Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Data Science”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,441 records · Page 80Linked to original sources

The impact of landsat satellite monitoring on conservation biology.

Landsat 7's recent malfunctioning will result in significant gaps in long-term satellite monitoring of Earth, affecting not only the research of the Earth science community but also conservation users of these data. To determine whether or how important Landsat monitoring is for conservation and natural resource management, we reviewed the Landsat program's history with special emphasis on the development of user groups. We also conducted a bibliographic search to determine the extent to which conservation research has been based on Landsat data. Conservation biologists were not an early user group of Landsat data because a) biologists lacked technical capacity--computers and software--to analyze these data; b) Landsat's 1980s commercialization rendered images too costly for biologists' budgets; and c) the broad-scale disciplines of conservation biology and landscape ecology did not develop until the mid-to-late 1980s. All these conditions had changed by the 1990s and Landsat imagery became an important tool for conservation biology. Satellite monitoring and Landsat continuity are mandated by the Land Remote Sensing Act of 1992. This legislation leaves open commercial options. However, past experiments with commercial operations were neither viable nor economical, and severely reduced the quality of monitoring, archiving and data access for academia and the public. Future satellite monitoring programs are essential for conservation and natural resource management, must provide continuity with Landsat, and should be government operated.

Biology↗

Overactive bladder in the male patient: epidemiology, etiology, evaluation, and treatment.

The urologist's approach to the diagnosis and treatment of lower urinary tract symptoms (LUTS) in male patients has changed significantly over the past decade. Advances in the basic science arena combined with a wealth of clinical data have pointed to the importance of bladder pathophysiology in the development of urinary symptoms. Historically, men with LUTS were diagnosed with "prostatism," an all-encompassing term that includes both voiding and storage symptoms that may or may not be related to prostatic obstruction. Parallel to the scientific advances in the field, the urologic lexicon began to evolve and has allowed us to more specifically describe, and therefore investigate and treat, different aspects of male LUTS. It is now well recognized that many men suffer from storage symptoms that may be more related to bladder dysfunction than to prostatic obstruction. It will be critical to integrate our knowledge of prostatic growth and obstruction, the bladder response to outlet obstruction, environmental and lifestyle factors, and age-related changes to fully understand the complex pathophysiology of male LUTS, specifically overactive bladder syndrome.

Algorithms↗

Toxicological information series, I. Toxicological information.

This paper presents a brief history of the evolution of toxicological information in the United States since 1966 when concern over the hazards of the ubiquitous chemicals in the environment was translated into recommendations for action by The Panel on the Handling of Toxicological Information of the President's Science Advisory Committee. It describes some of the data bases that were developed as a result of these recommendations and introduces a series of papers that discuss toxicology information resources, their content, and their accessibility. The series is a project of the Information Handling Committee of the Society of Toxicology. Papers II-V of this series will be published in subsequent issues of Fundamental and Applied Toxicology.

Information Services↗

Critical insights on the application of the theory of planned behaviour to food handlers' food safety practices.

Foodborne diseases remain a significant public health concern, often linked to unsafe food-handling practices. The Theory of Planned Behaviour (TPB) is widely used to predict and explain food safety behaviours, yet its application in this field has not been systematically and in-depth evaluated. This review evaluated how the TPB has been applied to study food handlers' behaviour, focusing on methodological approaches, use of the TACT (Target, Action, Context, and Time) framework, validity, elicitation studies, and reliability. Seventeen studies were included following a systematic search of four databases (Scopus, Web of Science, Wiley Online Library, and Taylor & Francis Online). Data were extracted on behaviour definition, aim of study, main findings, use of indirect and direct TPB measures, use of elicitation studies, internal consistency, content validation, analytical methods used, and any extensions to the original TPB framework. Key elements related to adherence to core TPB principles and measurement practices were extracted using a Checklist. Most studies used direct measures of TPB constructs, and only a few reported procedures for content validation. Considerable variability was found in the reporting of key measurement and psychometric practices. Five studies fully applied the TACT framework, while nine incorporated additional factors such as knowledge and moral norms. Elicitation studies were conducted in five cases where indirect measures were employed. Analytical approaches were mainly based on multiple linear regression, with limited use of more advanced techniques such as structural equation modeling. Twelve studies reported internal consistency results. Overall, the review highlights opportunities to strengthen methodological practices in future TPB research on food safety. Greater attention to conducting and reporting content validation, full application of the TACT framework, reporting of internal consistency, and consistent inclusion of elicitation studies when using indirect measures may enhance transparency, reinforcing the credibility and trustworthiness of research findings. A major methodological limitation of this review was that screening and data extraction were conducted by a single reviewer and no formal quality or risk-of-bias assessment of the included studies was performed. Despite these limitations, the findings provide practical guidance for the development and validation of TPB-based questionnaires and may support more robust food safety research, interventions, and policy initiatives aimed at improving food handlers' practices.

Humans↗

The biomechanical and clinical significance of the lumbar erector spinae flexion-relaxation phenomenon: a review of literature.

OBJECTIVES: The aim of this study was to review the biomedical literature to ascertain the biomechanical and clinical significance of the lumbar erector spinae flexion-relaxation phenomenon (FRP). DATA SOURCES: Index Medicus via PubMed, the Noble Science Library's e-journal archives, and the Manual Alternative and Natural Therapy Index System databases were searched using the same search terms. DISCUSSION: The presence of the FRP during trunk flexion represents myoelectric silence consistent with increased load sharing of the posterior discoligamentous passive structures. Passive contributions from erector spinae stretching during the flexion posture and active contributions from other muscles (quadratus lumborum and deep erector spinae among others) further assist in load sharing in the trunk flexion posture. A number of studies have shown differences in the FRP between patients with chronic low back pain and healthy individuals, and the reliability of the assessment. Persistent activation of the lumbar erector spinae musculature among patients with back pain may represent the body's attempt to stabilize injured or diseased spinal structures via reflexogenic ligamentomuscular activation thereby protecting them from further injury and avoiding pain. CONCLUSIONS: The myoelectric silencing of the erector spinae muscles in the trunk flexion posture is indicative of increased load sharing on passive structures, which tissues have been found to fail under excessive loading conditions and shown to be a source of low back pain. The studies that show differences in the presence of the FRP among patients and control subjects are encouraging for this type of clinical assessment and suggest that assessment of the FRP is a valuable objective clinical tool to aid in the diagnosis and treatment of patients with low back pain.

Biomechanical Phenomena↗

Stakeholder position paper: pork producer perspective on antibiotic use data.

Modern pork production uses a variety of tools to ensure the health, welfare and productivity of pigs. Therapeutic (treatment and prevention of disease) use and use for enhancing growth and feed efficiency (growth promotion) are the two options for use on the farm. Collecting meaningful and accurate antibiotic use data faces significant challenge because of the number and variety of production systems, the need for broad stakeholder analysis of the data and the lack of consistent and science-based definitions of antibiotic use categories. The National Animal Health Monitoring System (NAHMS) is one mechanism that estimates uses based on a statistical sample of the nation's swine herd. If, based on sound science, additional information on antibiotic use is considered necessary, stakeholders should discuss the best implementation strategies to achieve the desired result. Producers continue in their science-based commitment to ensure the safety of pork and to maintain consumer confidence.

Animals↗

On the energy dissipation in a tank-treading human red blood cell.

The energy dissipation in the membrane (ED mem) and in the cytoplasm (ED cyt) of tank-treading human red blood cells is estimated. The tank-tread motion of the membrane occurs when the cells in a sheared suspension assume a steady-state of orientation (Fischer et al., 1978, Science [Wash. D. C.], 202:894). The kinematic data used are from red cells suspended either in a dextran-saline solution at a low hematocrit, or in plasma at a hematocrit of 45%. The viscosities of the cytoplasm and the membrane are taken from the literature. The cell in dextran was subjected to seven different shear rates. Both ED mem and ED cyt showed a strong increase with shear rate. Their ratio, however, was always of the order of 1. From this value and the value which was given by Hochmuth et al. (1979, Biophys. J., 26:101) for a shape recovery of a red cell, it is concluded that the range of ED mem/ED cyt for all possible geometries is 1-100.

Energy Transfer↗

Adherence to HIV combination therapy.

The emergence of drug-resistant strains of HIV virus and treatment failure can result from non-adherence to antiretroviral therapy. While non-adherence to therapy is not a new issue or specific to HIV/AIDS, it has received renewed attention because of the complicated combination treatment regimens being prescribed. This paper reviews the relevant background literature on the contributions of social and behavioural science to non-adherence to HIV medications. Data indicating problems with adherence prior to combination therapy are reported. Despite limitations, even self-report assessments have already succeeded in showing that adherence to combination therapy is significantly related to HIV viral load. Recent research data are discussed. Implications of findings for counselling patients to increase their adherence are presented.

Anti-HIV Agents↗

Views of physicians in training on the ethical and legal issues in preliminary reporting of echocardiographic data.

Cardiac sonographers may be pressured by physicians into giving diagnostic interpretations of echocardiographic data. This study investigated the issue of preliminary reporting of echocardiographic data. A questionnaire was sent to 292 physicians; 85 physicians (29%) responded. Seventy-two physicians (87%) thought they had more than a minimal knowledge of echocardiography, 94% wanted a written or verbal preliminary report, and 84% thought that giving a preliminary report should be part of the cardiac sonographer's job. If abnormalities were found, 80% wanted the results before a cardiologist reviewed the study, and 56% would want a diagnostic rather than a descriptive report. Fifty-four physicians (64%) would pressure the cardiac sonographer into giving a preliminary echocardiographic report and would use this information to manage the patient. The majority of the physicians thought that it is legal for the cardiac sonographer to give a preliminary echocardiogram report. Eighty percent said that the cardiac sonographer would not be "practicing medicine without a license," and 82% that the sonographer would not be "aiding and abetting the unauthorized practice of medicine." This data would indicate that physicians at Oregon Health Sciences University want the cardiac sonographer to give preliminary echocardiographic results, even though the sonographer may be breaking state statutes.

Adult↗

PEG-covered lipid surfaces: bilayers and monolayers.

In this review paper we survey the ways in which various micropipet techniques have been used to study the mechanochemical and interactive features of lipid bilayer vesicles and monolayer-coated gas bubbles. Special emphasis will be made on characterizing the barrier properties of grafted PEG layers and how a hierarchical approach that uses a short barrier and extended ligand allows us to start to mimic nature's own solution to the problem of ubiquitous repulsion and specific attraction. The information gained from such studies not only characterizes the membrane and other lipid surfaces and their intersurface interactions from a fundamental materials science perspective, but also provides essential materials property data that are required for the successful design and deployment of lipid-based carriers and other capsules in applications involving this so-called 'stealthy' surface.

Journal Article↗

Regulation of cytosolic guanylyl cyclase by nitric oxide: the NO-cyclic GMP signal transduction system.

The understanding of guanylyl cyclase regulation by nitrovasodilators has provided a great deal of information explaining the mechanisms of action of these cardiovascular drugs that have been in clinical use for the past century. The biochemical characterization of guanylyl cyclases and their regulation by NO have also permitted us, and others, to understand the mechanism of action of endothelium-dependent vasodilators and, subsequently, the roles for the nitric oxide-cyclic GMP signal transduction system in numerous cells and tissues. The potential importance of this signal transduction cascade is probably not fully appreciated since numerous additional studies obviously need to be performed. Also, as in many areas of science, serendipitous experiments and observations have added critical data to our present understanding in this field.

Animals↗

Profiling 627 mitochondrial nucleotides via the analysis of a 23-plex polymerase chain reaction by liquid chromatography-electrospray ionization time-of-flight mass spectrometry.

We present a rapid and informative mitochondrial DNA profiling system, which has high forensic impact. The assay is based on the analysis of a 23-plex PCR by ion-pair reversed-phase high-performance liquid chromatography online hyphenated to electrospray ionization time-of-flight mass spectrometry (ICEMS). In a single 25-min run, an overall number of 627 nucleotide positions were screened. The vast majority of observed sequence variations were explainable by alterations of the allelic states of the 23 target SNPs, which were selected on their ability to increase forensic discrimination within West Eurasian populations. Within an Austrian population sample comprising 90 unrelated men, 14 different, nontarget SNP-related sequence variations--13 base substitutions and 1 deletion--were detected by ICEMS and confirmed by sequencing. All amplified sequences were located outside of the routinely sequenced hypervariable segments (HVS-I and HVS-II) of the noncoding control region. Accordingly, the genetic information obtained by the 23-plex PCR-ICEMS assay could be combined with HVS-I/HVS-II sequencing results to one highly discriminating mtDNA profile, which covered approximately 7.5% of the total mtDNA genome. With the 23-plex PCR-ICEMS assay, DNA mixtures were detected and the allelic ratios were accurately quantified. The observed robustness and sensitivity underlined the practical applicability of the assay in forensic science, which was proven by typing eight representative casework samples.

Alleles↗

Control of ethylene epoxidation selectivity by surface oxametallacycles.

Surface science experiments, DFT calculations, and kinetic isotope effect data are utilized to understand the elementary steps that govern the selectivity of silver catalysts for the partial oxidation of ethylene to produce ethylene oxide. It is proposed that selective and unselective pathways proceed via a common intermediate, the surface oxametallacycle. The structures of the transition states leading from this intermediate to selective and unselective products are calculated. From the calculated Gibbs free energies of activation for competing pathways, it is possible to predict selectivity to ethylene oxide as well as the magnitude of the kinetic isotope effect. The proposed mechanism is qualitatively and quantitatively in accord with experimental results.

Journal Article↗

Medical curricula in China and the USA: a comparative study.

To examine the differences between the content of curriculum of medical schools in China and the USA the authors compared the curricula of 82 Chinese and 125 American medical colleges. Great disparities were found in the framework of medical curricula, processes of teaching learning, types and numbers of preclinical courses, course hours, laboratory and practical training hours, and key disciplines of clinical practice. A significant difference was also found in the number of courses, lectures and laboratory and clerkship hours among Chinese medical colleges. The authors conclude that medical colleges in China should look again at the type of courses offered, revise curricular frameworks and reform the teaching learning process and approaches. New courses should be introduced, new content should be added to existing courses, and appropriate importance should be attached to clinical practice of subjects such as family and community medicine. To improve the quality of medical education, Chinese medical colleges need national medical education standards compatible with international standards.

Biological Science Disciplines↗

The 30 nm chromatin fiber as a flexible polymer.

Our analysis of the data of van den Engh, Sachs, and Trask (Science 257, 1410 (1992)), for the dependence of the mean square distance between pairs of hybridization sites (< L2n >, micron 2) on the known genomic distance (n, bp) separating these sites on chromosome number 4 in G1 human fibroblast nuclei, shows that < L2n > is proportional to n2v with v = 3/5 for n < 1 Mbp. The v-value of 3/5 is characteristic of flexible polymer chains with excluded volume effects in dilute good solutions. Since the DNA concentration in nuclei is very high (ca. 1-10 mg/ml), and theory (Flory, J. Chem. Phys. 17, 303, 1949) predicts v = 1/2 for overlapping polymers, the finding of v = 3/5 means that the chromatin fibers do not overlap in interphase nuclei. The dependence of < L2n > on n for n < 4 Mbp is consistent with the model of large (approximately 6 Mbp, 3 microns diameter) loops of interphase chromatin attached to nuclear membrane sites. Using the constant (e.g., Widom, Ann. Rev. Biophys. Biophys. Chem. 18, 365 (1989)) and variable (Williams & Langmore, Biophys. J. 59, 606 (1991)) diameter fiber models, the Kuhn statistical segment of the 30 nm chromatin fiber was estimated to have a length of 196-272 nm with a corresponding DNA content of 21-37 kbp.(ABSTRACT TRUNCATED AT 250 WORDS)

Biopolymers↗

Monoglycerides in membrane systems.

Monoglycerides are used abundantly in food systems, ingested and produced in vivo, and recognized as significant mediators in many biochemical processes, yet their function in various membrane systems is only understood at a hypothetical level. This paper provides a comprehensive review of the effects of monoglycerides in membrane systems from three diverse disciplines: nutrition, food science, and membrane biochemistry. An analysis of the data ranging from feeding studies to physical chemistry is given, detailing the role of these common molecules in biological membranes.

Chylomicrons↗