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PubMed1978

[Intestinal absorption in the short-bowel syndrome].

An extreme diminution of the absorption surface by resection or exclusion of the small intestine leads to the clinical picture of the short-intestine-syndrome. The absorption effect of the proximal small intestine can be exactly established with the help of the modified D-xylose-test. On the basis of three typical examples the high evidence of this functional test can be demonstrated. The pathophysiological principles of the intestinal adaptation after by-pass-operations and resections of the small intestine are discussed.

Crohn Disease↗
PubMed1977

Intestinal absorptive and digestive function in pernicious anemia.

We examined the digestive and absorptive function of the small intestinal mucosa in three patients with pernicious anemia to determine the functional correlates of the morphologic changes previously described. Digestive brush border enzymes (disaccharidases and leucyl-naphthylamidase) in jejunal biopsy specimens from the patients followed a normal distribution compared with those in the control group. With the exception of one patient with mild steatorrhea, the rest of the absorption test results were within the normal range. Jejunal perfusion studies, however, with glucose, sodium and water showed intestinal secretion of sodium and water, i.e., net movement of sodium and water from plasma to lumen, in the presence of normal glucose absorption. Follow-up studies in two patients after treatment with vitamin B12 did not reveal any significant improvement in the absorption rates from the pretreatment period. This abnormality of sodium and water transport in pernicious anemia represents another intestinal defect of a systemic disease which is not corrected by vitamin B12 replacement therapy.

Anemia, Pernicious↗