[Root canal treatment as a biological problem].
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The function of intradental sensory receptors is strongly affected by activation of the sympathetic nerves. This effect is most probably indirect and due to changes in pulpal blood flow. Also, in inflamed teeth the sensitivity changes of pulp nerves seem to be closely related to changes in the blood flow. Such inflammatory mediators as histamine, bradykinin and serotonin affect the sensitivity of intradental receptors in pulpal inflammation. In addition, many neuropeptides, for example substance P (SP) and calcitonin gene-related peptide (CGRP), seem to be involved and may interact with histamine or bradykinin. Recent studies indicate that intradental nerves with their neuropeptides may play a significant role in the inflammatory and defence reactions of the dental pulp.
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Clinical and histopathological examinations of 85 deciduous molars from children aged between 2.5 and 8 years show considerable disagreement between the microscopical picture and the clinical diagnosis according to the classification of WILGA. This calls in question the appropriateness of the histopathological classification for clinical diagnosis. For this reason, the present study was undertaken to elaborate a new classification of pulpal affections in the deciduous dentition with special regard to the various clinical pictures.
Clinical and pathomorphological studies of various pulpal affections in 55 deciduous molars from children aged between 2.5 and 8 years call in question the clinical appropriateness of the current classification of pulpal affections that makes use of the pathohistological nomenclautre. In this paper, a classification is suggested that is based on clinical symptoms and allows for current methods of therapy.
In experiments performed on green monkeys the molar pulp response to direct coating with calmecin and polycarboxylate cement saturated with the potassium nitric solution. Compared, the results of morphological pulp investigation showed the polycarboxylate cement with saturated potassium nitrate solution coating to be most effective. It had a rather good odontotropic effect and increased the protective action of the pulp. Polycarboxylate cement with saturated potassium nitrate solution coating is recommended for clinical trials to treat occasional pulp denudation.
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Experimental cavities were prepared in forty-six clinically intact premolars of young individuals to evaluate the biologic effects of 50 per cent phosphoric acid etchant containing 7 percent zinc oxide by weight. The experimental periods ranged from 30 minutes to 150 days. The remaining dentin thickness varied from 1.8 to 3.5 mm. The teeth treated with the acid showed no more than a moderate pulpal response at the varying time periods. All of the acid-treated teeth demonstrated pulpal imflammation in the absence of clinical pain. Acid etchants should not be used on exposed or unprotected dentin surfaces.
The results of clinical experimental with a new antibiotic, Miocamycin (Macroral Zambeletti), are reported. 300 patients suffering from the most varied infections of the oral cavity were treated. In view of its utility and the lack of side-effects, it is concluded that this antibiotic may be used with peace of mind in odontostomatological pathology.
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