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Effects of feeding an elemental diet during abdominal irradiation.

Rats fed with normal laboratory feed or elemental diet 3200-BD (Mead Johnson) were administered fractions of 240 rd (-60Co gamma-radiation) abdominally. Consumption of food and its nutrition efficiency were the parameters studied. Anorexia occurred rapidly following only one fraction of 240 rd and was unaffected by the feeding of the diet. Animals fed the latter, however, recovered normal appetite much faster upon completion of abdominal irradiation than those fed normally. While nutritional efficiency of the diet was smaller than that of normal feed with the controls, the opposite was obtained with irradiated animals.

Abdomen↗

Pattern of aganglionic megacolon in Calabar, Nigeria.

Hirschsprung's disease, a congenital condition resulting in functional intestinal obstruction, was seen in 21 children at the University of Calabar Teaching Hospital (UCTH) between January 1996 and December 1998. Late presentation of patients to hospital was observed and was attributed to ignorance and poverty. Patients presented only when repeated herbal enemas no longer offered relief. The main complaints were abdominal distension, constipation, wasting, diarrhoea and growth retardation. Surgical resection of the aganglionic segment and anastomosis is the treatment of choice and this procedure decreases mortality and morbidity. Palliative transverse colostomy was considered essential as it protects the anastomosis. Early diagnosis of this disease in our environment can only be achieved by means of a public awareness campaign. This will prevent many of the fatal complications associated with this condition.

Adolescent↗

[Mitochondrial abnormalities and ocular myopathies with downward-spreading evolution. Apropos of 2 new cases].

Two cases, one being probably familial, of ocular myopathy are reported. In both the onset was in childhood by ptosis of the eyelids and the course lasted more than 20 years. The patients (32 and 49 years) presented involvement of the ocular muscles as well as of the facial, pharyngolaryngeal, neck and limb muscles. There was, in both cases, marked body weight loss which could not be explained by the muscular atrophy alone, and a thyroid nodule which was not accompanied by evident change in thyroid function. Muscle biopsy studies were carried out : electron microscopy showed in both cases aggregates of mitochondria exhibiting various changes ; in one case histochemistry demonstrated that these changes were confined to type 1 muscle fibres. These cases of descending ocular myopathy can be included therefore in the group of the smaller than myopathies with abnormal mitochondria greater than.

Adenoma↗

Anorexia nervosa.

Anorexia nervosa occurs predominantly in white, middle-class, adolescent females with perfectionistic tendencies. Their solution to the intense guilt induced by any sensory pleasure is to deny themselves the pleasure of eating. Amenorrhea is universal. Diagnostic criteria include a 25 percent weight loss. Therapies are long and involved different approaches. All recognize that food is the medicine for the body and that some form of supportive psychotherapy is the medicine for the mind.

Adolescent↗

Gelatinous transformation of bone marrow.

Gelatinous transformation of bone marrow is usually encountered in patients of anorexia nervosa. We report two cases of gelatinous transformation of the marrow, one without any detectable cause and the other associated with visceral leishmaniasis.

Aged↗

[A case of severe juvenile pulmonary tuberculosis associated with malnutrition in special reference to nutritional assessment].

We reported a case who had suffered from severe pulmonary tuberculosis in association with severe malnutrition. A 19-year-old man was admitted complaining of high fever, productive cough and body weight loss. Before admission, he worked as a cook for long hours a day and had meals irregularly. On admission, he was cachexic. Coarse crackles were auscultated on the both lung field, and the liver was enlarged. Chest X-ray revealed multiple ringed and mottled shadows mainly in bilateral upper and middle lung field. Laboratory examination revealed inflammatory reaction defined by an increase of white blood cells, accelerated erythrocyte sedimentation rate and positive CRP, impairment of liver function and cell-mediated immunity, hypoxemia and restrictive lung dysfunction. Ziehl-Neelsen stain of sputum showed a large number of acid fast bacilli. The assessment of his nutritional status showed decrease in anthropometric measurements, visceral proteins and the Fischer ratio, which suggested that he was in the status of protein-calorie malnutrition in association with amino acid imbalance. He was treated with nutritional therapy in addition to antituberculous drugs, which improved his clinical symptoms, laboratory data and nutritional assessment. These results suggested the importance of nutritional assessment and nutritional therapy based on it.

Adult↗