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PubMed1993

An "intelligent" workstation for computer-aided diagnosis.

Computer-aided diagnosis (CAD) involves a computerized analysis of radiographs that is used as a "second opinion" by the radiologist. The approach presented incorporates computer vision and artificial intelligence techniques and includes schemes for the analysis of lung nodules, interstitial infiltrates, and cardiomegaly seen on chest radiographs; masses and clustered microcalcifications on mammograms; and stenoses and blood flow on angiograms. The demonstration of various CAD schemes in chest radiography and mammography on a six-monitor workstation simulates one possible clinical implementation of CAD in radiology. Whether soft- or hard-copy display media are used, the radiologist can refer to the CAD results and still use the original radiograph for the final diagnosis. Although initial impressions of this simulated "intelligent" workstation are encouraging, CAD is still in a preliminary stage of development. Various methods for effectively and efficiently integrating CAD into a clinical radiology department are being investigated.

Angiography↗
PubMed2002

Double-blind, placebo-controlled study of risperidone for the treatment of disruptive behaviors in children with subaverage intelligence.

OBJECTIVE: The short-term efficacy and safety of risperidone in the treatment of disruptive behaviors was examined in a well-characterized cohort of children with subaverage intelligence. METHOD: In this 6-week, multicenter, double-blind, parallel-group study of 118 children (aged 5-12 years) with severely disruptive behaviors and subaverage intelligence (IQ between 36 and 84, inclusive), the subjects received 0.02-0.06 mg/kg per day of risperidone oral solution or placebo. The a priori primary efficacy measure was the change in score from baseline to endpoint on the conduct problem subscale of the Nisonger Child Behavior Rating Form. RESULTS: The risperidone group showed significantly greater improvement than did the placebo group on the conduct problem subscale of the Nisonger Child Behavior Rating Form from week 1 through endpoint (change in score of -15.2 and -6.2, respectively). Risperidone was also associated with significantly greater improvement than placebo on all other Nisonger Child Behavior Rating Form subscales at endpoint, as well as on the Aberrant Behavior Checklist subscales for irritability, lethargy/social withdrawal, and hyperactivity; the Behavior Problems Inventory aggressive/destructive behavior subscale; a visual analogue scale of the most troublesome symptom; and the Clinical Global Impression change score. The most common adverse effects reported during risperidone treatment were headache and somnolence. The extrapyramidal symptom profile of risperidone was comparable to that of placebo. Mean weight increases of 2.2 kg. and 0.9 kg occurred in the risperidone and placebo groups, respectively. CONCLUSIONS: Risperidone was effective and well tolerated for the treatment of severely disruptive behaviors in children with subaverage IQ.

Aggression↗
PubMed1993

A neuropsychological approach to the Bannatyne recategorization of the Wechsler Intelligence Scales in adults with learning disabilities.

An investigation was conducted of the diagnostic ability of the Bannatyne recategorization of the Wechsler Adult Intelligence Scale-Revised (WAIS-R) into spatial, verbal-conceptual, and sequential components for adults with learning disabilities. A comparison among neuropsychological, intelligence, and achievement test data was made to evaluate the applicability of this recategorization. The Luria-Nebraska Neuropsychological Battery (LNNB), the WAIS-R, and the Wide Range Achievement Test-Revised (WRAT-R) were administered to 103 adult subjects with learning disabilities. The LNNB scales were cluster analyzed, and cluster membership was cross-tabulated against WAIS-R, WRAT-R, and demographic data. The major findings were that (a) the mean scores fit the Bannatyne pattern in two of the four clusters; and (b) the Bannatyne pattern was found in only about 20% of the total sample. It was concluded that identification of the Bannatyne pattern is of diagnostic utility, but its absence is inconclusive.

Adult↗
PubMed2003

Intelligent data analysis to interpret major risk factors for diabetic patients with and without ischemic stroke in a small population.

This study proposes an intelligent data analysis approach to investigate and interpret the distinctive factors of diabetes mellitus patients with and without ischemic (non-embolic type) stroke in a small population. The database consists of a total of 16 features collected from 44 diabetic patients. Features include age, gender, duration of diabetes, cholesterol, high density lipoprotein, triglyceride levels, neuropathy, nephropathy, retinopathy, peripheral vascular disease, myocardial infarction rate, glucose level, medication and blood pressure. Metric and non-metric features are distinguished. First, the mean and covariance of the data are estimated and the correlated components are observed. Second, major components are extracted by principal component analysis. Finally, as common examples of local and global classification approach, a k-nearest neighbor and a high-degree polynomial classifier such as multilayer perceptron are employed for classification with all the components and major components case. Macrovascular changes emerged as the principal distinctive factors of ischemic-stroke in diabetes mellitus. Microvascular changes were generally ineffective discriminators. Recommendations were made according to the rules of evidence-based medicine. Briefly, this case study, based on a small population, supports theories of stroke in diabetes mellitus patients and also concludes that the use of intelligent data analysis improves personalized preventive intervention.

Brain Infarction↗
PubMed2005

A dynamic neuro-fuzzy model providing bio-state estimation and prognosis prediction for wearable intelligent assistants.

BACKGROUND: Intelligent management of wearable applications in rehabilitation requires an understanding of the current context, which is constantly changing over the rehabilitation process because of changes in the person's status and environment. This paper presents a dynamic recurrent neuro-fuzzy system that implements expert-and evidence-based reasoning. It is intended to provide context-awareness for wearable intelligent agents/assistants (WIAs). METHODS: The model structure includes the following types of signals: inputs, states, outputs and outcomes. Inputs are facts or events which have effects on patients' physiological and rehabilitative states; different classes of inputs (e.g., facts, context, medication, therapy) have different nonlinear mappings to a fuzzy "effect." States are dimensionless linguistic fuzzy variables that change based on causal rules, as implemented by a fuzzy inference system (FIS). The FIS, with rules based on expertise and evidence, essentially defines the nonlinear state equations that are implemented by nuclei of dynamic neurons. Outputs, a function of weighing of states and effective inputs using conventional or fuzzy mapping, can perform actions, predict performance, or assist with decision-making. Outcomes are scalars to be extremized that are a function of outputs and states. RESULTS: The first example demonstrates setup and use for a large-scale stroke neurorehabilitation application (with 16 inputs, 12 states, 5 outputs and 3 outcomes), showing how this modelling tool can successfully capture causal dynamic change in context-relevant states (e.g., impairments, pain) as a function of input event patterns (e.g., medications). The second example demonstrates use of scientific evidence to develop rule-based dynamic models, here for predicting changes in muscle strength with short-term fatigue and long-term strength-training. CONCLUSION: A neuro-fuzzy modelling framework is developed for estimating rehabilitative change that can be applied in any field of rehabilitation if sufficient evidence and/or expert knowledge are available. It is intended to provide context-awareness of changing status through state estimation, which is critical information for WIA's to be effective.

Decision Support Techniques↗
PubMedDate not supplied

Speech intelligibility during respirator wear: influences of respirator speech diaphragm size and background noise.

This study assessed the effect of respirator speech device size on speech intelligibility and the impact of background noise on respirator communications effectiveness. Thirty-five subjects completed modified rhyme test (MRT) speech intelligibility testing procedures with and without a respirator under background noises of 40, 60, and 80 dBA. Respirator wear conditions included the use of one unmodified and three mechanical speech diaphragms modified to reduce the surface area of the vibrating inner membrane available for sound transmission. Average MRT scores decreased linearly as background noise levels increased for all conditions. Lower MRT scores were observed for all respirator speech diaphragm conditions compared to the nonrespirator condition within each noise category. Average MRT scores differed significantly between the unmodified speech diaphragm and one with a 70% reduced surface area with a 40-dBA background noise. However, MRT scores were similar between the modified and unmodified diaphragms at both the 60- and 80-dBA noise levels. These findings provide evidence that alternate designs of mechanical-type respirator speech devices can be achieved without further degradation of speech sound transmission.

Adult↗
PubMed1989

Personality assessment with children of superior intelligence: divergence versus psychopathology.

The perceptual and cognitive functioning of children with intelligence quotients greater than 135 was examined with the Rorschach Inkblot Test. A criterion measure, the Child Behavior Checklist, was also administered so as to determine whether deviations for Rorschach variables from age-appropriate norms indicated the presence of psychopathology or were evidence of nonentrenched, novel, or creative styles of encoding and processing information. Rorschach variables indicative of intellectual sophistication, nonentrenched thinking or inaccurate reality perception, and cognitive slippage were reliably elevated for this sample versus norms. Results for the Child Behavior Checklist demonstrated that the incidence of psychopathology in the intellectually superior and average samples were comparable. There was a lack of covariance between Rorschach makers of inaccurate reality perception, cognitive slippages, and schizophrenia, and the sum of behavior problems on the Child Behavior Checklist. Results for the Rorschach and Child Behavior Checklist variables were comparable for children with intelligence quotients greater than 150 versus between 136 and 140. It was concluded that the intellectually superior children did process the Rorschach stimuli in a manner that was nonentrenched and reliably different from norms, but that these differences should not routinely be considered as indications of psychopathology.

Adolescent↗
PubMed2004

The intelligent data management system for toxicogenomics.

Toxicogenomics is now emerging as one of the most important genomic application because the toxicity test based on gene expression profiles is expected to be more precise and efficient than current histopathological approaches in a pre-clinical phase. One of the challenging issues in toxicogenomics is the construction of intelligent database management system which can deal with heterogeneous and complex data from many different experimental and information sources. TEST(Toxicogenomics for Efficient Safety Test) database is especially focused on the connectivity of heterogeneous data and the intelligent query system which enable users to obtain relevant useful information from the complex data sets. The database deals with four kinds of information; compound, histopathology, gene expression, and annotation information. Currently, TEST database maintains toxicogenomics information for 16 compounds, 45 microarrays, 190 animal experiments, and customized 4.8 K rat clone set. Our presented system is expected to be a good information source for studying of toxicology mechanism in the genome-wide level and can also be applied to the designing toxicity test chip.

Animals↗
PubMed2001

The influence of acquired intelligence on cerebral impairment in the elderly.

During a psychopharmacological trial, the inpatients of three geriatric nursing homes underwent a psychometric examination in which the Multiple Choice Intelligence Test (MWT-B) was used to determine the level of premorbid intelligence. The results seem to indicate that older people with mild to moderate organic brain syndrome and healthy elderly individuals show little difference with regard to their cognitive plasticity. Shaping conditions of the social sphere, as well as a performance-stimulating environment which continuously encourages independent behavior, appear to be of decisive importance for the protection of specific cognitive abilities and mobilization of reserve capacities. (c) 2001 Prous Science. All rights reserved.

Journal Article↗
PubMed2003

An intelligent partner system for improving chronic illness care.

Chronic care consists of a sequence of actions to treat a specific clinical disorder over time as a function of the ways in which illness progresses and patients respond to management actions. Outcomes depend on physicians' skills to select the actions best suited for their patients and competent self-management. This paper presents the architecture of an intelligent partner system (IPS), which helps to provide doctors with relevant data and skills and empowers chronically ill patients with the information and confidence to manage their health wisely. The services of this intelligent system are presented as 'therapies' for the information-processing 'pathologies' associated with traditional chronic illness care.

Chronic Disease↗
PubMed1978

Relationships between MMPI measures of psychopathology and WAIS subtest scores and intelligence quotients.

This study investigated relationships between MMPI scale elevations and WAIS subtest deviation scores and Full Scale intelligence quotients in 272 psychiatric patients. Analysis indicated few significant relationships between MMPI elevations and WAIS deviation scores, especially when compared with the high proportion of significant relationships found between demographic variables and WAIS measures. MMPI elevations were significantly related to Full Scale IQ. Although the results do not support the idea that specific WAIS subtest scores are related to psychopathology, they do support the idea that general intelligence is negatively related to psychopathology.

Adolescent↗
PubMed1991

Relationships between scores on Wechsler Preschool and Primary Scale of Intelligence--Revised and Stanford-Binet IV.

The Wechsler Preschool and Primary Scale of Intelligence--Revised and the Stanford Binet-Intelligence Scale: Fourth Edition were given to 51 preschool, kindergarten, first, and second grade students. Twelve of 15 Pearson correlations between Wechsler IQs and composite and area scores of the Stanford-Binet IV were statistically significant. It is apparent that the two tests measure similar, but not identical, concepts.

Child↗
PubMed2001

Validity and reliability of the Japanese version of the Emotional Intelligence Scale among college students and psychiatric outpatients.

We examined the validity and reliability of the Japanese version of the Emotional Intelligence Scale in two samples of 267 college students and 398 psychiatric outpatients. Suitable validity and reliability of this scale were suggested by high correlations with scores on the NEO Personality Inventory, adequate internal consistency, and relatively high test-retest correlations. The Emotional Intelligence Scale seems suitable for both clinically distressed populations as well as comparative groups such as college students.

Adaptation, Psychological↗
PubMedDate not supplied

Intelligibility of distorted speech sounds shifted in frequency and time in normal children.

Distorted speech sounds were presented to normal children aged 4-11 years and to young adults in such a way that 20 monosyllables were distorted with a 'speech stretcher' which produced frequency expansion and compression and also time expansion and compression. The experiment was performed to observe the intelligibility of such distorted speech sounds and the development of the discrimination ability in normal children. The results were as follows: (1) discrimination decreased sharply with increasing frequency change in both frequency-expanded and frequency-compressed speech; (2) discrimination was relatively unaffected by time expansion. However, with time compression there was a gradual decrease in discrimination at 50% time compression followed by a rapid deterioration at 75% time compression; (3) for a given percentage of distortion, frequency shift degraded intelligibility of speech sounds more severely than time shift, and (4) discrimination ability clearly increased with age in normal children. There was no significant difference between boys and girls.

Age Factors↗
PubMedDate not supplied

Intelligibility of time-expanded speech with normally hearing and elderly subjects.

The effects of time-expanded monosyllabic words (NU-6) on the auditory discrimination performance of 15 young adults with normal hearing and 20 elderly subjects were studied. Three conditions of time expansion, 30, 60 and 100%, plus a 0% control condition, were presented at four sensation levels (8, 16, 24 and 32 dB). For the normally hearing subjects, auditory discrimination performance at all ratios of time expansion was equal to the 0% condition. Results for the elderly subjects indicated intelligibility was inversely related to time expansion at the 30 and 60% conditions. However, at the 100% condition, speech intelligibility improved over the 60% condition at 8 and 16 dB sensation level. At 24 and 32 dB sensation level, performance at 100% was equal to the 60% condition. With the normal and elderly subjects, ear and list effects were minimal. The results are discussed in terms of the clinical value of this procedure and in light of literature that reviews the performance of subjects on tests employing various temporally altered stimuli.

Acoustic Stimulation↗
PubMed1990

Factor analysis of the mainland Chinese version of the Wechsler Adult Intelligence Scale (WAIS-RC) in a brain-damaged sample.

We factor analyzed the Chinese revision of the Wechsler Adult Intelligence Scale (WAIS-RC) in a sample of 59 individuals with medically diagnosed brain damage. The Chinese subjects consisted of 42 males and 17 females with means for Verbal. Performance, and Full Scale IQ of 83.88 (SD = 22.11), 75.49 (SD = 20.63), and 78.42 (SD = 21.97), respectively. Clear support was found for a general intelligence factor (g) and the Full Scale IQ. Similarly, the two-factor solution provided support for Wechsler's (1981) Verbal and Performance IQ designations. The three-factor solution revealed the familiar Verbal-Comprehension and Perceptual-Organization factors. However, the Freedom From Distractibility factor was less clearly defined. Comparisons of Chinese and American factor structures for neurologically impaired persons demonstrated high coefficients of congruence, ranging from .93 to .98. Overall, the findings demonstrated substantial congruence cross culturally for Chinese and American brain-damaged samples and suggest that the WAIS-RC measures essentially the same constructs as the WAIS-R.

Adolescent↗
PubMed1985

Improvements in speech intelligibility in quiet and in noise produced by two-channel compression hearing aids.

Eight subjects suffering from bilateral sensorineural hearing losses with recruitment were fitted binaurally with two-channel compression hearing aids, worn behind the ear. After they had worn the aids for some time, measures of speech intelligibility were compared for two conditions: listening unaided, and listening aided. the dynamic range for speech, defined as the difference in level between the speech reception threshold in quiet and the highest comfortable level for speech, was substantially increased in the aided condition for seven of the eight subjects (the exception was a subject with almost normal low-frequency hearing). Speech reception thresholds were also measured in two levels of background noise ('babble'), 60 and 75 dB SPL. Seven of the eight subjects showed a reduced speech reception threshold (i.e. an improvement) in the aided condition for at least one of the two noise levels, although the size of the improvement differed considerably from one subject to another. The subjects were also given a battery of psycho-acoustical tests in an attempt to better characterise their hearing loss, and to gain more insight into individual differences. Results of measurements of frequency selectivity, frequency discrimination, temporal acuity and temporal masking are described and related to the measures of speech intelligibility.

Aged↗
PubMed1995

Paired comparisons between the Classic 300 bone-anchored and conventional bone-conduction hearing aids in terms of sound quality and speech intelligibility.

Fourteen experienced users of bone-anchored hearing aids conducted paired comparisons of sound quality and speech intelligibility for 6 and 4 different stimuli respectively in the Classic 300 and a bone-conduction hearing aid with a steel clip. Ten paired comparisons were made for each stimulus. The patient selected the best hearing aid and rated the chosen hearing aid on a scale of 'somewhat better', 'better' and 'much better'. The Classic 300 obtained a positive assessment in terms of sound quality and speech intelligibility far more frequently. All the patients chose the Classic 300 as the best hearing aid when they assessed the sound quality of the classical music stimulus.

Adult↗