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[Routine follow up after treatment for gynecological cancer].

BACKGROUND: Cancer patients are traditionally given follow-up. An earlier diagnosis of recurrent disease is thought to improve chances for curative treatment. The aim of this study was to investigate the approach to routine follow-up after treatment for gynecological cancer. MATERIALS AND METHODS: A questionnaire was sent to all gynaecologic departments in Norway. RESULTS: The number of examinations offered varies from eight to 15 during the first five-year period after primary treatment. Most departments offer four examinations during the first year, two during the second and third years, and one yearly thereafter. There are variations in the routine use of additional tests. Most departments use cytological tests for vulvar, cervical and uterine cancer patients. Chest roentgenography is used more frequently among cervical and uterine cancer patients compared with vulvar and ovarian cancer patients. For ovarian cancer patients, the use of ultrasound investigations is frequent; more than 90% of the departments use blood tests, CA-125 being the most common. INTERPRETATION: There are large variations in follow-up procedures. Advantages and disadvantages with routine examinations are discussed. Most recurrences are detected when they cause symptoms, most often in the interval between visits, and their effect on survival is uncertain. The protocols applied seem to be in line with the pattern of recurrence. Controlled trials investigating alternative protocols in relation to sensitivity, survival, cost and quality of life are important, especially for patients for whom potentially curative treatment is available.

Female↗

[Intrathoracic goiter].

AIM: A goiter, situated partly or on completely in the thoracic cavity is usually referred to as intrathoracic goiter (ITG). However, inadequate definition of intrathoracic malpositions of thyroid gland caused usage of different classifications. This produced different and, often unclear criteria for the grouping of intrathoracic thyroid malpositions and, consequently, very different results and difficulties in any attempt of parallel review or analysis. The aim of this research was to analyze the ITG that include goiters with more than 80% of tissue in the thoracic cavity and intrathoracic thyroid choristomas, and to point out the diagnostic problems and surgical dilemmas. METHODS: Source of the used data were the studies published in the last 50 years in English, French, Italian, German and Russian language. Data have been integrated and combined for the detailed analysis, while quantitative synthesis was achieved by statistical analysis. RESULTS: ITG was represented in 1% of operatively treated thyroid diseases. One third of patients were asymptomatic. Commonly observed symptoms were dyspnea, stridor and dysphagia, and there was no significant difference in appearance of these symptoms between the two groups of ITG. Chest roentgenography and CT scan could provide the maximal information with no need for expensive procedures. Accuracy of scintigraphy in revealing and discerning of ITG is 70%, averagely. In 20% of patients correct preoperative diagnosis was not established. Therapy of choice in the treatment of ITG was surgical, even in asymptomatic cases. Thoracic approach was used in 95% of cases and there was no significant difference between the two groups of ITG. Total thyroidectomy or total lobectomy was definitely obligatory with contralateral subtotal lobectomy. There was no significant difference in the frequency of operative complications between ITG and non-ITG, and between the two groups of ITG. CONCLUSIONS: ITG is rare, but might present a difficult diagnostic and complex surgical problem. Common clinical presentation and identical surgical approach in operative treatment justify the common review of the two groups of ITG. With timely and adequately performed surgical approach, in specialized institutions, frequency of complications in operative treatment of ITG was not higher if compared to operative treatment of non-ITG.

Goiter, Substernal↗

Immunohistochemical study with antibody to glycoprotein GCDFP-15 for metastatic lung cancer from breast cancer.

Even when gross pathologic specimens are available, evaluation is always complicated due to the difficulty in distinguishing the pathologic diagnosis of an adenocarcinoma as a pulmonary metastasis of the breast or lung. In this paper, we describe the usefulness of a preoperative immunohistochemical study using gross cystic disease fluid protein-15 (GCDFP-15). A 50-year-old woman, who had undergone a right radical mastectomy due to an infiltrating ductal carcinoma 4 years previously, was admitted because of an abnormal shadow on chest roentgenography. A chest CT scan showed a nodule 20 mm in diameter with an irregular margin and vascular involvement in the S3 region of the right lung. Though the specimen from a percutaneous CT guided needle biopsy revealed characteristic pathologic findings of a primary lung adenocarcinoma under H.E. stain, which was recommended for lobar resection, we re-examined that specimen immunohistochemically, which disclosed that the tumor cells were negative for the antibody to pulmonary surfactant apoprotein and were positive for GCDFP-15 antibody. Therefore, the diagnosis of a metastatic breast carcinoma in the lung was established. Upon her request, a wedge resection of the right upper lobe including the tumor was performed under video-assisted thoracoscopic surgery (VATS). Her postoperative course was uneventful.

Apolipoproteins↗

[Carcinoma of the stomach - our experience with surgical treatment].

Carcinoma of the stomach is among the commonest malignancies of the gastrointestinal tract regardless of the permanent tendency of its diffusion to decrease, observed in the last 25-30 years. The readily accessible methods of diagnosing the disease contribute greatly to its early detection. However, owing to diverse causes, in over 70 per cent of cases the diagnosis is usually made as late as in the advanced III-IV stages. The latter circumstance preordains largely the unfavourable long-term results of the treatment undertaken where surgery plays a major role. It is the purpose of this study to analyze the surgical strategy and tactics currently used in the management of gastric carcinoma. Over a 5-year period (Jan 1995 through Dec 1999), in the Chair of General and Operative Surgery of the Medical University--Sofia a total of 184 gastric carcinoma patients, including 116 men (63.1%) and 68 women (36.9%) with age ranging from 23 to 80 years, undergo operation. Diagnosing is based on past history, physical, laboratory and x-ray data, but first and foremost on evidence from FGS and histological assessment of biopsy material (carried out in all patients). With a view to precise preoperative staging of the lesion, roentgenoscopy + roentgenography of lungs, USD and CAT of the abdominal organs are also done. The following intervention are performed: gastrectomy 18 (9.8%), upper pole resection 43 (23.4%), subtotal resection of stomach 4 (2.2%), prosthetic replacement of cardia 8 (4.3%), derivations 22 (11.9%), and explorative laparotomies. Combined subtotal gastric resections of gastrectomies are necessitated in 73 patients (39.7%) because of carcinomatous infiltration of contiguous organs and/or presence of liver metastases. Morbidity involves 29 patients (15.7%) with lethality amounting to 16 (8.7%). The long-term postoperative results are discussed under a separate heading. Operative treatment of gastric carcinoma patients is the only chance of survival. The scope of indication for more aggressive surgical interventions, including combined resections and gastrectomies, are broadened leading in turn to a considerable reduction of the proportion of explorative laparotomies.

Adult↗

[Ultrasound study in the evaluation of the knee joint in osteoarthrosis deformans].

The paper analyzes a group of 50 patients aged 25 to 55 years who had osteoarthrosis deformans of the knee joint. A control group comprised 10 healthy individuals of the same age. All the patients underwent routine roentgenography in 2 projections and ultrasonography of the knee joint by the procedure of L. Rubaltelli. The main criteria of sonographic destructive joint changes correlate with X-ray signs. The stage of the disease is defined by the magnitude of joint structural changes and by the sequence of their appearance, as shown by ultrasound study.

Adult↗

[Clinical features, diagnosis and surgical treatment of solitary air cysts of the lungs].

86 cases of solitary air cysts of the lung (6.83% of all maldevelopments) were analyzed. This maldevelopment of bronchial tree is found most often in men (10:7) and more often in the right lung than in the left (18:13). There were no clinical symptoms in 33 (38.37%) patients. Uncomplicated course of the disease was in 51 (59.3%) patients, the disease was complicated by infection in 28 (32.56%) patients. Solitary bronchial cysts were complicated by spontaneous pneumothorax in 8.14% cases, by hemoptysis--in 6.98%. Roentgenography of the chest thorax on two projections and tomography (including CT) are enough for diagnosis of solitary air bronchial cysts. Bronchoscopy, bronchography and APG are not much informative in diagnosis of cysts and should be used on special indications. Cystectomy or cystectomy with partial resection of lung tissue were performed in 67.14% patients with good results.

Adolescent↗

The detection of acute experimental osteomyelitis with 67Ga citrate scannings.

Foci of experimental septic osteomyelitis became radioactive after the intravenous injection of 67Ga citrate. With this method, bone infection can be detected much earlier than with roentgenography. Because of its short half-life, 67Ga may be a suitable isotope for the detection of clinical, primary osteomyelitis in its early stages.

Animals↗

A practical approach to the diagnosis of abdominal aortic aneurysms.

In this study 217 patients with proved abdominal aortic aneurysm were reviewed and the diagnostic accuracy of ultrasonography was assessed in comparison with physical examination, plain abdominal roentgenography, and aortography for the evaluation of patients with a suspected abdominal aortic aneurysm. Ultrasonography is most accurate in detecting an aneurysm and in defining the size of the aneurysm. Routine aortography to evaluate the renal and iliac artery is not justified in the preoperative evaluation of patients with an abdominal aneurysm since the renal artery infrequently is involved by the aneurysmal process (3.7 percent) and the surgical results are consistently successful in those patients with renal and/or iliac artery involvement. If preoperatively needed, the renal status can be evaluated accurately with an isotope renogram combined with photoscan of the kidney. A practical approach to the diagnosis of pulsatile abdominal masses is proposed.

Adult↗

[Diagnosis and treatment of Tietze's syndrome].

In this work an estimation of the current state of the problem of the Tietz syndrome incidence is given, and data on observation and treatment of 78 patients are reported. A scheme of etiopathogenesis is suggested. It is the authors' opinion that a tumorous neoplasm is nothing but a regenerate at the site of a microtrauma of the costal cartilage. The diagnosis of the Tietz syndrome is difficult, therefore, roentgenography and needle biopsy should be the principal adjuvant diagnostic methods along with the clinic.

Adolescent↗

[The collagen-apatite implant and repair of jaw bone tissue defects].

The calcified material (the collagen and calcium hydroxyphosphate--base material) has been used for the first time with a high degree of the structural integrability of components. This material has been obtained according to an unique technology. The material was implanted in 17 patients: after cystectomy--12, after root apex resection--5. The teeth which were in the defective region were preimmobilized by means of archbar structures. The material biotransformation was checked by scintigraphy, roentgenography. According to the obtained data forming of bone tissue was registered on day 20-21 after the operation, after 2-2.5 months this process ended.

Adult↗

Traumatic rupture of the diaphragm. Report of eleven cases.

Rupture of the diaphragm is an unusual injury following blunt abdominal trauma. Due to its rather discrete initial symptoms, the diaphragmatic rupture is frequently overlooked in the acute stage. Of 11 patients operated on, only four ruptures were detected in association with the accident. The clinical picture was dominated by the patient's other injuries. Symptoms referable to the diaphragmatic rupture were pain in the upper abdomen and dyspnoea, especially in the recumbent position. The diagnosis was usually established by serial chest roentgenography, in a few cases supplemented by barium contrast studies, angiography or air insufflation in the abdomen (pneumoperitoneum). In the initial phase, an elevated and paradoxically moving diaphragm was usually seen on the injured side. Later, hermiation of viscera into the chest ensued, causeing respiratory impairment and, in about half of the cases, also gastro-intestinal disturbances. Early operation is advised in all cases of diaphragmatic rupture. Late complications are then avoided and the repair is technically easier to perform. In the presence of associated intra-abdominal injuries, e.g. rupture of the spleen, an abdominal incision is preferred. In isolated diaphragmatic ruptures, particularly in the late phase, the operation is more easily carried out through a low thoracotomy. The diaphragmatic rupture should be repaired with interrupted non-absorbable sutures--otherwise a risk of recurrence exists.

Abdominal Injuries↗

Randomized sequential trial of parenteral nutrition in healing of colonic anastomoses in man.

Adults who underwent elective colonic resection with anastomosis for both benign and malignant disease were randomly assigned to control or treated groups. Treated patients received daily 50 ml/kg of amino acid solution containing either 10 or 25 g/dl glucose by central or peripheral vein plus 500 ml of commercial soybean emulsion for 24 hours before operation and for 5 consecutive days after. Patients in both groups were examined by roentgenography after a water-soluble contrast enema, between 10 and 14 days after operation, and the integrity of the anastomosis was assessed radiologically without knowledge of the treatment given. Results were assessed by sequential analysis. After 21 pairs of subjects were entered,a boundary was crossed making the area favourable to treatment inaccessible, and the trial was terminated. Forty-seven patients were included in the trial: there were four anastomotic leaks in 23 control subjects and eight leaks in 24 treated subjects. The authors conclude that intensive perioperative parenteral nutrition in patients who undergo routine elective colonic resection does not improve the rate of healing of colonic anastomoses.

Aged↗

Management of multiple level spondylolysis of the lumbar spine in young males: a report of six cases.

The most common procedure for surgical treatment of lumbar spondylolysis is intertransverse processes spinal arthrodesis with instrumentation. However, this procedure is associated with significant morbidity on long-term follow up. Direct repair of spondylolysis is an alternative method for preservation of motion segment and anatomic continuity in young adults with multiple level spondylolysis. From 1992 through 1998, six soldiers with a diagnosis of multiple level spondylolysis who complained of persistent low back pain were treated in our hospital. Spondylolysis involved two levels in five cases and three levels in one case. All patients underwent serial roentgenography of the lumbar spine and a staged pars interarticularis infiltration test with bupivacain 0.5%. Five patients underwent direct repair of the pars interarticularis defects with hook screws, translaminar screws, and bone graft, while one patient received conservative treatment. All surgically treated patients had either good or excellent results at a mean of 34.4 months follow-up. One patient who was treated nonsurgically still complained of sport restriction at 16 months follow-up. Direct repair of multiple pars interarticularis defects after a positive staged pars infiltration test can restore anatomic stability, relieve back pain, and preserve a greater range of motion of the lumbar spine in young patients with intact disc height.

Adult↗

An Australian perspective on chiropractic spinography.

Daniel David Palmer and Wilhelm Conrad Roentgen were born in the same year, and each of them, at the age of fifty, made the discovery for which he came to be best known. Both of them built upon earlier theories and discoveries. Roentgen's discovery, x-ray, was to become an indispensable diagnostic tool for the profession which grew out of Palmer's discovery, chiropractic. This paper traces some of the developments which led to the discovery of x-ray, early milestones in applied radiography, and the emergence of spinography in chiropractic. Special emphasis is given to chiropractic innovations in roentgenography and the use of spinography by chiropractors practising in Australia.

Australia↗

Stress fracture of the proximal tibia after total knee arthroplasty: a case report.

Stress fracture of the proximal tibia after total knee arthroplasty (TKA) is very rare. We found only 16 cases in a review of the literature. We report the case of a 76-year-old obese woman who sustained a stress fracture of the right proximal tibia without trauma 18 months after TKA. Pain developed in the proximal medial aspect of the tibia during walking. Physical examination showed tenderness of the proximal medial aspect of the tibia and varus deformity of 15 degrees during stress test of the knee. Roentgenography 4 weeks after symptom onset showed an obvious stress fracture line. Treatment with bed rest and above-the-knee plaster cast immobilization for 8 weeks was successful. The causes of this rare complication may include increased level of activity after TKA, generalized osteoporosis, and varus deformity of the knee.

Aged↗

[The effect of local growth in long bones following two different epiphyseal-stimulating procedures: an experimental study].

OBJECTIVE: To study the effect of local growth in long bones of the rabbits following two different epiphyseal-stimulating procedures. METHODS: These were osteotomy in the metaphysis near the proximal tibial epiphyseal plate and hemicirecumferential periosteal excision on the proximal tibial epiphysis. Tibia roentgenography, tetracycline labelling, histological method and electron microscopy were used. RESULTS: The local stimulating effect following hemi-circumferential periosteal excision was more evident than following osteotomy. CONCLUSION: The procedure of periosteal excision could be good for the treatment of children knee' deformity.

Animals↗

Nerve conduction studies of lower extremities in pes planus subjects.

Pes planus is a condition in which the medial longitudinal arch is depressed. Pedoscop, eyeball visualization, ink mat and roentgenography were used in clinical evaluation. We performed nerve conduction studies on both feet of 28 pes planus subjects. Our results demonstrated mild prolongation distal latency of the medial and lateral plantar sensory nerves, and delayed sensory conduction velocity of the medial plantar sensory nerve. The presence of electrodiagnostic abnormalities in this study population helps to substantiate the presence of compression neuropathy of the medial or lateral plantar nerve in pes planus subjects.

Adolescent↗

[Reconstruction of the vas deferens: an experimental study on the rat].

BACKGROUND: A microsurgical technique for reconstruction of the vas deferens on an absorbable transanastomotic stent in the rat is described. METHODS: A microsurgical end-to-end anastomosis of the vas deferens was performed in a group of 10 rats (group A) by suturing with Nylon 10-0 interrupted stitches. In another 10 rats (group B) the same microsurgical anastomosis was performed after insertion of a 0.5 cm long intraluminal chromic catgut 4.0 stent. RESULTS: Sixty days postoperatively all 20 animals were submitted to roentgenography of the vas deferens. The vas deferens proved radiographically undetectable in 8/10 rats in the unstented group A (80%), whereas the entire course of the vas could be traced in 9/10 rats in group B (90%). CONCLUSIONS: The encouraging results obtained with this alternative technique, even on structures of limited diameter, suggests that it may be possible to use this procedure in children.

Animals↗