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PubMed1990

Stimulatory effect of some therapeutic drugs used for improving cerebral insufficiency on gastric acid secretion in rats.

Baclofen, gamma-amino-beta-hydroxybutyric acid (GABOB), calcium hopantenate (HOPA) and citicoline, which are clinically used for improving cerebral insufficiency, were tested for their effects on gastric acid secretion in the perfused stomach of urethane-anesthetized rats. These drugs were administered intravenously or subcutaneously. They produced a significant increase in gastric acid secretion, although the extents in increase were different. The duration of action was 1-2 h. The potency order was baclofen greater than GABOB greater than or equal to citicoline greater than or equal to HOPA. The stimulatory response to each drug was completely inhibited by atropine. In contrast, the peripheral secretory activity of each drug was not demonstrated in the isolated lumen-perfused stomach of mice. These results indicate that all the tested drugs produce an increase in gastric acid secretion probably via central cholinergic activation and that gastric acid stimulation by compounds improving the cerebral insufficiency might be included in side effects in their clinical use.

Animals↗
PubMed2000

In vitro infection of Cryptosporidium parvum to four different cell lines.

To determine a suitable condition for in vitro infection model of Cryptosporidium parvum, four different cell lines, AGS, MDCK, HCT-8 and Caco-2, were used as host cell lines which were cultured at various concentrations of added supplements. These supplement include fetal bovine serum (FBS), sodium choleate, ascorbic acid, folic acid, calcium pantothenate, para-aminobenzoic acid and pyruvate and their effects on the cell lines which were infected with C. parvum were evaluated. The results of this study showed that the AGS cell line was most susceptible to C. parvum whereas the Caco-2 cells appeared to be least susceptible to C. parvum. In regards to the serum condition, 10% FBS was suitable for the growth of AGS and HCT-8 cells, and 1% FBS was good for the growth of the MDCK cells when they were inoculated with C. parvum. Vitamins had a positive effect on the AGS cells, and pyruvate also showed positive effects on all of the cell lines except for Caco-2. Modified medium for each cell line was prepared by adding appropriate amounts of each supplement which resulted in the highest parasite infection number. Modified media increased the number of parasites infected on AGS cells to 2.3-fold higher when compared to the control media. In this study, we found that the AGS cell line was a suitable host model for evaluating C. parvum in vitro study and the media contents for the optimal infection conditions were suggested.

Animals↗