. Unilateral near vision of 0.1-0.2 is compatible with a positive TNO test. The average tolerance limit of the TNO test was 6% when produced by monocular induced refractive error. Otherwise, pure aniseikonia values of 5% to 9% produced by overall-size lenses are compatible with the TNO test.

Adult↗
PubMedDate not supplied

Intraocular lens implantation after penetrating keratoplasty.

Thirty-three postkeratoplasty eyes underwent extracapsular cataract extraction with posterior chamber lens implantation or secondary anterior chamber lens implantation 3 to 128 months following corneal transplantation. The mean follow-up after the secondary lens implantation was 24 months (range 2 to 70 months). Seven of the 33 corneas became cloudy 1 to 8 months after lens implantation. Prior to graft failure, 71% of the eyes achieved refractive errors within 2 diopters of emmetropia and 19 of 33 eyes (57%) achieved uncorrected visual acuities of 20/100 or better. In spite of surgical attempts to reduce preexisting astigmatism, the mean post-implant keratometry astigmatism was unchanged after secondary surgery. Compared with a concurrent series of triple procedures, the advantage of providing patients with refractive errors closer to emmetropia by performing surgery after a corneal transplant is outweighed by the increased risks to the graft, the increased costs and medical risks of two operations, the risk of increased astigmatism, and the delay in visual acuity recovery from the time of keratoplasty until obtaining a final refraction after secondary surgery.

Follow-Up Studies↗
PubMed2004

Asymmetrical increase in axial length in the two eyes of a monocular orthokeratology patient.

To report the myopia progression (change in axial length) of a boy in whom the progression was slower in the eye treated with overnight orthokeratology (ortho-k) than in the fellow eye with no visual correction. An 11-year-old boy was fitted with an ortho-k lens in his left eye in 1999 in a private practice. The refractive errors were OD -0.25 - 0.75 x 168 and OS -2.50 - 0.50 x 170 before commencing ortho-k lens wear. He participated in one of our research studies and made yearly visits to our clinic in 2001, 2002, and 2003. Logarithm of the minimum angle of resolution (logMAR) visual acuity, refraction, ocular health, and axial length were assessed at each visit. At the visit in 2003, the unaided visual acuity was OD 0.40 logMAR and OS -0.04 logMAR. Between 2001 and 2003, there was a small increase in axial length in the left eye (0.13 mm) but a significant increase in the axial length (0.34 mm) with a corresponding increase in spherical equivalent refractive error (0.75 D) in the right eye. This case suggests that myopia progression may have been slowed down by ortho-k lens wear in the eye undergoing treatment of a boy undergoing unilateral ortho-k treatment.

Adolescent↗
PubMed2000

[Ocular refraction and branch of retinal vein occlusion].

PURPOSE: To evaluate the significance of refractive errors in cases of branch retinal vein occlusion (BRVO). METHODS: We included in this study 179 patients with BRVO who attended our department between 1996-2000. We compared this group with an equal number of age, sex and associated diseases matched controls. The spherical equivalents of the refractive errors of patients in both groups were compared using the chi-square test and Student's t test. RESULTS: Hypermetropia was present in 114 patients wit BRVO (63.68%) and in 82 controls (45.8%, p = 0.00048). Myopia was present in 16 patient with BRVO (8.9%) and in 39 controls (21.8%, p = 0.0037). Emetropia was found in 49 patients (27.37%) and in 58 controls (32.4%, p = 0.299). CONCLUSIONS: Hypermetropia is significantly more common in patients with BRVO than in general population, but myopia is significantly less common in these patients than in controls.

Female↗
PubMed2006

Glaucoma in children: are we making progress?

BACKGROUND: Glaucoma in children presents difficult clinical challenges. Even when appropriately treated, blindness can occur. DESIGN: Retrospective interventional case series and literature review. METHODS: All clinical records of children seen by the author with a diagnosis of glaucoma established before 16 years of age were reviewed from 1977 to 2003. Glaucoma was classified as primary infantile, aphakic, syndrome-related, and secondary. The best-corrected visual acuity, refractive error, configuration of the optic nerve cup, and perimetry were recorded. The intraocular pressure (IOP) for each visit was recorded. IOP measurements of 19 mm Hg or less were considered "good." The percentage of "good" readings was calculated for each eye. Representative visual acuities, refractive errors, IOP, disk configuration, and perimetry were recorded at 6, 12, 18, and 24 years of age for each patient. The admitting ophthalmologic diagnosis for each child at the Western Pennsylvania School for Blind Children was recorded from 1887 to 2003. RESULTS: One hundred twenty-six children (204 eyes) were studied: infantile glaucoma, 52 eyes; aphakic glaucoma, 40 eyes; syndrome associated, 69 eyes; and secondary glaucoma, 43 eyes. The mean follow-up was 11.6 years (1 to 30 years). Overall, 60 (29.4%) of 204 eyes had a 6/12 (20/40) or better corrected visual acuity at the most recent visit. The percentage with this acuity remained stable throughout the follow-up period. Eyes with infantile glaucoma had the best acuity, and 40% had 6/12 (20/40) or better. Amblyopia was common and responded to treatment. Eyes with aphakic glaucoma had the worst acuity with only 10% achieving 6/12 or better. These eyes had a bimodal onset of glaucoma; eyes with an early onset had an angle closure configuration and eyes with a delayed onset had an open angle. Early cataract removal and microcornea were risk factors for glaucoma. If the IOP was maintained at 19 mm Hg or less (good) on 80% of the determinations over time, the optic nerve cup compared with the diameter of the optic nerve (C/D ratios) were stable. Eight patients had multiple, good quality, visual fields performed over 3 to 15 years. If the patients had "good" IOP on 70% of the measurements, the visual fields remained stable. A historical perspective of glaucoma control was gained by looking at the admitting diagnosis at the Western Pennsylvania School for Blind Children. From 1910 to 1970, an average of 9.2 children blind due to glaucoma were admitted each decade. From 1971 to 2003, there were only three children with glaucoma admitted over 30 years. CONCLUSION: Removal of congenital cataracts should be delayed until 3 to 4 weeks of age. Consideration should be given for using 19 mm Hg or less to measure the success of glaucoma treatment in children. Treatment of amblyopia is as important as IOP control in children. Imaging technology such as optical coherence tomography and measurement of central corneal thickness may play an important future role in the assessment of children with suspected or known glaucoma.

Child↗
PubMed2002

[Retinal thickness and changes with age].

PURPOSE: We studied the morphological changes occurring with aging in the macula using optical coherence tomography(OCT). METHODS: Forty-seven eyes from 47 normal volunteers were studied. The subjects ranged in age from 21 to 79 years and their refractive errors were within +/- 3.00 diopters. The measurement of the retinal thickness was done by OCT. The retinal thickness was evaluated at five points: the foveola, and 1 mm superior, inferior, nasal, and temporal to the foveola. The axial length of the eye and the refraction were also measured in all subjects. RESULTS: The retinal thickness was 142 +/- 15 microns at the foveola, 257 +/- 18 microns at the superior point, 255 +/- 18 microns at the inferior point, 246 +/- 20 microns at the temporal point, and 261 +/- 21 microns at the nasal point (mean +/- standard deviation). All points except the foveola showed reduced retinal thickness with age. Thus, attenuation of the retinal thickness in the parafoveal area was correlated significantly with age. However, no change in the retinal thickness at the foveola was observed with increasing age. Neither axial length nor refractive error biased this result. CONCLUSION: Our results demonstrated that the macular thickness changes with aging, but no obvious change could be detected in the foveola.

Adult↗
PubMed2003

Is it possible to differentiate early-onset accommodative esotropia from early-onset essential esotropia?

PURPOSE: To determine the frequency of > or =2.50 diopter (D) hyperopia in infantile esotropia with onset up to the age of 6 months and by evaluating the treatment results of these cases retrospectively, to find the factors that may help to differentiate early-onset accommodative esotropia from early-onset essential esotropia. METHODS: The charts of 256 patients with infantile esotropia were reviewed. Thirtyseven cases, with hyperopia of > or =2.50 D, no other systemic and neurologic disease, and at least 1 year of follow-up, were included in this study. The age at the start of therapy, refractive error, deviation angle, type of therapy (antiaccommodative therapy, surgery) and the presence of amblyopia, latent nystagmus, inferior oblique overaction, dissociated vertical deviation and cross-fixation were recorded for each case. RESULTS: The prevalence of high hyperopia was found to be 14.4% (37/256) in infantile esotropia. In 18 of the cases (48.6%), antiaccommodative therapy alone was found to be adequate (Group I). In the remaining 19, although antiaccommodative therapy was found to decrease the deviation angle significantly (P<0.001), surgery was also required (Group II). Groups were compared with respect to age at the initial examination, refractive error, deviation angle, presence of amblyopia, anisometropia, and inferior oblique overaction, but no factor could be determined to predict the pure refractive ones (P>0.05). Essential infantile esotropia-associated findings did not help because they are rarely evident at the time of initial diagnosis. CONCLUSIONS: Half of the high hyperopic infantile esotropes could be corrected fully by antiaccommodative therapy alone, while the remaining ones could also benefit significantly. It is strongly recommended to try spectacles at first in the treatment of infantile esotropia with hyperopia > or =2.5 D.

Accommodation, Ocular↗
PubMed2005

The eye care profile and outcomes of multi-handicapped adults residing in Wayne County, Michigan group homes.

BACKGROUND: Patients with multi-handicaps present clinical challenges and are underserved. Central nervous system dysfunction and ocular disorders with this population are prevalent and well-documented. However, vision care outcomes data are limited and specific visual function recommendations to caregivers are rarely cited. METHODS: The charts of 110 multiply handicapped adults residing in 22 group homes in Wayne County. Michigan were retrospectively studied to identify ocular profiles and predictors of visual function. RESULTS: Sixty-five percent of the subjects were male and 80% were ages 26 to 55 years. There was no expressive language in 41%, and 37% were non-ambulatory. The median visual impairment level was moderate in both eyes (based on WHO). Significant associations between visual impairment level and subpopulations (such as seizure disorder, mental retardation without specific etiology, cerebral palsy, and Down syndrome) were identified. Successful spectacle wear statistically increased with higher refractive errors. Associations between cataract, nystagmus, and strabismus with particular subpopulations were significant (all P values < 0.0182). CONCLUSIONS: Clinicians who evaluate patients with multi-handicaps have few known predictors of treatment success. This study indicates that useful predictors of visual function can be made from refractive error, systemic conditions, and ocular diagnoses. No significant relationship was found with cognitive level and either vision impairment or spectacle use. The authors attribute successful implementation of recommendations to communication with group home caregivers.

Adult↗
PubMed1992

Factors influencing normal perimetric thresholds obtained using the Humphrey Field Analyzer.

The relationships between dioptric blur, pupil size, retinal eccentricity, and retinal sensitivity were investigated in the central 5 degrees of the visual field in 10 normal subjects using the Humphrey Field Analyzer. Pupil size did not influence the foveal sensitivity or retinal profile in the unblurred condition. The slope of the retinal profile was significantly steeper in the 3 mm pupil size condition (-0.62 dB/degree) than when compared to the 8 mm pupil size condition (-0.34 dB/degree), when averaged over all dioptric blur conditions. The depth of focus for the 3 mm pupil size condition (3.86 diopters) was significantly greater than that found for the 8 mm pupil size condition (1.82 D). The retinal threshold doubling eccentricity (E2) was calculated to be similar to that of grating acuity and contrast sensitivity (3.71). The data suggest that while large depth of focus effects in small pupil sizes appear to reduce the need for accurate refractive error corrections in determining perimetric retinal sensitivities, variations in the slope of the retinal profile under conditions of uncontrolled dioptric blur and pupil size may result in the artifactual sensitivity decreases. Therefore, it is recommended that measurement of pupil size and accurate correction of near refractive errors be performed to minimize the possibility of incorrect detection of central visual field defects.

Adult↗
PubMed2005

Ocular higher-order aberrations in myopia and skiascopic wavefront repeatability.

PURPOSE: To study the distribution of ocular higher-order aberrations (HOAs) in a myopic population and to assess the repeatability of HOA measurements determined by a commercially available skiascopic wavefront sensor. SETTING: Department of Ophthalmology, Assaf Harofeh Medical Center, Zerifin, Israel. METHODS: Ocular HOAs were examined 3 times across a 6.0 mm naturally dilated pupil in 61 eyes using the Optical Path Difference (OPD)-scan wavefront aberrometer. Root-mean-square (RMS) values of HOAs, total spherical aberration (TSA), total coma (TC), and total trefoil (TT) were analyzed. Correlation analysis was performed to assess the aberration symmetry between right and left eyes. The repeatability of the OPD-scan measurements was assessed by calculating Pearson r correlation coefficients between each pair of measurements and the interclass correlation coefficients between the 3 measurements of each score. RESULTS: The mean RMS values of HOAs, TSA, TC, and TT were 0.347 microm +/- 0.252 (SD), 0.120 +/- 0.174 microm, 0.165 +/- 0.168 microm, and 0.252 +/- 0.157 microm, respectively. The HOAs, TSA, TC, and TT changed slightly and not significantly with increasing refractive error (all P>.05). The RMS level of HOAs and TTR of the 3rd measurement was significantly different from the 1st and 2nd measurements (P<.05), with overall low correlation between the 3 measurements for the HOAs, TSA, TC, and TT. CONCLUSIONS: The ocular wavefront aberrations varied greatly from subject to subject. Ocular HOAs were not correlated with refractive error. The repeatability of HOAs measurements with the OPD-aberrometry was low.

Adolescent↗
PubMed2000

Temporal variations in myopia progression in Singaporean children within an academic year.

PURPOSE: Excessive nearwork is believed to be associated with myopia development and progression. To investigate this further, we studied refractive error changes and their correlation with nearwork in a cohort of grade school children in Singapore. METHODS: Cycloplegic autorefraction was performed 5 times over 10 months on 168 children aged 7, 9, and 12 years who were further divided into myopic and nonmyopic subgroups based in their initial refractive errors. Information about nearwork was obtained through diaries filled out over 24 h at the commencement of the study. RESULTS: Myopia progression was high (overall mean: -0.87 D per year) and largely linear throughout the year, but significantly higher rates were seen after the final school examinations in 7-year-old myopes and nonmyopes. Overall, myopic groups exhibited higher progression rates than nonmyopic groups, although 33.6% of subjects from the latter groups had become myopic by the end of the study. Nearwork scores derived from the diaries were generally not well correlated with overall myopia progression. CONCLUSIONS: The tendency for myopia progression rates to increase after the final school examinations in 7-year-olds is interpreted as a delayed effect of the intense nearwork associated with preparing for them. The timing of nearwork-diary data collection at the beginning of the study could be responsible for the poor correlation between these data and overall myopia progression rates.

Child↗
PubMedDate not supplied

Hyperopia correction using an erodible mask excimer laser delivery system coupled to an axicon: preliminary results.

PURPOSE: This paper presents the results of the first human trial on the correction of hyperopia using an erodible mask excimer laser delivery system coupled to an axicon. METHODS: We treated 17 eyes of 17 patients (age range 34-62 years) for the correction of +3.21 +/- 1.04 D (range +1.00 to +4.00 D). The hyperopic correction was made using an erodible mask inserted on the laser optical pathway, to produce a circular ablation measuring 6.5 mm in diameter. An axicon was then used to create a blend transition zone from 6.5 mm up to 9.4 mm in diameter. Eyes were evaluated at one, three and six months after surgery. RESULTS: Reepithelization was always observed by the fifth postoperative day, despite the large area of deepithelization (diameter 9.5 mm). Mean refractive error one month after treatment was -2.44 +/- 1.59 D (range 0.00 to -6.50 D). Five eyes (29.4%) had a best corrected visual acuity loss more than two to three lines; all eyes showed mild annular haze not involving the central part of the cornea. Six months after treatment, mean refractive error was -0.88 +/- 0.99 D (range +0.50 to -3.00 D). Compared to preoperative status, 13 eyes (76.5%) showed an improvement in uncorrected distance visual acuity (1-8 lines), and 14 eyes (82.4%) showed an improvement in uncorrected vision at reading distance (3-7 lines). Two eyes (11.7%) showed a best corrected visual acuity loss of two of three lines. CONCLUSIONS: These preliminary results indicate this approach is effective in reducing hyperopia, while its predictability has still to be proved in a larger treatment group with longer follow-up. A cautious approach to this technique is still advisable, especially for higher hyperopic corrections, in view of the large best corrected visual acuity loss seen in two eyes at six months.

Adolescent↗
PubMed2005

Cornea-sparing laser in situ keratomileusis: ablation on the flap.

PURPOSE: To evaluate the safety and efficacy of laser ablation on the flap as a treatment for a refractive error. SETTING: Laser Sight Centres, Sydney, Australia. METHODS: In this noncomparative case series, 142 treatments were performed in 98 patients using cornea-sparing laser in situ keratomileusis (LASIK) with ablation of the corneal flap and, in some cases, also the stromal bed for spherical equivalent (SE) refractive errors from -0.50 diopter (D) to -12.38 D. The procedure was performed as a primary treatment in 104 eyes, an initial enhancement in 32 eyes, and a second enhancement in 6 eyes. Data were extracted for analysis by retrospective review of patients' charts. RESULTS: After LASIK, the mean SE was -0.20 D +/- 0.47 (SD) (range +0.87 to -2.35 D) excluding eyes with monovision. The 6 eyes with monovision had a mean SE of -1.90 D with myopia of -1.70 D (range -1.00 to -3.00 D) and mean astigmatism of -0.37 D (range 0 to -0.75 D). Excluding eyes with monovision, 97% of eyes achieved an uncorrected visual acuity of 6/12 or better and 64% of eyes, better than or equal to 6/6. Ninety-six percent were within +/-1.0 D of the intended correction (SE). The safety index was 1.02 and the efficacy index, 0.8. CONCLUSIONS: Laser ablation of the corneal flap achieved good visual results and enabled preservation of the posterior corneal stroma. This technique may aid the prevention of corneal keratectasia following LASIK.

Adult↗
PubMed2001

Asteroid hyalosis in a population: the Beaver Dam eye study.

PURPOSE: To estimate the prevalence of asteroid hyalosis and to examine correlates of asteroid hyalosis in a population-based cohort. METHODS: The population of Beaver Dam, Wisconsin, that was 43 to 86 years of age was examined from 1988 to 1990 (n = 4926). The population is predominantly white (99.4%) northern European. Asteroid hyalosis was determined from stereoscopic fundus photographs of three standard fields. RESULTS: Fundus photographs were gradable in 4747 subjects. Asteroid hyalosis was present in 1.2% (95% confidence interval, 0.9,1.5%). In subjects in which it was present, asteroid hyalosis was bilateral in 9%. Prevalence increased significantly (P <.001) with age from 0.2% in subjects 43 to 54 years to 2.9% in subjects 75 to 86 years. After adjusting for age, men were more likely (1.8%) to have asteroid hyalosis than women (0.8%). After adjusting for age and sex, asteroid hyalosis was significantly more likely to be found in subjects with greater body mass (P =.02) and higher alcohol consumption (P =.03). There were nonsignificant trends with systolic blood pressure (P =.07), serum cholesterol (P =.09), and serum albumin (P =.09). It was not significantly associated (P >.05) with diastolic blood pressure, hypertension, diabetes, cardiovascular disease history, high-density-lipoprotein cholesterol, serum calcium, cigarette smoking, physical activity, intraocular pressure, or refractive error. These relationships were confirmed in a multivariable logistic model. CONCLUSIONS: The current study documents the infrequency of asteroid hyalosis in the population as graded from three photographic fields of the fundus. It does not support previous observations of an association of asteroid hyalosis with diabetes or refractive error. The relevance of the new associations reported (body mass, alcohol) remains to be determined.

Adult↗